Supplementary Table 1 | Methods of clinical phenotyping and QST endophenotyping in musculoskeletal pain conditions
Feature assessed
Clinical pain
Global pain severity
Pain intensity &
unpleasantness
Temporal characteristics
Perceptual characteristics
Physical function/disability
Condition-specific functional
limitations
General pain-related
disability
Generic measures of
function/disability
Performance-based
measures
Psychosocial functioning
Global psychological
symptoms
Somatic awareness
Stress & life events
Pain-related cognitions &
pain coping
Method available
Brief Pain Inventory (BPI),S1 Graded Chronic Pain Scale (GCPS),S2 Multidimensional
Pain Inventory (MPI)S3
Numerical Rating Scale (NRS), Visual Analog Scale (VAS), Gracely Box Scales
Electronic Ecological Momentary Assessment (EMA)S4,S5
McGill Pain Questionnaire (MPQ),S6 Descriptor Differential Scale (DDS)S7
Fibromyalgia: FM Impact Questionnaire (FIQ),S8 FIQ-Revised (FIQ-R)S9
LBP: Roland Morris Disability Questionnaire (RMDQ),S10 Oswestry Disability Index
(ODI)S11
TMD: Jaw Function Limitation Scale (JFLS)S12
Interference scales from Brief Pain Inventory (BPI),S1 Graded Chronic Pain Scale
(GCPS),S2 and Multidimensional Pain Inventory (MPI)S3
Health Assessment Questionnaire (HAQ),S13,S14 Disability Rating Index (DRI),S15
Medical Outcomes Study Short Form-36 (SF-36®) physical functioning and role
limitation S16
Functional Capacity Evaluation (FCE), S17 timed walk test, actigraphy
Symptom Checklist-90-Revised (SCL-90R),S18 Positive and Negative Affect Scale
(PANAS),S19 Beck Depression Inventory (BDI),S20 Center for Epidemiological StudiesDepression Scale (CES-D),S21 Hospital Anxiety & Depression Scale (HADS),S22 State
Trait Anxiety Inventory (STAI)S23
SCL-90-R somatization,S18 Pennebaker Inventory of Limbic Languidness (PILL),S24
Pain Vigilance and Awareness Questionnaire (PVAQ),S25 Kohn Reactivity Scale
Perceived Stress Scale (PSS),S26 Impact of Events Scale (IES),S27 Life Experiences
Survey (LES),S28 Survey of Recent Life Events (SRLE),S29 Lifetime Stressor List/Post
Traumatic Stress Disorder Checklist-Civilian Version (LSL/PCL-C)S30
Fear Avoidance Beliefs Questionnaire (FABQ),S31 Tampa Scale for Kinesiophobia
(TSK),S32 TSK for TMD (TSK-TMD),S33 Pain Catastrophizing Scale (PCS), Coping
Strategies Questionnaire-Revised (CSQ-R),S34 Pain Anxiety Symptom Scale
(PASS)S35
QST
Nonpain somatosensation
Vibrotactile detection and habituation,S36,S37 mechanical detection,S38,S39 cool and
warm thresholdsS40
Generalized hyperalgesia
Pain threshold and tolerance,S38–S41 suprathreshold pain ratingsS42
Pain facilitatory function
Temporal summation of pain,S38,S39,S43 aftersensation of painS39
Pain inhibitory function
Conditioned pain modulation,S44 offset analgesiaS45,S46
Abbreviations: LBP, low back pain; QST, quantitative sensory testing; TMD, temporomandibular joint disorders.
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