Wound and Scar Formulations Indications and Prevalent Warnings

Wound Care Compounds
-Compounds for:
a) Misoprostol 0.0024%, Phenytoin 5%, Lidocaine 2%, Mupirocin 5%. Itraconazole 5%
in Spirawash
b) Misoprostol 0.0024%, Phenytoin 5%, Itraconazole 5% in Spirawash
c) Misoprostol 0.0024%, Phenytoin 5%, %, Mupirocin 5% in Spirawash
o
Misoprostol - is a synthetic prostaglandin E1 (PGE1) analog that is used for the
prevention of nonsteroidal anti-inflammatory drug (NSAID) induced gastric
ulcers. Misoprostol is also known to attenuate the inflammatory process and
promote collagen formation by inhibiting IL-1 and TNF. It is an ideal drug for
wound healing.

Prevalent Warnings – Use of misoprostol during pregnancy may cause
abortion, birth defects, or premature birth. It is not to be used to reduce
NSAID-induced ulcers in a woman of childbearing potential unless she is
capable of complying with effective contraceptive measures and is at high
risk of developing gastric ulcers and/or their complications.
o
Phentytoin – is classified as an anticonvulsant. Oral phenytoin is used widely for
the treatment of convulsive disorders and about half the patients treated develop
gingival overgrowth as a side effect. The apparent stimulatory effect has
prompted its assessment in wound healing. Studies have shown topical
phenytoin to promote healing of decubitus ulcers, venous stasis ulcers, diabetic
ulcers, traumatic wounds, burns, and leprosy trophic ulcers.

Prevalent Warnings – Severe dermatologic reactions, including toxic
epidermal necrolysis and Stevens-Johnson syndromes, although rarely
reportd, have resulted in fatalities. Drug should be discontinued if there
are any signs of rash and patient should be evaluated for signs and
symptoms of drug reaction with eosinophilia and systematic symptoms.
o
Lidocaine – is a topical analgesic and local aesthetic. Lidocaine is used to treat
minor cuts, burns, and abrasions of the skin.

Prevalent Warnings – Even though it may be rare, some people may
have unwanted reactions when using Lidocaine. Signs of an allergic
reaction, like rash, hives, itching, red, swollen, blistered, or peeling skin
with or without fever should be told to a physician right away.
o
Mupirocin – is a topical antibiotic. Topically, Mupirocin is used for the treatment
of impetigo or secondary infected traumatic skin lesions.

Prevalent Warnings - Even though it may be rare, some people may
have unwanted reactions when using Mupirocin. Signs of an allergic
reaction, like rash, hives, itching, red, swollen, blistered, or peeling skin
with or without fever should be told to a physician right away.
o
Itraconazole – is a antifungal agent. It prevents growth of several types of fungi
by preventing the fungi from producing the membranes that surround the fungal
cells.

Prevalent Warnings - The most common side effects of itraconazole
includenausea, vomiting, diarrhea, rash, edema, fatigue, dizziness. High
blood pressure (hypertension) and increased blood triglycerides may also
occur. Less common but more serious side effects include hepatitis
and congestive heart failure.

Scar Cream Compound –
Fluticasone Propionate 1%, Levocetirizine DiHdrochloride2%, Pentoxifylline 0.5%,
Prilocaine HCl 3%, Gabapentin 15%
o
Fluticasone Propionate – is a Topical Corticosteroid. It is mainly used in the
relief of inflammation and pruritus associated with corticosteroid-responsive
dermatoses; atopic dermatitis. It is also popular for the treatment of skin rashes.

Prevalent Warnings - Even though it may be rare, some people may
have unwanted reactions when using Fluticasone Propionate. Signs of an
allergic reaction, like rash, hives, itching, red, swollen, blistered, or peeling
skin with or without fever should be told to a physician right away.
o
Levocetirizine HCl – is a third-generation non-sedative antihistamine. It is used
is the treatment of skin manifestations (uncomplicated) of chronic idiopathic
urticaria.

Prevalent Warnings - Even though it may be rare, some people may
have unwanted reactions when using Levocetirizine. Signs of an allergic
reaction, like rash, hives, itching, red, swollen, blistered, or peeling skin
with or without fever should be told to a physician right away.
o
Pentoxifylline – is a blood viscosity reducer agent. It is used to treat intermittent
claudication resulting from obstructed arteries in the limbs, and vascular
dementia. Pentoxifylline improves blood flow through peripheral blood vessels
and therefore helps with blood circulation in the arms and legs. It is also used in
the treatment of venous leg ulcers with compression therapy.

Prevalent Warnings – Even though it may be rare, some people may
have unwanted reactions when using Pentoxifylline. Signs of an allergic
reaction, like rash, hives, itching, red, swollen, blistered, or peeling skin
with or without fever should be told to a physician right away.
o
Prilocaine – is a local anesthetic mainly used for dermal anesthesia.

Prevalent Warnings – Even though it may be rare, some people may
have unwanted reactions when using Prilocaine. Signs of an allergic
reaction, like rash, hives, itching, red, swollen, blistered, or peeling skin
with or without fever should be told to a physician right away.
o
Gabapentin - is a pharmaceutical drug, specifically a GABA analog. It was
originally developed to treat epilepsy, and currently is also used to
relieve neuropathic pain. It provides significant pain relief for diabetic peripheral
neuropathy, fibromyalgia, and postoperative pain.

Prevalent Warnings – Gabapentin's most common side effects in adult
patients include dizziness, fatigue, weight gain, drowsiness, and peripheral
edema (swelling of extremities); these mainly occur at higher doses in the
elderly.