Alimentary Canal Chart Organ Location Functions Cells & tissues Present Enzymes secreted Innervation Blood Supply Mouth Oral canal; on face Mastication with teeth and chemical breakdown of proteins via salivary enzymes Walls of mouth: Stratified squamous ET Gums, hard palate, and dorsum of tongue: keratinized stratified squamous Mouth injury: antimicrobial peptides called defensins Maxillary & mandibular branches of trigeminal nerve Sublingual artery, greater & lesser palatine arteries Pharynx Three subsections of the throat; posterior Passageway of food, fluids, and air Mucosa (innermost ): stratified squamous ET Mucous secreted from mucus producing glands in mucosa Vagus & glossopharyngeal nerves External carotid & subclavian arteries Esophagus Muscular tube that passes through the mediastinum of the thorax Carries food to stomach Mucosa (innermost ): nonkeratini zed stratified squamous ET Esophagusstomach junction: changes to simple columnar ET which is specialized for secretion Submucosa: mucous secreting esophageal glands, released when bolus stimulates the esophagus as it moves down, allowing it to act as a lubricant so food can pass easily Sympathetic: visceral branches or sympathetic trunk (postganglioni c fibers) Esophageal branches of thyroid artery, R bronchial artery, thoracic aorta Parasympathe tic: vagus nerve (preganglionic fibers) Stomach Small intestine Below the esophagus; upper left quadrant of peritoneal cavity, hidden by liver and diaphragm Chemical breakdown of proteins begins and food is converted into chime. Tube extending from pyloric sphincter in the epigastric region where it joins the large intestine; longest part of the alimentary canal Body’s major digestive organ; digestion is completed and virtually all nutrients are absorbed by the time is reaches the large intestine Lining ET of mucosa: simple columnar ET Middle region of gland: parietal cells Basal region of gland: chief cells Deep in gastric gland: enteroendocrine cells ET cells of the villus mucosa: absorptive simple columnar ET w/ microvilli and goblet cells Crypt ET cells: secretory cells that secrete intestinal juice Scattered through Crypt ET: enteroendocrine cells & T cells called intraepitheli al lymphocytes (IELs) for immunity Deep in Crypt: Paneth cells that release lysozymes and defensins Alkaline mucus from mucus neck cells, HCl, intrinsic factor, pepsinogen, lipases (fatdigesting enzymes), histamine, serotonin, somatostati n, gastrin Sympathetic: thoracic splanchnic nerves relayed through the celiac plexus Arterial supply: gastric and splenic branches of celiac trunk Parasympathe tic: Vagus nerve Venous supply: hepatic portal system draining into hepatic portal vein Submucosa: Peyer’s patches, which are lymphoid follicles Submucosa of duodenum only: Mucus secreting duodenal glands called Brunner’s glands; produce alkaline mucus to neutralize acidic chime Brunner’s glands and goblet cells: secrete intestinal juice Parasympathe tic: Vagus nerve Arterial supply: superior mesenteric artery Sympathetic: thoracic splenic nerves *both relayed through superior mesenteric and celiac plexuses Venous: drain into superior mesenteric vein > hepatic portal vein Large intestine Frames small intestine on all three sides and extends from ileocecal valve to the anus Absorb most of the remaining H2O from indigestible food residue Colon mucosa: Smooth muscle w/ simple columnar ET Goblet cells: mucus Sympathetic: celiac, superior mesenteric ganglia, and inferior mesenteric ganglia Superior mesenteric artery & Vagus nerve Parasympathe tic: Vagus nerve Anus Terminal end of the large intestine Accessory Digestive Organ Chart Open and close anus for defecation Anus: nonkeratinized stratified squamous ET; smooth muscle with internal and external sphincters Anal sinuses: mucus Inferior mesenteric and hypogastric plexuses Internal iliac artery > middle rectal artery Organ Location Functions Cells & tissues present Enzymes present Innervation Blood Supply Teeth Lie in sockets in the gumcovered margins of the maxilla and mandible Mastication of food (chewing); 20 deciduous teeth in children, 32 permanent teeth in adults N/A N/A Superior and inferior alveolar nerves, branches of the trigeminal nerve Superior and inferior alveolar arteries, branches of the maxillary artery Tongue Occupies the floor of the mouth and fills most of the oral cavity when mouth is closed Grips food to reposition it between teeth; also mixed food w/ saliva forming a bolus; initiates swallowing by pushing food down pharynx; helps form consonants as we speak; Bundles of skeletal muscle fibers: intrinsic are confined in the tongue and not attached to bone, extrinsic extend from their points of origin on bones of skull or soft palate (therefore altering tongue’s position; median septum of CT; mucosal fold called lingual frenulum secures tongue to floor of mouth Thin walled; Covered by visceral peritoneum N/A Anterior 2/3: Mandibular branch of trigeminal nerve for sensory, Chorda Tympani branch of facial nerve for taste, & motoric branches of hypoglossal nerve Lingual artery, a branch of the external carotid Gallbladder Green muscular sac located in a shallow fossa on the ventral surface of the liver Sores bile not immediately needed for digestion and concentrates it by absorbing H2O and ions; expels bile into cystic duct and then into bile duct when needed Posterior 1/3: Sensory branches of glossophary ngeal nerve N/A Sympathetic : celiac plexus Parasympat hetic: Vagus nerve Cystic artery and vein Salivary Glands Parotid: anterior to ear Submandibular: along medial aspect of mandibular body Produce slightly acidic saliva containing electrolytes and digestive enzymes Sublingual: anterior to submandibular , under tongue Liver Pancreas Largest gland in the body; occupies most of the R hypochondriac & epigastric regions; under the diaphragm almost entirely under the ribcage; R lobe is larger than L Produce bile for export to duodenum or storage in gallbladder Extends across the abdomen, encircled by the C-shaped duodenum; retroperitoneal , lies deep to the greater curvature of the stomach Produces enzymes that break down foodstuffs, then delivers it to the duodenum; both endocrine and exocrine Accessory Digestive Organ Chart Mucus cells: produce a stringy, viscous solution Serous cells: produce a watery secretion containing ions, enzymes, and mucin *Note: Parotid=only serous Sublingual= mostly mucus Hepatocytes (liver cells) Kuppfer cells (hepatic macrophages) Acinar cells Islets of Langerhans containing Alpha and Beta cells Salivary amylase, lingual lipase, lysozymes, defensins During injury, hepatocytes release vascular endothelial growth factor (VEGF), Endothelial cells will then proliferate and release hepatocyte growth factor (HGF) and interleukin 6 Pancreatic juice, proteases, amylase, lipase, nuclease, insulin, glucagon Parasympat hetic division of autonomic nervous system: mechano/ chemo receptors > salivary nuclei in brain stem > facial & glossopharyngeal nerves > salivation occurs Sympathetic division: release of thick, mucin rich saliva or complete inhibition of saliva Celiac ganglia; vagus nerve Vagus nerve External carotid artery Hepatic artery & hepatic portal vein which enter the liver at the porta hepatis & common hepatic duct Superior mesenteri c artery >inferior pancreati c duodenal arteries