DRUG SAFETY ELECTRONIC SUPPLEMENTARY MATERIAL IMPACT OF INTERVENTIONS DESIGNED TO REDUCE MEDICATION ADMINISTRATION ERRORS IN HOSPITALS: A SYSTEMATIC REVIEW Richard N Keers MPharm (corresponding author)1, 2 Steven D Williams MPhil1, 3 Jonathan Cooke PhD1, 4 Tanya Walsh PhD5 Darren M Ashcroft PhD1, 2 1 Centre for Pharmacoepidemiology and Drug Safety Research, Manchester Pharmacy School, University of Manchester, Manchester, United Kingdom, M13 9PT. Tel: (+44)161 275 2414, fax: (+44)1612752416, Email: richard.keers@manchester.ac.uk 2 NIHR Greater Manchester Patient Safety Translational Research Centre, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester, United Kingdom M13 9PT. 3 Pharmacy Department, University Hospital South Manchester NHS Foundation Trust, Southmoor Road, Wythenshawe, Manchester, United Kingdom M23 9LT. 4 Infectious Diseases and Immunity Section, Division of Infectious Diseases, Department of Medicine, Imperial College London, United Kingdom. 5 School of Dentistry, University of Manchester, Manchester, United Kingdom M13 9PT. Example complete search strategy for EMBASE Ran 29/11/2013 using ‘Keyword’ search of all fields (not including full text). Total hits: 8372 1. medication error$.mp. or exp medication error/ 2. exp error/ or error$.mp. 3. drug error$.mp. 4. drug safety.mp. or exp drug safety/ 5. medication safety.mp. 6. near miss$.mp. 7. adverse event$.mp. 8. adverse drug event$.mp. 9. potential adverse event$.mp. 10. potential adverse drug event$.mp. 11. preventable adverse event$.mp. 12. preventable adverse drug event$.mp. 13. ADE.mp. 14. clinical incident$.mp. 15. medication incident$.mp. 16. medical error$.mp. or exp medical error/ 17. treatment error$.mp. or exp therapeutic error/ 18. health care error$.mp. 19. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 20. rate.mp. 21. inciden$.mp. 22. prevalen$.mp. 23. exp epidemiology/ or epidemiol$.mp. 24. 20 or 21 or 22 or 23 25. 19 and 24 26. secondary care.mp. 27. secondary.mp. 28. tertiary care.mp. or exp tertiary health care/ 29. tertiary.mp. 30. hospital$.mp. or exp hospital/ 31. in-patient$.mp. or exp hospital patient/ 32. inpatient$.mp. 33. hospitali?ation.mp. 34. unit$.mp. 35. ward$.mp. or exp ward/ 36. health center$.mp. or exp health center/ 37. health centre$.mp. 38. 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 39. randomized controlled trial/ 40. controlled study/ 41. RCT.mp. 42. intervention stud$.mp. 43. exp experiment/ or experiment$.mp. 44. exp time series analysis/ 45. random$.mp. 46. impact$.mp. 47. intervention$.mp. 48. exp intervention study/ 49. (pretest or pre test).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 50. (post test or posttest).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 51. chang$.mp. 52. evaluat$.mp. 53. evaluation stud$.mp. 54. effect$.mp. 55. comparative stud$.mp. 56. exp comparative study/ 57. exp case control study/ or case control$.mp. 58. compara$.mp. 59. case stud$.mp. 60. control group$.mp. or exp control group/ 61. control subject$.mp. 62. control patient$.mp. 63. omission.mp. 64. commission.mp. 65. self administration$.mp. or exp drug self administration/ 66. self medicat$.mp. 67. exp self medication/ 68. drug utili?ation.mp. 69. drug administ$.mp. 70. medication administration$.mp. 71. medicine administration$.mp. 72. drug prepar$.mp. 73. dose prepar$.mp. 74. medication preparation$.mp. 75. medicine prepar$.mp. 76. drug suppl$.mp. 77. medication suppl$.mp. 78. medicine suppl$.mp. 79. drug deliver$.mp. 80. medication deliver$.mp. 81. medicine deliver$.mp. 82. drug handl$.mp. 83. medication handling.mp. 84. medicine handling$.mp. 85. 63 or 64 or 65 or 66 or 67 or 68 or 69 or 70 or 71 or 72 or 73 or 74 or 75 or 76 or 77 or 78 or 79 or 80 or 81 or 82 or 83 or 84 86. clinical trial/ 87. (before and after stud$).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 88. 39 or 40 or 41 or 42 or 43 or 44 or 45 or 46 or 47 or 48 or 49 or 50 or 51 or 52 or 53 or 54 or 55 or 56 or 57 or 58 or 59 or 60 or 61 or 62 or 86 or 87 89. 25 and 38 and 85 and 88 90. limit 89 to yr="1985 -Current"