Curriculum Vitae of Hamid Nadri (Pharm.D, Ph.D)
Personal History
First Name: Hamid
Last Name: Nadri
Date of Birth: 7.7.1981
Place of Birth: Gorgan, Iran
Nationality: Persian
Marital status: Married
Educational History
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Diploma: Experimental Sciences, Esterabadi High School, Gorgan, Iran (1999)
Doctorate of Pharmacy (Pharm. D): Mashhad University of Medical Sciences, Mashhad,
Iran (2005)
Pharm. D. thesis topic: Design and synthesis of some novel benzofuran derivatives as
potential dual Aromatase-Steroid sulphatase inhibitor.
Doctorate of Medicinal Chemistry (PhD): Tehran University of Medical Sciences, Tehran,
Iran (2010)
PhD thesis topic: Design, synthesis and anticholinesterase activity of some novel
benzofuran-3-one derivatives as potential agents for Alzheimer’s disease.
Supervisors:
Prof. Morteza Pirali Hamedani (Full Professor of Medicinal chemistry, Tehran University of
Medical Sciences, Tehran, Iran)
Prof. Alireza Foroumadi (Full Professor of Medicinal chemistry, Tehran University of
Medical Sciences, Tehran, Iran)
Prof. Mohammad Abdollahi(Full Professor of Pharmacology, Tehran University of Medical
Sciences, Tehran, Iran)
Professional History
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Teaching History
Teaching of medicinal chemistry I, II and III, Yazd, Since 2009.
Teaching of instrumental analysis (NMR, GC and HPLC), Yazd, Since 2011.
Teaching of organic chemistry I,II, Yazd, Since 2009.
Teaching of drug information, pharmacy practice and pharmacy internship, Yazd, Since
2011.
Teaching of general chemistry, Since 2009.
Teaching of practical analytical chemistry, Yazd, Since 2011.
Lab Experience
 Synthesis of pharmaceutical substances:
 Functional group interconversion in organic materials for lead optimization
 Structure determination of organic substances using spectral techniques: NMR, Mass
spectroscopy and IR
 Purification of the target compounds using preparative TLC, column chromatography, recrystallization etc.
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Biological evaluations of the synthesized compounds:
Evaluation of biological activity of the synthesized compounds against Acetylcholinesterase
Evaluation of biological activity of the synthesized compounds against Butyrylcholinesterase
Biological activity assay of the synthesized compounds against Lipoxygenase
Neuroprotective activity of the synthesized compounds in cell culture
Evaluation of antioxidant activity of the synthesized compounds
Evaluation of metal chelating activity of the synthesized compounds
 Statistical analysis of pharmacological data
 SPSS, PRISM and Sigmaplot
 Molecular Modeling:
 Homology Modeling using MODELLER, Discovery studio
 Docking of ligands on the target proteins, using Autodock,Vina and MOE in LINUX and
WINDOWS operating systems
 Molecular dynamic simulation with Gromacs and Macrodox
 Experiences in pharmacy practice and drug information counseling
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Academic Administrative Appointments
Assistant Professor of Medicinal Chemistry, Department of Medicinal Chemistry, Faculty of
Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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Executive Positions and Appointments
Head of Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi
University of Medical Sciences, Yazd, Iran, since 2013.
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Honors & Awards
Third, rank of the pharmacy basic sciences examination, March 2002.
Third rank student of the faculty of pharmacy, Mashhad university of medical sciences, 2005.
Second, rank of the PhD entrance examination, March 2005.
First, rank of the special board examination of medicinal chemistry, January 2008.
Distinguished professor of the faculty of pharmacy, Shahid Sadoughi University of Medical
Sciences, 2011
Publications
ISI Articles:
[1]
A. Mohammadi-Farani, A. Ahmadi, H. Nadri, A. Aliabadi, Synthesis, docking and
acetylcholinesterase inhibitory assessment of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3dione derivatives with potential anti-Alzheimer effects, Daru. 21 (2013) 47.
[2]
S.F. Razavi, M. Khoobi, H. Nadri, A. Sakhteman, A. Moradi, S. Emami, et al., Synthesis and
evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors, Eur. J. Med. Chem. 64
(2013) 252-9.
[3]
H. Nadri, M. Pirali-Hamedani, A. Moradi, A. Sakhteman, A. Vahidi, V. Sheibani, et al., 5,6Dimethoxybenzofuran-3-one
derivatives:
a
novel
series
of
dual
Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety, Daru. 21
(2013) 15.
[4]
M. Alipour, M. Khoobi, A. Foroumadi, H. Nadri, A. Moradi, A. Sakhteman, et al., Novel
coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site
acetylcholinesterase inhibitors, Bioorg. Med. Chem. 20 (2012) 7214-22.
[5]
A. Assadieskandar, M. Amini, M. Salehi, H. Sadeghian, M. Alimardani, A. Sakhteman, H.
Nadri, et al., Synthesis and SAR study of 4,5-diaryl-1H-imidazole-2(3H)-thione derivatives, as
potent 15-lipoxygenase inhibitors, Bioorg. Med. Chem. 20 (2012) 7160-6.
[6]
H. Nadri, M. Pirali-Hamedani, M. Shekarchi, M. Abdollahi, V. Sheibani, M. Amanlou, et al.,
Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives, Bioorg. Med. Chem. 18 (2010) 63606.
[7]
A. Sakhteman, M. Sharifzadeh, A. Moradi, H. Nadri, K. Tabrizian, M. Amanlou, A.
Asadipour, K. Divsalar, A. Shafiee, A.Foroumadi, Antinociceptive activity of some 1,4-substituted
piperidine derivatives using tail flick method in mice, Afric. J. Pharm. Pharmacol. 5 (2011) 352-357.
[8]
M. Alipour, M. Khoobi, H. Nadri, A. Sakhteman, A. Moradi, M. Ghandi, A. Foroumadi, A.
Shafiee, Synthesis of Some New 3-Coumaranone and Coumarin Derivatives as Dual Inhibitors of
Acetyl and Butyrylcholinesterase, Arch. Pharm. Chem. Life Sci. 2013, 346, 1–11.
[9]
N. Hosseinzadeh, M. Hasani, A. Foroumadi, H. Nadri, S. Emami, N. Samadi, M.A.
Faramarzi, P. Saniee, F. Siavoshi, N. Abadian, Y. Mahmoudjanlou, A. Sakhteman, A. Moradi, Abbas
Shafiee. 5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of
antibacterial agents, Med. Chem. Res. 22 (2013) 2293–2302.
[10] Mehdi Khoobi, Masoumeh Alipour, Amirhossein Sakhteman, Hamid Nadri, Alireza Moradi,
Mehdi Ghandi, Saeed Emami, Alireza Foroumadi, Abbas Shafiee, Design, synthesis, biological
evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as
acetylcholinesterase and butyrylcholinesterase inhibitors, EJMC, 68 (2013) 260-268.
[11] Mehdi Khoobi, Masoumeh Alipour, Alireza Moradi, Amirhossein Sakhteman, Hamid Nadri,
Seyyede Faeze Razavi, Mehdi Ghandi, Alireza Foroumadi, Abbas Shafiee, Design, synthesis,
docking study and biological evaluation of some noveltetrahydrochromeno [3’,4’:5,6]pyrano[2,3b]quinolin-6(7H)-one derivatives against acetyland butyrylcholinesterase, EJMC, 68, (2013), 291300.
[12] Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent
acetylcholinesterase inhibitors, A Asadipour, M Alipour, M Jafari, M Khoobi, S Emami, H Nadri, A
Sakhteman, et. al., EJMC, 70, (2013), 623-630.
[13] AH Sakhteman, H Nadri, A Moradi, M Amininasab, Homology modeling of human NMDA
receptor and studies of the channel symmetry using brownian dynamics simulation, Research in
Pharmaceutical Sciences 7 (5), (2012), S547
[14] H Nadri, AH Sakhteman, A Moradi, AR Vahidi, B Zare, SAS: A toolbox to represent the
structure activity similarity maps for the synthesized compounds, Research in Pharmaceutical
Sciences 7 (5), (2012), S562
Books:
1- PROTEIN-PROTEIN INTERACTIONS COMPUTATIONAL AND EXPERIMENTAL TOOLS.
Edited by Weibo Cai and Hao Hong, Chapter 12: G-Protein Coupled Receptors: Experimental and
Computational Approaches, by: A. Sakhteman, H. Nadri, A. Moradi. 2012, Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia, ISBN 978-953-51-0397-4.
2- Encyclopedia of Toxicology, 3rd Edition, A. Shafiee, M. Khoobi, H. Nadri. In Press.
Congresses:
1- The symmetry of Channel in human NR2B receptor, A Brownian dynamic simulation study,
International Conference of Medicinal Chemistry (ICM 2011), Beijing, China
2- The novel derivatives of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl)
pyridinium with potent anticholinesterase activity for Alzheimer’s disease treatment, 6th Koupio
Alzheimer Symposium June 14-16 2012 Koupio, Finland.
Adress: Faculty of Pharmacy, Shahid sadoughi University of medical sciences, Yazd, Iran
Tel: +98-351-8203419
Fax: +98-351-8203418
E-mail: hnadri@razi.tums.ac.ir