VCUHS HEMATOLOGY/ONCOLOGY FELLOWSHIP CURRICULUM MCV Hospital and VA Medical Center Inpatient Consultation Services Description of Rotation or Educational Experience The VCU Hematology-Oncology fellowship program MCV Hospital and VA Medical Center inpatient hematology-oncology consultation rotations are designed to allow the fellow to become proficient and independent in the provision of inpatient consultation services. The fellow is expected to participate in the care and management of adult patients admitted to the hospital for any variety of medical conditions in which the primary team has an acute hematologic and/or oncologic question. The fellow is responsible for efficiently synthesizing the available data from a variety of modalities and for augmenting the existing data with targeted, specialty/consult question-specific collection of additional primary information from the patient, family, outside providers, and additional diagnostics as necessary. The fellow is responsible for the development of the assessment and recommendations through their synthesis of the data and through their review of the literature and other resources. As the fellow functions as a specialty consultant to the primary admitting team, this rotation provides the opportunity for the fellow to develop skills necessary for the effective and timely evaluation of the patient and for the communication of the recommendations back to the consulting team. In addition, the rotation emphasizes the role of consultant as an educator to both the patient and the consulting provider. The fellow will be challenged to focus their clinical care and educational efforts on the specialty specific aspects of the patient’s care but put into context as they relate and interact with the patient’s other systemic illnesses and needs. All of this occurs under the supervision of the responsible faculty from the Division of Hematology, Oncology, and Palliative Care consult attending faculty members at the two facilities. Location: VCUHS MCV Hospital inpatient facilities Hunter Holmes McGuire VA Medical Center inpatient facilities Length of Experience: 4 week block – days only without specific weekend or in-house night coverage. Educational Goals Gain experience and knowledge in the diagnosis, prognosis, management, and complications of inpatients with nonmalignant, hematologic problems manifesting as a result of or in conjunction with acute medical conditions necessitating hospitalization. Gain experience and knowledge in the diagnosis, prognosis, management, and complications of inpatients with acute non-malignant, hematologic problems necessitating hospitalization. Gain experience and knowledge in the diagnosis, prognosis, management, and complications of inpatients with hematologic and solid tumor malignancies Gain experience in the diagnosis, prognosis, and management of acute hematologic and oncologic emergencies Gain experience in the diagnosis, prognosis, and management of complications of advanced malignancy Gain experience in the administration, monitoring, and toxicities of chemotherapy Gain additional experience in performing the procedures essential to the diagnosis and to the delivery of care of acute hematologic and oncologic disorders, including bone marrow biopsy and aspiration; lumbar puncture with the intrathecal administration of chemotherapy; and the access and administration of chemotherapy via an Omaya reservoir. Gain experience in communication with and the counseling of patients and families regarding their acute hematologic and oncologic medical conditions and in providing the necessary support and ancillary services to effectively meet their medical and psychosocial needs. 1 Gain experience in the management of end-of-life issues, including advanced directives, resuscitation status, surrogate decision making, and home/inpatient hospice resource utilization. Gain experience and knowledge in the unique aspects of the role of and effective functioning as a subspecialty inpatient consultant Gain experience in effective communication necessary to effective co-management Gain experience in the effective transferring of subspecialty care to the outpatient provide(s) YEAR 3 YEAR 2 YEAR 1 Progressive Responsibilities by Fellow Year The first year fellow is expected to focus on primary medical knowledge, communication skill and procedural skill development. Medical knowledge acquisition should focus on the routine diagnosis, natural history, staging, prognosis, and first-line management of the hematologic-oncologic conditions. Additionally, the first year fellow should focus on the pharmacologic mechanism of action, dosing considerations, and common toxicities of the medications being employed for the treatment of the hematologic-oncologic condition. Consult recommendations and care plans should be developed independently or in conjunction with attending physician and health care team but reviewed in full with the attending physician in advance of communication to the patient, family, and consulting providers. Initial counseling of the patient and family regarding the goals of care, the care plan, and chemotherapy counseling should be done with direct supervision of the attending physician or only after full review of the goals of care and care plan with the attending physician. (The PharmD may provide the direct supervision of chemotherapy counseling and consenting once the care plan has been established with the attending physician). The second year fellow is expected to refine their medical knowledge by focusing on an understanding of the underlying pathophysiology, the basis and use of molecular and genetic markers to refine prognostic determinations and treatment planning; and considerations/options in second-line and beyond. Consult recommendations and care plans should be developed independently with only moderate need for input from the attending physician though reviewed in full with the attending physician in advance of communication to the patient, family, and consulting providers. Initial counseling of the patient and family regarding the goals of care, the care plan, and chemotherapy counseling may be done independently but only after full review of the goals of care and care plan with the attending physician. The third year fellow is expected to demonstrate proficiency and independence. The third year fellow is expected to demonstrate full knowledge of the routine diagnosis, natural history, staging, prognosis, and first-line management of the hematologic-oncologic conditions. They should demonstrate a proficient understanding of the underlying pathophysiology, the basis and use of molecular and genetic markers to refine prognostic determinations and treatment planning; and considerations/options in second-line and beyond. Consult recommendations and care plans should be developed independently with minimal input from the attending physician though still reviewed with the attending physician. Initial counseling of the patient and family regarding the goals of care, the care plan, and chemotherapy counseling should be done independently though reviewed with the attending physician. Patient Care Goal Fellows must be able to provide patient care that is compassionate, appropriate, and effective for the treatment of health problems and the promotion of health. Please refer to overview of the fellowship curriculum for competencies/objectives for patient care. Specifically, fellows will see patients in acute inpatient hospital setting under the supervision of the appropriate subspecialty faculty member. Fellows will participate in the evaluation, counseling, and management of acutely and chronically ill hematology-oncology inpatients. This will provide the opportunity to learn the different approaches to inpatient management of these conditions. Fellows will additionally coordinate the care plan with the patient’s primary team and, as necessary for the coordination of the specific hematology-oncology aspects of care, with the patient’s multidisciplinary team of health professionals including pharmacists, nurses, physical therapies, occupational therapists, social workers, and care coordinators. 2 Competencies Fellows are expected to: Gather appropriate clinical information Synthesize information into a care plan Perform the procedures necessary for the effective diagnosis and management of acute hematologic and oncologic disorders Partner with patients/families in the implementation of the plan Coordinate care plans with the referring physicians, the inpatient multi-disciplinary team of health professionals, and the home health agencies Objectives Fellows are expected to: Develop skills in history/physical examination of the patient with hematologic and oncologic disorders Develop skills as an outpatient subspecialty consultant Integrate clinical data in the formation of a comprehensive care plan Recognize the common sources of error in the performance and interpretation of hematology laboratory assays Document the encounter in the medical record in sufficient detail to communicate to other physicians and meet billing requirements Provide compassionate, appropriate, and comprehensive patient care Medical Knowledge Goal Fellows must demonstrate knowledge of established and evolving biomedical, clinical, epidemiological, and social-behavioral sciences, as well as the application of this knowledge to patient care. Competencies Fellows are expected to demonstrate skills in: Acquisition of knowledge Analysis of information Application of knowledge Objectives All fellows are expected to: Demonstrate the ability to perform a comprehensive and accurate physical examination; demonstrate the ability to arrive at an appropriate differential diagnosis; outline a logical plan for specific and targeted investigations pertaining to the patient’s complaints; and formulate a plan for management and follow-up treatment of the patient Demonstrate their knowledge by presenting the results of a consultation orally and in writing and by defending the clinical assessment, differential diagnosis, and diagnostic and management plans First year fellows are expected to: Medical knowledge acquisition should focus on the routine diagnosis, natural history, staging, prognosis, and first-line management of the hematologic-oncologic conditions. Additionally, the first year fellow should focus on the pharmacologic mechanism of action, dosing considerations, and common toxicities of the medications being employed for the treatment of the hematologic-oncologic condition. Second year fellows are expected to: Medical knowledge acquisition should focus on an understanding of the underlying pathophysiology, the basis and use of molecular and genetic markers to refine prognostic determinations and treatment planning; and considerations/options in second-line and beyond. 3 Third year fellows are expected to: Medical knowledge acquisition should focus on mastery of the knowledge obtained as a first and second year fellow Content-Specific Objectives: The medical conditions experienced during any single block of this rotation can be quite variable. However, in an effort to provide guidance, the following core rotation-specific objectives outline specific medical knowledge content material that the fellow is expected to obtain during this rotation: Demonstrate a knowledge of the diagnostic evaluation of the patient with a newly diagnosed lung mass Demonstrate a knowledge of the diagnostic evaluation of the patient with newly diagnosed adenopathy Demonstrate a knowledge of the diagnostic evaluation of the patient with newly diagnosed metastatic cancer of undetermined primary Demonstrate a knowledge of the diagnostic and therapeutic approach to the patient presenting with new brain metastasis in both the setting of an undiagnosed primary malignancy and a known malignancy Demonstrate a knowledge of the diagnostic and therapeutic approach to the patient presenting with new cord compression in both the setting of an undiagnosed primary malignancy and a known malignancy Demonstrate a knowledge of the diagnostic and therapeutic approach to the patient presenting with new malignant leptomeningeal involvement in both the setting of an undiagnosed primary malignancy and a known malignancy Demonstrate a knowledge of the differential diagnosis, diagnostic approach and therapeutic management of the patient presenting with new superior vena cava syndrome in both the setting of an undiagnosed malignancy and a known malignancy Demonstrate a knowledge of the diagnostic and therapeutic approach to the patient presenting with bowel obstruction in both the setting of an undiagnosed primary malignancy and a known malignancy Demonstrate a knowledge of the diagnostic and therapeutic approach to the patient presenting with new malignant pleural effusion and/or ascites in both the setting of an undiagnosed primary malignancy and a known malignancy Demonstrate an understanding of the management options of malignancy-related pain including the role of pharmacologic agents, radiation, surgery, kyphoplasty, and neurologic blocks. Demonstrate a knowledge of the pathophysiologic mechanism leading to malignancy-associated hypercalcemia Demonstrate a knowledge of the diagnostic approach to the patient with malignancy-associated hypercalcemia Demonstrate a knowledge of the prognostic implications of malignancy-associated hypercalcemia in relationship to the underlying malignant etiology Demonstrate a knowledge of the therapeutic approach to the patient with malignancy-associated hypercalcemia including the indications, dosing, monitoring, toxicities, and therapeutic benefits of the hydration, bisphosphonates, calcitonin, glucocorticoids, calcimimetics, and dialysis Understand the use and calculate a patients performance status using the Eastern Cooperative Group and the Karnofsky performance scoring systems Demonstrate a knowledge of the pathophysiology, differential diagnosis, evaluation, and management of the acute complications of the sickle cell disorders, including vasoocclusive bone pain, sickle chest syndrome, stroke, priapism, acute hepatopathy, and acute hematologic crisis. Demonstrate an understanding of the differential diagnosis and evaluation of thrombocytosis in the inpatient setting Demonstrate an understanding of the pathophysiology, evaluation, diagnostic criteria, prognosis, and management of hematophagocytic lymphohistiocytosis Demonstrate a knowledge of the evaluation of the various anemia in the inpatient setting Demonstrate a knowledge of the evaluation of the patient with thrombocytopenia in the inpatient setting Demonstrate a knowledge of the pathophysiology, manifestations, diagnosis, and management of the different etiologies of microangiopathic hemolytic anemia including the ability to differentiate between thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), and disseminated intravascular coagulation (DIC) among others Recognize the morphologic features of a microangiopathic hemolytic anemia on a peripheral blood smear Demonstrate a knowledge of the pathophysiology, diagnosis, manifestations, and management of antiphopholipid 4 syndrome including the unique aspects of the presentation and management of catastrophic antiphospholipid syndrome. Demonstrate a knowledge of the pathophysiology, manifestations, diagnosis, and management of heparin induced thrombocytopenia (HIT) including the ability to determine pretest probability based on published literature. Demonstrate a knowledge of the diagnostic approach to the patient with acute coagulopathy Demonstrate a knowledge of the pathophysiology, diagnosis, manifestations, and management acute disseminated intravascular coagulopathy Recognize, diagnose, and manage the acute hematologic complications of pregnancy Recognize and diagnose, and manage the acute hematologic complications of end-stage liver disease Demonstrate a knowledge of the diagnostic evaluation and management of the patient presenting with a newly acquired coagulation factor autoantibody to Factor VIII Demonstrate practical competency with the specific factor replacement concentrates, inhibitor “bypass” products, antifibrinolytic agents, and the role of blood products for the management of bleeding disorders presenting with acute bleeding. The trainee should demonstrate a general understanding of the pharmacology dosing and administration of these agents as well as of their toxicity and potential interactions with other medications and factors. Demonstrate a knowledge of the routine management of a patient with a bleeding disorder presenting for elective surgical intervention, urgent surgical intervention, or obstetric delivery Demonstrate a comprehensive working knowledge of the clinical presentation, pathogenic mechanism, diagnosis and management of heparin-induced thrombocytopenia. The trainee should also demonstrate an understanding of the risk and consequences of thrombosis in these patients Demonstrate a comprehensive working knowledge and practical competency for diagnosing and managing the manifestations of antiphospholipid syndrome. This should include a comprehensive working knowledge of the different antibodies that can be assayed and used in the diagnosis of this syndrome and a practical competency for the use of prophylaxis for those patients at risk of thrombosis. The trainee should also demonstrate practical competency for recognizing and managing the clinical manifestations associated with antiphospholipid syndrome, including the implications and risks associated with pregnancy and surgery. Demonstrate practical competency with the specific factor replacement concentrates, inhibitor “bypass” products, antifibrinolytic agents, and the role of blood products for the management of bleeding disorders presenting with acute bleeding. The trainee should demonstrate a general understanding of the pharmacology dosing and administration of these agents as well as of their toxicity and potential interactions with other medications and factors. Practice- Based Learning and Improvement Goal Fellows must demonstrate the ability to investigate and evaluate their care of patients, to appraise and assimilate scientific evidence, and to continuously improve patient care based on constant self-evaluation and lifelong learning. The fellow is expected to present primary scientific and medical evidence to support their conclusions and care plans in the diagnosis, prognosis, management, and monitoring of the patients on the service. The fellow is expected to recognize their areas of deficiency. Depending upon the acuity of the care situation, the fellow is expected to be able to effectively utilize their resources to arrive at necessary information and to apply the information to their patient care. Moreover, the fellow is expected to recognize conditions and circumstances requiring escalation. Please refer to overview of the fellowship curriculum for competencies/objectives for practice based learning and improvement. Systems Based Practice Goal Fellows must demonstrate an awareness of and responsiveness to the larger context and system of health care, as well as the ability to call effectively on other resources in the system to provide optimal health care. Fellows will work within a multidisciplinary team of health professionals including the consulting providers, pharmacists, nurses, physical therapists, occupational therapists, social workers, and care coordinators. 5 Please refer to overview of the fellowship curriculum for competencies/objectives for systems based practice. Professionalism Goal Fellows must demonstrate a commitment to carrying out professional responsibilities and an adherence to ethical principles. The fellow is expected to model professional and courteous behavior in the treatment of the patient and in working with the entire health care team. The fellow is expected to complete documentation of their patient care, of their communications with the patient and health care providers, and of their procedures in a timely fashion within the medical record. The fellow is also expected to recognize the critical importance of their own education and the importance of life-long learning as part of their professional responsibility. As such, it is the obligation of the fellow to themselves, their profession, and their patients to attend and complete in a timely fashion all of fellowship training program’s expected educational activities. Please refer to overview of the fellowship curriculum for competencies/objectives for professionalism. Interpersonal and Communication Skills Goal Fellows must demonstrate interpersonal and communication skills that result in the effective exchange of information and teaming with patients, their families, and professional associates. Please refer to overview of the fellowship curriculum for competencies/objectives for interpersonal and communication skills. Teaching Methods Patient care/clinical experience Modeling of observed behaviors of attending physicians Case-based interactive discussions Didactic sessions Performance feedback Self-directed learning Assessment of Fellow Performance End-of-rotation evaluation of the fellow by the supervising attending physicians 360-evaluation by the medical students, interns, and residents when present as part of the team Mini-CEX by supervising attending physicians of a counseling and communication encounter Semi-annual self-assessment by the fellow Assessment of Rotation End-of-rotation evaluation of the supervising attending physicians by the fellow Annual program review Discussions with fellows during biannual review Review in-service and ABIM exam results Level of Supervision Indirect supervision with faculty immediately available Direct supervision by the faculty of select patient, family and professional health staff encounters to assess medical knowledge as conveyed in the provided counseling and care coordination, system-based practice, professionalism, and interpersonal communication skills 6 Educational Resources Devita, Hellman, and Rosenberg’s Cancer: Principles and Practice of Oncology (9th Edition) Hoffman Hematology: Basic Principles and Practice (4th Edition) UpToDate ASCO University ASCO Practice and Guidelines ASCO-SEP ASH-SEP NCCN Guidelines (www.nccn.org) NCI Common Cancer Types and Clinical Trails by Cancer Type/Disease (www.cancer.gov) The AJCC 7th edition TMN staging of Cancer Common Toxicity Criteria v4.0 (aka Common Terminology Criteria for Adverse Events) GAIL model Claus model Adjuvant! 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