By: YOUNG, JJ (YOUNG, JJ); JUNG, LJ (JUNG, LJ); LIU, WT (LIU, WT); HO, SN (HO, SN); CHANG, LR (CHANG,
LR); TSAI, YC (TSAI, YC); BHASKARAN, R (BHASKARAN, R); YU, C (YU, C)
JOURNAL OF ANTIBIOTICS
Volume: 47
Issue: 8
Pages: 922-931
Published: AUG 1994
View Journal Information
Abstract
Studies on the solution conformation of the cyclic depsipeptide antibiotic enopeptin A have been carried out using 2D
NMR and molecular modelling techniques. The proton resonances of the antibiotic in DMSO-d(6) have been assigned by the use of TOCSY and ROESY experiments. The interproton distance information obtained from the ROESY experiments have been used as the basis for elucidating the probable structures in solution. The restrained molecular dynamics technique was applied to calculate the structures in solution, and six resultant structures with fewer distance constraint violations were obtained that satisfy the experimental restraints very well. The conformation of the cyclic moiety of the molecule is well defined whereas the aliphatic chain segment is disordered.
Keywords
KeyWords Plus: NUCLEAR-MAGNETIC-RESONANCE ; ROTATING-FRAME ; X-RAY ; H-1-
NMR ; SPECTROSCOPY ; REFINEMENT ; PROTEIN ; DNA
Author Information
Addresses:
[ 1 ] NATL TSING HUA UNIV,DEPT CHEM,HSINCHU,TAIWAN
[ 2 ] NATL DEF MED CTR,INST PREVENT MED,TAIPEI,TAIWAN
[ 3 ] NATL CTR HIGH PERFORMANCE COMP,HSINCHU,TAIWAN
[ 4 ] BHARATHIDASAN UNIV,DEPT PHYS,TIRUCHCHIRAPPALLI 620024,INDIA
Publisher
JAPAN ANTIBIOT RES ASSN, 2 20 8 KAMIOSAKI SHINAGAWA KU, TOKYO 141, JAPAN
Categories / Classification
Research Areas: Biotechnology & Applied Microbiology; Immunology; Microbiology; Pharmacology & Pharmacy
Web of Science Categories: Biotechnology & Applied Microbiology; Immunology; Microbiology; Pharmacology &
Pharmacy
Document Information
Document Type: Article
Language: English
Accession Number: WOS:A1994PD96100011
PubMed ID: 7928680
ISSN: 0021-8820

Other Information
IDS Number: PD961
Cited References in Web of Science Core Collection: 24
Times Cited in Web of Science Core Collection: 3