Supplementary Tables
Supplementary Table 1. Specific causes of death according to the ICD-8 and ICD-10
Causes of death
ICD-8
ICD-10
Any
Any
All-cause
140-239
C00–D48
Neoplasms
Cancer of the digestive organs
150-157, 159
C15-C26
*
Cancer of the bronchus and lung
162
C34
Breast cancer
174
C50
290-315
F00–F99
Mental and behavioral disorders
Dementia
290
F00-F03
Mental and behavioral disorders due to use of alcohol
291, 303
F10
320-358
G00–G99
Diseases of the nervous system
Alzheimer’s disease
NA
G30
390-458
I00–I99
Diseases of the circulatory system
Ischemic heart disease
410–414
I20-I25
Cerebrovascular disease
430-438
I60-I69
460-519
J00–J99
Diseases of the respiratory system
Respiratory infections
460-486
J00-J22
Chronic obstructive pulmonary disease
491-492
J42-44
520–577
K00–K93
Diseases of the digestive system
Diseases of the liver
570–573
K70-K77
Diseases of esophagus, stomach and duodenum
530-537
K20-K31
240–279
E00–E90
Endocrine, nutritional or metabolic disease
Diabetes mellitus
250
E10-E14
000-136
A00-B99
Infection
Other**
*
Also includes cases of neoplasma malignum tracheae. ** Any cause of death that is not
included in the above-mentioned groups.
Abbreviations: ICD, International Classification of Disease; NA, not applicable
Supplementary Table 2. Causes of death and crude Cox regression analyses according to atopic status
Causes of death
Non-atopic, % (n), Atopic, % (n),
Atopics vs. non-atopics,
P-value
N=10854
N=3994
HR (95% CI), p-value*
13.6 (1472)
7.6 (304)
0.95 (0.84, 1.07)
P=0.395
All-cause
5.4 (584)
2.8 (112)
0.84 (0.68, 1.03)
P=0.089
Neoplasms
Cancer of the digestive organs
1.3 (142)
0.9 (35)
1.10 (0.76, 1.60)
P=0.613
Cancer of the bronchus and lung
1.5 (164)
0.6 (23)
0.60 (0.39, 0.93)
P=0.021
Breast cancer
0.5 (59)
0.1 (3)
0.24 (0.07, 0.76)
P=0.015
0.4 (40)
0.4 (14)
1.67 (0.90, 3.09)
P=0.106
Mental and behavioral disorders
Dementia
0.2 (17)
0.1 (5)
2.11 (0.78, 5.72)
P=0.144
Mental and behavioral disorders due
0.2 (21)
0.2 (7)
1.21 (0.51, 2.87)
P=0.664
to use of alcohol
0.4 (40)
0.2 (9)
1.23 (0.60, 2.56)
P=0.573
Diseases of the nervous system
Alzheimer’s disease
0.2 (16)
0.1 (4)
1.72 (0.57, 5.16)
P=0.333
3.8 (407)
1.9 (76)
0.89 (0.70, 1.14)
P=0.369
Diseases of the circulatory system
Ischemic heart disease
1.8 (194)
0.8 (31)
0.73 (0.50, 1.07)
P=0.102
Cerebrovascular disease
0.8 (88)
0.5 (20)
1.20 (0.74, 1.96)
P=0.468
1.1 (116)
0.4 (16)
0.78 (0.46, 1.32)
P=0.348
Diseases of the respiratory system
Respiratory infections
0.2 (20)
0.0 (0)
0 (0,-)
P=0.989
Chronic obstructive pulmonary
0.7 (79)
0.3 (13)
0.95 (0.53, 1.71)
P=0.858
disease
0.6 (69)
0.6 (23)
1.42 (0.88, 2.28)
P=0.153
Diseases of the digestive system
Diseases of the liver
0.3 (37)
0.5 (19)
1.87 (1.07, 3.26)
P=0.028
Diseases of esophagus, stomach and
0.1 (11)
0.1 (2)
1.09 (0.24, 4.95)
P=0.912
duodenum
0.3 (34)
0.3 (10)
1.45 (0.71, 2.96)
P=0.306
Endocrine, nutritional or
metabolic disease
Diabetes mellitus
0.2 (24)
0.2 (9)
1.89 (0.87, 4.09)
P=0.108
0.1 (14)
0.1 (5)
1.54 (0.55, 4.35)
P=0.416
Infection
1.6 (168)
1.0 (39)
0.99 (0.70, 1.41)
P=0.962
Other
*
Crude Cox regression analyses with time as the underlying time axis and a total of 14848 persons included in each
analysis, except for breast cancer where only women were included (n=7694).
Abbreviations: CI, confidence interval; HR, hazard ratio
Supplementary Table 3. Hazard ratios and 95% confidence intervals for the
associations between atopic status and mortality stratified by intake of alcohol
Cause of death
Events
HR& (95% CI), P-value
(persons
Atopic vs. non-atopic
included)
All-cause
Intake of alcohol, drinks/week
0
250 (1627)
1.06 (0.70, 1.59), P=0.792
>0-3
349 (3366)
0.67 (0.49, 0.92), P=0.013
>3-5
185 (1606)
0.70 (0.42, 1.17), P=0.177
>5-11
370 (3385)
1.02 (0.77, 1.36), P=0.870
>11
585 (3943)
1.30 (1.07, 1.59), P=0.008
Neoplasms
Intake of alcohol, drinks/week
0
92 (1627)
0.60 (0.27, 1.32), P=0.203
>0-3
140 (3366)
0.70 (0.44, 1.13), P=0.143
>3-5
75 (1606)
0.53 (0.23, 1.24), P=0.142
>5-11
152 (3385)
0.97 (0.62, 1.52), P=0.906
>11
223 (3943)
1.02 (0.73, 1.42), P=0.903
Diseases of the digestive system
Intake of alcohol, drinks/week
0
13 (1627)
3.21 (0.77, 13.38), P=0.110
>0-3
10 (3366)
0.78 (0.09, 6.67), P=0.802
>3-5
5 (1606)
2.34 (0.16, 34.68), P=0.536
>5-11
8 (3385)
0.77 (0.09, 6.88), P=0.815
>11
55 (3943)
1.64 (0.90, 2.99), P=0.105
Diseases of the liver
Intake of alcohol, drinks/week
0
5 (1627)
21.9 (2.05, 232.97), P=0.011
>0-3
1 (3366)
>3-5
1 (1606)
>5-11
8 (3385)
0.77 (0.09, 6.88), P=0.815
>11
40 (3943)
2.05 (1.04, 4.03), P=0.038
Complete case analysis.
&
Adjusted for study, gender (age is underlying time axis), education, season of blood
sample, physical activity, smoking habits, body mass index, systolic and diastolic blood
pressure, serum triglycerides and total cholesterol.
Abbreviations: CI, confidence interval; HR, hazard ratio