Supplement 2: Included articles The subscription drug

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Supplement 2: Included articles

The subscription drug-drug interaction databases (DIDs) Micromedex: DRUG-REAX® System appeared in 76 articles

[1-76], Lexicomp®: Lexi-Interact™ in 31 articles [4,10,11,17,51,53,58,61,65-67,73,74,77-94] and Stockley’s: Drug

Interactions in 10 articles [4,14,43,64,73,79,95-98].

The open access DIDs Epocrates Rx: Interaction Check appeared in 16 articles [3,8,11,17,27,51,53,78,84,95,99-104],

Drugs.com: Interactions Checker in 15 articles [10,47,48,52,57,75,76,87,105-111], Medscape: Drug Interaction

Checker in 13 articles [7,8,10,47,48,53,58,76,84,93,112-114], Drugbank: Interax Multi Interaction Search in nine articles [10,75,106,107,111,115-118]and RxList: Drug Interactions Checker in two articles [53,78].

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60. Roughead EE, Kalisch LM, Barratt JD, Gilbert AL (2010) Prevalence of potentially hazardous drug interactions amongst Australian veterans.

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68. Straubhaar B, Krahenbuhl S, Schlienger RG (2006) The prevalence of potential drug-drug interactions in patients with heart failure at hospital discharge. Drug Saf 29 (1):79-90

69. Teixeira JJ, Crozatti MT, dos Santos CA, Romano-Lieber NS (2012) Potential drug-drug interactions in prescriptions to patients over 45 years of age in primary care, southern Brazil. PLoS One 7 (10):e47062. doi:10.1371/journal.pone.0047062

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80. Dirin M, Mousavi S, Afshari A, Tabrizian K, Ashrafi M (2014) Potential drug-drug interactions in prescriptions dispensed in community and hospital pharmacies in East of Iran. Journal of Research in Pharmacy Practice 3 (3):104-107

81. Gholaminezhad S, Hadjibabaie M, Gholami K, Javadi MR, Radfar M, Karimzadeh I, Ghavamzadeh A (2014) Pattern and associated factors of potential drug-drug interactions in both pre- and early post-hematopoietic stem cell transplantation stages at a referral center in the Middle East.

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90. Roblek T, Trobec K, Mrhar A, Lainscak M (2014) Potential drug-drug interactions in hospitalized patients with chronic heart failure and chronic obstructive pulmonary disease. Archives of Medical Science 10 (5):920-932

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94. Yiu P, Nguyen NN, Holodniy M (2011) Clinically significant drug interactions in younger and older human immunodeficiency virus-positive patients receiving antiretroviral therapy. Pharmacotherapy 31 (5):480-489

95. Gavronski M, Hartikainen S, Zharkovsky A (2012) Analysis of potential interactions between warfarin and prescriptions in Estonian outpatients aged 50 years or more (Analisis de las interacciones potenciales entre warfarina y medicamentos prescritos en pacientes ambulatorios mayores de 50 anos en Estonia.). Pharmacy Practice 10 (1):9-16

96. Mendes-Netto RS, Silva CQV, Filho ADO, Rocha CE, Lyra-Junior DP (2011) Assessment of drug interactions in elderly patients of a family health care unit i Aracaju (Brazil): A pilot study. African Journal of Pharmacy and Pharmacology 5 (7):812-818

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98. Strandell J, Caster O, Bate A, Noren N, Edwards IR (2011) Reporting patterns indicative of adverse drug interactions: a systematic evaluation in

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99. Barrons R (2004) Evaluation of personal digital assistant software for drug interactions. American Journal of Health-System Pharmacy 61

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100. Dallenbach MF, Bovier PA, Desmeules J (2007) Detecting drug interactions using personal digital assistants in an out-patient clinic. Qjm 100

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101. Lubinga SJ, Uwiduhaye E (2011) Potential drug-drug interactions on in-patient medication prescriptions at Mbarara Regional Referral Hospital

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102. Ray S, Pramanik J, Bhattacharyya M, Todi S (2010) Prospective observational evaluation of incidences and implications of drug-drug interactions induced adverse drug reactions in critically ill patients. Indian journal of pharmaceutical sciences 72 (6):787-792

103. Strain JJ, Chiu NM, Brodsky M, Karim A, Caliendo G (2002) Comparison of three methods for identifying medical drug-psychotropic drug interactions. General hospital psychiatry 24 (5):311-315

104. Sutton J, Stockton L, McCord G, Gilchrist VJ, Fedyna D (2004) Handheld computer use in a family medicine clerkship. Academic medicine : journal of the Association of American Medical Colleges 79 (11):1114-1119

105. Chatsisvili A, Sapounidis I, Pavlidou G, Zoumpouridou E, Karakousis VA, Spanakis M, Teperikidis L, Niopas I (2010) Potential drug-drug interactions in prescriptions dispensed in community pharmacies in Greece. Pharmacy World and Science 32 (2):187-193

106. Gottlieb A, Stein GY, Oron Y, Ruppin E, Sharan R (2012) INDI: a computational framework for inferring drug interactions and their associated recommendations. Molecular systems biology 8:592

107. Iyer SV, Harpaz R, LePendu P, Bauer-Mehren A, Shah NH (2014) Mining clinical text for signals of adverse drug-drug interactions. Journal of the American Medical Informatics Association : JAMIA 21 (2):353-362

108. Kulkarni V, Bora SS, Sirisha S, Saji M, Sundaran S (2013) A study on drug-drug interactions through prescription analysis in a South Indian teaching hospital. Therapeutic Advances in Drug Safety 4 (4):141-146

109. Okuno MF, Cintra RS, Vancini-Campanharo CR, Batista RE (2013) Drug interaction in the emergency service. Einstein (Sao Paulo, Brazil) 11

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110. Pinto MCX, Malaquias DP, Ferre F, Pinheiro MLP (2013) Potentially inappropriate medication use among institutionalized elderly individuals in southeastern brazil. Brazilian Journal of Pharmaceutical Sciences 49 (4):709-717

111. Vilar S, Uriarte E, Santana L, Tatonetti NP, Friedman C (2013) Detection of Drug-Drug Interactions by Modeling Interaction Profile

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112. Neto VC, Garcia VP, Helena ETS (2010) Possible pharmacological interactions in hypertensive and/or diabetic elderly in family health units at

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113. Oshikoya KA, Oreagba IA, Ogunleye OO, Lawal S, Senbanjo IO (2013) Clinically significant interactions between antiretroviral and coprescribed drugs for HIV-infected children: Profiling and comparison of two drug databases. Therapeutics and Clinical Risk Management 9 (1):215-

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114. Patel P, Rana D, Suthar J, Malhotra S, Patel V (2014) A study of potential adverse drug-drug interactions among prescribed drugs in medicine outpatient department of a tertiary care teaching hospital. Journal of Basic and Clinical Pharmacy 5 (2):44-48

115. Cheng F, Zhao Z (2014) Machine learning-based prediction of drug-drug interactions by integrating drug phenotypic, therapeutic, chemical, and genomic properties. Journal of the American Medical Informatics Association : JAMIA 21 (e2):e278-286

116. Sun J, Zhao M, Fanous AH, Zhao Z (2013) Characterization of schizophrenia adverse drug interactions through a network approach and drug classification. BioMed research international 2013:458989

117. Tari L, Anwar S, Liang S, Cai J, Baral C (2010) Discovering drug-drug interactions: a text-mining and reasoning approach based on properties of drug metabolism. Bioinformatics (Oxford, England) 26 (18):i547-553

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