Supplemental table 1. Distribution of PAH concentrations (ng/g dust) measured in residential carpet dust
Median
Median
Detections1
95th percentile –
Detections1
(25th-75th
(25th-75th
controls
maximum
cases (%)
percentile)
percentile)
(%)
cases
cases
controls
1089.0 (603.21021.0 (530.715556.0-163180.0
2624.2)
2950.1)
Total PAH2
660 (97.6)
495 (96.9)
124.0 (61.9-309.5)
113.0 (56.0-348.0)
1910.0-30500.0
benzo[a]anthracene
656 (97.0)
495 (96.9)
145.5 (67.8-346.0)
121.0 (61.6-392.0)
2380.0-25500.0
benzo[a]pyrene
668 (98.8)
507 (99.2) 270.0 (142.5-698.5) 247.0 (123.0-798.0)
3960.0-47000.0
benzo[b]fluoranthene
634 (93.8)
466 (91.2)
97.7 (53.0-235.5)
88.6 (42.1-265.0)
1330.0-13100.0
benzo[k]fluoranthene
672 (99.4) 511 (100.0) 254.0 (146.0-556.6) 247.0 (128.0-674.0)
2710.0-28000.0
chrysene
493
(72.9)
343
(67.1)
34.7
(18.5-81.5)
34.0
(12.4-91.2)
497.0-4500.0
dibenzo[a]anthracene
651 (96.3)
495 (96.9)
153.0 (83.5-392.5)
149.0 (70.4-451.0)
2580.0-32300.0
indenopyrene
1
Usual detection limit = 20.8 ng/g dust
95th percentile –
maximum
controls
21414.0-180190.0
2910.0-26700.0
3170.0-30300.0
5990.0-44400.0
1820.0-16500.0
3940.0-35500.0
734.0-5590.0
3760.0-37200.0
2
Total PAH = Benz(a)anthracene + Benzo(a)pyrene + Benzo(b)fluoranthene + Benzo(k)fluoranthene + Chrysene + Dibenz(a,h)anthracene + Indeno(1,2,3-
c,d)pyrene
1
Supplemental table 2. Associations between PAH compounds and NHL overall, by study center
PAH
(ng/g dust)
Total PAH2
0-3471
3472-7645
7646-16706
>=16707
Continuous3
TEQ4
0-1182
1183-2846
2847-6038
>=6039
Continuous3
BaA
0-387
388-772
773-1769
>=1770
Continuous3
BaP
0-449
450-1110
1111-2429
>=2430
Continuous3
BbF
0-934
935-2010
2011-4399
>=4400
Continuous3
BkF
0-322
323-667
668-1519
>=1520
Continuous3
Chr
0-736
737-1450
1451-3239
Detroit
Cases/
Controls
OR1 (95% CI)
31/20
46/18
29/19
21/20
1.00
1.66 (0.75-3.69)
1.11 (0.48-2.52)
0.83 (0.35-1.97)
0.92 (0.72-1.17)
32/20
45/18
29/19
21/20
1.00
1.63 (0.73-3.61)
1.09 (0.48-2.48)
0.84 (0.35-1.98)
0.94 (0.74-1.19)
33/19
36/19
36/19
22/20
1.00
1.05 (0.47-2.36)
1.22 (0.54-2.74)
0.76 (0.32-1.78)
0.92 (0.73-1.17)
28/19
45/19
35/18
19/21
1.00
1.65 (0.74-3.70)
1.48 (0.64-3.41)
0.75 (0.31-1.80)
0.98 (0.78-1.23)
31/19
47/18
28/20
21/20
1.00
1.67 (0.75-3.71)
0.95 (0.41-2.16)
0.79 (0.33-1.88)
0.89 (0.70-1.14)
32/19
44/19
32/19
19/20
1.00
1.43 (0.64-3.16)
1.17 (0.51-2.66)
0.71 (0.29-1.70)
0.93 (0.73-1.19)
33/19
44/19
30/19
1.00
1.31 (0.59-2.88)
1.03 (0.45-2.34)
PAH
(ng/g dust)
Total PAH2
0-492
493-944
945-2416
>=2416
Continuous3
TEQ4
0-142
143-302
303-784
>=785
BaA
0-62
63-124
125-277
>=278
Continuous3
BaP
0-54
55-111
112-319
>=320
Continuous3
BbF
0-127
128-240
241-629
>=630
Continuous3
BkF
0-42
43-87
88-211
>=212
Continuous3
Chr
0-130
131-214
215-539
Iowa
Cases/
Controls
OR1 (95% CI)
42/36
45/37
71/38
37/36
1.00
1.05 (0.56-1.96)
1.64 (0.90-2.98)
0.87 (0.46-1.66)
0.97 (0.81-1.18)
39/37
40/37
74/37
42/36
1.00
1.05 (0.55-1.99)
2.00 (1.09-3.65)
1.11 (0.58-2.10)
1.02 (0.86-1.21)
49/37
47/36
55/37
44/37
1.00
1.01 (0.55-1.87)
1.15 (0.63-2.09)
0.89 (0.48-1.65)
0.96 (0.80-1.16)
33/37
50/37
70/36
42/37
1.00
1.48(0.78-2.80)
2.20(1.18-4.09)
1.24 (0.65-2.38)
1.03 (0.87-1.22)
41/36
47/37
69/37
38/37
1.00
1.15 (0.61-2.14)
1.65 (0.90-3.01)
0.91(0.48-1.73)
1.00 (0.83-1.19)
45/37
43/37
70/36
37/37
1.00
0.99 (0.53-1.85)
1.73 (0.95-3.16)
0.81 (0.43-1.53)
0.99 (0.83-1.17)
41/36
50/37
64/37
1.00
1.15 (0.62-2.14)
1.51 (0.82-2.77)
PAH
(ng/g dust)
Total PAH2
0-383
384-566
567-918
>=919
Continuous3
TEQ4
0-124
125-219
220-357
>=358
BaA
0-39
40-56
57-96
>=97
Continuous3
BaP
0-46
47-69
70-119
>=120
Continuous3
BbF
0-81
82-128
129-219
>=220
Continuous3
BkF
0-27
28-46
47-72
>=73
Continuous3
Chr
0-106
107-156
157-252
Los Angeles
Cases/
Controls
OR1 (95% CI)
39/32
29/31
49/32
52/31
1.00
0.77 (0.38-1.53)
1.25 (0.65-2.39)
1.40 (0.73-2.68)
1.01 (0.76-1.33)
33/35
40/28
48/30
48/33
1.00
1.51 (0.77-2.97)
1.69 (0.87-3.27)
1.57 (0.82-3.03)
1.08 (0.83-1.42)
43/31
30/32
56/31
40/32
1.00
0.68 (0.34-1.33)
1.30 (0.69-2.46)
0.91 (0.47-1.75)
0.96 (0.74-1.25)
46/31
34/32
44/31
45/32
1.00
0.70 (0.36-1.37)
0.95 (0.50-1.82)
0.97 (0.51-1.84)
1.02 (0.80-1.30)
34/32
31/31
59/31
45/32
1.00
0.94 (0.47-1.88)
1.81 (0.94-3.49)
1.35 (0.69-2.62)
1.03 (0.80-1.33)
34/31
28/32
48/31
59/32
1.00
0.79 (0.39-1.59)
1.38 (0.71-2.70)
1.68 (0.88-3.22)
1.16 (0.92-1.47)
40/30
33/33
55/31
1.00
0.75 (0.38-1.47)
1.35 (0.71-2.59)
PAH
(ng/g dust)
Total PAH2
0-640
641-1022
1023-1959
>=1960
Continuous3
TEQ4
0-190
191-366
367-647
>=648
BaA
0-66
67-113
114-206
>=207
Continuous3
BaP
0-68
69-121
122-257
>=258
Continuous3
BbF
0-139
140-258
259-539
>=540
Continuous3
BkF
0-50
51-95
96-168
>=169
Continuous3
Chr
0-135
136-252
253-437
Seattle
Cases/
Controls
OR1 (95% CI)
40/41
51/39
58/40
36/41
1.00
1.37 (0.74-2.50)
1.51 (0.83-2.75)
0.92 (0.49-1.72)
0.92 (0.77-1.11)
38/42
55/39
53/41
39/39
1.00
1.58 (0.86-2.89)
1.45 (0.79-2.64)
1.12 (0.60-2.10)
0.95 (0.80-1.13)
41/41
42/39
61/40
41/41
1.00
1.10 (0.59-2.04)
1.54 (0.86-2.79)
1.02 (0.55-1.89)
1.00 (0.84-1.18)
37/40
41/40
67/39
40/42
1.00
1.12 (0.60-2.10)
1.88 (1.03-3.41)
1.05 (0.56-1.96)
0.96 (0.82-1.13)
40/40
51/40
59/40
35/41
1.00
1.29 (0.70-2.36)
1.50 (0.82-2.72)
0.87 (0.46-1.64)
0.90 (0.75-1.07)
35/40
61/40
49/39
40/42
1.00
1.76 (0.96-3.23)
1.45 (0.78-2.69)
1.11 (0.59-2.08)
0.96 (0.81-1.13)
37/40
56/40
48/40
1.00
1.54 (0.84-2.82)
1.32 (0.71-2.45)
2
>=3240
Continuous3
DBaA
0-101
102-233
234-495
>=496
Continuous3
IdP
0-509
510-1170
1171-2629
>=2630
Continuous3
20/20
0.70 (0.30-1.67)
0.90 (0.71-1.15)
30/18
48/20
26/19
23/20
1.00
1.58 (0.71-3.52)
0.95 (0.40-2.23)
0.90 (0.37-2.14)
0.91 (0.72-1.14)
29/20
45/18
32/19
21/20
1.00
1.84 (0.82-4.10)
1.29 (0.56-2.94)
0.91 (0.38-2.16)
0.93 (0.73-1.17)
>=540
Continuous3
DBaA
0-9
10-27
28-68
>=69
Continuous3
IdP
0-59
60-125
126-310
>=311
Continuous3
40/37
0.93 (0.49-1.75)
0.91 (0.75-1.12)
37/36
48/37
67/37
43/37
1.00
1.37 (0.72-2.60)
1.94 (1.04-3.62)
1.17 (0.62-2.22)
1.04 (0.90-1.19)
37/36
51/37
59/37
48/37
1.00
1.40 (0.75-2.62)
1.60 (0.86-2.98)
1.29 (0.68-2.42)
1.00 (0.85-1.18)
>=253
Continuous3
DBaA
0-8
9-22
23-36
>=37
Continuous3
IdP
0-57
58-86
87-144
>=145
Continuous3
41/32
0.97 (0.50-1.88)
0.97 (0.74-1.27)
32/32
44/31
54/31
39/32
1.00
1.40 (0.71-2.74)
1.74 (0.90-3.39)
1.23 (0.62-2.42)
1.07 (0.88-1.30)
46/32
24/31
55/31
44/32
1.00
0.53 (0.26-1.07)
1.22 (0.65-2.31)
0.97 (0.51-1.84)
0.96 (0.76-1.21)
>=438
Continuous3
DBaA
0-16
17-34
35-62
>=63
Continuous3
IdP
0-84
85-160
161-316
>=317
Continuous3
44/41
1.19 (0.64-2.22)
0.93 (0.77-1.13)
40/41
60/38
42/41
43/41
1.00
1.63 (0.89-2.96)
1.06 (0.57-1.96)
1.08 (0.59-2.00)
0.98 (0.84-1.14)
41/41
65/39
42/40
37/41
1.00
1.70 (0.94-3.07)
1.06 (0.57-1.96)
0.92 (0.49-1.72)
0.92 (0.78-1.09)
1
Models adjusted for age and sex
2
Total PAH = Benz(a)anthracene + Benzo(a)pyrene + Benzo(b)fluoranthene + Benzo(k)fluoranthene + Chrysene + Dibenz(a,h)anthracene +
Indeno(1,2,3-c,d)pyrene
3
ORs per one ln(PAH) (ng/g dust)
4
TEQ = sum of Benz(a)anthracene + Benzo(a)pyrene + Benzo(b)fluoranthene + Benzo(k)fluoranthene + Chrysene + Dibenz(a,h)anthracene +
Indeno(1,2,3-c,d)pyrene, each weighted by their toxic equivalency factor (TEF).
3