PDB ID Ligands Nucleotide Neck-Linker Reference 1RY6 2ZFM 1BG2 1CZ7 1F9V 1F9W 1GOJ 1I6I 1IA0 1II6 1MKJ 1N6M 1Q0B SO4 ADP ACT, ADP, MG ADP, MG ADP, MG ADP, MG ADP, MG ACP, MG, TRS GTP, GDP, TXL, ACP, MG ADP, MG, NO3 ADP, MG, SO4 ADP, MG ADP, MG, NAT NA DP DP DP DP DP DP TP TP DP DP DP DP Shipley et al. Embo J. (2004) Nitta et al. Nat.Struct.Mol.Biol. (2008) Kull et al. Nature (1996) Kozielski et al. Structure Fold.Des. (1999) Yun et al. EMBO J. (2001) Yun et al. EMBO J. (2001) Song et al. Embo J. (2001) Kikkawa et al. Nature (2001) Kikkawa et al. Nature (2001) Turner et al. J.Biol.Chem. (2001) Sindelar et al. Nat.Struct.Mol.Biol. (2002) Yun et al. EMBO J. (2003) Yan et al. J.Mol.Biol. (2004) 1SDM 1T5C 1VFV 1VFW 1VFX 1VFZ 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 ADP, MG ADP, MG, NO3, PIN ANP, MG ANP, MG ADP, AF3, MG, TRS ADP, MG, VO4 ADP, MG, NAT ADP, L47, MG ADP, MG, N2T ADP, MG, N4T ADP, MG, N5T 3QC, ADP, MG ADP, MG, N9H 2AZ, ADP, MG DP DP TP TP DP TP DP TP DP DP DP DP DP DP DP DP 2H58 2HXF 2IEH 2KIN 2NCD 2P4N ADP, MG, UNX GTP, MG, GDP, TA1, ANP ADP, CL, K, MG, MOY, PG4 ADP, SO4, ADP, SO4 MG, ZN, GDP, GTP, TA1, ADP DP TP DP DP DP DP A A A A A A PD A A U FD A Chain A: PD, Chain B: A FD FD FD FD A A PD A A A A A A Chains: A-C-D PD, Chain B: A A FD PD FD A A Vinogradova et al. J.Biol.Chem. (2004) Garcia-Saez et al. J.Mol.Biol. (2004) Nitta et al. Science (2004) Nitta et al. Science (2004) Nitta et al. Science (2004) Nitta et al. Science (2004) Maliga et al. TO BE PUBLISHED (NA) Cox et al. BIOORG.MED.CHEM.LETT. (2005) Fraley et al. Bioorg.Med.Chem.Lett. (2006) Fraley et al. Bioorg.Med.Chem.Lett. (2006) Fraley et al. Bioorg.Med.Chem.Lett. (2006) Tarby et al. Bioorg.Med.Chem.Lett. (2006) Cox et al. Bioorg.Med.Chem.Lett. (2006) Kim et al. Bioorg.Med.Chem.Lett. (2006) Wang et al. To be Published (NA) Kikkawa et al. Embo J. (2006) Garcia-Saez et al. J.Biol.Chem. (2007) Sack et al. Biochemistry (1997) Sablin et al. Nature (1998) Sindelar et al. J.Cell Biol. (2007) 2PG2 2Q2Y 2Q2Z 2REP 2UYI 2UYM 2VVG 2WBE 2WOG ADP, K01, MG ADP, MG, MKR ADP, MG, MKK ADP, MG, UNX ADP, K02, MG ADP, K03, MG ADP, MG MG, GDP, TA1, ANP, GTP ADP, MG, ZZD DP DP DP DP DP DP DP TP DP A A A A A A FD FD Chains A-B: PD, Chain C: U Pinkerton et al. Bioorg.Med.Chem.Lett. (2007) Roecker et al. Bioorg.Med.Chem.Lett. (2007) Roecker et al. Bioorg.Med.Chem.Lett. (2007) Zhu et al. To be Published (NA) Pinkerton et al. Bioorg.Med.Chem.Lett. (2007) Pinkerton et al. Bioorg.Med.Chem.Lett. (2007) Hoeng et al. Mol.Biol.Cell (2008) Bodey et al. J.Mol.Biol. (2009) Kaan et al. Biochem.J. (2010) 2X2R ADP, MG, X2O DP Kaan et al. J.Med.Chem. (2011) 2X7C 2X7D 2X7E 2XAE ADP, KZ9, MG ADP, EGB, MG ADP, MG, X7E 2XA, ADP, CL, MG, SO4 DP DP DP DP 2XT3 2Y5W 2Y65 3B6U 3CJO 3CNZ 3COB 3DC4 3DCB 3DCO DP DP DP DP DP DP DP DP TP DP 3GBJ 3H4S ADP, MG ADP, MG ADP, MG, ADP, MG, UNX ADP, K30, MG ADP, MG ADP, MG ADP, MG ANP, MG MG, ZN, GDP, GTP, TA1, ADP ADP, MG, UNX ADP, MG, CA Chain A: PD, Chain B: A, Chain C: U PD PD PD Chains A-B: PD, Chain C: U A FD FD FD A FD FD A A A DP DP A U 3HQD 3K3B 3K5E 3KAR 3KEN ANP, MG, PO4 ADP, CL, L31, MG, NO3, PEG ADP, K5E, MG ADP, MG ADP, KEN, MG, ZZD TP DP DP DP DP PD U A A PD Kaan et al. J.Med.Chem. (2010) Kaan et al. J.Med.Chem. (2010) Kaan et al. J.Med.Chem. (2010) Kaan et al. J.Med.Chem. (2011) Klejnot et al. Acta Crystallogr.,Sect.D (2012) Kaan et al. Science (2011) Kaan et al. Science (2011) Zhu et al. To be Published (NA) Cox et al. J.Med.Chem. (2008) Vinogradova et al. J.Struct.Biol. (2008) Vinogradova et al. J.Struct.Biol. (2008) Cochran et al. Cell (2009) Cochran et al. Cell (2009) Cochran et al. Cell (2009) Tong et al. To be Published (NA) Vinogradova et al. Proc.Natl.Acad.Sci.USA (2009) Parke et al. J.Biol.Chem. (2010) Barsanti et al. Bioorg.Med.Chem.Lett. (2010) Crawley et al. To be Published (NA) Gulick et al. Biochemistry (1998) Kim et al. J.Biol.Chem. (2010) 3KIN 3L1C 3L9H ADP, ADP, MG ADP, EMQ DP DP DP FD A A 3PXN 4A14 ADP, MN ADP, MG DP DP A A Kozielski et al. Cell (1997) Heuston et al. Bmc Struct.Biol. (2010) Schiemann et al. Bioorg.Med.Chem.Lett. (2010) Cochran et al. To be Published (NA) Klejnot et al. Acta Crystallogr.,Sect.D (2012)