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Nucleophilic Substitution Reactions of 5-Bromo-4-sulfur-substituted 5,6Dihydro-2-Pyridones
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周善行
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Shang-Shing P. Chou
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Nucleophilic Substitution Reaction Pyridone
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malonate anion, acetylacetone anion,ethyl acetoacetate anion, dimethyl
cuprate)å 應，會進行SN2'å æ‡‰ï¼Œè€Œé žSN2å
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This thesis mainly studied the substitution reactions of bromo compound
5 and its sulfone derivative 19 with carbon nucleophiles, and explored the
reactivity, solvent effect, and regioselectivity of the reaction. Compounds
5 or 19 underwent nucleophilic substitution reactions with dimethyl
malonate anion,acetylacetone anion, ethyl acetoacetate anion, and
dimethyl cuprate in a SN2' fashion. Aromatic derivative 21 underwent
nucleophilic substitution reaction only with dimethyl malonate anion to
give product 23, whereas its reaction with other nucleophiles yielded only
addition products.
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Synthesis 2001, 2450. 15. æ´ªå®¶æˆ å šå£«è«–æ–‡, è¼”ä» å¤§å¸åŒ–
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M admin Y2008.M7.D3 23:17 61.59.161.35