Peptides in Paris Symposium PIPS 2014 October 5-8, 2014 Site of Gennevilliers University of Cergy-Pontoise, France (RER C: Gennevilliers) https://iascolloque.u-cergy.fr SCIENTIFIC PROGRAM Sunday October 5, 2014 13:00-14:30 – Registration & Poster Hanging 14:30-14:50 – Introduction Hung The Diep, Anna-M. Papini & Solange Lavielle 14:50-15:00 - Chairs: Solange Lavielle & Claudio Toniolo 15.00-15:40 - Aphrodite Kapurniotu. Technische Universität München (Germany). “Cross-Amyloid Peptide Inhibitors of Protein Aggregation in Cell Degenerative Diseases” 15:40-16:00 - Lucie Khemtémourian. Laboratoire des BioMolécules, UMR 7203 Université Pierre et Marie Curie, CNRS, ENS, Paris (France). “Cholesterol modulates the interaction of the islet amyloid polypeptide with membranes” 16:00-16:30 - Ikuo Fujii. Department of Biological Science, Osaka Prefecture University (Japan). “MicroAntibodes: Generation of Molecular-targeting Peptides by Directed Evolution in Phage-displayed Libraries of Conformationally Constrained Peptides” 17:00-17:20 - Nicolas Gilles, Institut de Biologie et Technologies de Saclay (iBiTec-S), Service d’Ingénierie Moléculaire des Protéines (SIMOPRO), ??? (DSV), CEA Saclay (France). “Mambaquaretin, a green mamba toxin as a new therapeutic agent for polycystic kydney diseases” 17:20-18:00 - Jean-Louis Banères. IBMM, University of Montpellier 1 & 2 (France). “Signaling Through a G Protein-Coupled Receptor: a Matter of Conformational Adaptations” 18:00-19:30 – Welcome Reception. Monday October 6, 2014 9:00-9:10 - Chairs: Luis Moroder & Waleed Danho 9:10-9:50 - Lars Baltzer. Department of Chemistry, BMC, Uppsala Universitet (Sweden). “The Conjugation of Small Molecules to Polypeptides and the Role of Polypeptide Conjugates in Drug Development” 9:50-10:10 - Ana Iris Fernández-Llamazares. Institute for Research in Biomedicine Barcelona, Barcelona (Spain). “The backbone N-(4-azidobutyl) linker for the preparation of peptide chimera” 10:10-10:40 – Luca Gentilucci. Departments of Chemistry “G. Ciamician” of Pharmacy and Biotechnology, University of Bologna, (Italy). “TRYptophan-COntaining Non-Cationizable Opioid PeptideS (TRYCONCOPS): A new paradigm for opioid peptides” 11:10-11:30 - Gregory Upert. Institut de Biologie et Technologies de Saclay (iBiTec-S), Service d’Ingénierie Moléculaire des Protéines (SIMOPRO), Laboratoire de Toxicologie Moléculaire et Biotechnologies (LTMB), CEA Saclay (France). “Efficient Synthesis and Refolding of Two-DisulfideBridges Toxins” 11:30-12:10 - Alicia Boto. Instituto de Productos Naturales y Agrobiología CSIC, Tenerife (Spain). “Creating Diversity in Peptide Libraries: New Customizable Units for the Site-Selective Modification of Peptides” 14:00-14:10 - Chairs: Luis Moroder & Waleed Danho 14:10-14:50 - Galia Maayan. Technion – Israel Institute of Technology (Israel). “Metallopeptoids: from Structure to Function” 14:50- 15:10 - Meital Reches. Institute of Chemistry The Hebrew University of Jerusalem (Israel). “Interaction of Individual Amino Acids and Peptides with Inorganic Surfaces” 15:10-15:50 - Nedjliko Budisa. Department of Chemistry, Technische Universität Berlin (Germany). “Coupling Bioorthogonal Chemistries with Artificial Metabolism” 16:20-16:40 - Evelien Wynendaele. University of Gent (Belgium). “How does the human microbiome affect cancer outcome?” 16:40-17:20 - Derek Woolfson. School of Chemistry, University of Bristol (United Kingdom). “De Novo Proteins: Faster, Better, Fitter” Tuesday October 7, 2014 9:00-9:10 - Chairs: Michael Chorev & Anna M. Papini 9:10-9:50 - Giancarlo Morelli. Department of Pharmacy, University of Naples "Federico II" (Italy). "Peptides as Delivery tools of Supramolecolar Carriers for Diagnostic and Therapeutic Applications" 9:50-10:10 - Jean-Marie Swiecicki. Laboratoire des Biomolécules, UPMC/CNRS/ENS, Paris (France). “Unraveling the penetration mechanisms and subcellular distribution of cell penetrating peptides” 10:10-10:30 – Margherita Di Pisa. Laboratoire des Biomolécules, UPMC/CNRS/ENS, Paris (France). “Design, synthesis and evaluation of the penetration properties of short cationic lipopeptides” 11:10-11:30 - Renata Grzywa. Division of Medicinal Chemistry and Microbiology Faculty of Chemistry, Wroclaw University of Technology (Poland). “IgY antibodies specific toward selected cancer antigens and their diagnostic potential” 11:30-12:10 - Fernando Formaggio. Department of Chemistry, University of Padova (Italy). “Peptaibiotics: Investigation of their Membrane Action by an Integrated Synthetic and Spectroscopic Approach”. 14:30-14:40 - Chairs: Michael Chorev & Anna M. Papini 14:40-15:20 - Assaf Friedler. Institute of Chemistry, The Hebrew University of Jerusalem (Israel). “Intrinsically Disordered Proteins as Drug Targets” 15:20-15:40 - Simona Pascarella. French-Italian Interdepartmental Laboratory of Peptide & Protein Chemistry & Biology, NEUROFARBA, University of Florence (Italy). “Mimicking Serine Protease Inhibitor H1 Chaperone Function in Collagen Biosynthetic Pathway via the Template Assembled Synthetic Protein Approach” 15:40-16:10 – Coffee break 16:10-16:50 - Ashraf Brik. Ben-Gurion University of the Negev (Israel). “Unraveling the Mysteries of the Ubiquitin Signal Using Chemical Protein Synthesis” 16:50-17:10 – Young Investigator to be assigned 17:10-17:50 - Philip E. Dawson. The Scripps Research Institute, La Jolla (CA, USA). “Mimicking Viral Surface Glycoproteins Using Synthetic Nanoparticles” Wednesday October 8, 2014 9:00-9:10 - Chairs: Claudio Toniolo & Solange Lavielle 9:10-9:50 - Christian Becker. Department of Chemical Biology, University of Vienna (Austria). “Chemical Protein (Semi-)Synthesis - Generating Tailor-Made Proteins for Biology & Biotechnology” 9:50-10:10 - Anthoula Tapeinou. Department of Chemistry, University of Patras (Greece). “Design, synthesis and evaluation of linear and cyclic peptide analogues implicated in Multiple Sclerosis” 10:10-10:40 - Shlomo Yitzchaik. Institute of Chemistry, The Hebrew University, Jerusalem (Israel). “Molecular self-assembly of peptides at bioelectronic interfaces” 10:40-11:10 – Coffee break 11:10-11:50 - Stephen Kent. Institute for Biophysical Dynamics, University of Chicago (IL, USA). “Bringing the Science of Proteins into the Realm of Organic Chemistry” 11:50-12:20 - Concluding remarks: William D. Lubell Combined Events of the Thematic Semester Peptides & Proteins Molecules of Life Supported by the Institute of Advanced Studies of the University of Cergy-Pontoise Peptides in Paris Symposium – PIPS 2014 - October 5-8, 2014 & 1st Peptide & Protein Chemistry & Biology for Postdoctoral fellows & PhD students - October 8-10, 2014 Training Workshop For further information please contact via e-mail: mol2014@ml.u-cergy.fr https://iascolloque.u-cergy.fr Congress registration fees Registration fees Symposium Regular Industrial PhD students & Postdoctoral fellows Price in Euros 150,00 250,00 75,00 Registration fees Symposium Training course PhD student & Postdoctoral fellow & Price in euros Registration fees Training course PhD student & Postdoctoral fellow 150,00 Price in euros 100,00 The fees for the Symposium includes: admission to the oral and poster sessions, book of abstracts, detailed program, access to welcome reception and coffee breaks. The fees for the Training course allows access to the tutorials and training course discussions. Program Organizers: Anna Maria Papini, William Lubell & Solange Lavielle. Organizing Training Committee: Olivier Monasson, Fabienne Burlina, Maud Larregola, Francesca Nuti, Cédric Rentier, Matthea Ieronymaki, Feliciana RealFernandez & Elisa Peroni. Scientific & Organizing Committee of the Institut d’Etudes Avancées: Hung The Diep, Florence Brouillaud, Ratana Pok.