Reviewer (Patricia Gerbarg) Minor Essential Revisions 1) Title has been changed 2) Introduction 2.1 Paragraph 2: The studies on metabolic syndrome and oxygen consumption have all been published since our article was submitted. These papers have now been referred to. 2.2 “mind-body coherence” has been defined as well as appropriate changes have been made 3) Material and Methods 3.1 Point is noted for future studies 3.2 All necessary changes have been made in paragraph 3 of discussion 4) Results 4.1 We are reluctant to comment on the kapalbhati breathing as it is uncertain whether the NY and MS groups performed this correctly and the NY and MS groups performed KB breathing at a different rate. 5) Discussion 5.1 Noted with thanks 5.2 We have edited the last sentence and also added an appropriate reference with mitochondrial efficiency 5.3 A reference has been added with ‘relaxation response’ and mitochondrial efficiency 5.4 Alteration has been made in the first sentence of Paragraph 7 5.5 As suggested appropriate changes have been made in paragraph 8 6) Conclusion 6.1 As suggested the changes have been made to flexibility and adaptability 6.2 Appropriate correction have been made in second and third sentence 7) Letter ‘a’ is added to Patanjali Reviewer Marshall Hagnis Major Compulsory Changes 1. As suggested, the appropriate changes, clearly stating that the study design has been made in paragraph 3 of discussion 2. As suggested appropriated alteration have been made in paragraph 3 of discussion. However we would like to state that the breathing rate in this experimental study was not controlled and participants were instructed to breath at their spontaneous frequency. However during Kapalbahati breathing experimental phase participants were instructed to breathe at prefixed frequency of approx. 48-breath/min. As this is strenuous procedure and to avoid dizziness, the metabolic syndrome participants were suggested to continue a cycle of spontaneous breathing in the event of discomfort. We have been careful during the analysis therefore we limited our discussion to mental arithmetic stress test only. 3. The results of our statistical analysis showed the greatest variability among yoga practitioners across all experimental phases and we have already reported it in paragraph 5 of subsection ‘Inferential results for metabolic variability’ in result section. The following statement is clearly mentioned reflecting variability “The Yoga Practitioner group demonstrated the largest variability across the nine phases, as evidenced by the significant main effect for group reported above, and the higher p value of .95 for the yoga group in the group within phase simple main effect test.” 4. As suggested the correction have been made and references with metabolic syndrome have been added in paragraph 2 of Introduction 5. The results and statistical analysis showed the greatest variability among yoga practitioners yoga practices compared to other two groups reliability 6. The evidence of variability among yoga practitioners and other groups are evident in result section under statistical analysis. Minor Essential Revisions Essential changes of alcohol, smoking and diet regime for yoga practitioners associated have been made in the subsection ‘population’ under section ‘Materials and methods’. For non-yoga practitioners the diet regime we do not know as they were the temporary resident, residing in the campus for > 5 days at the time of experiment. We have updated in paragraph 2 of discussion and reference has been added for similar indirect calorimetry method As suggested, Table 4 has been updated and the p values are Bonferroni adjusted alpha values and asterisks (*) indicating significant values has been added in other tables also of the manuscript