Dominance - (12 Years and Older) Protocol Id 020602 Description of Protocol Questions to determine which hand the participant uses for a series of activities. Specific Instructions None Protocol Text The following protocol is part of a personal interview in which the participant reports on his/her own hand usage. Young Adult and Adult handedness is assessed using an 11-item scale. Please indicate your preferences in the use of hands in the following activities by putting a 1 in the appropriate column (for right only, left only, or both hands) for each item that you use. Right hand Left hand Both hands 1. Write 2. Draw 3. Throw 4. Hold a racquet 5. Clean teeth 6. Hammer 7. Strike a match 8. Use an eraser 9. Deal cards 10. Thread a needle 11. Cut food with a knife Total Scoring: The participant indicates use by a "1" in the appropriate column (for right, left, or both) for each item that an adult uses. Add the "1"s in each column to get a total for that column. The sum of all three column totals is the cumulative total. To calculate the score: 100 x (right total - left total)/cumulative total. Handedness is then classified as follows: Scoring Less than -40 left-handed Greater than or equal to -40 and less than 40 Greater than or equal to 40 right-handed mixed-handed Note: The activities listed in the Edinburgh Handedness Inventory method have been modified by the PhenX Anthropometrics Working Group. Selection Rationale The Edinburgh Handedness Inventory was selected because of the detail of the activities that are performed. Source Oldfield, R.C. (1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia, 9, 97-113. Language English Participant This measure includes two protocols, each relating to a specific age of the participant. Consistent hand dominance starts to develop between 2 and 3 years of age and is usually completed by 6 years of age. Hand preference that appears before the age of 18 months may signal impaired neurological control of the other hand. Avon Longitudinal Study of Parents and Children Protocol (ALSPAC) Child beginning at 42 months of age Edinburgh Handedness Inventory Participant aged 12 and older Personnel and Training Required The trained interviewer should be able to administer a questionnaire and have the ability to probe for information as necessary. Equipment Needs None Standards Standard Name ID Source Common Data Elements (CDE) Preference Hand Laterality 2180147 CDE Browser Logical Observation Identifiers Names and Codes (LOINC) Hand dom- 12Y proto EHI 56101-9 LOINC General References Porac, C., & Coren, S. (1981). Lateral preferences and human behavior. New York: Springer-Verlag. Protocol Type Question Derived Variables None Requirements Requirement Category Required Average time of greater than 15 minutes in an unaffected individual No Average time of greater than 15 minutes in an unaffected individual Major equipment No This measure requires a specialized measurement device that may not be readily available in every setting where genome wide association studies are being conducted. Examples of specialized equipment are DEXA, Echocardiography, and Spirometry Specialized requirements for biospecimen collection No This protocol requires that blood, urine, etc. be collected from the study participants. Specialized training This measure requires staff training in the protocol methodology and/or in the conduct of the data analysis. No