PDB ID Ligands Nucleotide Neck-Linker Reference 1RY6 SO4 NA A

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PDB ID
Ligands
Nucleotide
Neck-Linker
Reference
1RY6
2ZFM
1BG2
1CZ7
1F9V
1F9W
1GOJ
1I6I
1IA0
1II6
1MKJ
1N6M
1Q0B
SO4
ADP
ACT, ADP, MG
ADP, MG
ADP, MG
ADP, MG
ADP, MG
ACP, MG, TRS
GTP, GDP, TXL, ACP, MG
ADP, MG, NO3
ADP, MG, SO4
ADP, MG
ADP, MG, NAT
NA
DP
DP
DP
DP
DP
DP
TP
TP
DP
DP
DP
DP
Shipley et al. Embo J. (2004)
Nitta et al. Nat.Struct.Mol.Biol. (2008)
Kull et al. Nature (1996)
Kozielski et al. Structure Fold.Des. (1999)
Yun et al. EMBO J. (2001)
Yun et al. EMBO J. (2001)
Song et al. Embo J. (2001)
Kikkawa et al. Nature (2001)
Kikkawa et al. Nature (2001)
Turner et al. J.Biol.Chem. (2001)
Sindelar et al. Nat.Struct.Mol.Biol. (2002)
Yun et al. EMBO J. (2003)
Yan et al. J.Mol.Biol. (2004)
1SDM
1T5C
1VFV
1VFW
1VFX
1VFZ
1X88
1YRS
2FKY
2FL2
2FL6
2FME
2G1Q
2GM1
ADP, MG
ADP, MG, NO3, PIN
ANP, MG
ANP, MG
ADP, AF3, MG, TRS
ADP, MG, VO4
ADP, MG, NAT
ADP, L47, MG
ADP, MG, N2T
ADP, MG, N4T
ADP, MG, N5T
3QC, ADP, MG
ADP, MG, N9H
2AZ, ADP, MG
DP
DP
TP
TP
DP TP
DP TP
DP
DP
DP
DP
DP
DP
DP
DP
2H58
2HXF
2IEH
2KIN
2NCD
2P4N
ADP, MG, UNX
GTP, MG, GDP, TA1, ANP
ADP, CL, K, MG, MOY, PG4
ADP, SO4,
ADP, SO4
MG, ZN, GDP, GTP,
TA1, ADP
DP
TP
DP
DP
DP
DP
A
A
A
A
A
A
PD
A
A
U
FD
A
Chain A: PD,
Chain B: A
FD
FD
FD
FD
A
A
PD
A
A
A
A
A
A
Chains: A-C-D PD,
Chain B: A
A
FD
PD
FD
A
A
Vinogradova et al. J.Biol.Chem. (2004)
Garcia-Saez et al. J.Mol.Biol. (2004)
Nitta et al. Science (2004)
Nitta et al. Science (2004)
Nitta et al. Science (2004)
Nitta et al. Science (2004)
Maliga et al. TO BE PUBLISHED (NA)
Cox et al. BIOORG.MED.CHEM.LETT. (2005)
Fraley et al. Bioorg.Med.Chem.Lett. (2006)
Fraley et al. Bioorg.Med.Chem.Lett. (2006)
Fraley et al. Bioorg.Med.Chem.Lett. (2006)
Tarby et al. Bioorg.Med.Chem.Lett. (2006)
Cox et al. Bioorg.Med.Chem.Lett. (2006)
Kim et al. Bioorg.Med.Chem.Lett. (2006)
Wang et al. To be Published (NA)
Kikkawa et al. Embo J. (2006)
Garcia-Saez et al. J.Biol.Chem. (2007)
Sack et al. Biochemistry (1997)
Sablin et al. Nature (1998)
Sindelar et al. J.Cell Biol. (2007)
2PG2
2Q2Y
2Q2Z
2REP
2UYI
2UYM
2VVG
2WBE
2WOG
ADP, K01, MG
ADP, MG, MKR
ADP, MG, MKK
ADP, MG, UNX
ADP, K02, MG
ADP, K03, MG
ADP, MG
MG, GDP, TA1, ANP, GTP
ADP, MG, ZZD
DP
DP
DP
DP
DP
DP
DP
TP
DP
A
A
A
A
A
A
FD
FD
Chains A-B: PD,
Chain C: U
Pinkerton et al. Bioorg.Med.Chem.Lett. (2007)
Roecker et al. Bioorg.Med.Chem.Lett. (2007)
Roecker et al. Bioorg.Med.Chem.Lett. (2007)
Zhu et al. To be Published (NA)
Pinkerton et al. Bioorg.Med.Chem.Lett. (2007)
Pinkerton et al. Bioorg.Med.Chem.Lett. (2007)
Hoeng et al. Mol.Biol.Cell (2008)
Bodey et al. J.Mol.Biol. (2009)
Kaan et al. Biochem.J. (2010)
2X2R
ADP, MG, X2O
DP
Kaan et al. J.Med.Chem. (2011)
2X7C
2X7D
2X7E
2XAE
ADP, KZ9, MG
ADP, EGB, MG
ADP, MG, X7E
2XA, ADP, CL, MG, SO4
DP
DP
DP
DP
2XT3
2Y5W
2Y65
3B6U
3CJO
3CNZ
3COB
3DC4
3DCB
3DCO
DP
DP
DP
DP
DP
DP
DP
DP
TP
DP
3GBJ
3H4S
ADP, MG
ADP, MG
ADP, MG,
ADP, MG, UNX
ADP, K30, MG
ADP, MG
ADP, MG
ADP, MG
ANP, MG
MG, ZN, GDP, GTP,
TA1, ADP
ADP, MG, UNX
ADP, MG, CA
Chain A: PD,
Chain B: A, Chain C:
U
PD
PD
PD
Chains A-B: PD,
Chain C: U
A
FD
FD
FD
A
FD
FD
A
A
A
DP
DP
A
U
3HQD
3K3B
3K5E
3KAR
3KEN
ANP, MG, PO4
ADP, CL, L31, MG, NO3, PEG
ADP, K5E, MG
ADP, MG
ADP, KEN, MG, ZZD
TP
DP
DP
DP
DP
PD
U
A
A
PD
Kaan et al. J.Med.Chem. (2010)
Kaan et al. J.Med.Chem. (2010)
Kaan et al. J.Med.Chem. (2010)
Kaan et al. J.Med.Chem. (2011)
Klejnot et al. Acta Crystallogr.,Sect.D (2012)
Kaan et al. Science (2011)
Kaan et al. Science (2011)
Zhu et al. To be Published (NA)
Cox et al. J.Med.Chem. (2008)
Vinogradova et al. J.Struct.Biol. (2008)
Vinogradova et al. J.Struct.Biol. (2008)
Cochran et al. Cell (2009)
Cochran et al. Cell (2009)
Cochran et al. Cell (2009)
Tong et al. To be Published (NA)
Vinogradova et al. Proc.Natl.Acad.Sci.USA
(2009)
Parke et al. J.Biol.Chem. (2010)
Barsanti et al. Bioorg.Med.Chem.Lett. (2010)
Crawley et al. To be Published (NA)
Gulick et al. Biochemistry (1998)
Kim et al. J.Biol.Chem. (2010)
3KIN
3L1C
3L9H
ADP,
ADP, MG
ADP, EMQ
DP
DP
DP
FD
A
A
3PXN
4A14
ADP, MN
ADP, MG
DP
DP
A
A
Kozielski et al. Cell (1997)
Heuston et al. Bmc Struct.Biol. (2010)
Schiemann et al. Bioorg.Med.Chem.Lett.
(2010)
Cochran et al. To be Published (NA)
Klejnot et al. Acta Crystallogr.,Sect.D (2012)
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