Spring Semester 2013
Instructor:
Office Location:
Jim McGill
Rhodes Hall 201B
Office Telephone: 651-2347
E-mail Address:
Office Hours: jmcgill@semo.edu
M W F 10:00 to 11:00 am or by appointment
Section 01 Meets: Monday 05:30 – 09:20 pm in Magill Hall 235
Section 02 Meets: Thursday 08:00 – 11:50 am in Magill Hall 235
Course Website:
I. http://cstl-csm.semo.edu/mcgill/Spring/2013/CH344
Course Description
Students will perform selected organic syntheses and develop skills in semimicro qualitative
II.
III. organic chemistry. Four lab hours. Pre or Co-requisites: CH 343 or consent of instructor.
Required Materials
Text: John W. Lehman, Multiscale Operational Organic Chemistry, 2nd Ed., Prentice Hall,
2009.
Goggles: The cost of your goggles is included in your lab fee.
Laboratory Coat: Available for purchase from Chemistry Club during the first two weeks of class.
Bound Laboratory Notebook: You will need to purchase this.
Course Policies
You are expected to attend your assigned laboratory section and complete your laboratory work during the assigned time. You will not be allowed to work outside of the scheduled lab period except for weighing product and taking melting points. If you are ill or cannot attend lab due to an emergency, you will be permitted to make up the lab if you have appropriate documentation verifying the reason for your absence. If you must miss lab for other reasons, contact me ahead of time so we can make arrangements.
Laboratory reports are to be submitted to me during the first five minutes of lab on the date that they are due. Late reports will be accepted under the following conditions. The score you receive on a late report will be decreased by 5% of the total value for each day the report is late, up to five days. After five school days, late reports will no longer be accepted and a grade of zero will be recorded. Late reports must be turned in to me personally.
Students are required to adhere to the University’s policies on academic honesty. As college students and responsible members of society it is imperative that you maintain your integrity at all times. This is all the more true for individuals who aspire to enter the fields of science or medicine. Absolute integrity is essential to the functioning of the professional community. I will defer to the official University policies on academic honesty found in the
Undergraduate Bulletin and the Student Code of Conduct, with the added note that students working in pairs are still required to prepare and submit their own individual laboratory

IV.
V. reports that are the product of their own intellectual work. Any students found in violation of any of these policies will be afforded due process but will be dealt with to the fullest extent allowable under said policies.
Pre-Lab Preparation
Before you come to lab each week, you must do some preparation. The better prepared you are for the laboratory, the quicker you will be able to perform the laboratory exercise.
Adequate preparation should also make you a safer laboratory worker.
Your laboratory notebook must accompany you to lab each week. This is the instrument in which you will record all data and observations. Please use right-hand pages only. This will make a neater notebook. Make all entries in ink. If you make a mistake, draw a single line through your error, initial and date your strike-out, and continue. If you need to eliminate a large section, draw an X through that portion of your notebook; initial and date.
Laboratory Notebook Guidelines
Place your name, course and section number on the front cover of your notebook.
Number all pages in the upper right-hand corner. Use page one for a table of contents.
For each lab, the following must be completed before coming to lab. I will check each notebook at the beginning of each lab.
 Title of Experiment


Balanced chemical equation for reaction if appropriate.
Table of Reagents, properties, and quantities
 Procedure. The procedure need not be in complete sentences, but there must be enough information so you can do the experiment from your notebook. Use the left half of the page for the procedure. This will leave the right half for data and observations (as seen below):
VI. Laboratory Reports
Laboratory reports should follow the report format provided to you for each individual experiment and will be graded accordingly. Reports must be the product of only one individual student, even if the actual experiment was performed in a group.

VII. Safety
By nature, the organic lab is a hazardous location. Your strict attention to safety considerations is a must. Each week, I will identify special safety considerations and ask you to do your work with those in mind. Many safety issues will be raised, but three specific issues on which I have no latitude for flexibility are the following:
 Approved safety goggles must be worn at all times while in the laboratory unless I specifically instruct you otherwise.
 Closed toe shoes must be worn at all times while in the laboratory.
 An approved laboratory coat must be work at all times in the laboratory.
If you do not meet these requirements, you will not be permitted to work in the lab.
You will need to complete the on-line safety quiz before February 28. You will have 2 attempts at the quiz. You must score 90% or better on the quiz in order to proceed in lab.
VIII. Basis for Student Evaluation
Component
Laboratory Reports
Preparation and Safety
Final Examination
TOTAL
IX.
%
80 %
10 %
10 %
100%
90 – 100%
80 – 89%
65 – 79%
55 – 64%
0 – 54%
Grading Scale
A
B
C
D
F
Student Learning Outcomes
 Demonstrate proficiency in theory and safe practices of common separation and purification techniques.
 Apply theory of modern spectroscopic techniques with emphasis on structural elucidation/confirmation of starting materials and products.
 Perform organic reactions and other laboratory operations in a safe manner.
 Plan and execute a multistep synthesis or develop a new synthetic methodology.
 Keep an accurate record of lab activities in a notebook and report them in an appropriate format.
X. Questions, comments or requests regarding this course or program should be taken to your instructor. Unanswered questions or unresolved issues involving this class may be taken to
Professor Philip Crawford, Chairperson of the Department of Chemistry.

XI.
Date
Laboratory Schedule*
Experiment Title Reading pages Due
01/14
01/17
Laboratory drawer check-in; Safety in the Organic Laboratory
Online Safety Quiz Assigned
01/21
01/24
MLK Holiday Observance—No Labs
01/28
01/31
Preparation for Class: The Laboratory Notebook, Set-Up, and
Safety Considerations
02/04
02/07
Friedel-Crafts Acylation of Anisole
02/11
02/14
Friedel-Crafts Acylation of Anisole (continued)
02/18
02/21
Spectroscopy Review Exercises
02/25
02/28
Preparation of Lidocaine
03/04
03/07
Thin-Layer Chromatographic Analysis of Drug Components
03/11
03/14
Column Chromatography. Separation of Vanillin from Vanilla
Extract
03/18
03/21
Spring Break—No Labs
03/25
03/28
Multi-Step Synthesis (To Be Announced)
04/01
04/04
Multi-Step Synthesis (To Be Announced)
04/08
04/11
Multi-Step Synthesis (To Be Announced)
04/15
04/18
Multi-Step Synthesis (To Be Announced)
04/22
04/24
Multi-Step Synthesis (To Be Announced)
04/29
05/01
Multi-Step Synthesis (To Be Announced);
Laboratory Check-out
05/08
05/09
Final Examination, 4:00 PM
*Schedule subject to change at instructor’s discretion
Laboratory Safety (13-30)
Environment (31-38)
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Handout
Experiment 37 (323-332)
Experiment 37 (323-332)
Handout
Handout
Experiment 15 (147-151)
Handout
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TBA
TBA
TBA
TBA
TBA
TBA
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02/28
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02/18
02/21
02/18
02/21
03/11
03/14
02/25
02/28
03/04
03/07
03/11
03/14
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TBA
TBA
TBA
TBA
TBA
TBA
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