Table 2: Quality of articles assessed using the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) Magnitude Confounding Author Year Design Bias Imprecision Indirectness Heterogeneity of effect Adjustment 25 Gardiner et al. 2011 Cross-sectional -1 -1 -1 -1 0 1 26 Lynch et al. 2011 Cross-sectional -1 -1 -1 0 0 1 27 Maeba et al. 2010 Cross-sectional -1 0 -1 0 0 1 28 George et al. 2011 Cross-sectional 2 -1 -1 0 0 1 Stamatakis et al.29 2012 Cross-sectional -1 0 -1 0 0 1 30 Frank et al. 2010 Cross-sectional -2 -1 -1 0 0 1 31 Gomez-Cabello et al. 2012 Cross-sectional -1 -1 -1 0 1 0 32 Gomez-Cabello et al. 2012 Cross-sectional -1 -1 -1 0 0 0 Buman et al.33 2010 Cross-sectional -2 0 -1 0 0 1 34 Hamer et al. 2012 Cross-sectional -2 0 -1 0 0 1 35 Hamer et al. 2012 Cross-sectional -2 -1 -1 0 0 1 36 Bankoski et al. 2011 Cross-sectional 0 -1 -1 0 0 1 37 Gao et al. 2007 Cross-sectional 0 -1 -1 0 1 1 Inoue et al.38 2012 Cross-sectional -2 -1 -1 0 0 1 39 Dogra et al. 2012 Cross-sectional -1 -1 0 0 1 1 40 Gennuso et al. 2013 Cross-sectional 0 -1 -1 0 1 1 41 Geda et al. 2011 Cross-sectional -1 0 -1 0 1 1 Geda et al.42 2012 Case-Control -1 -1 -1 0 1 0 43 Balboa-Castillo et al. 2011 Prospective Cohort -2 -1 0 0 1 1 44 Campbell et al. 2013 Prospective Cohort -1 0 0 0 0 1 45 Martinez-Gomez et al. 2013 Prospective Cohort -1 0 0 0 1 1 46 Pavey et al. 2012 Prospective Cohort -1 0 0 0 1 1 León-Muñoz et al.47 2013 Prospective Cohort -1 0 0 0 1 1 48 Verghese et al. 2003 Prospective Cohort -2 0 0 0 1 1 Doseresponse 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 1 0 0 1 1 0 Rating 1 1 1 3 1 1 1 1 1 1 1 1 3 1 2 3 2 1 2 2 3 4 4 2