CURRICULUM VITAE
Date of Document: 9/9/15
Jozef Lazar, M.D., Ph.D.
Faculty Research Investigator
HudsonAlpha Institute for Biotechnology
Office Address:
HudsonAlpha Institute for Biotechnology
601 Genome Way
Huntsville, AL 35806
Phone: 256-327-9554
Fax:
256-327-0978
Email: jlazar@hudsonalpha.org
Place of Birth:
Sahy, Czechoslovakia/Slovak Republic
Citizenship:
U.S.A.
Major Research Interests:
1. Genetic basis of human rare and complex diseases
2. Next generation sequencing in undiagnosed genetic disorders
3. Validation human sequence variants
Education:
1969 - 1973
Gymnasium
Zvolen, Czechoslovakia
1974 – 1980
M.D.
Doctor of Medicine cum laude
School of Medicine
Comenius University
Martin, Czechoslovakia
1983 – 1987
Ph.D.
The hormones of thyroid gland during postnatal
ontogenesis (thesis) (Physiology)
Comenius University
Bratislava, Czechoslovakia
1990 – 1995
Postdoctoral Fellow
NIH-NIDDK
Bethesda, MD
J. Lazar, M.D., Ph.D.
Page 1
Scientific and teaching career:
1980 - 1985
Research Fellow
1986 - 1989
Assistant Professor
1990 - 1995
Fogarty Fellows in Genetics and Biochemistry
Branch – Mechanisms of Gene Regulation Section
Department of Medical Biology
School of Medicine
Comenius University
Martin, Czechoslovakia
Department of Medical Biology
School of Medicine
Comenius University
Martin, Czechoslovakia
NIH NIDDK
Bethesda, MD
1995 -1998
Research Assistant
1998 - 2002
Senior Investigator - Molecular Biologist
2002 – 2006
Assistant Professor
2007 – 2015
Associate Professor
Department of Psychiatry
University of Maryland
School of Medicine
Baltimore, MD
Molecular Neurovirology Unit
VAMC, Medical Research Service
Baltimore, MD
Department of Dermatology
Medical College of Wisconsin
Human & Molecular Genetics Center
Milwaukee, WI
Department of Dermatology
Department of Physiology
Human & Molecular Genetics Center
Medical College of Wisconsin
Milwaukee, WI
J. Lazar, M.D., Ph.D.
Page 2
2015 – Present
Faculty Investigator
HudsonAlpha Institute for Biotechnology
Huntsville, AL
Awards:
1990
1993
Editorial boards/Journal reviews:
Local committee positions:
2005 – 2008
Fogarty fellowship – NIH Bethesda
Travel Award
67th Meeting American Thyroid Association
Tampa, FL
Psychoneuroendocrinology
Circulation
Physiological Genomics
American Journal Physiology
Journal of Dermatological Science
Folia Biologica
Journal of Hypertension
Journal of Cardiovascular Translational Research
Member
Institutional Biosafety Committee (IBS)
2006
Thesis Committee Member
2008 – 2015
Member
For Nancy E. Schlick
Department of Physiology
Medical College of Wisconsin
Milwaukee, WI
Institutional Animal Care and Use Committee
Medical College of Wisconsin
Milwaukee, WI
Research grants/awards/contracts/projects:
Active
2011 – 2016
2013 – 2017
National Institutes of Health
Genetic & Physiological Basis of Salt-Induced Hypertension
Co-Investigator
National Institutes of Health
Evaluation of Human Variants in Disease Models for End Stage Renal
J. Lazar, M.D., Ph.D.
Page 3
Disease
Co-Investigator
Pending
2015 – 2020
Completed
2013 – 2018
2009 – 2014
2009 – 2013
2008 – 2013
2006 – 2011
2006 – 2011
2007 – 2010
2007 – 2009
2007 – 2008
2001 – 2005
2000- 2005
2 P01 GM066730-11 National Institutes of Health
Mechanisms of Anesthetic Protection
Co-Investigator
National Institutes of Health
Gene Targeted Rat Resource for the Study of Complex Disease
Co-Investigator
National Institutes of Health
Wisconsin Center of Excellence in Genomic Science
Co-Investigator
National Institutes of Health
Genetic and Cellular Basis of Resistance/Sensitivity to Myocardial
Ischemia
Co-Investigator
National Institutes of Health
Anesthetic Induced Cardiac Preconditioning
Co-Investigator
National Institutes of Health
Genetic & Physiological Basis of Salt-Induced Hypertension
Co-Investigator
National Institutes of Health
Physiological Genomics of Hypertensive Renal Disease
Co- Investigator
National Institutes of Health
Molecular Pathways and the Pathophysiology of Diabetic Nephropathy.
PI on Pilot and Feasibility project
National Institutes of Health
Integrative Biology of Childhood Kidney Disease
Co-Investigator
Medical College of Wisconsin
Development of Rapid Screening Tool of Pharmaceutical Candidates
Against Various Genomic Strains of Rats Using Engineered Tissues
PI
National Institutes of Health
Physiological Genomics of Hypertensive Renal Disease
Co-Investigator
National Institutes of Health
Molecular Genetics of Cardioprotection in SCOR – Ischemic Heart Disease
in Blacks
J. Lazar, M.D., Ph.D.
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2000- 2005
1999- 2004
Co- Investigator
National Institutes of Health
Development of Assay for Creutzfeldt - Jakob disease
Co-PI
VA Merit Review
Quantitation of TSE Infectivity in Blood During Preclinical Infection
Co-Investigator
INVITED LECTURES/WORKSHOPS/PRESENTATIONS:
National
1997 Invited Speaker
Role of Thyroid Hormones in Neurological Develop
Workshop on Chemicals that Alter Thyroid Hormone Homeostasis, Action
and Function
Sponsored by the US Environmental Agency
Duke University
Durham, NC
2004
Invited Speaker
2005
Invited Speaker
2005
Invited Speaker
2007
Invited Speaker
2008
Invited Speaker
Understanding Cardiovascular Function through Physiological Genomics
Lillehei Heart Institute-Lecture Series
Minneapolis, MN
Genetic Dissection of Complex Diseases Using Consomic and Congenic
Rats
University of Minnesota, Medical School
Minneapolis, MN
From Genome to Phenome: The Translational Biology of Cardiovascular
Disease Mining Systems Profiling
American Heart Association
Dallas, TX
Functional Cardiac Abnormalities in Animal Models with Type 2 Diabetes
Mellitus
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
Engineered Heart Tissue: High-throughput platform Dissection of
Complex Diseases
J. Lazar, M.D., Ph.D.
Page 5
International Society for Cardiovascular Translational Research
San Diego, CA
International
2006
Invited Speaker
2008
Invited Speaker
2008
Invited Speaker
2008
Invited Speaker
2008
Invited Speaker
2008
Invited Speaker
Rapid Phenotyping System to Study Responses of
Different Rat Strains to Stressors Using Engineered Tissue
16th International Workshop on Rat Genetic Systems
Melbourne, Australia
Engineering Heart Tissue as a Platform for Positional Cloning
Hypertension, Berlin, Germany
Using Heart Tissue to Accelerate Positional Cloning
13th International SHR, Prague, Czech Republic
Functional Impact of Mitochondrial Genome Substitution on the Same
Nuclear Genome
Institute of Experimental Endocrinology, Bratislava, Slovak Republic
Polymorphism in Mitochondrial Genome: The Role in Health and
Disease
Comenius University, Martin, Slovak Republic
Role of Mitochondrial Genome in Modulating Hypoxic Dilation in
Cerebral Arteries of Animal Models with Type 2 Diabetes Mellitus.
Cold Spring Harbor Laboratory/Wellcome Trust Conference
Hinxton, UK
2012
Invited Speaker
2012
Invited Speaker
2014
Targeting Human Blood Pressure Loci by Zinc Finger Nucleases.
24th Meeting of ISH, Sydney, Australia
High Throughput Validation and Discovery of Human Genomic
Functional Elements. 15th International SHR symposium and 48th
Japanese SHR meeting, Melbourne, Australia
Invited Speaker
Genetically Modified Animal Models to Dissect Human Complex
J. Lazar, M.D., Ph.D.
Page 6
Diseases. XXII Congress of Brazilian Society of Hypertension,
Salvador, Brasil
Bibliography:
REFEREED JOURNAL PUBLICATIONS/ORIGINAL PAPERS:
1. Samel, M., Lazar, J.: Thyroxine turnover rate and radiothyroxine distribution in infant rats.
Folia Med Martiniana 14: 15-21, 1987
2. Samel, M., Lazar, J.: Kinetics of thyroxine in ontogenesis studies using the metabolism of
radiothyroxine. Bratisl Lek Listy 90(9): 640-645, 1989. PMID:2590848
3. Lazar, J., Pullmann, R., Bukovska, E., Dobias, J., Samel, M.: Changes in levels of lipids in
serum and heart after thyroxine treatment. Folia Med Martiniana 16: 109-113, 1991
4. Jannini, E.A., Ulisse, S., Piersanti, D., Carosa, E., Muzi, P., Lazar, J., D’Armiento, M.: Early
thyroid hormone treatment in rats increases testis size and germ cell number. Endocrinology
132(6): 2726-2728, 1993. PMID: 8504773
5. Pec, M., Visnovsky, P., Dobrota, D., Dobias, J., Lazar, J.: The role of platelet activating
factor in the pathogenesis of asthma. Batisl Lek Listy 94(9): 507-509, 1993. PMID: 8004503
6. Lazar, J., Desvergne, B., Zimmerman, E.C., Zimmer, D.B., Magnuson, M.A., Nikodem, V.M.:
A role of intronic sequences on expression of thyroid hormone receptor alpha gene. J Biol
Chem 269(32): 20352-20359, 1994. PMID: 8051130
7. Samel, M., Pullmann, R., Dobias, J., Bukovska, E., Lazar, J.: The development of lipid
metabolism. Effect of short-term application of thyroxine on the level of fatty acids and
albumin in serum during ontogenesis in rat. Bratisl Lek Listy 95(2): 57-63, 1994. PMID:
7922627
8. Samel, M., Pullmann, R., Dobias, J., Bukovska, E., Lazar, J.: Development of brown adipose
tissue in the rat and thyroxine administration influence. Bratisl Lek Listy 95(8): 339-43,
1994. PMID:7812835
9. Pullmann, R., Samel, M., Lazar, J., Dobias, J., Bukovska, E., Koskova, E.: Changes in
cholesterol and triacylglycerol serum levels in rats during postnatal ontogenesis. Bratisl Lek
Listy 95(10): 465-8, 1994. PMID: 7882062
10. Pullmann, R., Samel, M., Lazar, J., Dobias, J., Bukovska, E., Koskova, E.: Short-term
administration of increasing doses of thyroxine has different effect on serum lipids in male
rats and female rats. Bratisl Lek Listy 95(11): 512-4, 1994. PMID: 7882067
11. Tomura, H., Lazar, J., Phyillaier, M., Nikodem, V.M.: The unique N-terminal region (A/B) of
rat thyroid hormone receptor alpha 1, beta 1 but not 2, contains a strong thyroid hormone-
J. Lazar, M.D., Ph.D.
Page 7
dependent transactivation function. PNAS 92(12): 5600-4, 1995. PMID: 7539921; PMCID:
PMC41744
12. *Farsetti, A., Lazar, J., Phyillaier, M., Lippoldt, R., Nikodem, V.M.: Active repression by
thyroid hormone receptor splicing variant alpha2 requires specific regulatory elements in the
context of native triiodothyronine-regulated gene promoters. Endocrinology 138(11): 470512, 1997. PMID: 9348197 *A.F. and J.L. contributed equally to this study
13. DeVito, M., Biegel, L., Brouwer, A., Brown, S., Brucker-Davis, F., Cheek, A.O., Christensen,
R., Colborn, T., Cooke, P., Crissman, J., Crofton, K., Doerge, D., Gray, E., Hauser, P.,
Hurley, P., Kohn, M., Lazar, J., McMaster, S., McClain, M., McConnell, E., Meier, C., Miller,
R., Tietge, J., Tyl, R.: Screening methods for thyroid hormone disruptors. Environ Health
Perspect 107(5): 407-15, 1999. PMID: 10210697; PMCID: PMC:1566416
14. Lazarova, Z., Yee, C., Lazar, J., Yancey, K.B.: IgG autoantibodies in patients with antiepiligrin cicatricial pemphigoid recognize the G domain of the laminin 5 alpha- subunit. Clin
Immun 101(1): 100-5, 2001. PMID: 11580232
15. Phillips, S.A., Rotman-Pikielny, P., Lazar, J., Ando, S., Hauser, P., Skarulis, M.C., BruckerDavis, F., Yen, P.M.: Extreme thyroid hormone resistance in a patient with a novel truncated
TR Mutant. J Clin Endocrinol Metab 86(11): 5142-7, 2001. PMID: 11701667
16. Nobrega, M.A., Fleming, S., Roman, R. J., Shiozawa, M., Schlick, N., Lazar, J., Jacob, H.J.:
Initial Characterization of a Rat Model of Diabetic Nephropathy. Diabetes 53(3): 735-42,
2004. PMID: 14988259
17. Vitt, U., Gietzen, D., Stevens, K., Wingrove, J., Becha, S., Bulloch, S., Burrill, J., Chawla, N.,
Chien, J., Crawford, M., Ison, C., Kearney, L., Kwong, M., Park, J., Policky, J., Weiler, M.,
White, R., Xu, Y., Daniels, S., Jacob, H.J., Jensen-Seaman, M. I., Lazar, J., Stuve, L.,
Schmidt, J.: Identification of candidate disease genes by EST alignments, synteny and
expression and verification of Ensembl genes on rat chromosome 1q43-54. Genome
Research 14(4): 640-50, 2004. PMID: 15060005; PMCID: PMC383308
18. Gibbs, R.A., Weinstock, G.M., Metzker, M.L., Muzny, D.M., Sodergren, E.J., Scherer, S.,
Scott, G., Steffen, D., Worley, K.C., Burch, P.E., Okwuonu, G., Hines, S., Lewis, L., DeRamo,
C., Delgado, O., Dugan-Rocha, S., Miner, G., Morgan, M., Hawes, A., Gill, R., Celera, Holt,
R.A., Adams, M.D., Amanatides, P.G., Baden-Tillson, H., Barnstead, M., Chin, S., Evans,
C.A., Ferriera, S., Fosler, C., Glodek, A., Gu, Z., Jennings, D., Kraft, C.L., Nguyen, T.,
Pfannkoch, C.M., Sitter, C., Sutton, G.G., Venter, J.C., Woodage, T., Smith, D., Lee, H.M.,
Gustafson, E., Cahill, P., Kana, A., Doucette-Stamm, L., Weinstock, K., Fechtel, K., Weiss,
R.B., Dunn, D.M., Green, E.D., Blakesley, R.W., Bouffard, G.G., De Jong, P.J., Osoegawa, K.,
Zhu, B., Marra, M., Schein, J., Bosdet, I., Fjell, C., Jones, S., Krzywinski, M., Mathewson, C.,
Siddiqui, A., Wye, N., McPherson, J., Zhao, S., Fraser, C.M., Shetty, J., Shatsman, S., Geer,
K., Chen, Y., Abramzon, S., Nierman, W.C., Havlak, P.H., Chen, R., Durbin K.J., Egan A.,
Ren Y., Song X.Z., Li, B., Liu, Y., Qin, X., Cawley, S., Worley, K.C., Cooney, A.J., D'Souza,
L.M., Martin, K., Wu, J.Q., Gonzalez-Garay, M.L., Jackson, A.R., Kalafus, K.J., McLeod, M.P.,
Milosavljevic, A., Virk, D., Volkov, A., Wheeler, D.A., Zhang, Z., Bailey, J.A., Eichler, E.E.,
J. Lazar, M.D., Ph.D.
Page 8
Tuzun, E., Birney, E., Mongin, E., Ureta-Vidal, A., Woodwark, C., Zdobnov, E., Bork, P.,
Suyama, M., Torrents, D., Alexandersson, M, Trask, B.J., Young, J.M., Huang, H., Wang, H.,
Xing, H., Daniels, S., Gietzen, D., Schmidt, J., Stevens, K., Vitt, U., Wingrove, J., Camara, F.,
Mar Alba, M., Abril, J.F., Guigo, R., Smit, A., Dubchak, I., Rubin, E.M., Couronne, O.,
Poliakov, A., Hubner, N., Ganten, D., Goesele, C., Hummel, O., Kreitler, T., Lee, Y.A., Monti,
J., Schulz, H., Zimdahl, H., Himmelbauer, H., Lehrach, H., Jacob, H.J., Bromberg, S.,
Gullings-Handley, J., Jensen-Seaman, M.I., Kwitek, A.E., Lazar, J., Pasko, D., Tonellato, P.J.,
Twigger, S., Ponting, C.P., Duarte, J.M., Rice, S., Goodstadt, L., Beatson, S.A., Emes, R.D.,
Winter, E.E., Webber, C., Brandt, P., Nyakatura, G., Adetobi, M., Chiaromonte, F., Elnitski,
L., Eswara, P., Hardison, R.C., Hou, M., Kolbe, D., Makova, K., Miller, W., Nekrutenko, A.,
Riemer, C., Schwartz, S., Taylor, J., Yang, S., Zhang, Y., Lindpaintner, K., Andrews, T.D.,
Caccamo, M., Clamp, M., Clarke, L., Curwen, V., Durbin, R., Eyras, E., Searle, S.M., Cooper,
G.M., Batzoglou, S., Brudno, M., Sidow, A., Stone, E.A., Venter, J.C., Payseur, B.A.,
Bourque, G., Lopez-Otin, C., Puente, X.S., Chakrabarti, K., Chatterji, S., Dewey, C., Pachter,
L, Bray, N., Yap, V.B., Caspi, A., Tesler, G., Pevzner, P.A., Haussler, D., Roskin, K.M.,
Baertsch, R., Clawson, H., Furey, T.S., Hinrichs, A.S., Karolchik, D., Kent, W.J., Rosenbloom,
K.R., Trumbower, H., Weirauch, M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam
M., Shteynberg D., Copley R.R., Taylor, M.S., Riethman, H., Mudunuri, U., Peterson, J.,
Guyer, M., Felsenfeld, A., Old S., Mockrin, S., Collins, F.: Rat Genome Sequencing Project
Consortium. Genome sequence of the Brown Norway rat yields insights into mammalian
evolution. Nature 428 (6982): 493-521, 2004. PMID: 15057822
19. Liang, M., Cowley, A.W. Jr., Hessner, M.J., Lazar J., Basile, D.P., Pietrusz, J.L.:
Transcriptome analysis and kidney research: toward systems biology. Kidney Int 67(6):
2114-22, 2005. PMID: 15882254
20. Van Dijk, S.J., Specht, P.A.C., Lazar, J., Jacob, H.J., Provoost, A.P.: Renal damage
susceptibility and autoregulation in RF-1 and RF-5 congenic rats. Nephron Exp Nephrol
101(2): e59-66, 2005. PMID: 159765509
21. Rangel-Filho, A., Sharma, M., Datta, Y.H., Moreno, C., Roman, R.J., Iwamoto, Y., Provoost,
A.P., Lazar J., Jacob HJ.: The RF-2 gene modulates proteinuria and albuminuria
independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J
Am Soc Nephrol 16(4): 852-6, 2005. PMID: 15758045
22. Shi, Y., Hutchins, W., Ogawa, H., Chang, C.C., Pitchard, K.A., Zhang, C., Khampang, P.,
Lazar, J., Jacob, H.J., Rafiee, P., Baker, J.E.: Increased resistance to myocardial ischemia in
the Brown Norway vs Dahl S rat: role of nitric oxide synthase and Hsp90. J Mol Cell Cardiol
38(4): 625-35, 2005. PMID: 15808839
23. Van Dijk, S.J., Specht, P.A.C., Lazar, J., Jacob, H.J., Provoost AP.: Interactions between Rf-1
and Rf-4 quantitative trait loci increases susceptibility to renal damage in double congenic
rats. Kidney Int 68(6): 2462-72, 2005. PMID: 16316323
24. Lazar, J., Moreno, C., Jacob, H.J., Kwitek, A.E.: Impact of genomics on research in the rat.
Genome Res 15(12): 1717-28, 2005. PMID: 16339370
J. Lazar, M.D., Ph.D.
Page 9
25. Alexeeva, I., Elliott, E.J., Rollins, S., Gasparich, G.E., Lazar, J., Rohwer, R.G.: Absence of
spiroplasma or other bacterial 16S rRNA genes in brain tissue of hamsters with scrapie. J
Clin Microb 44(1): 91-7, 2006. PMID: 163390954; PMCID: PMC:1351941
26. Van Dijk, S.J., Specht, P.A.C., Lazar, J., Jacob, H.J., Provoost, A.P.: Synergistic QTL
interactions between Rf-1 and Rf-3 increase renal damage susceptibility in double congenic
rats. Kidney Int 69(8): 1369-76, 2006. PMID: 16541022
27. Lopez, B., Ryan, R.P., Moreno, C., Sarkis, A., Lazar, J., Provoost, A.P., Jacob, H.J., Roman,
R.J.: Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawnhooded hypertensive rats. Am J Physiol 290(5): F1213-21, 2006. PMID: 16303858
28. Roman, R.J., Hoagland, K.M., Lopez, B., Kwitek, A.E., Garrett, M.R., Rapp, J.P., Lazar, J.,
Jacob, H.J., Sarkis, A.: Characterization of blood pressure and renal function in chromosome
5 cogenic strains of Dahl S rats. Am J Physiol Renal Physiol 290(6): F1463-71, 2006. PMID:
16396943
29. Van Dijk, S.J., Specht, P.A., Lazar, J., Jacob, H.J., Provoost, A.P.: Absence of an intercation
between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats. Nephron
Exp Nephrol July 104(3): e96-e102, 2006. PMID: 16837819
30. Schlick, N.E., Jensen-Seaman, M.I., Orlebeke, K., Kwitek, A.E., Jacob, H.J., Lazar, J.:
Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat
strain. Am J Physiol Cell Physiol 291(6): C1183-92, 2006. PMID: 16855218
31. Stobart, M.J., Parchaliuk, D., Simon, S.L., Lemaistre, J., Lazar, J., Rubenstein, R., Knox,
J.D.: Differential expression of interferon responsive genes in rodent models of transmissible
spongiform encephalopathy disease. Mol Neurodegener 2(5): 1-13, 2007. PMID: 17367538;
PMCID: PMC1847514
32. Moreno, C., Kaldunski, M.L., Wang, T., Roman, R.J., Greene, A.S., Lazar, J., Jacob, H.J.,
Cowley, Jr. A.W.: Multiple blood pressure loci on rat Chromosome 13 attenuate the
development of hypertension in the Dahl S hypertensive rat. Physiol Genomics 31(2): 22835, 2007. PMID: 17566075
33. Petersen, M.C., Lazar, J., Jacob, H.J., Wakatsuki, T.: Tissue engineering: a new frontier in
physiological genomics. Physiol Genomics 32(1): 28-32, 2007. PMID: 17956999
39.Moreno C., Lazar J., Jacob H.J., Kwitek A.E. Comparative genomics for detecting
human disease genes. Adv Genet 60: 655-97, 2008. PMID: 18358336
34. Lazar, J., Jacob, H.J., Wakatsuki, T.: Engineered heart tissue: high throughput platform for
dissection of complex diseases. J Cardiovasc Trans Res 1(3): 232-5, 2008. PMID 20559925
35. Williams, J.M., Sarkis, A., Hoagland, K.M., Fredrich, K., Ryan, R.P., Moreno, C., Lopez, B.,
Lazar, J., Fenoy, F.J., Sharma, M., Garrett, M.R., Jacob, H.J., Roman, R.J.: Transfer of the
J. Lazar, M.D., Ph.D.
Page 10
CYP4A of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. A J Physiol Renal
Physiol 295(6): F1764-77, 2008. PMID: 18842817; PMCID: PMC2604826
36. Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ, Robinson C, Mandich A, Derge
JG, Lewis J, Shoaf D, Collins FS, Jang W, Wagner L, Shenmen CM, Misquitta L, Schaefer
CF, Buetow KH, Bonner TI, Yankie L, Ward M, Phan L, Astashyn A, Brown G, Farrell C,
Hart J, Landrum M, Maidak BL, Murphy M, Murphy T, Rajput B, Riddick L, Webb D, Weber
J, Wu W, Pruitt KD, Maglott D, Siepel A, Brejova B, Diekhans M, Harte R, Baertsch R, Kent
J, Haussler D, Brent M, Langton L, Comstock CL, Stevens M, Wei C, van Baren MJ, SalehiAshtiani K, Murray RR, Ghamsari L, Mello E, Lin C, Pennacchio C, Schreiber K, Shapiro N,
Marsh A, Pardes E, Moore T, Lebeau A, Muratet M, Simmons B, Kloske D, Sieja S, Hudson
J, Sethupathy P, Brownstein M, Bhat N, Lazar J, Jacob H, et al.: The completion of the
Mammalian Gene Collection (MGC). Genome Res 19(12): 2324-33, 2009. PMID 19767417;
PMCID: PMC2792178
37. Lu, L., Li, P., Yang, C., Kurth, T., Misale, M., Skelton, M., Moreno, C., Roman, R.J., Greene,
A.S., Jacob, H.J., Lazar, J., Liang, M., Cowley, A.W.Jr.: Dynamic convergence and
divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive
hypertension. Physiol Genomics 41 (1): 63-70, 2010. PMID: 200090007; PMCID:
PMC2841498
38. Adamovic, T., McAllister, D., Wang, T., Adamovic, D., Rowe, J.J., Moreno, C., Lazar, J.,
Jacob, H.J., Sugg, S.L.: Identification of novel carcinogen-mediated mammary tumor
susceptibility loci in the rat using the chromosome substitution technique. Genes
Chromosomes Cancer 49(11): 1035-45, 2010. PMID: 20737482; PMCID: PMC2943010
39. Jacob, H.J., Lazar, J., Dwinell, R.M., Moreno, C., Geurts, A.M.: Gene targeting in the rat:
advances and opportunities. Trends Genet 26(12): 510-8, 2010. PMID: 20869786; PMCID:
PMC3043997
40. O’Meara, C.C., Lazar, J., Hoffman, M., Moreno, C., Jacob, H.J.: Refined mapping of the renal
failure RF-3 quantitative trait locus. J Am Soc Nephrol 22(3): 518-25, 2011. PMID:
21127141; PMCID: PMC3060445
41. Bulbul, M., Babygirija, R., Zheng, J., Ludwig, K., Xu, H., Lazar, J., Takahashi, T.: Food intake
and interdigestive gastrointestinal motility in ghrelin receptor mutant rats. J Gastroenterol
46(4): 469-78, 2011. PMID: 21258824
42. Moreno, C., Williams, J.M., Lu, L., Liang, M., Lazar, J., Jacob, H.J., Cowley, A.W.jr., Roman,
R.J.: Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl
SS-13BN congenic strains. Am J Physiol Heart Circ Physiol 300(4): H1530-5, 2011. PMID:
21257920; PMCID: PMC3075031
43. Moreno, C., Hoffman, M., Stodola, T.J., Didier, D.N., Lazar, J., Geurts, A.M., North, P.E.,
Jacob, H.J., Greene, A.S.: Creation and characterization of a renin knockout rat.
Hypertension 57(3): 614-9, 2011. PMID: 21242461; PMCID: PMC3513323
J. Lazar, M.D., Ph.D.
Page 11
44. Williams, J.M., Burke, M., Lazar, J., Jacob, H.J., Roman, R.J.: Temporal characterization of
the development of renal injury in FHH rats and FHH1BN congenic strains. Am J Physiol
Renal Physiol 300(2): F330-8, 2011. PMID: 21048028; PMCID: PMC3043997
45. Dwinell, M.R., Lazar J., Geurts, A.M. The emerging role for rat models in gene discovery.
Mamm Genome 22(7-8): 466-75, 2011. PMID: 21732192; PMCID: PMC3643810
46. Feng, D., Yang, C., Geurts, A.M., Kurth, T., Liang, M., Lazar, J., Mattson, D.L., O’Connor,
P.M., Cowley, A.W. Jr.: Increased expression of NAD(P)H oxidase subunit p67(phox) in the
renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Cell
Metabolism 15(2): 201-8, 2012. PMID: 22326221; PMCID: PMC3280886
47. O’Meara, C.C., Lutz, M.M., Sarkis, A.B., Xu, H., Kothinti, R.K., Hoffman, M., Moreno, C.,
Tabatabai, N.M., Lazar, J., Roman, R.J., Jacob, H.J.: A 4.1-Mb congenic region of Rf-4
contributes to glomerular permeability. J Am Soc Nephrol 23(5): 825-33, 2012. PMID:
22343117; PMCID: PMC3338295
48. Flister, M.J., Prisco, S.Z., Sarkis, A.B., O’Meara, C.C., Hoffman, M., Wendt-Andrea, J.,
Moreno, C., Lazar, J., Jacob, H.J.: Identification of hypertension susceptibility loci on rat
chromosome 12. Hypertension 60(4): 942-8, 2012. PMID: 22868394; PMCID: PMC3873777
49. Kriegel, A.J., Didier, D.N., Li, P., Lazar, J., Greene, A.S.: Mechanisms of cardioprotection
resulting from Brown Norway chromosome 16 substitution in the salt-sensitive Dahl rat.
Physiol Genomics 44(16): 819-27, 2012. PMID: 22759922; PMCID: PMC3774569
50. Sethumadhavan, S., Vasquez-Vivar, J., Migrino, R.Q., Harmann, L., Jacob, H.J., Lazar, J.:
Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling. J Biol
Chem 287(26): 22174-82, 2012. PMID: 22544750; PMCID: PMC3381178
51. Williams, J.M., Fan, F., Murphy, S., Schreck, C., Lazar, J., Jacob, H.J., Roman, R.J.: Role of
20-HETE in the antihypertensive effect of transfer of chromosome 5 from Brown Norway to
Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol 302(10): R1209-18, 2012.
PMID: 22442195; PMCID: PMC3362151
52. Katter, K., Geurts, A.M., Hoffmann, O., Mates, L., Landa, V., Hiripi, L., Moreno, C., Lazar, J.,
Bashir, S., Zidek, V., Popova, E., Jerchow, B., Becker, K., Devaraj, A., Walter, I.,
Grzybowski, M., Corbett, M., Filho, A.R., Hodges, M.R., Bader, M., Ivics, Z., Jacob, H.J.,
Pravenec, M., Bosze, Z., Rulicke, T., Izsvak, Z.: Transposon-mediated transgenesis,
transgenic rescue, and tissue-specific gene expression in rodents and rabbits. FASEB J
27(3): 930-41, 2013. PMID: 23195032; PMCID: PMC3574282
53. Doctrow, S.R., Lopez, A., Schock, A.M., Duncan, N.E., Jourdan, M.M., Olasz, E.b., Moulder,
J.E., Fish, B.L., Mader, M., Lazar, J., Lazarova, Z.: A synthetic superoxide
dismutase/catalase mimetic EUK-207 mitigates radiation dermatatitis and promotes wound
healing in irradiated rat skin. J Invest Dermatol 133(4): 1088-96, 2013. PMID: 23190879;
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54. Pabbidi, M.R., Juncos, J.P., Juncos, L.A., Renic, M., Tullos, H., Lazar, J., Jacob, H.J.,
Harder, D.R., Roman, R.J.: Identification of a region of rat chromosome 1 that impairs the
myogenic response and autoregulation of cerebral blood flow in fawn- hooded hypertensive
rats. Am J Physiol Heart Circ Physiol 304(2): H311-7, 2013. PMID: 23144316; PMCID:
PMC3543673
55. Burke, M., Pabbidi, M.R., Fan, F., Ge, Y., Williams, J.M., Sarkis, A.B., Lazar, J., Jacob, H.J.,
Roman, R.J.: Genetic basis of the impaired renal myogenic response in FHH rats. Am J
Physiol Renal Physiol 304(5): F565-77, 2013. PMID: 23220727; PMCID: PMC3602705
56. Rangel-Filho, A., Lazar, J., Moreno, C., Geurts, A., Jacob, H.J.: Rab 38 modulates proteinuria
in model of hypertension-associated renal disease. J Am Soc Nephrol 24 (2): 283-92, 2013.
PMID: 23291471; PMCID: PMC3559491
57. Flister, M.J., Tsaih, S.W., O’Meara, C.C., Endres, B., Hoffman, M.J., Geurts, A.M., Dwinell,
M.R., Lazar, J., Jacob, J.H., Moreno, C.: Identifying multiple causative genes at a single
GWAS locus. Genome Res 23(12): 1996-2002, 2013. PMID: 24006081; PMCID:
PMC3847770
58. Lazar, J., O’Meara, C.C., Sarkis, A.B., Prisco, S.Z., Xu, H., Fox, C.S., Chen, M.H., Broeckel,
U., Arnett, D.K., Moreno, C., Provoost, A.P., Jacob, H.J.: SORCS1 contributes to the
development of renal disease in rats and human. Physiol Genomics 45(16): 720-8, 2013.
PMID:23780848; PMCID: PMC3742914
59. Jacob, H.J., Abrams, K., Bick, D.P., Brodie, K., Dimmock, D.P., Farrell, M., Geurts, J.,
Harris, J., Helbling, D., Joers, B.J., Kliegman, R., Kowalski, G., Lazar, J., Margolis, D.A.,
North, P., Northup, J., Roquemore-Goins, A., Scharer, G., Shimoyama, M., Strong, K.,
Taylor, B., Tsaih, S.W., Tschannen, M.R., Veith, R.L., Wendt-Andrae, J., Wilk, B., Worthey,
E.A.: Genomic in clinical practice: lessons from the front lines. Sci Transl Med
5(194):194cm5, 2013. PMID: 23863829
60. Nabbi, R., Gadicherla, A.K., Kersten, J.R., Stowe, D.F., Lazar, J., Riess, M.L.: Genetically
determined mitochondrial preservation and cardioprotection against myocardial ischemiareperfusion injury in a consomic rat model. Physiol Genomics 46(5): 169-76, 2013. PMID:
24380873; PMCID: PMC3949105
61. Muravyeva, M., Baotic, I., Bienengraeber, M., Lazar, J., Bosnjak, Z.J., Sedlic, F., Warltier,
D.C., Kersten, J.R.: Cardioprotection during diabetes: The role of mitochondrial DNA.
Anesthesiology 120 (4): 870-9, 2014. PMID: 24346177; PMCID: PMC3975667
62. Cowley, A.W.Jr., Moreno, C., Jacob, H.J., Peterson, C.B., Stingo F.C., Ahn, K.W., Liu, P.,
Vannucci, M., Laud, P.W., Reddy, P., Lazar, J., Evans, L., Yang, C., Kurth, T., Liang, M.:
Characterization of biological pathways associated with a 1.37Mbp genomic region
protective of hypertension in Dahl S rats. Physiol Genomics 46(11): 398-410, 2014. PMID:
24714719; PMCID: PMC4042181
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63. Prisco, S.Z., Prokop, J.W., Sarkis, A.B., Yeo, N.C., Hoffman, M.J., Hansen, C.C., Jacob, H.J.,
Flister, M.J., Lazar, J.: Refined mapping of hypertension susceptibility locus on rat
chromosome 12. Hypertension 64(4): 883-90, 2014. PMID: 25001272; PMCID: PMC4162822
64. Prisco, S.Z., Priestley, J.R., Weinberg, B.D., Prisco, A.R., Hoffman, M.J., Jacob, H.J., Flister,
M.J., Lombard, J.H., Lazar, J.: Vascular dysfunction precedes hypertension associated with a
blood pressure locus on rat chromosome 12. Am J Physiol Heart Circ Physiol 307(8): H110310, 2014. PMID: 25320330; PMCID: PMC4200336
65. Flister, M.J., Endres, B.T., Rudemiller, N., Sarkis, A.B., Santarriaga, S., Roy, I., Lemke, A.,
Geurts, A.M., Moreno, C., Ran, S., Tsaih, S.W., De Pons, J., Carlson, D.F., Tan, W.,
Fahrenkrug, S.C., Lazarova, Z., Lazar, J., North, P.E., LaViolette, P.S., Dwinell, M.B., Shull,
J.D., Jacob, H.J.: CXM: a new tool for mapping breast cancer risk in the tumor
microenvironment. Cancer Res 74(22): 6419-29, 2014. PMID: 25172839; PMCID:
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66. Yeo, N.C., O'Meara, C.C., Bonomo, J.A., Veth, K.N., Tomar, R., Flister, M.J., Drummond,
I.A., Bowden, D.W., Freedman, B.I., Lazar, J., Link, B.A., Jacob, H.J.: Shroom3 contributes
to the maintenance of the glomerular filtration barrier integrity. Genome Res 25(1): 57-65,
2015. PMID:25273069
67. Flister, M.J., Hoffman, M.J., Lemke, A., Prisco, S.Z., Rudemiller, N., O’Meara, C.C., Tsaih,
S.W., Moreno, C., Geurts, A.M., Lazar, J., Adhikari, N., Hall, J.L., Jacob, H.J.: SH2B3 is a
genetic determinant of cardiac inflammation and fibrosis. Circ Cardiovasc Genet 8(2): 294304, 2015. PMID: 25628389
68. Araujo, F.C., Milsted, A., Watanabe, I.K., Puerto, H.L., Santos, R.A., Lazar, J., Reis, F.M.,
Prokop, J.W.: Similarities and differences of X and Y chromosome homologous genes, SRY
and SOX3, in regulating the renin-angiotensin system promoters. Physiol Genomics 47(5):
177-86, 2015. PMID: 25759379; PMCID: PMC4421791
69. Olasz, E.B., Seline, L.N., Shock, A.M., Duncan, N.E., Lopez, A., Lazar, J., Flister, M.J., Lu, Y.,
Liu, P., Sokumbi, O., Harwood, C.A., Proby, C.M., Neuburg, M., Lazarova, Z.: MicroRNA135b regulates leucine zipper tumor suppressor 1 in cutaneous squamous cell carcinoma.
PloS One 10(5): e0125412, 2015. PMID: 25938461
70. Flister, M.J., Prokop, J.W., Lazar, J., Shimoyama, M., Geurts, A.: 2015 Guidelines for
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J. Lazar, M.D., Ph.D.
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ABSTRACTS:
1. Lazar J, Samel M, Pullmann R: Effect of adrenalectomy on heart hypertrophy induced by
hyperthyroidism during ontogenesis in the rat. Physiol Bohemoslov 34, 266, 1985
2. Lazar J, Samel M, Pullmann R: Effect of propanolol on the thyroxine-induced heart and
kidney hypertrophy during ontogenesis in rats. Physiol Bohemoslov 34, 348, 1985
3. Samel M, Lazar J, Pullmann R: Heart hypertrophy induced by hyperthyroidism during
ontogenesis in the rats. Physiol Bohemoslov 34, 276, 1985
4. Samel M, Lazar J, Pullmann R: Throxine induces marked kidney hypertrophy during
ontogenesis in rats. Physiol Bohemoslov 34, 276, 1985
5. Pullmann R, Samel M, Koskova E, Lazar J: Changes in serum enzyme activities of
aminotransferases AST, ALT, creatine kinase and lactatedehydrogenase induced by
thyroxine administration during ontogenesis of the rat. Physiol Bohemoslov 34, 274-275,
1985
6. Pullmann R, Koskova E, Lazar J, Samel M: Enzyme activity changes in cytosolic fraction of
myocardial homogenates induced by thyroxine administration during ontogenesis in rats.
Physiol Bohemoslov 34, 453, 1985
7. Lazar J, Mesik J, Dobias J, Bukovska E, Samel M: Differences in thyroid hormone action
during ontogenesis. Physiol Bohemoslov 39, 262, 1990
8. Samel M, Lazar J, Knopp J, Pullmann R, Bukovska E, Dobias J, Mesik J: Effect of age and
thyroxine administration on the brown adipose tissue and liver malic enzyme activities in
rats. Physiol Bohemoslov 39, 262, 1990
9. Samel M, Lazar J, Pullmann R, Dobias J, Bukovska E: The possible role of brown adipose
tissue in lipogenesis of suckling rats after injections of thyroxine. In “Hormones and
Bioactive Substances in Milk,” p. 24, 1990
10. Desvergne B, Farsetti A, Lazar J, Nikodem VM: Functional and in vitro binding studies of TR
alpha and beta to native TREs of malic enzyme and myeline basic protein genes. J Cellular
Biochem 16C (Suppl. I), 26, 1992
11. Lazar J, Desvergne B, Magnuson M A, Nikodem V M: A role of intronic sequences on
expression of thyroid hormone receptor alpha gene. American Thyroid Association Suppl 3:
T 122, 1993
12. Lazar J, Desvergne B, Zimmerman E, Zimer D, Magnuson M A, Nikodem VM: Cloning and
characterization of the promoter region of the rat c-erbA alpha gene. NIH Research Festival,
Bethesda, September 19-23, 1994
J. Lazar, M.D., Ph.D.
Page 15
13. Nikodem VM, Tomura H, Lazar J: A role for N-terminal region of the thyroid hormone
receptors on the thyroid hormone dependent transactivation function. 2nd International
Workshop of Thyroid Hormone Resistance, Padua, Italy, May 12-13, 1995
14. Farsetti A, Lazar J, Phyillaier M, Lippoldt R, Nikodem VM: Requirement of regulatory
elements for thyroid hormone (TH) receptor (TR) beta 2 inhibition of TH-TR beta 1
dependent transactivation. Keystone Symposium March 17-23, 1996
15. Hauser P, Schultheiss MB, Jordan P, Du Busc E, Laney C, Lazar J: A quantitative MRI study
of brain structures in subjects with resistance to thyroid hormone (RTH). 24th Annual
Meeting of ETA, Munich, August, 1997
16. Lazar J, Yu S-F, Detolla LJ, Hauser P: A transgenic mouse model for resistance to thyroid
hormone: Implications for brain and behavioral research. 24th Annual Meeting of ETA,
Munich, August, 1997
17. Mong JA, Lazar J, Dellovate TL, Kapadia M, Detolla LJ, Yu S-F, Pfaff DW, Hauser P,
McCarthy MM
astroglial morphology in the CA3 region of the hippocampus and reduced behavioral
sensitivity to estrogene. 29th Meeting of the Conference on Reproductive Behavior,
Baltimore, May 28-31, 1997
18. Yu S-F, Lazar J, Hauser P, DeTolla L: Mutation in thyroid hormone receptor causes heart
and eye defects in transgenic mice. Annual Meeting of AAALS, Anaheim, November 17-21,
1997
19. Hauser P, Greene K, Lazar J, Yu S-F, DeTolla LJ, Edwards E: Memory impairment reversed
by amphetamine in a transgenic mouse expressing the thyroid receptor gene mutation
Q340H. Annual Meeting of ATA, Portland, September, 1998
20. Lazarova Z, Yee C, Lazar J, Yancey KB: Laminin 01 alpha 3-specific autoantibodies in
patients with anti-epiligrin cicatricial pemphigoid (AECP) recognize the G domain of this
polypeptide. J Invest Dermatol 113, 104, 1999
21. Alexeeva I, Rollins S, Theisen P, Gasparich GE, Lazar J, Rohwer RG.: Absence of
Spiroplasma or other bacterial DNA in sufficient concentration to account for the high levels
of infectivity in hamster brains infected with 263K strain of scrapie. 5th Annual Symposium
on the Neurovirology and Neuroimmunology of Schizophrenia and Bipolar Disorder.
Bethesda, November 4-6, 1999
22. Lazar J, Jensen-Seaman MI, Shiozawa M, Barreto NE, Jene S, Majewski R, Provoost AP,
Roman RJ, Jacob HJ: Physical mapping and congenic development for a renal failure QTL
(Rf-1) in a rat model. ASN, Philadelphia, 2002
23. Rafiee P, Shi Y, Heidemann J, Jacob HJ, Lazar J, Baker JE: Functional proteomic analysis:
Evidence for cardioprotective proteins in the Brown Norway vs. Dahl S rat. American Heart
Association, Chicago, November 2002
J. Lazar, M.D., Ph.D.
Page 16
24. Provoost AP, van Dijk SJ, Specht PAC, Lazar J, Jacob HJ: Impaired renal blood flow
autoregulation in ACI.FHH-Rf1B congenic rats underlies increased susceptibility to renal
damage. Satellite Symposium on the genetics of experimental and human hypertension.
From Mendel to Humans. Brno, June 2002
25. Shi Y, Pritchard A, Ogawa H, Hutchins WC, Jacob HJ, Lazar J, Rafiee P, Baker JE: Increased
association of HSP90 with NOS3 in hearts of Brown Norway rats increases resistance to
myocardial ischemia. American Heart Association, Chicago, November 2002
26. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Susceptibility to renal damage and
renal blood flow autoregulation in ACI.FHH-Rf-1B, Rf-4, and Rf-5 congenic rats. Nederland
Hypertensie Genootschap. Nijmegen, September 2002
27. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Susceptibility to renal damage and
renal blood flow autoregulation in ACI.FHH-Rf-1B, Rf-4, and Rf-5 congenic rats. Nederland
Vereniging Voor Nefrologie. Utrecht, September 2002
28. Provoost AP, van Dijk SJ, Specht PAC, Lazar J, Jacob HJ: Renal blood flow autoregulation
and renal damage susceptibility in ACI.FHH-Rf-1B, Rf-4, and Rf-5 congenic rats. The XIVth
International workshop on genetic systems in the rat. Kyoto, October 2002
29. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Impaired renal blood flow
autoregulation in ACI.FHH-Rf-1B congenic rats. J Am Soc Nephrol 13: 332A, 2002
30. Khan S, Jiang N, Lazar J, Tackes J, Jene S, Tschannen M, Provoost A, Hessner M, Jacob HJ:
Using microarray gene expression profiling to determine genes involved in end-stage renal
disease. FASEB A80, 2003
31. Moreno C, Khan S, Jiang N, Lazar J, Tschannen M, Jensen-Seaman M, Tackes J, Jene S,
Hessner M, Jacob HJ Microarray analysis of gene expression changes in the kidney of the
Rf-1 congenic strain of the Fawn-Hooded rat. Rat genetics Symposium. Cold Spring Harbor,
December 2003.
32. Baker JE, Shi Y, Pritchard KA, Heidemann J, Jacob HJ, Lazar J, Rafiee P: Functional
proteomic analysis: Evidence for cardioprotective proteins in the Brown Norway vs Dahl S
rat. FASEB A159, 2003
33. Jensen-Seaman MI, Lazar J, Shiozawa M, Barreto N, Lemke AM, Gore DR, Jacob HJ: A
comparative genomics approach to positionally cloning a gene for renal failure. FASEB A
492, 2003
34. Rangel-Filho A, Jensen-Seaman MI, Datta Y, Lazar J, Provoost A, Jacob HJ: Comparative
genomics of the renal failure (Rf-2) region. FASEB A492, 2003
J. Lazar, M.D., Ph.D.
Page 17
35. Feldmann MM, Jensen-Seaman MI, Lazar J, Provoost A, Jacob HJ: An in silico approach to
the physical and comparative mapping of Rf-4, a locus involved in hypertension-induced
renal failure. FASEB A492, 2003
36. Orlebeke KI, Jensen-Seaman MI, Kennedy K, Twigger KS, Kwitek A, Lazar J, Jacob HJ:
Linkage disequlibrium (LD) assessment in the rat. FASEB A492, 2003
37. Van Dijk S, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Renal damage susceptibility and
renal blood flow autoregulation in ACI.FHH-Rf-1, Rf-4, and Rf-5 congenic rats. JASN 14:
615A, ASN San Diego, 2003
38. Mathis J, Shimoyama M, Hughes A, Cruz ND, Wang C, Twigger S, Jensen-Seamen M,
Feldmann M, Rangel-Filho A, Lazar J, Jacob HJ, Tonellato P: Identifying and annotating
disease specific rat genome sequences. International Conference on Intelligent Systems for
Molecular Biology, 2003
39. Feldmann MM, Jensen-Seaman MI, Lazar J, Lemke A, Jacob HJ: An in silico approach to the
physical and comparative mapping of Rf-4, a locus involved in hypertension-induced renal
failure. The 18th Annual National MD/PhD Student Conference, Aspen, Colorado, 2003
40. Vitt U, Wingrove J, Gietzen D, Stevens K, Becha SJ, Chien J, Kwong M, Weiler M, Jacob HJ,
Jensen-Seaman MI, Lazar J, Daniels S, Schmidt J: Selection of candidate disease genes by
EST-based identification of genomic gene loci and synteny between rat and human. Cold
Spring Harbor, December 11-14, 2003
41. Khampang P, Lazar J, Shi Y, Hutchins W, Cabigas B, Fitzpatrick C, Jacob HJ, Baker J E: Gene
expression profiling in left ventricle of hearts from SSBN13 consomic and SS rats after
exposure to ischemia. Cold Spring Harbor, December 11-14, 2003
42. Lutz MM, Jensen-Seaman MI, Lazar J, Provoost AP, Jacob HJ: Identification of sequence
variations between the ACI and FHH strains in candidate genes for the Rf-4 locus. Cold
Spring Harbor, December 11-14, 2003
43. Majewski RR, Hessner M, Lazar J, Kwitek AE, Lemke A, Orlebeke K, Oberg E, Gould MN,
Jacob HJ: High-throughput production of rat knockout models for hypertension using ENU
mutagenesis and a Yeast truncation assay. Cold Spring Harbor, December 11-14, 2003
44. Moreno Q, Khan S, Jiang N, Lazar J, Tschannen M, Jensen-Seaman MI, Provoost A, Hessner
MJ, Jacob HJ: Temporal patterns of gene expression in the kidney of the Rf-1 congenic rat
strain. Cold Spring Harbor, December 11-14, 2003
45. Rangel-Filho A, Jensen-Seaman MI, Datta Y, Lazar J, Provoost AP, Jacob HJ: “In Silico”
physical mapping and annotation of renal failure and bleeding disorder QTLs in the Fawn
Hooded hypertensive rat. Cold Spring Harbor, December 11-14, 2003
J. Lazar, M.D., Ph.D.
Page 18
46. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Renal blood flow autoregulation
and renal damage susceptibility in ACI.FHH-RF-1B, RF-4, and RF-5 congenic rats. Cold
Spring Harbor, December 11-14, 2003
47. Moreno C, Khampang P, Schippers D, Lazar J, Kaldunski ML, Greene AS, Roman RJ, Kwitek
AE, Jacob HJ, Cowley AWJr: Renal expression and sequence comparison of cyclooxygenase
2 in salt-sensitive hypertension. FASEB Washington DC, April 17-21, 2004
48. Lopez B, Ryan RP, Moreno C, Lazar J, Jacob HJ, Provoost AP and Roman RJ: Identification
of a QTL on region of chromosome 1 for impaired autoregulation of RBF in Fawn-Hooded
Hypertensive rats. Council of High Blood Pressure Research, September 2004
49. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Increased susceptibility to renal
damage and impaired autoregulation in Rf-1, and Rf-1+4 congenic rats compared to ACI
and Rf-4 rat. Genetic systems in the rat, XVth International workshop. Kopenhagen,
September 2004
50. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Increased susceptibility to renal
damage and impaired autoregulation in Rf-1, and Rf-1+4 congenic rats compared to ACI
and Rf-4 rat. Nederlandse Federatie voor Nefrologie, October 2004
51. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Genetics of renal damage
susceptibility in rats. The 9th international Workshop on Developmental Nephrology, Barossa
Valley, August 2004
52. Moreno C, Khan S, Jiang N, Jensen-Seaman M, Lazar J, Provoost A, Hessner MJ, Jacob HJ:
Patron temporal de expresión genetica en el rinon de la rata congenica ACI.FHH.RF-1”. 9ª
Reunión Nacional, Sociedad Española de Hipertensión, Liga Española para la lucha contra
la Hipertensión Arterial, 2004
53. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Genetics of renal damage
susceptibility in rats. The 13th international Paediatric Nephrology Association, Adelaide,
September 2004
54. Moreno C, Kaldunski ML, Lazar J, Roman RJ, Greene AS, Jacob HJ, Cowley AW:
Identificación de un locus de hipertensión sal-sensible mediante el uso de lincage genetico
en ratas consomicas. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga
Española para la lucha contra la Hipertensión Arterial, 2004
55. Van Dijk SJ, Specht, PAC, Lazar J, Jacob HJ, Provoost AP: Increased susceptibility to renal
damage and impaired autoregulation in Rf-1, and Rf1+4 congenic rats compared to ACI and
Rf-4 rats. JASN 15: 207A, ASN St. Louis, October 2004
56. Moreno C, Lazar Jjr, Khan S, Wen X, Jiang N, Tschannen MI, Chen M, Provoost A, Hessner
MJ, Lazar J, Jacob HJ: Temporal patterns of gene expression during the development of
renal failure. JASN 15: 434A, ASN St. Louis, October 2004
J. Lazar, M.D., Ph.D.
Page 19
57. Lutz MM, Andrae JW, Sharma M, Lazar J, Moreno C, Provoost AP, Jacob HJ: Focusing in on
Rf-4: The use of subcongenic rat strains to narrow the region of chr. 14 involved in
hypertensive renal failure. JASN 15: 434A, ASN St. Louis, October 2004
58. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Remant kidney: A not so good
model to compare the susceptibility to renal damage in congenic rats? JASN 15: 828A, ASN
St. Louis, October 2004
59. Sharma M, Lazar J, Lutz M, Barreto N, Andrae JW, Moreno C, van Dijk SJ, Provoost AP,
McCarthy ET, Savin VJ, Jacob HJ: In vitro glomerular permeability (Palb) as an early
phenotypic marker of renal injury. JASN 15: 206A, ASN St. Louis, October 2004
60. Moreno C, Khampang P, Schippers D, Lazar J, Kaldunski ML, Greene AS, Roman RJ, Kwitek
AE, Jacob HJ, Cowley AW: Renal expression and sequence comparison of cyclooxygenase 2
in salt-sensitive hypertension. FASEB, Washington DC, April 2004
61. Strohl KP, Moreno C, Lazar J, Tschannen M, Erokwu B, Feroah T, Jacob HJ: A GenomeWide Scan for Respiratory Frequency in Male Rats. American Thoracic Society, 2004
62. Rangel-Filho A, van Dijk S, Provoost A, Lazar J, Datta YH, Jacob HJ: Missense mutation in
the Rab38 gene in the fawn-hooded rat is the probable cause of Hermansky-Pudlak
syndrome-like phenotype. FASEB, San Diego, April 2-6, 2005
63. Lutz MM, Lazar J, Sharma M, Moreno-Quinn C, Andrea JW, Provoost AP, Jacob HJ:
Narrowing Rf-4, a locus on rat chromosome 14 linked to hypertension-induced renal failure.
FASEB San Diego, April 2-6, 2005
64. Schlick NE, Lazar J, Orlebeke K, Jensen-Seaman MI, Jacob HJ: The role of mtDNA in the
onset and progression of diabetes and renal disease in type II diabetic rats. FASEB San
Diego, April 2-6, 2005
65. Moreno C, Tschannen M, Chen M, Lazar Jjr, Khan S, Jing N, Hessner A, Provoost A, Lazar J,
Jacob HJ: Early detection of markers of end-stage renal disease in the fawn-hooded
hypertensive rat. FASEB San Diego, April 2-6, 2005
66. Sarkis A, Lopez B, Hoagland KM, Moreno C, Fenoy FJ, Lazar J, Jacob HJ, Kwitek AE, Garrett
MR, Rapp JP, Roman RJ: Transfer of the CYP4A region from Lewis rats into Dahl S
background reduces renal injury. 59th Annual Fall Conference and Scientific Sessions of the
Council for High Blood Pressure Research in association with the Council on the Kidney in
Cardiovascular Disease. Hypertension, Vol 46, No 10, Washington DC, September 21–24,
2005
67. Lazar J, Dwinell MR, Broeckel U, Baker JE, Jacob HJ: Understanding myocardial infarction
through comparative genomic and chromosome substitution. From genome to disease II. A
symposium of high throughput Biology. NIH, Bethesda, July 19-20, 2005
J. Lazar, M.D., Ph.D.
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68. Provoost AP, van Dijk SJ, Specht PA, Lazar J, Jacob HJ: The effects of the Rf1 and Rf2/Bpfh1 region from the FHH rat on renal damage susceptibility, blood pressure and renal
autoregulation. 59th Annual Fall Conference and Scientific Sessions of the Council for High
Blood Pressure Research, Washington DC, September 21-24, 2005
69. Lazar J, Khampang P, Barreto NE, Tschannen M, Andrae JW, Broeckel U, Baker JE, Jacob
HJ: Myocardial infarction and the role of evolutionary conserved region. Cold Spring Harbor,
December 8-11, 2005
70. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Renal damage susceptibility in Rf1A+2 double congenic rats compared to FHH and FHL rats. JASN 16, 183A, 2005
71. Rangel-Filho A, Lazar J, Provoost AP, Jacob HJ: Rab38 influences proteinuria, albuminuria,
melanosome maturation, platelet function and alcohol intake in FHH and congenic rats.
JASN 16, 20A, 2005
72. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Synergistic QTL interactions
between Rf-1 and Rf-3 increase renal damage susceptibility in double congenic rats. ASN
16, 794A, 2005
73. Schlick NE, Lazar J, Stekiel TA, Contney SJ, Bosnjak ZJ, Jacob HJ: The role of mitochondrial
DNA and mitochondrial function in the onset and progression of diabetic nephropathy. Cold
Spring Harbor, December 8-11, 2005
74. Rangel-Filho A, Datta Y, Provoost A, Lazar J, Jacob HJ: Renal disease, coat color, platelet
function and alcohol intake are modulated by the RF-2 locus in the Fawn-Hooded Rat. Cold
Spring Harbor, December 8-11, 2005
75. Lutz MM, Lazar J, Sharma M, Moreno C, Andrae JW, Provoost AP, Jacob HJ: Sequence and
gene expression comparison in a narrowed region of RF-4 locus in ACI, FHH and Double
Congenic rats. Cold Spring Harbor, December 8-11, 2005
76. Moreno C, Andrae JW, Lutz M, Orlebeke K, Lazar J, Greene AS, Twigger SN, Jacob HJ:
Concordance of allele characterization project data with SNP distribution across rat strains.
Rat genomics & models, Cold Spring Harbor, December 8-11, 2005
77. Majewski RR, Lazar J, Hessner M, Moreno C, Kwitek AE, Jursinic J, Lemke A, Andrae JW,
Jacob HJ: High-throughput production of rat knockout models for hypertension using ENU
mutagenesis and a tilling assay. Rat genomics & models, Cold Spring Harbor, December 811, 2005
78. Strohl KP, Moreno C, Lazar J, Tschannen M, Erokwu B, Jacob HJ: A genome scan for
breathing frequency in Sprague Dawley and Brown Norway rats. Cold Spring Harbor,
December 8-11, 2005
79. Moreno C, Rogge R, Lazar J, Tschannen M, Kaldunski ML, Cowley AW, Jacob HJ:
Characterization of blood pressure and protein excretion in chromosome 18 congenic strains
J. Lazar, M.D., Ph.D.
Page 21
of Dahl S rats. 16th International Workshop on Rat Genetic Systems, Melbourne, December
1-2, 2006
80. Majewski RR, Lazar J, Hessner M, Moreno C, Kwitek AE, Dwinell M, Lemke A, Andrae JW,
Jacob HJ: High-throughput production of rat knockout models for hypertension using ENU
mutagenesis and a TILLING assay. 16th International Workshop on Rat Genetic Systems,
Melbourne, December 1-2, 2006
81. Moreno C, Kaldunski ML, Wang T, Lazar J, Roman RJ, Greene AS, Jacob HJ, Cowley
AWJr: Existence of multiple blood pressure loci on rat chromosome 13 of the Dahl S
Hypertensive rat. FASEB/Experimental Biology, San Francisco, April 2006
82. Lutz MM, Sharma M, Lazar J, Provoost AP, Jacob HJ: Identification of sequence and
expression variants in a narrowed region of the Rf-4 locus related to renal failure.
FASEB/Experimental Biology, San Francisco, April 2006
83. Moreno C, Rogge R, Lazar J, Tschannen M, Kaldunski M, Cowley AW, Jacob HJ:
Characterization of blood pressure and protein excretion in chromosome 18 congenic strains
of Dahl S rats. The Australian Health & Medical Research Congress, Melbourne, Australia,
December 2006
84. Jacob HJ, Lazar J, Rangel-Filho A, Lutz M, Sharma M, van Dijk SJ, Roman RJ, Moreno C,
Provoost A. Genetic complexity of hypertension associated renal failure. International
Society of Nephrology – Nature Genetics Forefronts Symposium on Nephrogenetics: from
Development to Physiology. Danvers, MA, March 2007
85. Lazar J, Petersen M, Michalkiewicz M, Geurts A, Rangel-Filho A, Wakatsuki T, Jacob HJ: High
throughput phenotyping platform for positional cloning using engineered heart tissue. Cold
Spring Harbor Laboratory, The Biology of Genomes, Cold Spring Harbor, NY, May 2007
86. Carol Moreno, Matt Duran, Micheline M. de Resende, Mary L. Kaldunski, Jozef Lazar, Julian
Lombard, Andrew S. Greene, Allen W. Cowley Jr and Howard J. Jacob. Pleiotropic effects of
the rennin loci. Rat Genomics & Models, Cold Spring Harbor Laboratory, NY, December 2007
87. O’Meara C, Lazar J, Moreno C, Tschannen M, Provoost AP, Jacob HJ: Investigating a triple
congenic rat model to determine genes contributing to renal failure. Rat Genomics &
Models, Cold Spring Harbor Laboratory, NY, December 2007
88. Rangel-Filho A, Lazar J, Michalkiewicz M, Jacob HJ: Applications of viral vectors in rat
genomics. Rat Genomics & Models, Cold Spring Harbor Laboratory, NY, December 2007
89. Schilling RR, Lazar J, Hessner M, Moreno C, Dwinell M, Lemke A, Andrae JW, JacobHJ: Highthroughput production of rat knockout models for hypertension using ENU mutagenesis and
a tilling assay. Rat Genomics & Models, Cold Spring Harbor Laboratory, NY, December
2007.
J. Lazar, M.D., Ph.D.
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90. Moreno C, Dwinell MR, Schilling RR, Kwitek AE, Greene AS, Roman RJ, Lazar J,Mattson DL,
Lombard JH, McQuestion GD, Cowley AW and Jacob HJ. Modeling cardiovascular disease in
rat by ENU mutagenesis. 21st International Mammalian Genome Conference. Kyoto,
Japan, October 2007
91. Lazar J, Wakatsuki T, Jacob HJ: Using engineered heart tissue to accelerate positional
cloning. Hypertension, Berlin, Germany, June 14-19, 2008
92. Lazar J: Engineered heart tissue: high-throughput platform for dissection of complex
diseases. First Annual ISCTR Meeting, San Diego, CA, February 9-10, 2008
93. Lazar J: Role of mitochondrial genome in modulating hypoxic dilation in cerebral arteries of
animal models with type 2 diabetes mellitus. Cold Spring Harbor Laboratory/Wellcome Trust
Conference, Rat Genomics & Models, December 3-6, 2008
94. Moreno C, O’Meara C, Sweeney WE, Lazar J, Avner ED, Jacob HJ: Towards mapping
modifier loci for ARPKD. Cold Spring Harbor Laboratory/Wellcome Trust Conference, Rat
Genomics & Models, December 3-6, 2008
95. Lazar J: Using engineered heart tissue to accelerate positional cloning. 13th Intl SHR
Symposium, Prague Czech Republic, June 20- 22, 2008
96. O’Meara C, Lazar J, Moreno C, Provoost AP, Jacob HJ: The Contribution of the RF-3QTL in
the development of renal failure. Cold Spring Harbor Laboratory/Wellcome Trust
Conference. Rat Genomics & Models. December 3-6, 2008
97. Roman RJ, Moreno C, Lazar C, Cowley Jr AW. and Jacob HJ. Narrowing of a region on rat
chromosome 13 that protects against the development of hypertension using overlapping
Dahl SS.13BN congenic strains. Council of High Blood Pressure, Atlanta, September 2008.
98. Moreno C, Sweeney WE, Lazar J, Jacob HJ and Avner ED. Development of a rat model of
ARPKD to study genetic modifier loci. American Society of Nephrology.
Philadelphia,November 2008
99. Jacob HJ, Provoost AP, Broeckel U, Lazarova Z, Lazar J: Identification of Rf1. Cold Spring
Harbor Laboratory/Wellcome Trust Conference. Rat Genomics & Models. December 3-6,
2008.
100. O’Meara C, Lazar J, Moreno C, Provoost AP, Jacob HJ: The Contribution of Genes on
Chromosome 3 to Renal Failure in the Fawn Hooded Hypertensive Rat. Experimental
Biology, New Orleans, April 2009
101. Moreno C, Rogge R, Tschannen M, Barreto N, Lazar J, Jacob HJ: Multiple Blood Pressure loci
on rat Chromosome 18 attenuate the development of hypertension in the Dahl S
Hypertensive rat. Experimental Biology, New Orleans, April 2009
J. Lazar, M.D., Ph.D.
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102. Lu L, Li P, Yang C, Kurth T, Misale M, Skelton M, Moreno C, Greene AS, Jacob HJ, Roman
RJ, Lazar J, Liang M, Cowley, Jr AW: Dynamic utilization of biological pathways in protection
against salt-sensitive hypertension. Council of High Blood Pressure, Chicago, September
2009
103. O’Meara C, Lazar J, Moreno C and Jacob HJ: Physiological genomics of the renal failure 3
(Rf-3) quantitative trait locus. Rat Genomics and Models. Cold Spring Harbor, NY.
December 2009
104. Strohl KP, Moreno C, Lazar J, Dostal J, Tschannen M, Erokwu B, Jacob HJ: Linkage to posthypoxic ventilatory behavior in the rat. Rat Genomics and Models. Cold Spring Harbor, NY.
December 2009
105. Lazar J, Rai D, Moreno-Quinn C, Sweeney W, Jacob HJ: Differential effect of a western diet
on GK and T2DN rats. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 25
106. Rao V, Lazar J, Sarkis A, Wakatsuki T, Lam V, Jacob HJ: Engineered heart tissues help to
identify potential sensitivity of a rat model to myocardial ischemia. Rat Genomics & Models
meeting, Cold Spring Harbor NY 2009 Dec 2-5
107. Sarkis A, Rao V, Wakatsuki T, Lazar J, Jacob HJ: Decellularized heart matrix as a scaffold for
development of engineered heart tissue. Rat Genomics & Models meeting, Cold Spring
Harbor NY 2009 Dec 2-5
108. Jacob HJ, Rangel-Filho A, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H,
Lazar J, Moreno-Quinn C, Geurts AM: Validation of RAB38 using transgenic rescue and gene
KO. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5
109. Moreno C, Hofman M, Lazar J, Lombard JH, Greene AS, Jacob HJ: Narrowing the blood
pressure loci around the renin gene
110. O’Meara C, Lazar J, Moreno C, Jacob HJ: Physological genomics of the renal failure 3 RF-3)
quantitative trait locus. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec
2-5
111. Strohl KP, Moreno C, Lazar J, Dostal J, Tschannen M, Erokwu B, Jacob HJ: Linkages to post
hypoxic ventilatory behavior in the rat. Rat Genomics & Models meeting, Cold Spring
Harbor NY 2009 Dec 2-5.
112. Nabbi R, Kersten JR, Stowe DF, Lazar J, Boelens AD, Riess ML: Resistance to
Ischemic Preconditioning in rat isolated hearts is genetically determined. Anesth Analg
2010; 110(3): SCA12. Experimental Biology 2010, Anaheim CA
113. Nabbi R, Kersten JR, Stove DE, Lazar J, Aldakkak M, Reiss ML: Characterizing the
cardioprotective phenotype of Brown Norway rats: importance of optimal ischemia duration.
FASEB J 2010; 24:1037.6
J. Lazar, M.D., Ph.D.
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114. Sethumadhavan S, Lazar J, Martin M, Vivar JV: Mitochondrial dysfunction in diabetic rat
heart. SFRBM’s 17th Annual meeting, November 17-21, 2010, Orlando, FL. Published Free
Radical Biology and Medicine, Vol 49, 2010, p S41
115. Jacob HJ, Geurts AM, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H, Lazar J,
Dwinell MR, Moreno C for GO grant team: From GWAS to function using sensitized strains,
transgenic rescue and gene KO. The Biology of Genomes, May 11-15, 2010
116. Cowley AW Jr, Jacob HJ, Moreno C, Greene A, Lombard J, Mattson D, Lazar J, Dwinell MR,
Geurts AM: Unraveling the genomic basis of hypertension: rat model systems. International
Congress of Pathophysiology, Montreal, Canada, September 2010
117. Geurts AM, Schilling R, Lemke A, Grzybowski M, Kalloway S, Foeckler J, Klotz J, Weiler H,
Lazar J, Dwinell MR, Moreno C, Jacob HJ: From genetics to function for human disease
using transgenic rescue and gene KO in sensitized rat strains. International Congress of
Pathophysiology, Montreal, Canada, September 2010
118. Jacob HJ, Geurts AM, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H, Lazar J,
Dwinell MR, Moreno C, for the GO Grant Team: From GWAS to function using sensitized
strains, transgenic rescue and gene KO. American Heart Association HBPR 2010.
Washington, DC Oct 13-16, 2010
119. Moreno C, Hoffman M, Didier D, Geurts M, Lazar J, Greene A, Jacob HJ: Initial
Characterization of the Renin Knockout Rat. American Heart Association HBPR 2010.
Washington, DC Oct 13-16, 2010
120. Lazar J, Xu H, O’Meara C, Lazarova Z, Moreno C, Jacob HJ: A candidate gene for kidney
failure. 43rd Annual Meeting & Scientific Exposition, American Society of Nephrology Nov.
16-21 2010
121. Jacob HJ, Schilling RR, Lazar J, Moreno C: Using gene knock-outs and transposon based
transgenics in sensitized rat strains to study genes nominated by human GWAS for renal
disease. 43rd Annual Meeting & Scientific Exposition, American Society of Nephrology 2010
Nov. 16-21
122. Nabbi R, Kersten JR, Stowe DF, Lazar J, Riess ML: Genome-dependent resistance to
Anesthetic Preconditioning in rat isolated hearts. 2010, ASA Meeting
http://www.asaabstracts.com, #903
123. Zheng S, Flister MJ, Sarkis AB, Hoffman M, Moreno C, Lazar J, Jacob HJ: Narrowing genetic
regions on rat chromosome 12 involved in cardiovascular disease. Rat Genomics and
Models. Cold Spring Harbor, New York, Dec 7-10, 2011
124. Nabbi R, Kersten JR, Lazar J, Stowe DF, Riess ML: Genome-dependent preservation of
cardiac mitochondria redox state by anesthetic preconditioning. Anesth Analg 2011; 112
(SCA Suppl); SCA 28
J. Lazar, M.D., Ph.D.
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125. Flister MJ, Zheng S, Sarkis AB, Hoffman M, Lemke A, Schilling RR, Tsaih S, Dwinell MR,
Moreno-Quinn C, Lazar J, Jacob HJ: Role of GWAS nominated gene SH2B3 in cardiac
inflammation and remodeling. Rat Genomics and Models. Cold Spring Harbor, New York,
Dec 7-10, 2011
126. Xiao B, Hoffman M, Tsaih SW, Sarkis A, Flister M, Zheng S, Lemke A, O’Meara C, Lazar J,
Jacob HJ, Moreno C: Identification of a gender-specific gene for salt-sensitive hypertension.
Cold Spring Harbor, New York, Dec 7-10, 2011
127. Sarkis AB, Xiao B, Tsaih SW, Flister MJ, Lazar J, Lemke A, Zheng S, Hummel O, Saar K,
Hübner N, Worthey EA, Jacob HJ, Moreno C: Whole-genome SNP Map Of The Dahl Saltsensitive And The Fawn-hooded Hypertensive Rats. American Heart Association’s High Blood
Pressure Research 2011 Scientific Sessions. Abstract #828, Orlando, Sept 21-24, 2011
128. Flister MJ, Geurts AM, Sarkis AB, O’Meara CC, Hoffmann B, Tsaih S, Lazar J, Moreno C,
Dwinell MR, Cowley AW, Lombard JH, Mattson DL, Jacob HJ: Role of GWAS nominated gene
SH2B3 in T-cell mediated renal damage and hypertension. High Blood Pressure Research
Scientific Sessions, Council for High Blood Pressure, Orlando FL, September 2011
129. Sarkis AB, Xiao B, Tsaih S, Flister MJ, Lazar J, Hummel O, Saar K, Hübner N, Worthey EA,,
Jacob HJ, Moreno C: Association Between mRNA Abundance and Genome-wide Single
Nucleotide Variant Analysis in Dahl Salt-Sensitive and Fawn-Hooded Hypertensive Rats. High
Blood Pressure Research Scientific Sessions, Council for High Blood Pressure, Orlando FL,
September 2011
130. Sarkis AB, Tsaih SW, Flister MJ, Lazar J, and Jacob HJ: Using RNA-Seq data to identify
genes contributing to ischemia response in rat cardiac fibroblasts. Gordon Research
Conference 2011
131. Moreno C, Mattson DL, Geurts AM, Dwinell M, Lazar J, Schilling R, Hoffman M, Roman RJ,
Cowley AW Jr., Jacob HJ: Characterization of Nap5 KO rat for blood pressure and associated
phenotypes. Experimental Biology, Washington, April 2011
132. Hoffman M, Barreto N, Graff P, Lazar J, Jacob HJ, Moreno C: Narrowing of candidate region
on rat chromosome 18 responsible for attenuating the development of hypertension in the
Dahl S hypertensive rat. Experimental Biology, Washington, April 2011
133. Takizawa A, Dwinell MR, Rood WA, Hecht A, Schilling RR, Moreno-Quinn C, Geurts A, Lazar
J, Jacob HJ: Establishing a high-integrity cryopreservation system for KO rats. Cold Spring
Harbor, New York, Dec 7-10, 2011
134. O’Meara C, Sweeney WE, Hoffman M, Yeo NC, Tsaih SW, Lazar J, Jacob HJ, Avner ED,
Moreno C: Role of genetic modifiers in an orthologous model of ARPKD. FASEB PKD
meeting, Vermont, June 2011
J. Lazar, M.D., Ph.D.
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135. Riess ML, Nabbi R, Aldakkak M, Lazar J, Kersten JR, Stowe DF: Genome-Dependent
Cardioprotection is Linked to Preservation of Mitochondrial Function. Eur J Anaesth 2011; 28
(Suppl 48): 52. 4AP5-7
136. Sethumadhavan S, Vasquez-Vivar J, Migrino RQ, Harmann L, Jacob HJ, Lazar J: Myocardial
Dysfunction in a New Conplastic Rat Model of Type 2 Diabetes: Assessing the Role of
Different Mitochondrial Genomes.18th SFRBM Annual Meeting, November 16-20, 2011,
Atlanta, GA.Abstract published: Free Radical Biology and Medicine, Volume 51, issue
(November 1, 2011), p. S66
137. Nabbi R, Gadicherla AK, Kersten JR, Stowe DF, Lazar J, Aldakkak M, Riess ML:
Cardioprotection in Brown Norway rats is linked to mitochondrial complex I preservation.
Biophys J, 2011, 100(3), Suppl 1: A233
138. Flister MJ, Jia S, Tsiah S, Sarkis A, Zheng S, Geurts A, Moreno-Quinn C, Lazar J, Jacob H,
Hessner M: The rs3184504 [T] allele of SH2B3 elevates inflammatory response in Type 1
diabetes. American Diabetes Association Scientific Sessions Annual Meeting 2012,
Philadelphia PA, June 2012
139. Flister MJ, Jia S, Tsiah S, Sarkis A, Zheng S, Geurts A, Moreno C, Lazar J, Hessner M, Jacob
HJ: GWAS nominated gene SH2B3 increases cardiac remodeling and inflammation
associated with type 1 diabetes (T1D). Experimental Biology Annual Meeting 2012, San
Diego, California, April 2012
140. Nabor DS, Cheng Q, Kersten JR, Stowe DF, Lazar J, Riess DL: Differential cardioprotection
by ischemic preconditioning mediated by rat cromosme 6 is nitric oxide-dependent.
Experimental Biology Annual Meeting 2012, San Diego, California, April 2012
141. Feng D, Yang C, Lazar J, Mattson DL, O’Connor P, Cowley AWJr: Genetic regulation and
functional relevance of the p67phox gene in salt-sensitive hypertension. Experimental
Biology Annual Meeting 2012, San Diego, California, April 2012
142. Moreno C, Hoffman MJ, Flister MJ, Endres B, Greene AS, Lazar J, Jacob HJ, Xiao B: Narrow
congenics reveal multiple gender-specific blood pressure loci around the renin gene.
Experimental Biology Annual Meeting 2012, San Diego, California, April 2012
143. Nabor DS, Cheng Q, Kersten JR, Stowe DF, Lazar J, Riess ML: Differential cardioprotection
by chromosomal substitution in a consomic rat mode. Role of nitric oxide in anesthetic
preconditioning. 2012 IARS Meeting
144. Yeo NC, O’Meara C, Lazar J, Jacob HJ: Dissection of the renal failure-3 QTL. Experimental
Biology Annual Meeting 2012, San Diego, California, April 2012
145. Stowe D, Nabor D, Chen Q, Lazar J, Riess M: Differential cardioprotection by ischemic
preconditioning mediated by rat chromosome 6 is nitric oxide-dependent. Experimental
Biology Annual Meeting 2012, San Diego, California, April 2012
J. Lazar, M.D., Ph.D.
Page 27
146. Plasz EB, Neuburg M, Lazar J, Duncan NE, Schock AM, Seline L, Lopez A, Lu Y, Liu P,
Lazarova Z: MicroRNAs signature in cutaneous squamous cell carcinomas of
immunocompetent and organ transplant patients.
147. Lazar J: Targeting human blood pressure loci by zinc finger nucleases. 24th Meeting of ISH,
Sydney 2012, Septomber 30 – October 4
148. Lazar J, Flister MJ, Tsaih S-W, Endres B, Geurts AM, Dwinell MR, Moreno C, Jacob HJ:
Systematic characterization of the GWAS nominated loci using genome editing. Rat
genomics and models. Cambridge, December 3-6, 2012
149. Prisco ZS, Flister MJ, Sarkis AB, O’Meara CC, Hoffman M, Andrea WJ, Moreno C, Lazar J,
Jacob HJ: Dissecting hypertension susceptibility loci on rat chromosome 12. Rat genomics
and models. Cambridge, December 3-6, 2012
150. Takizawa A, Dwinell M, Klotz J, Schilling R, Lazar J, Geurts A, Jacob H: Establishing a highintegrity cryopreservation system for gene modified rat strains. Rat genomics and models.
Cambridge, December 3-6, 2012
151. Sarkis A, Lazar J, Jacob HJ: Use of next generation sequencing in genetic dissection of
hypertension. 24th Meeting of ISH, Sydney 2012, Septomber 30 – October 4
152. Lazar J: High throughput validation and discovery of human genomic functional elements.
Cardiovascular genetics incorporating the 15th International SHR Symposium and 48th
Japanese SHR meeting, Melbourne 27-28 September, 2012
153. Flister MJ, Jia S, Tsiah S, Sarkis A, Zheng S, Geurts A, Moreno C, Lazar J, Jacob HJ, Hessner
M: The rs3184504 [T] allele of SH2B3 elevates inflammatory response in Type 1 diabetes.
American Diabetes Association Scientific Sessions Annual Meeting 2012, Philadelphia PA,
June 2012
154. Sarkis AB, Flister MJ, Tsaih S-W, Santosh A, Aitman TJ, Hubner N, Hummel O, Moreno C,
Lazar J, Jacob HJ: Use of next generation sequencing in genetic dissection of hypertension.
J Hypertension. 30: e40, 2012
155. Bradley E, Sarkis AB, Moreno C, Flister MJ, Dwinell MR, Mattson DL, Cowley AWJr, Jacob HJ,
Geurts A, Lazar J: Targeting human blood pressure loci by zinc finger nucleases. J
Hypertension. 30: e321, 2012
156. Moreno C, Yang C, Liu P, Kurth T, Zappa A, Xiao B, Lazar J, Jacob HJ, Liang M, Cowley AW:
Characterization of a 1.45 Mbp blood pressure QTL in rat chromosome 13. Hypertension.
60: A 361, 2012
157. Geurts AM, Schilling R, Klotz J, Kalloway S, Foecker J, Grzybowski M, Hansen C, Casati M,
Richter S, Lazar J, Dwinell M, Moreno C, Cowley AW, Lombard J, Mattson D, Jacob HJ:
Rapid gene editing in rat models of human disease using targeted nucleases. Hypertension.
60:A353, 2012
J. Lazar, M.D., Ph.D.
Page 28
158. Endres B, Sarkis AB, Priestley J, Casati M, Hoffman M, Lazar J, Schilling R, Dwinell M,
Lombard J, Cowley AW, Mattson D, Moreno C, Geurts A, Jacob HJ: GWAS candidate gene
knockout in rats reveals a role for Erk/Mapk signaling in hypertension. Hypertension. 60:
A154, 2012
159. Casati M, Hoffman M, Schilling R, Flister M, Geurts AM , Dwinell M, Lazar J, Jacob HJ,
Moreno C: Characterization of a Comt knock-out rat for blood pressure and associated
phenotypes. Hypertension. 60: A160, 2012.
160. Lazar J, Flister MJ, Tsaih S-W, Endres B, Geurts AM, Dwinell MR, Moreno C, Jacob HJ:
Systematic characterization of the GWAS nominated loci using genome editing. Rat
genomics and models. Cambridge, December 3-6, 2012
161. Flister MJ, Tsaih S, Endres B, Sarkis A, Geurts A, Lazar J, Moreno-Quinn C, Dwinell M, Jacob
HJ: Characterization of the GWAS-nominated AGTRAP-PLOD1 Locus Using ZFN-mutated
Rats. High Blood Pressure Research 2012 Scientific Sessions, American Heart Association,
Washington D.C.
162. Flister MJ, Moreno C, Hoffman MJ, Prisco SZ, Lazar J, Hall JL, Jacob HJ: Role of SH2B3 in
genetic susceptibility to heart failure” New Frontiers in Cardiovascular Genetics Beyond
GWAS, Keystone Symposia Conference. Lake Tahoe, CA
163. Flister MJ, Moreno C, Hoffman MJ, Prisco SZ, Lazar J, Hall JL, Jacob HJ: The inflammatory
mediator SH2B3 increases risk of heart failure” Experimental Biology Annual Meeting.
Boston, MA
164. Moreno C, Hoffman MJ, Flister MJ, Endres B, Greene AS, Lazar J, Jacob HJ, Xiao B: (2012)
Narrow Congenics Reveal Multiple Gender-Specific Blood Pressure Loci around the Renin
Gene [Poster Presentation]. Experimental Biology 2012; 2012 Apr 21-25; San Diego,
CA. FASEB Journal 26
165. Prisco SZ, Priestley JR, Flister MJ, Sarkis AB, Hoffman MJ, Lazar J, Lombard JH, Jacob HJ:
Chromosome 12 and hypertension. Rat Genomics and models. Cold Spring Harbor
Laboratory, NY, December 11-14, 2013
166. Schilling RR, Dwinell M, Lazar J, Geurts AM, Grzybowski M, Temple A, Hoffman MJ, Zappa A,
Kalloway S, Foeckler J, Jacob HJ: Gene editing rat resource center. Rat Genomics and
models. Cold Spring Harbor Laboratory, NY, December 11-14, 2013
167. Flister M, Endres B, Geurts A, Lazar J, Shull J, Jacob HJ: CXM-a new tool for genetic
mapping breast cancer risk in the tumor microenvironment. Rat Genomics and models. Cold
Spring Harbor Laboratory, NY, December 11-14, 2013
168. Yeo N-C, Link BA, Lazar J, Jacob HJ: Identifying mutations in SHROOM3 that cause impaired
glomerular function. Cold Spring Harbor Laboratory, NY, December 11-14, 2013
J. Lazar, M.D., Ph.D.
Page 29
169. Prokop JW, Lazar J, Jacob HJ: Using protein modeling to understand the impact of genetic
variants and evolution. Rat Genomics and models. Hinxton, UK, December 1-4, 2014
170. Lazar J, Yeo N-C, Flister MJ, Prokop JW, Dwinell MR, Geurts A, Link B, Duncan S, Jacob HJ:
Utilization of different experimental modalities to test sequence variants nominated by
human studies. Rat Genomics and models. Hinxton, UK, December 1-4, 2014
171. Geurts A, Jacob HJ, Dwinell M, Lazar J, Baker D, Choi S: Progress engineering the rat
genome: startegies and resources for producing novel disease models. Rat Genomics and
models. Hinxton, UK, December 1-4, 2014
172. Schilling R, Dwinell M, Lazar J, Geurts AM, Grzybowski M, Lemke A, Miller J, Temple A,
Zappa A, Lazcares L, Kalloway S, Foecker J, Takizawa A, Jacob HJ: 2014 update: Gene
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