AP Biology Unit 4 Syllabus Cellular Biology Chapters 6, 7 and 11 Assignment Date Wednesday November 18 Class Discussion Topic/Activity Intro to Cells, Organelles Path of a Protein Learning Objectives Chapter 6: A Tour of the Cell (sections 6.2-6.5 only) 1. I can explain how cells exchange matter with the environment to grow, reproduce and maintain organization. a. CHNOPS are used to build cellular components. 2. I can explain how internal membranes facilitate cellular processes by minimizing competing interactions and by increasing surface area where reactions can occur. 3. I can explain internal membranes and organelles contribute to cell functions, such as: a. Endoplasmic reticulum b. Mitochondria c. Chloroplasts d. Golgi complex e. Nuclear envelope 4. I can explain how Archaea and bacteria generally lack internal membranes and organelles and have a cell wall. 5. I can use a model to describe the differences in prokaryotic and eukaryotic cells. 6. I can explain that ribosomes are small, universal structures composed of two interacting parts: ribosomal RNA and protein, and are the site of protein synthesis. 7. I can explain how the endoplasmic reticulum (ER) occurs in two forms: smooth and rough. a. Rough endoplasmic reticulum functions to compartmentalize the cell, serves as mechanical support, provides site-specific protein synthesis with membranebound ribosomes and plays a role in intracellular transport. b. In most cases, the smooth ER synthesizes lipids. 8. I can explain how the Golgi complex is a membrane-bound structure that consists of a series of flattened membrane sacs (cisternae). a. The Golgi complex functions include synthesis and packaging of materials (small molecules) for transport (in vesicles) and production of lysosomes. 9. I can explain how mitochondria specialize in energy capture and transformation. a. Mitochondria have a double membrane that allows compartmentalization within the mitochondria and is important to its function. b. The outer membrane is smooth, but the inner membrane is highly convoluted, forming folds called cristae. c. Cristae contain enzymes important to ATP production; cristae also increase the surface area for ATP production. 10. I can explain how lysosomes are membrane-enclosed sacs that contain hydrolytic enzymes, which are important to intracellular digestion, the recycling of a cell’s organic materials and programmed cell death (apoptosis). Lysosomes carry out intracellular digestion in a variety of ways. 11. I can explain how a vacuole is a membrane-bound sac that plays roles in intracellular digestion and the release of cellular waste products. a. In plants, a large vacuole serves many functions, from storage of pigments or poisonous substances to a role in cell growth and allows for a large surface area to volume ratio. 12. I can explain how chloroplasts are specialized organelles found in algae and higher plants that capture energy through photosynthesis. a. The structure and function relationship in the (Unless otherwise noted assignments are due the next day class meets) Read, take notes chapter 6 chloroplast allows cells to capture the energy available in sunlight and convert it to chemical bond energy via photosynthesis. b. Chloroplasts contain chlorophylls, which are responsible for the green color of a plant and are the key lighttrapping molecules in photosynthesis. There are several types of chlorophyll, but the predominant form in plants is chlorophyll a. c. Chloroplasts have a double outer membrane that creates a compartmentalized structure, which supports its function. i. Thylakoids are membrane-bound structures are organized into stacks known as grana that are responsible for energy-capturing reactions of photosynthesis. 13. I can explain that areas or compartments perform a subset of functions related to energy and matter, and these parts contribute to the whole. a. At the cellular level, the plasma membrane, cytoplasm, and (for eukaryotes), the organelles contribute to the overall specialization and functioning of the cell. Thursday November 19 Cells Lab Friday November 20 Cell Membranes (7.1) Chapter 7: Membrane Structure and Function 1. 2. Passive Transport (7.2-7.3) 3. 4. I can explain that cell membranes separate the internal and external environment. I can explain that selective permeability is a direct consequence of membrane structure, as described by the fluid mosaic model. a. Cell membranes consist of a structural framework of phospholipid molecules, embedded proteins, cholesterol, glycoproteins and glycolipids. b. Phospholipids give the membrane both hydrophilic and hydrophobic properties. i. Hydrophilic phosphate portions are oriented toward the aqueous external or internal environments. ii. Hydrophobic fatty acid portions face each other within the interior of the membrane itself. c. Embedded proteins can be hydrophilic, with charged and polar side groups, or hydrophobic, with nonpolar side groups. d. Small, uncharged polar molecules and small nonpolar molecules, such as N2, freely pass across the membrane. e. Hydrophilic substances such as large polar molecules and ions move across the membrane through embedded channel and transport proteins. f. Water moves across membranes and through channel proteins called aquaporins. I can explain how cell walls provide a structural boundary, as well as a permeability barrier for some substances to the internal environments. a. Plant cell walls are made of cellulose and are external to the cell membrane. b. Other examples are cell walls of prokaryotes and fungi. I can explain that passive transport does not require the input of metabolic energy; the net movement of molecules is from high concentration to low concentration. a. Passive transport plays a primary role in the import of resources and the export of wastes. Videos: Bozeman Biology: Tour of the cell Cellular organelles Compartmentalization OR Crash course: Animal Cells Plant Cells Extra help links: Cell structures Cellular functions Cell size and scale Prezi cell structures and functions Mastering Biology chapter 6 quiz by 11:59p Read, take notes chapter 7 b. 5. 6. Monday November 23 AP Lab 4: Diffusion & Osmosis Membrane proteins play a role in the facilitated diffusion of charged and polar molecules through a membrane, such as: i. Glucose transport ii. Na+/K+ transport c. External environments can be hypotonic, hypertonic, or isotonic to internal environments of cells. I can explain that active transport requires free energy to move molecules from regions of low concentration to regions of high concentration. a. Active transport is a process where free energy (often provided by ATP) is used by proteins embedded in the membrane to “move” molecules and/or ions across the membrane and to establish and maintain concentration gradients. b. Membrane proteins are necessary for active transport. I can explain that the processes of endocytosis and exocytosis move large molecules from the external environment to the internal environment and vice versa, respectively. a. In exocytosis, internal vesicles fuse with the plasma membrane to secrete large macromolecules out of the cell. b. In endocytosis, the cell takes in macromolecules and particulate matter by forming new vesicles derived from the plasma membrane. Tuesday November 24 Wednesday November 25 Thursday November 26 AP Lab 4: Diffusion & Osmosis No School – Thanksgiving Break No School – Thanksgiving Break Friday November 27 (Eat lots of turkey… beware of tryptophan!) No School – Thanksgiving Break (Black Friday… happy shopping!) Videos: Bozeman Biology: Cell membranes Transport OR Crash course: Transport Extra help links: Cellular membranes Prezi on cellular structure and support Prezi on Transport Ch. 6 One Pager due Monday November 30 Tuesday December 1 AP Lab 4: Diffusion & Osmosis AP Lab 4: Diffusion & Osmosis Wednesday December 2 AP Lab 4 Report due Monday, December 7 Active Transport (7.4-7.5) Chapter 7 One Pager due Thursday December 3 Practice ACT 9th, 10th, and 11th graders Mastering Biology chapter 7 quiz by 11:59p Read, take notes chapter 11 Friday December 4 Cell Communication Webquest Chapter 11: Cell Signaling 1. 2. 3. 4. 5. 6. 7. Monday December 7 Review webquest Tuesday Cell Communication POGIL Intro Cell I can explain that correct and appropriate signal transduction processes are generally under strong selective pressure. I can explain that communication involves transduction of stimulatory or inhibitory signals from other cells, organisms, or the environment. I can explain how signaling begins with the recognition of a chemical messenger, a ligand, by a receptor protein. a. Different receptors recognize different chemical messengers, which can be peptides, small chemicals or proteins, in a specific one-to-one relationship. b. A receptor protein recognizes signal molecules, causing the receptor protein’s shape to change, which initiates transduction of the signal, such as: i. G-protein linked receptors ii. Ligand-gated ion channels iii. Receptor tyrosine kinases I can explain that signal transduction is the process by which a signal is converted to a cellular response. a. Signaling cascades relay signals from receptors to cell targets, often amplifying the incoming signals, with the result of appropriate responses by the cell. b. Second messengers are often essential to the function of the cascade, such as: i. Ligand-gated channels ii. Second messengers, such as cyclic GMP, cyclic AMP, calcium ions (Ca2+), and inositol triphosphate (IP3) I can explain that many signaling transduction pathways include: a. Protein modifications b. Phosphorylation cascades in which a series of protein kinases add a phosphate group to the next protein in the cascade sequence I can explain that conditions where signal transduction is blocked or defective can be deleterious, preventative, or prophylactic, such as: a. Diabetes, heart disease, neurological disease, autoimmune disease, cancer, cholera b. Effects of neurotoxins, poisons, pesticides c. Drugs (hypertensives, anesthetics, antihistimines, and birth control) I can explain how programmed cell death (apoptosis) plays a role in the normal development and differentiation, such as: a. Morphogenesis of fingers and toes Videos: Bozeman Biology: Cell communication OR Crash course: Signal Transduction Pathways Extra help links: Prezi on Cell signaling December 8 Wednesday December 9 Communication & Disease Project Mastering Biology chapter 11 quiz by 11:59p Work on project Thursday December 10 Friday December 11 Present projects Chapter 11 One Pager due Review Unit 4 Test AP Lab 1: Artificial Selection Report due Monday, December 14 Monday December 14 Tuesday December 15 Test Corrections Wednesday December 16 Thursday December 17 Friday December 18 Midterm Review Final Exams 4, 3, 5 (your midterm for this class will be given 3rd period for those of you in Period 2/3) (your midterm for this class will be given 5th period for those of you in Period 5/6) Final Exams 6, 2, 7 Final Exams 1, 8 (Make up day for all exams) (you are not required to be here for 2nd/6th period but I do have to take attendance so a parent must call you in or you are welcome to come in and work) Enjoy your Winter Break!!!! End of 2nd Quarter/Semester 1