Table S2. Clinical characteristics
Group
Age/Sex
Diagnosis
Organism*
Outcome
28 days
Clinical Summary
1
78 M
Hepatic abscess
21
Alive
5
4
Alive
Alive
4
1
3
2
15
Alive
Alive
Alive
Alive
Alive
5
6
Alive
Alive
Initial admission with presumed pneumonia, transferred to ICU
for observation due to persistent tachycardia on day 3. CT scan
– hepatic abscess - drained percutaneously. Discharged on IV
antibiotics.
Infected tracheostomy site. IV antibiotics on ward.
Fever cough and dyspnea. Treated with antibiotics and
oseltamivir on ward.
Fever and headache. Initial workup for meningitis negative.
Lobar pneumonia – initial IV antibiotics then discharged home.
Perianal abscess treated with IV antibiotics on ward.
Infected skin wound – IV antibiotics on ward.
Intravenous drug user – S Aureus bacteraemia without
endocarditis. IV antibiotics on ward.
Acute pyelonephritis – IV antibiotics on ward.
Hypostatic pneumonia due to multiple sclerosis. IV antibiotics
on ward.
1
1
83 M
73 M
S Pneumonia
1
1
1
1
1
25 F
19 M
35 M
54 M
22 F
Wound infection
Viral
pneumonitis
Mastitis
Pneumonia
Skin abscess
Skin abscess
Skin abscess
S Aureus
S Aureus
Pus
Blood
1
1
27 F
52 F
Pyelonephritis
Pneumonia
Enterococcus
Urine
2
85 M
Cellulitis
12
Died
2
60 M
Pneumonia
2
Alive
2
56 M
Necrotizing
fasciitis
32
Alive
2
73 F
Urosepsis
6
Alive
2
67 M
Cellulitis
19
Alive
E Coli
Source
Blood
Urine
LOS (days)
Admitted with bilateral cellulitis with respiratory/ renal failure.
Day 10 developed acute small bowel perforation and elected for
non-operative management. Palliated and died.
Atypical pneumonia with acute kidney injury (creatinine
225umol/L) – responded to fluid resuscitation on ward.
Rapidly progressive forearm cellulitis requiring surgical
debridement. Intubated for respiratory distress day 2 of
admission. Influenza isolated from sputum by PCR.
Septic shock on background of hepatic carcinoma.
Fluids/antibiotics and vasopressors on ward.
Septic shock requiring noradrenalin infusion in ICU.
Background of lymphoma (in remission).
2
2
2
66 F
80 M
35 F
Urosepsis
Cholecystitis
Pneumonia
19
14
10
Alive
Alive
Alive
E Coli
S Pneumonia
2
59 M
Pneumonia
S Pneumonia
2
86 M
Urosepsis
K Pneumonia
2
74 F
S Pyogenes
2
85 M
P Aeruginosa
2
66 F
Septic shock
presumed from
radiation colitis
Gram negative
sepsis
Urosepsis
Blood
Sputu
m
Sputu
m
Urine
&
blood
Blood
E Coli
2
80 M
2
33 M
Gram negative
sepsis
Septic shock
2
71 F
2
52 M
Meningococcal
sepsis
Gastroenteritis
Altered conscious state with fever and high lactate.
Gram negative sepsis with shock requiring vasopressors in ICU.
Lobar pneumonia with septic shock requiring vasopressors in
ICU
Lobar pneumonia with septic shock requiring vasopressors in
ICU.
Nursing home resident with gram-negative sepsis and high
lactate. Managed on ward.
6
Alive
7
Alive
7
Alive
Septic shock requiring vasopressors in ICU. Radiotherapy for
cervical carcinoma.
Blood
1
Died
8
Alive
Capnocytophaga
Urine
and
blood
Blood
Nursing home resident with gram-negative sepsis. Managed in
ward. Died day 2.
Acute renal failure with septic shock requiring vasopressors in
ICU.
18
Alive
Gram-negative sepsis with multi-organ failure.
S Pyogenes
Blood
13
Alive
N Meningitis
Blood
17
Died
Intravenous drug user, multiple skin lesions, multi-organ
failure managed in ICU.
Shock and progressive multi-organ failure. Died day 17 in ICU.
6
Alive
Diarrheal illness and septic shock requiring vasopressors in
ICU. Cultures negative.
Group 1 – Infection with SIRS/uncomplicated sepsis. Group 2 – severe sepsis/septic shock. *Organism isolated from sample collected
within first 24h of admission.