Table S9. GO terms enrichment of the top 1% iHS windows in Collas with EASE-score <0.01.
Category
Aging
Apoptosis
Cell proliferation/
development
DNA regulation
General
EASE score
0.0068
0.0013
0.0014
0.0020
0.0025
0.0077
0.0088
0.0006
0.0020
0.0045
0.0056
0.0087
0.0090
0.0091
0.0099
0.0013
0.0014
0.0014
0.0014
0.0014
0.0018
0.0021
0.0040
0.0049
0.0051
0.0058
0.0060
0.0077
0.0001
0.0001
0.0004
0.0004
0.0005
0.0009
0.0009
0.0011
0.0011
0.0015
0.0016
0.0017
0.0018
0.0019
0.002
0.0022
0.0023
0.0024
0.0027
0.0031
0.0032
GO term
regulation of telomerase activity
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
anti-apoptosis
regulation of apoptotic process
regulation of programmed cell death
regulation of cell proliferation
negative regulation of cell proliferation
cell cycle phase
regulation of cell cycle
cell cycle
regulation of anatomical structure morphogenesis
regulation of cell cycle arrest
tissue development
sequence-specific DNA binding transcription factor
activity
nucleic acid binding transcription factor activity
regulation of chromosome organization
regulatory region DNA binding
regulatory region nucleic acid binding
regulation of transcription, DNA-dependent
chromatin modification
transcription regulatory region DNA binding
histone modification
covalent chromatin modification
positive regulation of histone modification
sequence-specific DNA binding
regulation of gene expression
transferase activity
chromosome organization
transferase activity, transferring acyl groups
N-acyltransferase activity
chromatin organization
positive regulation of chromosome organization
multi-organism process
N-acetyltransferase activity
catalytic activity
organelle organization
regulation of cell adhesion
transferase activity, transferring acyl groups other than
amino-acyl groups
macromolecule modification
cell cycle process
regulation of RNA biosynthetic process
protein modification process
protein heterodimerization activity
acetyltransferase activity
enzyme regulator activity
positive regulation of nucleobase-containing compound
metabolic process
negative regulation of biological process
Enriched
genes
3/8
15/430
15/435
15/452
9/179
20/820
20/831
23/828
14/401
12/338
15/507
12/371
13/426
8/178
12/378
19/644
19/646
6/ 60
11/245
11/245
34/1611
11/260
10/238
8/158
8/159
4/26
14/457
35/1823
30/1137
16/391
10/167
7/70
13/301
5/30
17/517
6/ 57
49/2689
26/1069
10/207
8/130
29/1275
17/555
34/1619
28/1223
10/219
6/69
18/630
21/813
36/1805
Category
EASE score
0.0044
0.0047
0.0053
0.0056
0.0061
0.0062
General
Heart
Immune response
Ion related
Metabolism
Morphogenesis
Nitrogen
0.0069
0.0078
0.0085
0.0089
0.0090
0.0091
0.0092
0.0100
0.0005
0.0007
0.0015
0.0064
0.0075
0.0049
0.0011
0.0011
0.0011
0.0014
0.0018
0.0018
0.0018
0.0032
0.0055
0.0065
0.0067
0.0075
0.0097
0.0063
0.0037
0.0072
0.0089
0.0029
0.0085
RNA regulation
0.0087
RNA regulation
Stress response
0.0095
0.0007
0.0010
0.0023
0.0024
0.0085
GO term
DNA metabolic process
enzyme activator activity
cellular response to cytokine stimulus
regulation of cellular macromolecule biosynthetic
process
positive regulation of cellular biosynthetic process
negative regulation of nucleobase-containing compound
metabolic process
positive regulation of biosynthetic process
regulation of macromolecule biosynthetic process
macromolecular complex
negative regulation of developmental process
transferase activity, transferring phosphorus-containing
groups
DNA binding
peptidyl-amino acid modification
response to cytokine stimulus
cardiac ventricle formation
cardiac chamber formation
response to virus
cellular response to interleukin-1
response to other organism
ion transmembrane transport
carbohydrate metabolic process
catabolic process
regulation of hydrolase activity
positive regulation of hydrolase activity
macromolecule glycosylation
protein glycosylation
glycosylation
cellular carbohydrate metabolic process
cellular protein metabolic process
regulation of nucleobase-containing compound
metabolic process
hydrolase activity
protein O-linked glycosylation
protein metabolic process
cartilage development
positive regulation of nitrogen compound metabolic
process
negative regulation of nitrogen compound metabolic
process
regulation of nitrogen compound metabolic process
regulation of RNA metabolic process
negative regulation of transcription from RNA
polymerase II promoter
regulation of transcription from RNA polymerase II
promoter
positive regulation of RNA metabolic process
cellular response to stress
response to DNA damage stimulus
cellular response to abiotic stimulus
response to oxidative stress
response to stress
Enriched
genes
14/440
11/291
10/249
34/1717
21/863
17/626
21/873
34/1752
37/1978
12/372
17/652
27/1284
11/322
11/326
4/10
4/11
8/126
4/27
9/216
8/158
16/473
25/982
18/580
14/384
9/170
9/170
9/170
13/372
30/1439
36/1877
29/1389
5/57
33/1705
5/54
21/827
17/636
34/1654
11/318
19/769
18/715
20/663
14/372
7/101
9/178
28/1345
Category
Structure
EASE score
0.0000
0.0001
0.0003
0.0003
0.0004
0.0005
0.0005
0.0007
0.0009
0.0013
0.0014
0.0022
0.0056
0.0058
0.0064
0.0079
0.0091
0.0097
0.0099
GO term
membrane part
endoplasmic reticulum
integral to membrane
chromosomal part
intrinsic to membrane
nucleoplasm part
intrinsic to plasma membrane
protein complex
integral to plasma membrane
apical plasma membrane
plasma membrane part
chromatin
perinuclear region of cytoplasm
nuclear chromosome part
insoluble fraction
organelle part
nuclear part
nucleoplasm
cohesin complex
Enriched
genes
55/2829
19/494
47/2397
14/323
47/2443
18/543
22/761
37/1743
21/733
9/161
29/1252
8/136
12/349
8/163
18/687
51/3061
33/1698
16/599
3/10