Appendix E1
Supplementary table 1. Electronic search strategy for Medline, Embase and
Cochrane databases
Search details
Medline search
1
2
3
4
5
6
7
8
Time period: January 1983 – March 2014
9
10
11
12
13
Crohn’s disease
Crohn [tiab]
Inflammatory bowel disease
1 OR 2 OR 3
Computed tomography
CT [tiab]
MRI
“Magnetic resonance” [All fields] OR (“magnetic” [All fields]
AND “resonance” [All fields])
Ultrasound
Scintigraphy
Emission computed tomography
5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11
4 AND 12
Embase search
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
Crohn’s disease.ab,ti,sh,kw
Inflammatory bowel disease.ab,ti,sh,kw
1 OR 2
Computer Assisted Tomography.ab,ti,sh,kw
Exp Computer Assisted Tomography/
Nuclear magnetic resonance imaging.ab,ti,sh,kw
Exp Nuclear magnetic resonance imaging/
Echography.ab,ti,sh,kw
Exp echography/
Scintigraphy.ab,ti,sh,kw
Exp scintigraphy/
Positron emission tomography.ab,ti,sh,kw
Exp positron emission tomography/
4 OR 5 OR 6 OR 7 OR 8 OR 9 OR 10 OR 11 OR 12 OR 13
3 AND 14
Cochrane
search
1
2
3
4
5
Crohn disease [Mesh]
Inflammatory bowel disease [Mesh]
1 OR 2
Diagnostic techniques and procedures [Mesh]
3 AND 4
Appendix E2
Supplementary table 2. Exclusions after full-text evaluation (n=130)
No imaging features used for grading disease activity defined (n=58)
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enterography in the detection of recurrence after surgery]. Radiologia 53:552-559
Incorrect type of work (n=1)
Gandolfi L (1996) Comparison of magnetic resonance imaging and endoscopy in distinguishing
the type and severity of inflammatory bowel disease. Gastrointest Endosc 43:Article not in English, German, French, Italian, Spanish or Dutch (n=1)
Li WJ, Jiang WY, Zhang XF, Liu XS, Shi RH, Zhang HJ (2013) Value of CT enteroclysis in the
diagnosis of Crohn's disease. World Chinese Journal of Digestology 21:220-225
Appendix E3
Supplementary table 3. Three-by-three contingency table for studies evaluating computed tomography (CT)
Study
Reference test
None
Mild
Frank
CT
None
Mild
Frank
None
Mild
Frank
None
Mild
Frank
Mao [16]
3
1
0
1
3
5
0
0
19
Mohamed [17]
0
0
0
0
0
0
0
1
25
51
0
0
5
2
0
1
3
8
Per-patient
Per-segment
Kolkman [18]
CT = Computed Tomography
Supplementary table 4. Three-by-three contingency tables for studies evaluating magnetic resonance imaging (MRI)
Study
Reference test
None
Mild
Frank
MRI
None
Mild
Frank
None
Mild
Frank
None
Mild
Frank
Schill [19]
0
0
0
0
4
0
0
1
71
Gallego [20]
4
1
0
0
24
9
0
4
19
Koilakou [21]
2
1
0
0
5
1
0
0
17
Horsthuis [22] observer 1
0
0
0
3
1
1
2
2
6
Horsthuis [22] observer 2
0
0
0
4
0
1
1
5
4
Horsthuis [22] observer 3
0
0
0
0
3
2
0
3
7
Girometti [23]
14
2
0
2
12
0
0
0
15
Horsthuis [24] observer 1
0
5
0
0
8
1
0
3
3
Horsthuis [24] observer 2
4
1
0
1
7
1
0
2
4
Florie [25] observer 1
6
3
1
0
4
4
0
4
9
Florie [25] observer 2
5
4
1
2
3
3
1
2
10
Shoenut [26]
0
0
0
0
1
0
0
0
11
Shoenut [27]
0
0
0
0
0
4
0
1
14
Schreyer [28]
112
1
1
11
3
1
14
3
30
Schreyer [29]
46
0
0
25
2
0
1
1
7
Per-patient
Per-segment
MRI = Magnetic Resonance Imaging
Supplementary table 5. Three-by-three contingency tables for studies evaluating ultrasound (US)
Study
Reference test
None
Mild
Frank
US
None
Mild
Frank
None
Mild
Frank
None
Mild
Frank
5
1
2
5
5
5
0
5
4
Neye [31]
54
4
0
12
7
6
3
6
34
Bozkurt [32]
51
26
3
9
29
35
0
11
28
Per-patient
Drews [30]
Per-segment
US = Ultrasound
Supplementary table 6. Three-by-three contingency tables for studies evaluating scintigraphy
Study
Reference test
None
Mild
Frank
Scintigraphy
None
Mild
Frank
None
Mild
Frank
None
Mild
Frank
1
0
0
2
3
1
1
2
0
Kolkman [18]
50
1
0
4
2
1
1
3
8
Scarrietta [34]
10
0
0
4
24
4
0
4
42
Per-patient
Biancone [33]
Per-segment