Genetics II: Genes, Chromosomes, and Alleles I. Benchmark/ Standard: B4.1 Genetics and Inherited Traits a. Hereditary information is contained in genes, located in the chromosomes of each cell. Cells contain many thousands of different genes. One or many genes can determine an inherited trait of an individual, and a single gene can influence more than one trait. Before a cell divides, this genetic information must be copied and apportioned evenly into the daughter cells. i. B4.1A Draw and label a homologous chromosome pair with heterozygous alleles highlighting a particular gene location. ii. B4.1B Explain that the information passed from parents to offspring is transmitted by means of genes that are coded in DNA molecules. These genes contain the information for the production of proteins. iii. B4.1c Differentiate between dominant, recessive, codominant, polygenic, and sex-linked traits. iv. B4.1d Explain the genetic basis for Mendel’s laws of segregation and independent assortment. v. B4.1e Determine the genotype and phenotype of monohybrid crosses using a Punnett Square. I. Behavioral/ Objective: Students will draw and label a homologous chromosome pair with heterozygous alleles highlighting a particular gene location and differentiate between dominant, recessive, codominant, polygenic, and sexlinked traits by creating punnett squares of each and then defining the genotype and phenotypes of the possible outcomes. II. Anticipatory Set: Each student should collect a mini white board, dry erase marker, and eraser. Project the following prompts under the doc cam one at a time. Ask students to complete the punnett square crosses and determine the genotype and phenotype. a. In dogs, wire hair (S) is dominant to smooth (s). Cross a homozygous wirehaired dog with a smooth-haired dog. b. In fruit flies, long wings (L) are dominant to short wings (l). Cross a short winged fly with a heterozygous fly. c. The ability to curl your tongue up on the sides (T, tongue rolling) is dominant to not being able to roll your tongue. A woman who can roll her tongue marries a man who cannot. Their first child has his father's phenotype. What are the genotypes of the mother, father, and child? III. Objective/ Purpose: “Yesterday we were introduced to a lot of new terms. Today we are going to talk about genes, chromosomes and alleles and what they look like. I think we have a pretty good grip on dominant and recessive traits, so today we are going to focus on co-dominant, polygenic, and sex-linked traits.” IV. Input: a. Task Analysis: i. Give each student a Ziploc bag with the following inside 1. One pipe cleaner cut in half. 2. Four pony beads, two red and two blue ii. Demonstrate the following under the document camera for students. 1. Blue beads are dominant, red beads are recessive (R=red/recessive) 2. The two pipe cleaners represent a homologous pair of chromosomes. On each chromosome there are many genes. 3. The bead represents an allele. 4. Use different combinations of beads to explain genotypes and phenotypes. a. Two reds=recessive trait b. Two blues= dominant trait c. One red and one blue= dominant trait iii. Show the class a Karyotype on the projector. Humans have 23 pairs of homologous chromosomes 1. http://ghr.nlm.nih.gov/handbook/illustrations/normalkaryo type 2. http://www.biotechnologyonline.gov.au/images/contentpag es/karyotype.jpg iv. Human genome project: explain to students and show website on the projector. 1. http://www.ornl.gov/sci/techresources/Human_Genome/h ome.shtml v. Students should use their models to draw model in their notes. Circulate and check work. vi. “On our pipe cleaners we have dominant and recessive alleles, but what about co-dominance, polygenic and sex-linked traits?” Dominant Recessive Co-dominant Polygenic Sex-linked Definition Example vii. Students should work in pairs to fill in the chart. Put the chart on the Smart Board. Choose ten students, each one should go up to the board and fill in a space. viii. Number students 1-5. Depending on the number, they should complete a punnett square cross and state the genotype and phenotype as an example of: 1. Dominant 2. Recessive 3. Co-dominant 4. Polygenic 5. Sex-linked ix. Share an example of each on the document camera. x. Learning Log on the back of the chart, students should divide the paper into six boxes: label the boxes: 1. What I knew already, New vocabulary, Important to remember, Draw it, This reminds me of, Not so sure about this xi. For the next class students should find and read a science article related to genetics. They should prepare a brief summary of the article. How did the article relate to what we have learned in class? What is something new or interesting you learned from the article? 1. Recommended resources: V. VI. VII. a. http://www.sciencedaily.com b. http://sciencefriday.com c. http://www.biologynews.net Thinking Levels: i. Knowledge: recognize and define genetic vocabulary. ii. Comprehension: restate definition in their own words and discuss the new vocabulary as a class. iii. Application: use pipe cleaners and beads to represent chromosome structure. Learning Styles: i. Visual: board work, chart, learning log, and pipe cleaner model. ii. Auditory: lecture and discussion of structure and new vocabulary iii. Kinesthetic: pipe cleaner model, board work. Methods and Materials: i. Ways of presenting: Lecture, document camera, board work. ii. Materials needed: document camera, computer, projector, white board. Ziplocs, pipe cleaners, pony beads. VIII. Modeling: a. Model homologous pairs and alleles on chromosomes using pipe cleaners and beads. IX. Check for understanding: a. Draw homologous chromosome with heterozygous alleles b. Chart c. Learning Log Guided Practice: Teacher will circulate answer questions and assist students filling in the charts and learning logs. X. XI. Independent Practice: a. Complete the learning log. b. Science article and summary XII. Closure: Learning Log