Study Name
Follow
up
1 to 5
Mortality
TVR
Stroke
MI
MACCE
All cause
death
Any repeat
revascularization
Q-wave or Non Q
wave or post
procedural MI
Death,MI,stroke,TVR
Boudriot2
1
2
Any repeat
revascularization
Any repeat
revascularization
Q wave or post
procedural MI
Q-wave or Non Q
wave or post
procedural MI
Death, MI and TVR
Shimizu11
All cause
Death
All cause
Death
FND with
irreversible
brain
damage
-
Chieffo12
1&5
All cause
Death
1
All cause
Death
Ghenim14
1
NA
Makikallio15
1
All cause
Death
Repeat
revascularization
anywhere in LM
or 10 mm distal
to LM in the LAD
or LCx
Q-wave or Non Q
wave or post
procedural MI
Q-wave or Non Q
wave or post
procedural MI
Q-wave or Non Q
wave or post
procedural MI
Non Q wave MI and
STEMI
Death,MI,stroke,TVR
CUSTOMIZE13
Repeat
revascularization
of LM, LAD , LCx
Revascularization NA
in target
segment
Any repeat
NA
revascularization
Rittger16
1
All cause
Death
Two fold rise in
creatinine kinase
levels
Death,MI,stroke,TLR
San Martin17
1
Stroke
Q-wave MI
Death,MI,stroke,TVR
Kawecki18
1
All cause
Death
Cardiac
Death
Repeat
revascularization
of the same
segment or 5
mm distal to the
original lesion
NA
NA
ESC criteria for ACS
NA
Luo19
2
Palmerini20
2
Neurological
deficits
NA
ESC/ACCF/AHA/WHF Death , MI , Stroke
definition
Q-wave or Non Q
wave or post
procedural MI
Morice1
Cardiac
Death
Any cause
Repeat
revascularization
of the same
segment or 5
mm distal to the
original lesion
NA
NA
Irreversible
brain
damage or
permanent
body
impairment
from
impaired
cerebral
circulation
Stroke, TIA,
RIND
Permanent
body
impairment
from
impaired
cerebral
circulation
Stroke, TIA,
RIND
Death,MI,stroke,TVR
Death, MI and TVR
Death , MI , Stroke
-
PRECOMBAT21 1 & 2
Cardiac
Death
Zhao22
2
All cause
Death
Gijong YI23
5
Cardiac
Death
All cause
Death
Kang24
1 to 3
Credo Kyoto
225
DELTA
Registry26
1 to 3
ASAN27
4
All cause
Death
All cause
Death
5
All cause
death
1 to 4
All cause
death
Chang29
5
All cause
death
Qin30
3
All cause
Death
1&2
Cardiac
Death
MAIN
COMPARE32
4&5
All cause
death
Capodanno33
3
All cause
death
Wu28
Park Registry
31
Any repeat
revascularization
Sudden
onset of
vertigo,
numbness,
aphasia or
dysarthria
from
vascular
lesions of
the brain
Repeat
Neurological
revascularization deficits on
of LM, LAD , LCx
imaging
Revascularization NA
in target vessel
Repeat
Stroke
revascularization
of LM, LAD , LCx
Any repeat
Stroke
revascularization
revascularization Stroke, TIA,
of the target
RIND
vessel
Repeat
Neurological
revascularization deficits on
of LM, LAD , LCx
imaging.
Repeat
Neurological
revascularization deficits on
of LM, LAD , LCx
imaging.
Repeat
Neurological
revascularization deficits on
of LM, LAD , LCx
imaging.
Repeat
Stroke and
revascularization TIA
of LM, LAD , LCx
Any repeat
revascularization
Sudden
onset of
vertigo,
numbness,
aphasia or
dysarthria
from
vascular
lesions of
the brain
Repeat
Neurological
revascularization deficits on
of LM, LAD , LCx
imaging.
Revascularization NA
in target
segment
Q wave or post
procedural MI
Death,MI,stroke,TVR
Q wave MI
Death,MI,stroke
Q wave MI or STEMI
Death,MI,stroke,TVR
ESC/ACCF/AHA/WHF Death,MI,stroke,TVR
definition
ARTS definition
Death,MI,stroke
Q-wave or Non Q
wave or post
procedural MI
Q wave MI
Death,MI,stroke,TVR
Q-wave or Non Q
wave or post
procedural MI
Q wave MI
Death,MI,stroke,
Ischemia symptom,
Ischemic EKG,
increased
biomarkers
Q wave or post
procedural MI
Death,MI,stroke,TVR
Q wave MI
Death,MI,stroke
NA
Death,MI,stroke,TVR
Death,MI,stroke,
Death,MI,stroke
Death,MI,stroke,TVR
Online Table 1: Definition of Major End Points in the included studies. TVR- target vessel revascularization, MI – myocardial
infarction, MACCE – major adverse cardiovascular and cerebrovascular events, FND – focal neurological deficits, LM – left main
coronary artery , LAD – left anterior descending artery , LCx – left circumflex coronary artery , RIND – reversible ischemic
neurological deficit , ESC – European Society of Cardiology , ACS – acute coronary syndrome , ACCF – American College of
Cardiology foundation, AHA – American Heart Association, WHF – World Health Federation , TIA – transient ischemic attack ,
NA – not available .
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