Cutan Ocul Toxicol. 2010 Mar;29(1):70-2.
Nicolau syndrome and perforator vessels: a new
viewpoint for an old problem.
Okan G, Canter HI.
Source
Medical Park Bahcelievler Hospital, Department of Dermatology, Istanbul,
Turkey. gokhanokan8@hotmail.com
Abstract
Nicolau syndrome is rare cutaneous adverse reaction following injection of
various drugs. The disease has been associated with almost all classes of
medications, such as nonsteroidal anti-inflammatory drugs, local anesthetics,
corticosteroids, antibiotics, vitamin B complexes, antihistamines, and vaccines.
The most severe cases of this complication occur after injection of nonsteroidal
anti-inflammatory drugs. Subcutaneous injection is an important factor in the
pathogenesis of the syndrome. We report a case of Nicolau syndrome resulting
from intramuscular injection of diclofenac and discuss some precautions to
prevent this complication