Organix Comprehensive Profile - Urine
Go Beyond the Symptoms with an Organic Acid Test
Since 1992, Metametrix has offered the Organix Profile, a complete quantitative organic acids
test. The Organix provides a view into the body's cellular metabolic processes and the efficiency
of metabolic function. Identifying metabolic blocks or problems with detoxification, gut
dysbiosis, or oxidative stress that can be treated nutritionally allows for individual tailoring of
interventions. Targeted treatment can help maximize patient responses and lead to improved
patient outcomes.
Advantages of the Organix Comprehensive Profile
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Extensive Analyte List - The Organix Comprehensive contains one of the most
extensive analyte lists in the industry. Including markers such as Quinolinate, DArabinitol, and 8-Hydroxy-2'deoxyguanosine, the Organix offers great value.
Innovative Method - The LC/MS-MS method, which is also used to screen newborns for
metabolic disorders, requires very little sample preparation and processing. This
technology provides more stability, accuracy, and sensitivity in measuring organic acids
at low levels for optimum test results.
Single Urine Specimen - A single overnight urine collection is easy for patients, leading
to increased patient compliance.
Why use an organic acid test?
Organic acids are metabolic intermediates produced in pathways of central energy production,
detoxification, neurotransmitter breakdown, and intestinal microbial activity. Accumulation of
specific organic acids in urine often signals a metabolic inhibition or block. This abnormality
may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect.
Testing for organic acids helps reveal activity and changes at the metabolic level, helping
practitioners discover hidden issues and pinpoint where therapeutic focus is needed.
The Organix Profile provides important information in the areas of:
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Vitamin and mineral insufficiencies
Amino acid insufficiencies like carnitine and N-acetyl cysteine (NAC)
Oxidative damage and antioxidant sufficiency markers
Indicators to assess detoxification sufficiency
The best functional markers of B-complex deficiency
Neurotransmitter metabolites to assess central nervous system (CNS) function
Mitochondrial energy production assessment via citric acid cycle components
Methylation sufficiency status
Lipoic acid and CoQ10 sufficiency markers
Specific dysbiosis markers for bacterial and yeast overgrowth
The Organix Profiles can provide important information for treating certain
conditions, including:
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Fatigue
Sleep abnormalities
Mood changes
Blood sugar dysregulation
Weight gain
Nausea
Multiple chemical sensitivity
Bloating
Distention
Joint pain
Gas
Reflux
Autoimmune disorders
Dermatitis
Depression
Anxiety
Cancer
Inflammation
Headaches
Early aging
Additional Organix Profiles:
Organix Basic - A great option for follow-up testing when dysbiosis markers are not
needed.
Organix Dysbiosis - Measures the by-products of microbial metabolism to access
overgrowth and help guide and monitor therapy.
Test name(s)
0091 - Organix Comprehensive Profile
0391 Organix Comprehensive Profile NY
Description
The Organix Comprehensive Profile provides a view into the body's cellular metabolic
processes and the efficiency of metabolic function. Identifying metabolic blocks that can
be treated nutritionally allows individual tailoring of interventions that maximize patient
responses and lead to improved patient outcomes. Organic acids are metabolic
intermediates that are produced in pathways of central energy production, detoxification,
neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of
specific organic acids detected in urine often signals a metabolic inhibition or block. The
metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic
build-up or drug effect. Several of the analytes are markers of intestinal bacterial or yeast
overgrowth.
Method
LC/MS-MS Tandem Mass Spectrometry
Turnaround Time
8-14 days, 12 days average
Analytes
FATTY ACID METABOLISM
Adipate
Suberate
Ethylmalonate
CARBOHYDRATE METABOLISM
Pyruvate
L-Lactate*
Beta-Hydroxybutyrate
ENERGY PRODUCTION (CITRIC ACID CYCLE)
Citrate
cis-Aconitate
Isocitrate
Alpha-Ketoglutarate
Succinate
Fumarate
Malate
Hydroxymethylglutarate
B-COMPLEX VITAMIN MARKERS
Alpha-Ketoisovalerate
Alpha-Ketoisocaproate
Alpha-Keto-Beta-Methylvalerate
Xanthurenate
Beta-Hydroxyisovalerate
METHYLATION COFACTOR MARKERS
Methylmalonate
Formiminoglutamate
NEUROTRANSMITTER METABOLISM MARKERS
Vanilmandelate
Homvanillate
5-hydroxyindoleacetate
Kynurenate
Quinolinate
Picolinate*
OXIDATIVE DAMAGE AND ANTIOXIDANT MARKERS
p-Hydroxyphenyllactate
8-Hydroxy-2'-deoxyguanosine*
DETOXIFICATON INDICATORS
2-Methylhippurate
Orotate
Glucarate
Alpha-Hydroxybutyrate
Pyroglutamate
Sulfate
BACTERIAL-GENERAL
Benzoate
Hippurate
Phenylacetate
Phenylpropionate
p-Hydroxybenzoate
p-Hydroxyphenylacetate
Indican
Tricarballylate
L.ACIDOPHILUS/GENERAL BACTERIA
D-Lactate*
CLOSTRIDIAL SPECIES
3,4 Dihydroxyphenylpropionate
YEAST/FUNGAL
D-Arabinitol*
Creatinine
*Not available in New York