Recombinant Botulinum neurotoxin type F(botF)
Catalog Number: CSB-EP341192CLQ
Product Name：
Recombinant Botulinum neurotoxin type F(botF)
Alternative names:
Bontoxilysin-F
Catalog Number：
CSB-EP341192CLQ
Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal
synapses, is internalized and moves by retrograde transport up the axon into the spinal cord
Relevance ：
where it can move between postsynaptic and presynaptic neurons. It inhibits
neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of
the '58-Gln-|-Lys-59' bond of synaptobrevins-1 and -2.
Mol. Weight：
63kD
Product Info ：
His-tagged
Source：
E.coli derived
Images
Purity：
>90%(SDS-PAGE)
Storage Buffer：
20mM Tris-HCl, 0.5M NaCl, PH 8.0,50% glycerol
Storage ：
Store at -20℃, for extended storage, conserve at -20℃ or -80℃.
Notes ：
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to
one week.
MPVAINSFNYNDPVNDDTILYMQIPYEEKSKKYYKAFEIMRNVWIIPERNTIGTNPSDFDPPA
SLKNGSSAYYDPNYLTTDAEKDRYLKTTIKLFKRINSNPAGKVLLQEISYAKPYLGNDHTPID
EFSPVTRTTSVNIKLSTNVESSMLLNLLVLGAGPDIFESCCYPVRKLIDPDVVYDPSNYGFG
AA sequence：
SINIVTFSPEYEYTFNDISGGHNSSTESFIADPAISLAHELIHALHGLYGARGVTYEETIEVKQA
PLMIAEKPIRLEEFLTFGGQDLNIITSAMKEKIYNNLLANYEKIATRLSEVNSAPPEYDINEYKD
YFQWKYGLDKNADGSYTVNENKFNEIYKKLYSFTESDLANKFKVKCRNTYFIKYEFLKVPNL
LDDDIYTVSEGFNIGNLAVNNRGQSIKLNPKIIDSIPDKGLVEKIVKFCKSVIPRK
"Sequence of the gene encoding type F neurotoxin of Clostridium botulinum."
References：
East A.K., Richardson P.T., Allaway D., Collins M.D., Roberts T.A., Thompson D.E.
FEMS Microbiol. Lett. 75:225-230(1992)