Additional file 4. Gene Ontologies for the genes from cluster 1. GO ID term Number of genes Cellular component mitochondrial part mitochondrion mitochondrial envelope mitochondrial membrane organelle membrane organelle envelope envelope mitochondrial inner membrane organelle inner membrane mitochondrial membrane part mitochondrial ribosome organellar ribosome clathrin coated vesicle membrane axon coated vesicle membrane respiratory chain ribosome mitochondrial lumen mitochondrial matrix mitochondrial small ribosomal subunit organellar small ribosomal subunit synapse part synaptic vesicle membrane 13 16 9 8 13 9 9 6 6 4 3 3 3 4 3 3 4 4 4 2 2 4 2 Biological Process synaptic transmission transmission of nerve impulse neurological system process response to endogenous stimulus oxidative phosphorylation monovalent inorganic cation transport nitrogen compound biosynthetic process cell-cell signaling purine ribonucleotide biosynthetic process ribonucleotide biosynthetic process purine ribonucleotide metabolic process ribonucleotide metabolic process purine nucleotide biosynthetic process response to organic nitrogen transmembrane transport reproductive cellular process retinol metabolic process spermatogenesis male gamete generation generation of precursor metabolites and energy purine nucleotide metabolic process nucleotide biosynthetic process nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process nucleobase, nucleoside and nucleotide biosynthetic process multicellular organism reproduction reproductive process in a multicellular organism ATP biosynthetic process neuropeptide signaling pathway cellular respiration response to extracellular stimulus purine ribonucleoside triphosphate biosynthetic process 7 7 13 7 4 6 6 8 4 4 4 4 4 3 7 4 2 5 5 5 4 4 4 4 6 6 3 3 3 4 3 ribonucleoside triphosphate biosynthetic process purine nucleoside triphosphate biosynthetic process response to hormone stimulus positive regulation of transport germ cell development nucleoside triphosphate biosynthetic process response to amino acid stimulus ATP metabolic process positive regulation of insulin secretion response to organic substance positive regulation of secretion cation transport urogenital system development learning or memory gonad development gamete generation cell morphogenesis involved in differentiation electron transport chain purine ribonucleoside triphosphate metabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process L-amino acid transport multicellular organism growth diterpenoid metabolic process vitamin A metabolic process retinoid metabolic process positive regulation of peptide secretion ion transport reproductive developmental process reproductive structure development response to acid development of primary sexual characteristics gluconeogenesis terpenoid metabolic process nucleoside triphosphate metabolic process Molecular Function structural molecule activity P-P-bond-hydrolysis-driven transmembrane transporter activity primary active transmembrane transporter activity structural constituent of ribosome ATPase activity, coupled to transmembrane movement of ions retinol binding retinal binding alkali metal ion binding structural constituent of eye lens ATPase activity, coupled to transmembrane movement of substances ATPase activity, coupled to movement of substances hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances retinoid binding isoprenoid binding proton-transporting ATPase activity, rotational mechanism potassium ion binding 3 3 5 4 3 3 2 3 2 7 3 6 3 3 3 5 4 3 3 3 3 2 2 2 2 2 2 7 4 3 2 3 2 2 3 8 4 4 4 3 2 2 4 2 3 3 3 2 2 2 3