Additional file 4 - Molecular Neurodegeneration

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Additional file 4. Gene Ontologies for the genes from cluster 1.
GO ID term
Number
of genes
Cellular component
mitochondrial part
mitochondrion
mitochondrial envelope
mitochondrial membrane
organelle membrane
organelle envelope
envelope
mitochondrial inner membrane
organelle inner membrane
mitochondrial membrane part
mitochondrial ribosome
organellar ribosome
clathrin coated vesicle membrane
axon
coated vesicle membrane
respiratory chain
ribosome
mitochondrial lumen
mitochondrial matrix
mitochondrial small ribosomal subunit
organellar small ribosomal subunit
synapse part
synaptic vesicle membrane
13
16
9
8
13
9
9
6
6
4
3
3
3
4
3
3
4
4
4
2
2
4
2
Biological Process
synaptic transmission
transmission of nerve impulse
neurological system process
response to endogenous stimulus
oxidative phosphorylation
monovalent inorganic cation transport
nitrogen compound biosynthetic process
cell-cell signaling
purine ribonucleotide biosynthetic process
ribonucleotide biosynthetic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide biosynthetic process
response to organic nitrogen
transmembrane transport
reproductive cellular process
retinol metabolic process
spermatogenesis
male gamete generation
generation of precursor metabolites and energy
purine nucleotide metabolic process
nucleotide biosynthetic process
nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process
nucleobase, nucleoside and nucleotide biosynthetic process
multicellular organism reproduction
reproductive process in a multicellular organism
ATP biosynthetic process
neuropeptide signaling pathway
cellular respiration
response to extracellular stimulus
purine ribonucleoside triphosphate biosynthetic process
7
7
13
7
4
6
6
8
4
4
4
4
4
3
7
4
2
5
5
5
4
4
4
4
6
6
3
3
3
4
3
ribonucleoside triphosphate biosynthetic process
purine nucleoside triphosphate biosynthetic process
response to hormone stimulus
positive regulation of transport
germ cell development
nucleoside triphosphate biosynthetic process
response to amino acid stimulus
ATP metabolic process
positive regulation of insulin secretion
response to organic substance
positive regulation of secretion
cation transport
urogenital system development
learning or memory
gonad development
gamete generation
cell morphogenesis involved in differentiation
electron transport chain
purine ribonucleoside triphosphate metabolic process
ribonucleoside triphosphate metabolic process
purine nucleoside triphosphate metabolic process
L-amino acid transport
multicellular organism growth
diterpenoid metabolic process
vitamin A metabolic process
retinoid metabolic process
positive regulation of peptide secretion
ion transport
reproductive developmental process
reproductive structure development
response to acid
development of primary sexual characteristics
gluconeogenesis
terpenoid metabolic process
nucleoside triphosphate metabolic process
Molecular Function
structural molecule activity
P-P-bond-hydrolysis-driven transmembrane transporter activity
primary active transmembrane transporter activity
structural constituent of ribosome
ATPase activity, coupled to transmembrane movement of ions
retinol binding
retinal binding
alkali metal ion binding
structural constituent of eye lens
ATPase activity, coupled to transmembrane movement of substances
ATPase activity, coupled to movement of substances
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of
substances
retinoid binding
isoprenoid binding
proton-transporting ATPase activity, rotational mechanism
potassium ion binding
3
3
5
4
3
3
2
3
2
7
3
6
3
3
3
5
4
3
3
3
3
2
2
2
2
2
2
7
4
3
2
3
2
2
3
8
4
4
4
3
2
2
4
2
3
3
3
2
2
2
3
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