ADVANCED CELL BIOLOGY GMS 6421 (Spring-2016) Course Director: Satya Narayan PhD (snarayan@ufl.edu) Lecture Rooms: TBA Recommended Reference Book – Molecular Biology of Cell, Fifth Edition, by: Alberts B, Johnson A, Lewis J, Raff M, Roberts K, and Walter P Week 1 Day & Date Time T 01/05/16 W 01/06/16 F 01/08/16 4:00-4:50 PM 4:00-4:50 PM 3:00-4:40 PM M 01/11/16 T 01/12/16 F 01/15/16 4:00-4:50 PM 4:00-4:50 PM 3:00-4:40 PM W 01/20/16 F 01/22/16 3:00-3:50 PM 3:00-4:40 PM M 01/25/16 W 01/27/16 F 01/29/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 02/01/16 W 02/03/16 F 02/05/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 02/08/16 W 02/10/16 F 02/12/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 02/15/16 W 02/17/16 F 02/19/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 02/22/16 W 02/24/16 F 02/26/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 03/07/16 W 03/09/16 F 03/11/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 03/14/16 W 03/16/16 F 03/18/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 03/21/16 W 03/23/16 F 03/25/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 03/28/16 W 04/30/16 F 04/01/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 04/04/16 W 04/06/16 F 04/08/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 04/11/16 W 04/13/16 F 04/15/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM M 04/18/16 W 04/20/16 F 04/22/16 3:00-3:50 PM 3:00-3:50 PM 3:00-4:40 PM 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Topic Membrane biology L1: Membrane microdomains L2: ER - Translocation L3. Paper discussion Secretory pathway L4: ER - Protein folding and quality control L5: Vesicular transport and Golgi L6: Paper discussion Endocytic and lysosomal pathways L7: Sorting to lysosomes and endocytosis L8: Paper discussion Turnover pathways L9: Autophagy, lysosomes, proteasomes L10: Autophagy and cancer drug development L11: Paper discussion Cytoskeleton L12: Actin dynamics and regulation L13: Microtubules and motors in mitosis L14: EXAM 1 Mitochondria L15: Mitochondrial gene defects L16: Mitochondrial dynamics L17: Paper discussion Nucleus L18: Nuclear dynamics and architecture L19. Heterochromatin and gene silencing L20: Paper Discussion Epigenetics L24: High order chromatin structure L25: Epigenetics and gene regulation L26: Paper Discussion MicroRNAs L21: MicroRNAs in innate monocyte response L22: MicroRNAs in cancer cell biology L23: Paper Discussion Signal transduction networks L27: DNA damage response dynamics L28: Drug targets and signaling networks L29: EXAM 2 Cell polarity L30: Cell polarity in tissue morphogenesis L31: Cell polarity and cancer L32: Paper discussion Cell cycle L33: Cell cycle dynamics and checkpoints L34: Apoptosis L35: Paper discussion Stem cells L36: Stem cell pluripotency L37: Cancer stem cells L38: Paper discussion Cellular mechanisms of diseases L39: Cell pathogen interactions L40: Cell biology of urinary tract infection L41: Paper discussion Cancer cell biology L42: Oncogenes / molecular biology of cancer L43: Inherited cancer syndrome L44: EXAM 3 Lecture Aris Aris Aris Aris Aris Aris Dunn Dunn Dunn Dunn Dunn Holliday Holliday Narayan Leeuwenburgh Leeuwenburgh Leeuwenburgh Ishov Ishov Ishov Qiu Qiu Qiu Chan Chan Chan Narayan Narayan Narayan Linser Linser Linser Liao Liao Liao Terada Terada Terada Daaka Daaka Daaka Zajac-Kaye Zajac-Kaye Narayan