Pharmacy Handbook CONTENTS 1. Preface ············································ 3 2. Information about Prescriptions ······ 5 3. Drug Formulary ······························ 10 Appendix ① Index ② WADA’s Prohibited List 2 Ⅰ. Preface GUOC will provide an efficient and effective pharmacy service for the FISU Family and NUSF(National University Sports Federation) Teams during the 28th Universiade Gwangju 2015. This Pharmacy Guide, approved by the FISU Medical Committee (FISU CM) Chairman, contains the definitive list and prescription procedures of medications available from the athletes' village polyclinic pharmacy, basic drug information about each medication and information on the status of the drugs, such as substances that are prohibited by the World Anti-Doping (WADA) Code and special requirements of the FISU CM. The Athletes Village polyclinic is located in the International Zone and it is open from 9am to 9pm, with 24-hour emergency services. Its pharmacy offers a range of medications, at free of charge, for the treatment of immediate and/or acute medical conditions. However, each team is advised to bring sufficient quantities of necessary / prescribable items, such as dressings and sterilized gauze for individuals with a chronic condition, in order for the usage during their stay in Korea. Medications will only be dispensed from the Athletes Village polyclinic pharmacy upon the submission of a correctly completed official Universiade clinic prescription form which will be reviewed by a polyclinic doctor. Prescribed Medications should be prescribed for specific individuals, in quantities required for immediate and necessary use. Upon necessity, the polyclinic manager reserves the right to review each prescription, which is prepared by NUSF team doctors. The pharmacy does not provide the medications which are not included in the pharmacy list. 3 Special procedures are in place for the prescription of medications classified as "Prohibited" to athletes. The Prohibited List 2015 of WADA, an International Standard of the Code, will be applicable and enforced during the 28th Universiade Gwangju 2015. Doctors writing prescriptions, as well as the athletes for whom the prescriptions are written, should acquaint themselves with the WADA Code, particularly the WADA’s Prohibited List 2015. Special attention is needed for the prescription of medications classified as "Prohibited" It is the responsibility of the athletes to determine whether a substance they are using, or considering using for medical purposes, is prohibited. Before and during the games, athletes are strongly advised to check the status of the medication they are taking or intend to take through the following websites: 1 2 Global Drug Reference Online http://www.globaldro.com/ KADA Website (Korean) http://www.kada-ad.or.kr ※Korea Anti-Doping Agency The temporary registration of NUSF team doctors for the period of the 28th Universiade Gwangju 2015 is restricted to caring for members of their own team or to members of other teams where there is a prior agreement. The medical program will provide comprehensive, convenient and effective health care services to all participants of the 28th Universiade Gwangju 2015. Further information can also be found in Medical Care Guidance for the Universiade Gwangju 2015. 4 Ⅱ. Information about Prescriptions 1. General Guidelines All medications will be dispensed by prescription only. There are electronic prescriptions and handwritten prescriptions. Electronic prescriptions will be prescribed by the polyclinic doctors for patients, while handwritten prescriptions will be prescribed by registered NUSF team doctors. Dedicated handwritten prescription pads will be available at the pharmacy of the Athletes Village polyclinic. The pharmacy will not provide medication according to the prescription handwritten by a team doctor. Once the prescription has been handwritten and submitted, a polyclinic doctor will electronically process it for submission to the pharmacy where the medication can be received after checking the receiver’s identification through their AD card. Both handwritten and electronic prescription will be stored in the Athletes Village pharmacy. A prescription for an outpatient can be submitted once it has been fully completed according to the outpatient’s medical exam results. In case a disagreement occurs between the team doctor and the polyclinic doctor regarding prescribed details, the decision of the polyclinic shall be followed. All prescriptions written during the Universiade Gwangju 2015 must be completed clearly in Korean or English according to the form. The use of Latin and abbreviations will not be accepted. Please write instructions in a manner such as, "20mg, three times daily", and avoid Latin or written abbreviations on the prescriptions. 5 Each prescription must be written completely, including; - Venue and Date - Patient's name, accreditation number and NUSF - Gender and age - Diagnosis - Name of medicine - Daily dosage, total days for use, directions for use - "Prohibited" substance or not - Doctor's name and signature Athlete's signature is required when prescribing "Prohibited" substances The prescribing doctor's name (clearly printed) and signature are required for all prescriptions. Prescriptions can be written for up to three days (or five days for antibiotics). And doctors have the right not to repeat the prescription according to the patient's condition, before the last prescription is used up. 2. Prescribing "Prohibited" substances The pharmacy of the Athletes Village polyclinic will stock a limited number of prohibited medications. These will be flagged as such on the pharmacy computer system and clearly branded at the time of dispensing. The status of these medications is identified in this guide, next to the medication. Intravenous infusions and/or injections of more than 50mL per 6-hour period are prohibited except for those legitimately received in the course of hospital admissions or clinical investigations. All substances are classified as; Permitted substances: These are drugs and methods that are neither prohibited nor subject to any restrictions according to the WADA Code Prohibited substances: These are drugs and methods that, according to the WADA’s Prohibited List 2015, cannot be used by athletes who will be competing 6 in the Universiade unless they have a valid TUE(Therapeutic Use Exemption) for the substance. 2.1. Prescribing Substances that have received approval from the FISU Therapeutic Use Exemption Sub Committee (FISU TUEC) If an athlete attending the Universiade Gwangju 2015 requires the "Prohibited" Substances, he/she should apply TUE to the FISU CMI or TUEC following the procedures to obtain TUE. Procedures ① The Prescribing doctor must confirm that the athlete has granted approval of a TUE by the FISU TUEC; ② The Prescribing doctor must explain to the athlete that a "Prohibited" Substances is being prescribed and the possible consequences of this action. ③ The Prescribing doctor and the athlete (if conscious and able to do so) receiving the medication will be asked to sign and print his/her name on the prescription to confirm that he/she is aware of the medication's status. ④ The pharmacists will confirm with the prescribing doctor that the athlete has granted approval of a TUE by the FISU TUEC. The pharmacists will stamp the prescription "Approval Use". ⑤ The medication is dispensed when the pharmacists confirm the accuracy between the TUE application Form and prescribing information. The medication will be clearly branded "Prohibited". The copy of the TUE application Form and TUEC Decision Form will be kept in the pharmacy of the athletes' village polyclinic. 7 2.2. Prescribing Substances that haven't received approval from the FISU TUEC The use of prohibited substances, indicated on WADA’s Prohibited List 2015, should be avoided for athletes except during a medical emergency in which there is no alternate to using a "Prohibited" substance. If the prohibited medication is to be administered in a venue, the venue medical officer must notify the GUOC medical officer who will notify the Chairman of the FISU TUEC. If the medication is to be administered and dispensed at a designated hospital, the administering doctor/pharmacist shall notify the clinic Manager who, in turn, will notify the GUOC medical officer who is responsible of notifying the Chairman of FISU TUEC. If an NUSF administers or prescribes the medication, they will be responsible for notifying the Chairman of the FISU TUEC. In all cases, the NUSF will be responsible for initiating a TUE application to the FISU TUEC. The form must be completed as soon as possible after the incident and forwarded to the Doping Control Center in the Athletes Village. The Doping Control Center will forward the completed TUE application form to the FISU TUEC or FISU CM. Procedures ① The prescribing doctor must explain to the athlete that a "Prohibited" substance is being prescribed explain the possible consequences of this action. ② The prescribing doctor and the athlete (if conscious and able to do so) receiving the medication will be asked to sign and print his/her name on the prescription to confirm that he/she is aware of the medication's status. ③ The pharmacists will confirm with the prescribing doctor that they have prescribed a "Prohibited" substance. 8 ④ The pharmacists will stamp prescription "Prohibited" and the medication will be branded "Prohibited" clearly. ⑤ Either the NUSF prescribing doctor or the clinic manager must notify the FISU TUEC that a "Prohibited" substance has been dispensed / administered to an athlete. 9 Ⅲ. Drug Formulary The drugs included in the Drug Formulary Guide are arranged according to pharmacological/therapeutic classification. The following prescribing information is included; Drug classification - Generic drug name - Brand: It depends on the pharmacy circumstances; the brand name of medications may vary change within same substances. - Available form: Strength and formulation - Major indications; Common indications are included, although the drug may be used for other medically justified purposes. - Dosage: The Usual recommended dose is included for a health adult with normal renal and live function. - Side effects: The most common side effects are listed for each drug. - Status: All substances are classified as Permitted and Prohibited. 10 Athletes Village Pharmacy 1. Psychiatric Drugs 2. AntipyreticㆍAnalgesicㆍAnti-inflammatory Drugs 3. Musculoskeletal relaxants 4. Autonomic Nervous System Drugs 5. Circulatory System Drugs 6. Endocrinology Drugs 7. Steroids 8. Respiratory Drugs 9. Antihistamines 10. Dental Drugs for Oral Cavity 11. Digestive System Drugs 12. Antibiotics 13. Eye Drops 14. ENT Drugs 15. Dermatology 16. Vitamins 17. Gynecology Medication 18. Immune Globulin 19. Local Anesthetic 20. Hemostatics 21. Transfusion and Fluids 11 22. Disinfectants 23. Others 12 1. Psychiatric Drugs ♣ Drug : Diazepam Brand : Diazepam Available form : 2mg/T, 10mg/2ml/A Indication : Sedatives & Anxiolytics Dosage - Tab : 2-10mg Ea, 2-4 times per day - Inj : 2-10mg, IV or IM Side Effects : dependence & withdrawal symptoms , dizziness, headache, tachycardia, low blood pressure Status : Permitted ♣ Drug : Midazolam Brand : Midazolam Available form : 5mg/5mL/A Indication : Sedatives, anesthetic, sleep indneer Dosage : - Intramuscular Injection : 0.07~0.08mg/kg, sedation before surgery - Intravenous Injection : priming dose of 2~2.5mg(0.035mg/kg) by intravenous infusion for 2-3 min. - Anesthesia Induction : Inject 0.3-0.35mg/kg for 20-30 seconds Side Effects : Laryngismus, bronchospasm, bigeminy, retrograde amnesia, blurred vision, rash, etc. Status : Permitted ♣ Drug : Dimenhydrinate Brand : Bonaling-A Available form : 50mg/T Indication : Nausea, Vomiting, Dizziness Dosage : 50mg Ea, 3-4 times per day. Preventive dose 30min-1hr 1T 50-100mg. Side Effects : fatigue, headache, dizziness, vision problems, redness, heartburn, dry mouth etc. Status : Permitted 13 ♣ Drug : Zolpidem Brand : Stilnox Available form : 10mg/T Indication : Hypnotics (sleeping pills) Dosage : 10mg Side Effects : headache, dizziness, restless, fatigue etc. Status : Permitted ♣ Drug : Lorazepam Brand : Ativan Available form : 0.5mg/T, 4mg/1ml/A Indication : Sedatives & Anxiolytics Dosage : - Tab : 1-4mg, 2-3 times divided dose per day. Maximum 10mg per day for severe cases - Inj : Before Anesthesia : 0.05mg/kg IV, IM. Anxiety : 0.025-0.03mg/kg, q6h Side Effects : Dependence & Withdrawal Symptoms , fatigue, dizziness, headache, low blood pressure etc. Status : Permitted 14 2. Antipyretic ㆍ Analgesic ㆍ Anti-inflammatory Drugs ♣ Drug : Aceclofenac Brand : Airtal Available form : 100mg/T Indication : NSAIDs Dosage : 1T b.i.d. per day Side Effects : ulcer, indisgestion, stomachache, nausea, dizziness, elevation of liver enzymes etc. Status : Permitted ♣ Drug : Acetaminophen Brand : Tacenol ER Available form : 650mg/T Indication : Antipyretic, Analgesic Dosage : 2T Ea, t.i.d. per day Side Effects : nausea, hypersensitivity, anaphylaxis symptoms, redness, blood disorders, hepatotoxicity etc. Status : Permitted ♣ Drug : Aspirin Brand : Bayer Aspirin Available form : 500mg/T Indication : Antipyretic, Analgesic Dosage : 1 ~3 T b.i.d. 2-3 times/day Side Effects : anaphylaxis symptoms, redness, nausea, vomiting, stomachache, stevens-johnson syndrome Status : Permitted 15 ♣ Drug : Dexibuprofen Brand : Mexibupen ER tab Available form : 300mg/T Indication : NSAIDs Dosage : 600mg b.i.d. Max 1,200 mg/day. Side Effects : Indigestion, abdominal bloating, heartburn Status : Permitted ♣ Drug : Diclofenac Sodium Brand : Toraren Available form : 75mg/2ml/A Indication : NSAIDs Dosage : 1~2 times IM per day Side Effects : shock, peptic ulcer, GI bleeding, nausea, abdominal pain, diarrhea, skin rush, urticaria, edema etc. Status : Permitted ♣ Drug : Ibuprofen 200mg/Arginine 185mg Brand : Carol - F Available form : 200mg/T, 185mg/T Indication : rheumatoid arthritis, osteoarthritis, abdominal pain, headache, menstrual pain, posttraumatic, etc. Dosage : 1-2T, every 4-6 hours with water Side Effects : nausea, hypersensitivity, anaphylaxis, rash, etc. Status : Permitted ♣ Drug : Ketorolac tromethamine Brand : Trolac Available form : 30mg/1ml/A Indication : NSAIDs Dosage : Initial dose 10mg for IM & IV. Maintenance dose 10-30mg q4-6h . Maximum 90mg per day. Side Effects : nausea, vomiting, indigestion, diarrhea, edema, constipation, itchness, headache, dizziness etc. Status : Permitted 16 ♣ Drug : Streptokinase · Streptodornase Brand : Mucolase Available form : 10mg/T Indication : anti-inflammatory Dosage : 1~2T Ea. 4times per day Side Effects : nausea, hypersensitivity, anaphylaxis symptoms redness, blood disorder, Skin rush, diarrhea Status : Permitted ♣ Drug : Talniflumate Brand : Somalgen Available form : 370mg/T Indication : NSAIDs Dosage : 1T Ea, t.i.d. per day Side Effects : nausea, vomiting etc. Status : Permitted ♣ Drugs : Tramadol HCl Brand : Zipan Available form : 50mg/1mL/A Indication : serious and moderate chronic and acute pain(cancer, etc.), pain after diagnosis and surgery Dosage : IV, IM 50-100mg, maximum 400mg/day Side effects : seizure, heart acceleration, shock, anaphylaxis, drowsiness, discomfort, nausea, vomiting, etc. Status : Permitted( 2015 Monitoring Program) ♣ Drug : Morphine Sulfate Brand : Morphine Sulphate Available form : 5mg/5mL/A Indication : Relieves serious pain Dosage : 15~30mg every 4 hours Side Effects : respiratory depression, derangement, amnesia, head trauma, increased intracranial pressure, atelectasis Status : Prohibited (S7. Narcotics) 17 ♣ Drug : Frovatriptan Brand : Migard Available form : 2.5mg/T Indication : Migraine headache Dosage : 1T Ea. If reoccurs, 1T q2-3h. Maximum 2T per day Side Effects : dizziness, fatigue, abnormal sensation , headache, redness etc. Status : Permitted ♣ Drug : Celecoxib Brand : Celebrex Available form : 200mg/C Indication : NSAIDs Dosage : 200mg - 400mg per day Side Effects : dizziness, headache, indigestion, stomachache, nausea, redness, edema, insomnia etc. Status : Permitted 18 3. Musculoskeletal relaxants ♣ Drug : Eperisone HCL Brand : Mulex Available form : 50mg/T Indication : muscle relaxants Dosage : 50mg, t.i.d. per day Side Effects : shock, redness, insomnia, nausea, vomiting, dizziness, headache, diplegia, ineffectualness etc. Status : Permitted ♣ Drug : Gallamine triethiodide Brand : Myraxan Available form : 10mg/A Indication : muscle relaxants Dosage : 10 - 20mg Ea q8-12h IM or IV * 3d. Side Effects : Anaphylaxis, hypertension, tachycardia, respiratory failure etc. Status : Permitted 4. Autonomic Nervous System Drugs ♣ Drug : Cimetropium bromide Brand : Algiron Available form : 50mg/T, 5mg/1ml/A Indication : Anticonvulsion Dosage - Tab : 50mg Ea, t.i.d. - Inj : 5㎎ Ea, IM, IV. Side Effects : dry mouth, urinary problems, headache, dizziness, constipation, nausea etc. Status : Permitted 19 ♣ Drug : Epinephrine Brand : Epinephrine Available form : 1mg/1ml/A Indication : Asthma, serum disease, rash, Angioneurotic edema, shock, cardiac arrest, prolonged effect of local anesthetic Dosage : Varies depending on symptoms Side Effects : palpitation, tachycardia, respiratory distress, dizziness, anxiety, tremor etc. Status : Prohibited (S6. Stimulants) ♣ Drug : Norepinephrine bitartrate Brand : Norpin Available form : 10mL/A Indication : acute low blood pressure or shock, assistive treatment for cardiac arrest Dosage : Dilute 8mg (4mg of NE) in 5%DW or 5%DS 1000ml IV drops 2-3ml/min. Increase gradually. 0.5-1ml/min. Side Effects : palpitation, bradycardia, headache, dizziness, anxiety, tremor, nausea, vomiting. etc. Status : Permitted ♣ Drug : Atropine sulfate Brand : Atropine Sulfate Available form : 0.5mg/1ml/A Indication : Anticonvulsion Dosage : 0.5mg SC or IM, if need IV Side Effects : eye problems, palpitation, headache, dry mouth, nausea, vomiting, redness, urinary disorders etc. Status : Permitted 20 5. Circulatory System Drugs(incl. diuretics) ♣ Drug : Amlodipine besylate Brand : Norvasc Available form : 5mg/T Indication : hypotensive agent, Calcium channel blocker Dosage : 5mg q.d. Maximum 10mg/day Side Effects : redness, fatigue, edema, dizziness, headache, stomachache, nausea, palpitation etc. Status : Permitted ♣ Drug : Atenolol Brand : Tenormin Available form : 25mg/T, 50mg/T Indication : hypotensive agent, Beta blocker Dosage - hypertension : 50mg q.d. Maximum 100mg/day. - Angina : 100mg/day # 1-2times. Maximum 100mg/day Side Effects : bradycardia, cold sensation, palpitation, redness, itchiness, dizziness, edema etc. Status : Prohibited (P2. Beta-Blockers) ♣ Drug : Captopril Brand : Capril Available form : 12.5mg/T, 25mg/T, 50mg/T Indication : hypotensive agent, ACE inhibitor Dosage - hypertension : 50~100mg/day (# 1-2times) light to moderate status, 450mg/day for severe status. - Congestive heart failure : 25~50mg, Ea. t.i.d.. Side Effects : kidney disorders, decreased blood counts, potassium elevation, nausea, vomiting, redness, dizziness, liver disorder etc. Status : Permitted 21 ♣ Drug : Carvedilol Brand : Dilatrend Available form : 6.25mg/T, 12.5mg/T, 25mg/T Indication : hypotensive agent, Beta blocker Dosage - Essential hypertension : 12.5mg – 25mg/day. Maximum dose each 25mg. 50mg/day. - Chronic stable angina : 12.5mg – 50mg Ea. b.i.d. - Congestive heart failure : 3.125mg – 25mg Ea, b.i.d. Maximum 50mg-100mg/day Side Effects : dizziness, headache, fatigue, bradycardia, nauseahypotension, respiratory depression, asthma, attack, etc. Status : Prohibited (P2. Beta-Blockers) ♣ Drug : Digoxin Brand : Digoxin Available form: 0.25mg/T, 0.25mg/1ml/A Indication : Cardiac stimulant Dosage: - Tab : initial dose 0.5-1mg. Afterward, 0.5mg q6-8h Maintenance dose 0.25-0.5mg /day. - Inj : 0.25-0.5mg q 2-4h until effective IV. Maintenance dose 0.25mg /day. Side Effects : nausea, vomiting, diarrhea, arrhythmia, vision problems, dizziness, headache, redness etc. Status : Permitted ♣ Drug : Diltiazem HCL Brand : Herben Retard Tab Available form : 90mg/T Indication : angina, hypertension, Calcium channel blocker Dosage : 90mg Ea, b.i.d. Maximum 90-180mg Ea. Side Effects : headache, rhinitis, sore throat, constipation, increased cough, edema, diarrhea, muscle ache, general weakness, indigestion etc. Status : Permitted 22 ♣ Drug : Dopamine HCl Brand : Dopramine Available form : 200mg/5ml/A Indication : sympathetic nervous system stimulant Dosage : 2-5mcg/kg/min IV. For severe condition, 5-10mcg/kg/min or 2050mcg/kg/min Side Effect : arrhythmia, superficial ischemia, palpitation, nausea, respiratory distress, vomiting, stomachache, anxiety, headache etc. Status : Permitted ♣ Drug : Furosemide Brand : Furix, Lasix Available form : 40mg/T, 20mg/2ml/A Indication : Diuretic Dosage - Tab : 20-80mg/day. If severe status, maximum 0mg/day. For hypertension, 80mg #2times/day. - Inj : 20-40mg q.d., IV or IM. Side Effects : Postural Hypotension, Dizziness, Headache, Anorexia, Rash, Lethargy Etc. Status : Prohibited (S5. Diuretics and Other Masking Agents) ♣ Drug : Hydrochlorothiazide Brand : Dichlozid Available form : 25mg/T Indication : Diuretic Dosage - Edema: 25-100mg, 1-2 times/day - Hypertension: Divided dosa of 25-50mg # 1-2times. Side Effects : Hypokalemia, Nausea, Vomiting, Orthostatic Hypotension, Lethargy, Rash, Photosensitive Etc. Status : Prohibited (S5. Diuretics and Other Masking Agents) 23 ♣ Drug : Losartan potassium Brand : Cozaar Available form : 50mg/T Indication : Hypotensive agent, Angiotensin II Receptor Antagonists Dosage : 50mg q.d. Maximum 100mg q.d. Side Effects : muscle ache, dizziness, headache, cough, fatigue upper respiratory infection, indigestion, diarrhea etc. Status : Permitted ♣ Drug : Nicorandil Brand : Sigmart Available form : 5mg/T Indication : angina Dosage : 5mg Ea. t.i.d. Side Effects : headache, nausea, vomiting, dizziness, redness, fatigue etc. Status : Permitted ♣ Drug : Nifedipine Brand : Nifedix ER, Adalat oros Available form : 30mg/T, 60mg/T Indication : angina, hypertension, Calcium channel blocker Dosage : 30mg - 60mg /day. Maximum 120mg/day Side Effects : headache, dizziness, chest pain, palpitation, blushing, indigestion, edema, paresthesia Status : Permitted ♣ Drug : Nitroglycerin Brand : Nitroglycerin sublingual tab, Perlinganit 0.1% Available form : 0.6mg/T, 50mg/50mL/VI Indication : angina Dosage : 0.3mg or 0.6mg Ea., Sublingual.(Administer q5min, maximum 3times) Side Effects : sudden hypotension, palpitation, redness, headache, nausea, vomiting Status : Permitted 24 ♣ Drug : Valsartan Brand : Diovan Available form : 80mg/T Indication : hypotensive agent, Angiotensin II Receptor Antagonists Dosage - Essential hypertension : 80mg q.d. Maximum 160mg-320mg /day. - Heart failure : 40mg-160mg Ea., b.i.d. Maximum 320mg/day. Side Effects : BUN elevation, headache, dizziness, cough, indigestion, diarrhea, general weakness, muscleache etc. Status : Permitted ♣ Drug : Ginko Biloba Extract Brand : Tanamin Available Form : 80mg/T Indication : circulatory disturbance in peripheral artery, dizziness, vascular and degenerative tinnitus, headache, etc. Dosage : 40 mg 3 times/day, 80mg 2 times/day Side Effects : discomfort in gastrointestinal tract, headache, allergic skin reaction Status : Permitted ♣ Drug : Amiodarone HCL Brand : Cordarone Available Form : 200mg/T, 150mg/3ml/A Indication : ventricular tachyarrhythmias treatment that does not react to other tachyarrhythmias Dosage : N/S 50mL+150mg for 10min(15mg/min) Side Effects : hypersensitivity /interstitial/pulmo-alveolar pneumonia Status : Permitted ♣ Drug : Spironolactone Brand : Aldacton Available form : 25mg/T Indication : Diuretic Dosage : Take divided dose of 50-100mg Side Effects : Nausea, Vomiting, Myasthenic reaction, Rash, Gynecomastia, Dizziness, Lethargy, Diarrhea Etc. Status : Prohibited (S5. Diuretics and Other Masking Agents) 25 6. Endocrinology Drugs ♣ Drug : Glimepiride Brand : Euglex Available form : 2mg/T Indication : PO Sulfonylurea antidiabetic drugs Dosage : Initial dose 1mg q.d. Maintenance dose 1-4mg/day. Maximum 8mg/day. Side Effects : hypoglycemia, vision problem, stomachache, nausea, vomiting, allergic response, dizziness etc. Status : Permitted ♣ Drug : Insulin Brand : Humulin 70/30 PEN, Humalog Vial Available form : Insulin human(RI30:NPH70) : Humulin70/30 pen 300IU/3mL Insulin lispro : Humalog 1000IU/10mL Indication : diabetes Dosage : control dosage by individual needs Side Effects : hypoglycemia, hypersensitivity reaction, neuralgia, abnormality of injection area, and refraction abnormalities, etc. Status : Prohibited (S4. Hormone and Metabolic Modulators) ♣ Drug : Metformin HCl Brand : Diabex XR Available form : 500mg/T Indication : PO Biguanide antidiabetic drugs Dosage : 500mg Ea., 2-3times /day. Maximum 2500mg./day Side Effects : abdominal distention, diarrhea, stomachache, nausea, vomiting, taste change, hypoglycemia, Lactic acidosis, etc. Status : Permitted 26 7. Hormone Drugs ♣ Drug : Prednisolone Brand : Solondo Available form : 5mg/T Indication : Adrenal Corticosteroides Dosage : 5-60mg # 1-4times /day. Side Effects : Peptic Ulcer, Heart Burn, Insomnia, Acne, Edema, Diabetes Etc. Status : Prohibited (S9. Glucocorticosteroids) ♣ Drug : Methylprednisolone Sodium succinate Brand : Solumedrol, Predisol Available form : 125mg/VI, 500mg/VI Indication : Adrenal Corticosteroides Dosage : Varies depending on severity of symptoms Side Effects : Gastric Ulcer, Edema, Diabetes, Hot Flush, Acne, Cushing's Syndrome, convulsion Etc. Status : Prohibited (S9. Glucocorticosteroids) ♣ Drug : Dexamethasone Sodium phosphate Brand : Dexamethasone Available form : 5mg/1mg/A Indication : adrenocortical hormone drug Dosage : IV, IM : 2-8mg, every 3-6 hours instillation : 2-10mg, 1-2times/day Side Effects : peptic ulcer, heartburn, insomnia, acne, edema, diabetes, etc. Status : Prohibited(S9. Glucocorticosteroids) 27 8. Respiratory Drugs ♣ Drug : Acebrophylline Brand : Acebro Available form : 100mg/C Indication : other kind of respiratory drug Dosage : 1times 100mg, 1 day 2times Side Effects : abdominal discomfort, digestive disorder, nausea etc. Status : Permitted ♣ Drug : Acetylcysteine Brand : Muterin, Spatam Available form : 200mg/C, 300mg/3ml/A Indication: expectorant Dosage - Cap: 200mg 2-3times /day - Inj : IV : 600-900mg 2-3times /day(mix: 1:1 dilution with 0.9% N/S or D/W) IM : 300mg 1-2times/day Side Effects : nausea, vomiting, diarrhea, hypersensitivity etc. Status : Permitted ♣ Drug : Ambroxol HCL Brand : Ambrect, Aroxol Available form : 30mg/T, 15mg/2mL/A Indication : expectorant Dosage : Tab: 30mg 2-3times /day Inj: 15-30mg/dose, 2-3 times/day, intramuscular or slow intravenous injection Side Effects : skin damage, indigestion, nausea, vomiting, dry mouth, taste change etc. Status : Permitted 28 ♣ Drug : Aminophylline Brand : Aminophyllin Available form : 250mg/10mL/A Indication : bronchial asthma, asthmatic bronchitis, pulmonary emphysema, chronic bronchitis, congestive heart failure, etc. Dosage : 250mg/day, 5-10 min. IV by dilution 1-2 times, maximum dose 12mg/kg per day Side Effects : headache, insomnia, stimulated central nervous system, anxiety, dizziness, heart acceleration, nausea, etc. Status : Permitted ♣ Drug : Budesonide + Formoterol fumarate dihydrate Brand : Symbicort Turbuhaler 160/4.5mcg Available form : 60dose/BT(Budesonide 160mcg, Formoterol 4.5mcg)/times Indication : asthma (steroids with bronchodilator) Dosage : 1-2times Ea., 1-2times inhalation/day. Maximum 4 inhalations/time, 8 inhalations/day. Side Effects : headache, tremor, palpitation, irritation, hoarseness, sore throat oral & pharynx candidiasis etc. Status : Prohibited(S3. Beta-2 Agonists, Specific Substances) ♣ Drug : Fluticasone propionate Brand : Flixotide diskus Available form : 250mcg/times, 60dose/BT Indication : asthma (steroids) Dosage : 100-1,000mcg, b.i.d. Side Effects : oral & pharyngolaryngeal candidiasis, hoarseness, skin hypersensitivity Status : Permitted ♣ Drug : Salbutamol sulfate Brand : Ventolin Evohaler Available form : 100mcg/times, 200dose/BT Indication : asthma (bronchodilator) Dosage : single spray Ea., spray twice if needed. For chronically used, twice ea. 4 times/day. Side Effects : headache, tremor, tachycardia, oral & pharynx irritation, nervousness, muscle ache etc. Status : Prohibited (S3.Beta-2Agonists) 29 ♣ Drug : Erdosteine Brand : Erdos Available form : 300mg/C Indication : Expectorant, cough & cold remedies Dosage : 2~3 times per day Side Effects : Vomiting, diarrhea, fatigue, GI trouble, abdominal pain etc. Status : Permitted ♣ Drug : Caffeine anhydrous / Chlorpheniramine maleate / Dihydrocodeine Tartrate / DI-methylephedrine HCl Brand : Neo-Medicough Available form : 1 Tab: Caffeine anhydrous 10mg, Chlorpheniramine maleate 1.5mg, Dihydrocodeine Tartrate 5mg, DI-methylephedrine HCl 17.5mg Indication : cough, phlegm Dosage : 2T/day, 3 times after meal Side Effects : rash, erythema, nausea, vomiting, constipation, drowsiness, loss of appetite, etc. Status : Prohibited (S6. Stimulants) ♣ Drug: Ammonium Chloride + Chlorpheniramine Maleate + Dihydrocodeine Tartrate + DI-methylephedrine HCl Brand : Cough syrup Available form : 20mL/PK Indication : cough, phlegm Dosage : 3-4 times/day after meal and before sleep. Adult dosage 20mL Side Effects : rash, erythema, nausea, vomiting, constipation, loss of appetite, dizziness, etc. Status : Prohibited (S6. Stimulants) 30 ♣ Drug : Dry ivy leaf 30% ethanol ext.(5-7.5:1) Brand : HEBron-F Available form : 25mg/T Indication : improves chronic inflammatory bronchial symptoms, relieves acute inflammation of the respiratory organ with coughing Dosage : 25mg t.i.d, 50mg b.i.d Side Effects : diarrhea, nausea, erythema, itch, difficulty with breathing, fever, pus phlegm, etc. Status : Permitted ♣ Drug: Theobromine Brand : Anycough Available form : 300mg/C Indication : rhinitis, sinusitis, relieves cough due to acute or chronic bronchitis Dosage : 1 C, b.i.d PO Side Effects : itch, rash, drowsiness, abdominal inflation, hyperuricemia, edema, etc. Status : Permitted 9. Antihistamine ♣ Drug : Ebastine Brand : Ebastel Available form : 10mg/T Indication : Antihistamine Dosage : 1T 10mg q.d. Side Effects : fatigue, excitement, fatigue, nausea, vomiting, dry mouth, abdominal discomfort. etc. Status : Permitted 31 ♣ Drug : Fexofenadine HCl Brand : Allegra Available form : 30mg/T Indication : Antihistamine (120mg : allergic rhinitis, 180mg: allergic skin irritation) Dosage : 1T q.d. Side Effects : headache, fatigue, dizziness, nausea, upper respiratory infection etc. Status : Permitted ♣ Drug : Fexonadine HCl Brand : Fexonadine Available form : 180mg/T Indication : relieves symptoms related with allergic skin diseases Dosage : once/day, 180mg before meal with water PO Side Effects : headache, drowsiness, low back pain, sleep disorder, rash, hives, fatigue, etc. Status : Permitted ♣ Drug : Hydroxyzine HCl Brand : Adipam Available form : 10mg/T Indication : Antihistamine, anxiolytic Dosage - dermatology : 30-60mg/day # 2-3times. - psychiatry : 75-150mg/day # 3-4times. Side Effects: fatigue, headache, tremor, dry mouth, fatigue etc. Status : Permitted ♣ Drug : Lovocetirizine HCl Brand : Xyzal Available form : 5mg/T Indication : Antihistamine Dosage : 1T q.d. Side Effects : fatigue, fatigue, nausea, dry mouth, headache, dizziness, stomachache, palpitation, indigestion etc. Status : Permitted 32 ♣ Drug: Chlorpheniramine Maleate Brand : Peniramin, Chlorpheniramine Maleate Inj. Available form : 2mg/T, 4mg/2ml/A Indication : hay fever, hives, dermatitis pruritis, runny nose, cough, etc. Dosage : Tab: 2~6mg, 2~4 times/day Inj : 5-10mg, 1-2 times/day, SC, IM or IV Side Effects : cyanoderma, shock, spasm, confitsion, rash, urinary frequency, hemolytic anemia, etc. Status : Permitted 10. Dental Drugs for Oral Cavity ♣ Drug : Benzydamine HCl Brand : Tantum verde nebulizer Available form : 1.5mg/ml, 30ml/BT Indication : Drugs for oral cavity and pharynx Dosage : 2-6 times/day 4-8 times per dose Side Effects : Numbness in mouth, piercing feeling, heating sensation, hypersensitivity reaction Status : Permitted ♣ Drug : Chlorhexidine gluconate Brand : Hexamedine soln (gargle) Available form : 1mg/g, 250ml/BT Indication : Drugs for oral cavity and pharynx Dosage : 15ml * 2times. Brush teeth for 1 min. Side Effects : Rash, Increased coloration on teeth Etc. Status : Permitted 33 11. Digestive System Drugs ♣ Drug: Diomagnite Brand : Diogel Suspension Available form : 3.8g/17g/PK Indication : esophagitis, gastritis, allopathy for gastroduodenal ulceration Dosage : 1PK after meal and for pain relief, dissolve in 1/2 cup of water Indication : discomfort, phosphorous metabolism problems, diarrhea Status : Permitted ♣ Drug : Bacillus Subtilis + Streptococcus faecium Brand : Medilac DS Available form : 250mg/enteric cap Indication : intestinal drug Dosage : 1 capsule, 2-3 times/day Status : Permitted ♣ Drug : Bromelin + Dimethicone + Pancreatin Brand : Beszyme Available form : 1T (Bromelin 30mg, Dimethicone 40mg, Pancreatin 400mg) Indication : Digestive Dosage : 1T t.i.d. Status : Permitted ♣ Drug : Bisacodyl + Docusate sodium Brand : Duorax Available form : Composed of 1T(Bisacodyl 5mg, Docusate sodium 16.75mg) Indication : laxative Dosage : 2T q.d. Side Effects : stomachache, diarrhea, vomiting etc. Status : Permitted 34 ♣ Drug : Dioctahedral smectite Brand : Smecta suspension Available form : 3g/20ml/PK Indication : antidiarrhea Dosage : 20mL t.i.d. Side Effects : constipation Status : Permitted ♣ Drug : Domperidone maleate Brand : Motilium-M Available form : 10mg/T Indication : for G.I. motility Dosage : 1Tabs Ea., t.i.d. Side Effects : diarrhea, stomachache, constipation, abdominal stress, etc. Status : Permitted ♣ Drug : Itopride HCl Brand : Ganakhan Available form : 50mg/T Indication : for G.I. motility Dosage : 1T, t.i.d. Side Effects : diarrhea, constipation, stomachache, headache, sleep disorders etc. Status : Permitted ♣ Drug : Loperamide HCl Brand : Loperamide Available form : 2mg/C Indication : antidiarrhea Dosage : Initial 4mg, add 2mg as needed. 2-8mg/day. Maximum 16mg/day. Side Effects : constipation, dizziness, nausea, abdominal convulsion etc. Status: Permitted ♣ Drug : Magnesium Hydroxide 35 Brand : Magmil Available form : 500mg/T Indication : Laxatives, drastic cathartics Dosage - Stomach, duodenal ulcer, gastritis, acid indigestion : 1 day 2-5 T several times. - Constipation : 1 day 2-4T, 1-2 times. Side Effects : diarrhea Status : Permitted ♣ Drug : Metoclopramide HCl Brand : Mecool Available form : 10mg/2ml/A Indication : for G.I. motility Dosage : 10mg /dose, IM or IV slowly for at least 3 min. Maximum 0.5mg/kg /day or 30mg/day Side Effects : stomachache, diarrhea, constipation, fatigue, shock, headache, high fever, nerve paralysis syndrome etc. Status : Permitted ♣ Drug : Mosapride citrate Brand : Gasmotin Available form : 5mg/T Indication : GI Tract Regulator & Antispasmodics Dosage : 15mg/day, 3 times reflacta dosi Side Effects : soft stool, thirst, fatigue, liver disorder, hypersensitivity, etc. Status : Permitted ♣ Drug : Ranitidine HCl Brand : Curan Available form : 150mg/T Indication : for Ulcer (H2 blocker) Dosage : 1T, 2 times/day Side Effects : constipation, diarrhea, skin itchness, eosinophil elevation (fatigue, fever) Status : Permitted ♣ Drug : Sucralfate 36 Brand : Ulcerlmin suspension Available form : 1g/15ml/PK Indication : for Ulcer Dosage : 1PK(15mL) t.i.d. Side Effects : constipation, dry mouth, nausea etc. Status : Permitted ♣ Drug: Trimebutine maleate Brand : Polybutin Available form : 100mg/T Indication : gastrointestinal motility control and anticonvulsant Dosage : 1-2 T, 3 times/day before meal Side Effects : fatigue, diarrhea, nausea, vomiting, constipation, etc. Status : Permitted ♣ Drug: Plantaginis Ovatae Semen + Plantaginis ovate testa + Sennae fructus angustifoliae Brand : Alaxyl Available form : 8g/PA ( 4g = sennae fructus angustifoliae 0.47g, plantaginis ovatate semen 2.08g, plantaginise ovatae test 0.09g) Indication : relieves constipation symptoms, laxative Dosage : 4g-8g/dose, 1-2 times/day Side Effects : abdominal pain, diarrhea, vomiting, etc. Status : Permitted 12. Antibiotics ♣ Drug : Cefazoline sodium Brand : Cefazolin Available form : 1g/VI Indication : First Generation Cephalosporin Dosage : 1g b.i.d. IV or IM. Maximum 5g/day. Side Effects : Nausea, Vomiting, Rash, Urticaria Etc. Status : Permitted 37 ♣ Drug : Cefroxadine Brand : Tiroxin Available form : 250mg/C Indication : First Generation Cephalosporin Dosage : 250-500mg 2-3 times/day Side Effects : Nausea, Vomiting, Diarrhea, Abdominal pain, Elevated Liver Function Status : Permitted ♣ Drug : Cefaclor Brand : Cefaclor Available form : 250mg/C Indication : Second Generation Cephalosporin Dosage : 250mg/dose, every 8 hours Side Effects : anaphylaxis reaction(flushing all over the body, edema, breathing problems, angioedema), rash, hives, stevens Johnson syndrome, nausea vomiting, diarrhea Status : Permitted ♣ Drug : Ceftriaxone sodium Brand : Ceftriaxone Available form : 1g/VI, 2g/VI Indication : Third Generation Cephalosporin Dosage : 1-2g q.d. IV or IM. Maximum 4g q.d. Side Effects : Nausea, Vomiting, Diarrhea, Headache, Dizziness, Elevated Liver Function, Rash Etc. Status : Permitted ♣ Drug: Cefditoren Pivoxil Brand : Meiact Available form : 100mg/T Indication : Third Generation Cephalosporin Dosage : 100mg, PO 3 times/day after meal Side Effects : nausea, vomiting, diarrhea, rash, hives, eosinophilia Status : Permitted 38 ♣ Drug : Hydroxychloroquine sulfate Brand : Oxiklorin Available form : 100mg/T, 200mg/T Indication : Antimalarial, Rheumatoid Arthritis Dosage - Early Rhrumatoid Arthritis : initial dose 200-400mg/day. Maximum 6.5mg/kg/day. - Treatment of malaria · Acute phase : initial dose 800mg, 400mg q6-8h * 3 times, total 2g for 2days. · Acute disease by plasmodium falciparum or plasmodium vivax : 800mg single dose · Malaria Prevention : 2 weeks before exposure, 6mg/kg (generally 400mg/wk) once a week. Side Effects : Visual impairment, rash, diarrhea, abdominal pain, headache, hallucination, myasthenic, etc. Status : Permitted ♣ Drug : Metronidazole Brand : Furacinil Available form : 250mg/T Indication : antiprotozoal agent Dosage - Trichomoniasis : 250mg, 2 times/day for 10 days - Amoebiasis: 750mg, 3 times/day for 5- 10 days · Anaerobic bacteria : 500mg/dose, 3-4 times/day for 7-10 days. 4g maximum dose/day Side Effects : Rash, itching, headache, convulsion, confusion, visual impairment, etc. Status : Permitted ♣ Drug : Acyclovir Brand : Zovirax Available form : 400mg/T Indication : antiviral agents 39 Dosage : 200mg-800mg, 2-6 times/day Side Effects : hypersensitivity, rash, fever, nausea, vomiting, diarrhea, etc. Status : Permitted ♣ Drug : Amoxicillin sodium + Clavulanate potassium Brand : Augmentin(375mg), Moxicle(625mg), Augmentin Available form : 375mg/TAB(Amoxicillin 250mg, Clavulanate potassium 125mg) 625mg/TAB(Amoxicillin 500mg, Clavulanate potassium 125mg) 1.2g/V (Amoxicillin 1g, Clavulanate potassium 200mg) Indication : Penicillin Antibiotics Dosage : Tab: Amoxicillin 250mg-500mg, q.i.d. Inj : 1.2g IV every 8 hours, or every 6 hours for serious infection Side Effects : Diarrhea, pseudomembranous colitis, stomatitis, dyspepsia, rash, dermatitis etc. Status : Permitted ♣ Drug : Ciprofloxacin Brand : Cycin Available form : 250mg/T, 500mg/T Indication : Quinolones Dosage : 250-500mg, 2 times/day or 750mg per dose 2 times/day for serious infection Side Effects : Diarrhea, nausea, vomiting, abdominal pain, headache, dizziness, hypersensitivity, etc. Status : Permitted ♣ Drug : Ciprofloxacin Brand : Cycin Available form : 400mg/T, 200mg/Bag Indication : Quinolones Dosage : 100-400mg, 2 times/day IV for at least 60 min. Side Effects : Diarrhea, nausea, vomiting, abdominal pain, headache, dizziness, hypersensitivity, etc. Status : Permitted 40 ♣ Drug : Levofloxacin Brand : Levoxacin Available form : 100mg/T Indication : Quinolones Dosage : 100mg, 2-3times/day. If not in effect, increase to 200mg, t.i.d. Side Effects : Hypersensitivity Reaction, Insomnia, Dizziness, Headache, Nausea, Vomiting, Diarrhea, Abdominal pain Etc. Status : Permitted ♣ Drug : Sulfamethoxazole + Trimethoprim Brand : Septrin Available form : 1 tab (Sulfamethoxazole 400mg & Trimethoprim 80mg) Indication : Sulfa Antibiotics Dosage : 2T b.i.d. For prolonged intake more than 14days, 1T b.i.d. Maximum 3T Ea. Side Effects : agranulocytosis, liver disorder, headache, gastro enteric trouble, vomiting, nausea, diarrhea, etc. Status : Permitted ♣ Drug : Doxycycline monohydrate Brand : Doxycycline Available form : 100mg/T Indication : Tetracycline-based Dosage : Initial dose of 100mg, every 12 hours, then 100mg 1-2 times reflacta dosi Side Effects : Anemia, loss of appetite, hypersensitivity, nausea, vomiting, diarrhea, etc. Status : Permitted ♣ Drug: Clindamycin Phosphate Brand : Fullgram Available form : 600mg/4mL/A Indication : antibiotic 41 Dosage : 600-1200mg/day for serious infection, split dose 2-4 times by IV Side Effects : maculopapule rash, hives, jaundice, acute heart failure, polyarthritis, cardiac arrest, etc. Status : Permitted 42 13. Eye Drops ♣ Drug : Acyclovir Brand : Herpecid eye oint Available form : 30mg/g, 3.5g/TU Indication : Ophthalmic ointment Dosage : 1drop q4h, 5 times/day Side Effects : irritation, conjunctivitis, eye ulcer etc. Status : Permitted ♣ Drug: Epinastine HCl Brand : Relestat oph. soln 0.05% Available form : 0.5mg/ml, 5ml/BT Indication : eye drop (prevents and relieves itchiness of allergic conjunctivitis) Dosage : 1 drop, b.i.d Side Effects : burning sensation, allergic conjunctivitis, blepharoptosis, headache, asthma, etc. Status : Permitted ♣ Drug : Cyclopentolate HCL Brand : Ocucyclo eye drop Available form : 10mg/ml, 15ml/BT Indication : mydriasis Dosage : 1-2drops or 1 additional drop 5 min later Side Effects : heat sensation ,conjunctivitis, etc. Status : Permitted ♣ Drug : Dorzolamide HCL +Timolol maleate Brand : Cosopt Oph Soln Available form : 5ml/BT (1ml, dorzolamide hydrochloride 22.26mg, timolol maleate 6.83mg) Indication : eye drop(glaucoma, intraocular pressure decrease) Dosage : 1 drop, b.i.d Side Effects : irritation, conjunctivitis, etc. Status : Prohibited[P2. Beta-blockers] 43 ♣ Drug: Fluorometholone Brand : Ocumetholone eye drop Available form : 1mg/1ml, 5mL/BT Indication : eye drop(steroid) Dosage : 1-2 drops, 2-4 times/day Side Effects : increased intraocular pressure, hyperaemia conjunctivae, etc. Status : Permitted ♣ Drug : Levofloxacin Brand : Cravit oph. Soln. Available form : 5mg/ml, 5ml/BT Indication : antibiotic Dosage : 1drop t.i.d. Side Effects : irritation, itchiness, redness etc. Status: Permitted ♣ Drug : Ofloxacin Brand : Ocuflox eye drop / Ocuflox eye oint. Available form : 5ml/BT(3mg/ml), 3.5g/TU(3mg/1g) Indication : antibiotic Dosage : 1 drop, t.i.d Side Effects : irritation, itchiness, redness etc. Status: Permitted ♣ Drug: Olopatadine HCl 1.11mg Brand : Olopanol Eye Drops Available form : 1.11mg/ml, 5mL/BT Indicative : eye drop(allergic conjunctivitis) Dosage : 1 drop, b.i.d Side Effects : cold, pharyngitis, blurry vision, burning sensation, etc. Status : Permitted 44 ♣ Drug : Prednisolone acetate Brand : PRED Forte 1% eye drop Available form : 10mg/ml, 10ml/BT Indication : steroids Dosage: 1-2 drops, 2-4times/day Side Effects : intraocular pressure elevation, redness of conjunctiva, irritation etc. Status : Prohibited(S9. Glucocorticosteroids) ♣ Drug : Sodium hyaluronate Brand : Hyaludrop Eye Drops Available form: 1mg/ml, 10ml/BT Indication: Artificial eye drops Dosage: 1 drop, 5-6 times/day Side Effects: irritation, eye lid itchness, bleeding, hordeolum etc. Status: Permitted ♣ Drug : Tobramycin Brand : Tobra eye drop Available form : 3mg/ml, 5ml/BT Indication : antibiotic Dosage : 1-2 drops q4h Side Effects : irritation, eyelid itchness etc. Status : Permitted ♣ Drug : Carboxymethylcellulose sodium Brand : Refresh plus eye drop Available form : 5mg/ml, 15ml/BT Indication : Artificial eye drops Dosage : 1-2 drops as needed Side Effects : pain, bloodshot etc. Status : Permitted 45 ♣ Drug: Potassium iodide + Sodium iodide Brand : Curelen eye drop Available form : 10mL/BT(1ml, Potassium iodide 3mg, Sodium iodide 3mg) Indicative form : Eye drop(hemorrhage, lens clouding due to senescence, myopia, hypertension, diabetes, periphlebitis) Dosage : 1 drop in eye, 1-3 times/day Side Effects : burning sensation, increased tear secretion, may cause hyperthyroidism Status : Permitted ♣ Drug: Tropicamide + Phenylephrine HCl Brand : Mydrin-P Oph Soln Available form : 10mL/BT (1ml, Tropicamide 5mg, phenylephrine HCl 5mg) Indicative : mydriasis Dosage : - mydriasis : 1-2 drops or 1 drop every 3-5 min. two times - cycloplegia : 1 drop every 3-5 min. 2-3 times Side Effects : conjunctivitis, increased intraocular pressure, itchiness, rash, hives, etc. Status : Permitted ♣ Drug : Neomycin sulfate + Polymixin B sulfate + Dexamethasone Brand : Maxitrol eye drop Available form : Dexamethasone 1mg, Neomycin sulfate 3.5mg (3500IU), Polymyxin 6000IU in 1ml, 5ml/BT Indication : antibiotic with steroids Dosage : 1-2 drops on conjunctiva, 4-6times q.d. Side Effects : allergic reaction, intraocular pressure elevation etc. Status : Prohibited(S9. Glucocorticosteroids) 46 ♣ Drug: Proparacaine HCl 5mg Brand : Alcain Eye drop Available form : 5mg/ml, 15mL/B Indicative : local anesthetics for ophthalmology Dosage : - Tonometry, foreign body or suture removal : 1-2 drops before surgery - Deep ophthalmic anesthesia 5-10 min. 1 drop each 5-7 times Side Effects : irriation, burning sensation, conjunctiva redness, etc. Status : Permitted ♣ Drug: Moxifloxacin HCl Brand : Vigamox eye drop Available form : 5.45mg/ml, 5ml/BT Indicative : eye drop Dosage : 1 drop, 3-5 times/day Side Effects : conjunctivitis, fever, cough, infection, shock, anaphylaxis reaction, etc. Status : Permitted ♣ Drug: Bromfenac Sodium Hydrate 5mg/5mL Brand : Bronuck oph. Soln. Available form : 1mg/ml, 5mL/BT Indication : eye drop (non-steroid anti-inflammatory analgesic drug) Dosage : 1 drop, b.i.d Side Effects : cornea inflammation, conjunctivitis, blepharitis, irriation, ophthalmalgia, corneal epithelia detachment, etc. Status : Permitted ♣ Drug: Povidone 20ml Brand : Povidone eye drop. Available form : 10ml/BT Indication : eye drop (decongestant, ophthalmic anesthesia, antiphlogistils) Dosage : 2 drops, 4-5 times/day Status : Permitted 47 14. ENT Drugs ♣ Drug : Azelastine HCl Brand : Azeptin nasal spray Available form : 0.14mg/spray, 10ml/BT Indication : allergic rhinitis (antihistamine) Dosage : Into a nostril q.d., 2 sprays /day. Side Effects : bitter taste, headache, sleepy, heat sensation in nose, epistaxis Etc. Status : Permitted ♣ Drug : Fluticasone furoate Brand : Avamys nasal spray Available form : 27.5mcg/spray, 120dose/BT Indication : allergic rhinitis (steroids) Dosage : 2 sprays to each nostril q.d.. After symptom relieved: 1 spray to each nostril Side Effects: Headache, epistaxis, pharyngitis Etc. Status : Permitted ♣ Drug : Ofloxacin 15mg/5mL Brand : Effexin otic soln, Available form : 3mg/ml, 5mL/BT Indication : otitis media(OM), otitis externa Dosage : 6-10 drops, b.i.d., let soln. absorb for 10 min. Side Effects : otalgia, hypersensitivity, etc. Status : Permitted ♣ Drug : Ciprofloxacin HCl + Hydrocortisone + Benzylalcohol Brand : Cyroxacin HC otic suspension Available form : 1ml (ciprofloxacin HCL 2.33mg, Hydrocortisone 10mg, Benzyl alcohol 9mg, 7ml/BT Indication : acute external ear infection Dosage : 3 drops b.i.d, for 7 days Side Effects : Headache, coughing, skin rash, itchiness Etc. Status : Prohibited(S9. Glucocorticosteroids) 48 15. Dermatology Drugs ♣ Drug : Acyclovir Brand : Vivir cream Available form : 50mg/g, 5g/TU Indication : Topical antiviral Dosage : 5 times a day every 4 hours, 5 days Side Effects : Contact dermatitis, rash erythematous, rash, allergic reaction Status : Permitted ♣ Drug: Sertaconazole Nitrate (Cream) Brand : (Cream) Dermofix Available form : 20mg/g, 30g/TU Indication : antifungal cream for external use Dosage : 1-2 times every day on or around the affected area Side Effects : erythema, burning sendation, itch, discolored skin, crack, etc. Status : Permitted ♣ Drug : Methylprednisolone aceponate Brand : Advantan cream Available form : 1mg/g, 15g/TU Indication : external steroids, eczema Dosage : q.d. Side Effects : skin irritation, heat sensation, Itching, Rash Etc. Status : Prohibited (S9. Glucocorticosteroids) ♣ Drug : Mupirocin Brand : Bactroban oint Available form : 20mg/ml, 10g/TU Indication : External antibiotic Dosage : Apply as needed 2-3 times to the site Side Effects : Local irritation, Itching, Rash, Dry skin Etc. Status : Permitted 49 ♣ Drug : Prednicarbate Brand : Titibe oint Available form : 2.5mg/g, 10g/TU Indication : external steroids Dosage : 1-2 times/day Side Effects : skin irritation, heat sensation, Itching, Rash Etc. Status : Permitted ♣ Drug : Oxytetracycline HCL + Polymixin B sulfate Brand : Terramycin oph oint Available form : 3.5g/TU(Oxytetracycline hydrochloride 17.5mg Polymixin B sulfate 35000IU Indication : ophthalmic oint(antibiotic) Dosage : 1.3cm, 2~4 times per day Side Effects : blennophthalmia, pyrosis, blepharitis Etc. Status : Permitted ♣ Drug : Urea . Brand : Urea Cream Available form : 200mg/g, 50g/TUB Indication : keratodermia tylodes palmaris progressive, keratodermia on hand and foot, etc. Dosage : 1-@ times/day, rub thoroughly after washing the affected area Side Effects : pain, heat sensation, flush, hypersensitivity, eczematization, skin cracking, papule Status : Permitted ♣ Drug : Clobetasol propionate Brand : Prosol lotion Available form : 0.5mg/ml, 110g/BT Indication : external steroids Dosage : Apply as needed b.i.d on affected area. Do not use more than 2 weeks or more than 50ml per week. Side Effects : Skin irritation, heat sensation, Itching, redness Etc. Status : Permitted 50 ♣ Drug : Ketoprofen gel Brand : Rheuma gel, Kenfentec-L Plasta Available form : 50g/TU(30mg/g), 30mg/10cm*7cm 1 sheet Indication : External NSAIDs Dosage : Gel : apply 1-4 times/day on affected area Plasta : stick s.i.d on affected area Side Effects : Flare, Rash, Itching, irritation Etc. Status : Permitted ♣ Drug: Calamine + zinc oxide Brand : Calamin lotion Available form : 100mL/BTL (1ml, calamine 80mg, zinc oxide 80mg) Indication : heat rash, erosion relieve and improvement Dosage : 1-@ times/day Side Effects : hypertension, rash, flare, itchiness, irritation, etc. Status : Permitted ♣ Drug: beta sitosterol Brand : Mebo oint Available form : 5mg/g, 40g/TUB Indication : burn, abrasion Dosage : apply thinly on wound 2-3 times/day Side Effects : pruritus, flare, swelling, popular vesicopustule Status : Permitted 51 16. Vitamins ♣ Drug : Vitamin K1 (phytonadione) Brand : Vitamin K1 Available form : 10mg/1ml/A Indication : Vitamin K Dosage - Anticoagulant Inductive Prothrombin Deficiency : Initial dose 2.5-10mg, maximum 25mg. Repeat dose if needed after 6-8h - Hypoprothrombinemia from different cause : 2.5-25mg, max 50mg. Side Effects : Flughing, Dizziness, Tachycardia, Hypotension, Dyspnea, Rash Etc. Status : Permitted ♣ Drug : Vitamin(multi) Brand : M.V.H. Available form : 5ml/VI (1 vial: Ascorbic acid 500mg, Dexpanthenol 25mg, Ergocalciferol 25μg, Nicotinamide 100mg, Pyridoxine HCl 15mg, Retinol Palmitate 6.65mg, Riboflavin sodium phosphate 12.7mg, Thiamine HCl 50mg, Tocopherol acetate 5mg) Indication : Multi vitamin Dosage : 5mL q.d. IVF drops diluted in 500-1000ml of DW or NS Side Effects : Rash, Nausea, Vomiting, Diarrhea, Fever Etc. Status : Permitted 17. Gynecology Medication ♣ Drug : Levonorgestrel Brand : Norlevo 1 Available form : 1.5mg/T Indication : Contraceptives Dosage : Once 1.5mg Side Effects : Dizziness, headache, nausea, mild abdominal pain Status : Permitted 52 18. Immune Globulin ♣ Drug : Human anti-tetanus immunoglobulin Brand : Hyper-Tet Available form : 250IU/1mL/VI Indication : Tetanus Dosage - Prevention : 250IU, If symptoms relieve after tetanus - occurred: 5000IU IM. Side Effects : Shock, Fever, Rash, Pain, Induration, etc. Status : Permitted ♣ Drug : Adsorbed Diphtheria Toxoid + Adsorbed Tetanus Toxoid (TD) Brand : TD-pur Available form : 0.5ml/PFS Indication : Diphtheria, Tetanus prevention Dosage - If injured, Tetanus shot : IM. 5-10 yrs since the latest tetanus shot: 0.5mL, Over 10yrs: 0.5mL + Tetanus Immuno Globulin 250IU. Side Effects : Localized flare, Pain, common cold symptoms, Rash Etc. Status : Permitted 53 19. Local Anesthetic ♣ Drug : Lidocaine HCl Brand : Lidocaine Available form : 400mg/20ml/VI Indication : Local anesthetic, for arrhythmia Dosage : It varies depending on individuals Side Effects : shock, high fever, convulsion, dizziness, rash etc. Status : Permitted ♣ Drug : Lidocaine HCl, Epinephrine Brand : Lidocaine. Epinephrine(1:100,000) Available form : 1.8ml/A (1Amp =Mix Lidocaine HCl 36mg & Epinephrine 18mcg) Indication : Local anesthetic Dosage - Nerve block for dental, infiltration anesthesia: 0.3-2ml. - Oral surger: 3-5ml. Side Effects : shock, high fever, convulsion, dizziness, rash etc. Status : Prohibited (S6. Stimulants) ♣ Drug: Etomidate Brand : Etomidate Lipuro Available form : 20mg/10mL/A Indication : general anesthesia inducing agent Dosage : 0.15~0.3mg/kg IV Side Effects : laryngismus, reduction of peripheral vessel resistance, apnea, hyperpnea, stricture of respiratory system, etc. Status : Permitted 54 ♣ Drug : Lidocaine Brand : Beracaine spray Available form : 10mg/1 spray, 10% 50ml/BT Indication : Local anesthetic Dosage - Adult, Max 200mg(20times spraying). - Dental : 10-50㎎(1-5times spraying). - ENT : 30㎎(3times spraying). - For catheter insertion in respiratory and digestive canals : 200㎎(up to 20 times of spraying possible). - Ob/GY : up to 200㎎ (20times spraying), adults Maximum 200㎎(20times spraying). Side Effects : shock, high fever, convulsion, dizziness, rash etc. Status : Permitted 20. Hemostatics ♣ Drug: Hemocoagulase Brand : Botropase Available form : 2IU/2mL/A Indication : Hemostatics Dosage : 1~2KU/day, IV in case of emergency. Repeat administration if required Side Effects : itch, flare, rash, hives, facial blushing, etc. Status : Permitted 55 21. Transfusion and Fluids ♣ Drug: Calcium chloride + Potassium chloride + Sodium chloride + Sodium lactate Brand : Hartman soln Available form : 500mL/BAG(500ml = calcium chloride 135mg, potassium chloride 200mg, sodium chloride 3g, sodium lactate 1.61g) Indication : blood substitution Dosage : 500~1,000mL drip IV, 300~500mL/h Side Effects : Cerebral edema, pulmonary edema, peripheral edema due to high dosage or sudden administration Status : Permitted ♣ Drug : Dextrose Brand : Dextrose injection Available form : 10% 500ml(bag), 5% 1000ml(bag), 5% 500ml(bag). Indication: DW Side Effects : electrolytes imbalance, congestion Etc. Status : Permitted ♣ Drug : D-Mannitol Brand : D-Mannitol Available form : 0.15g/ml, 500ml/BT Indication : Diuretic Side Effects : Tachycardia, headache, nausea, chill, etc. Status : Prohibited (S5. Diuretic and Other Masking Agents) ♣ Drug : Sodium chloride Brand : Normal saline Available form : (0.9%) 1000ml/bag, 500ml/bag, 100ml/PP Indication : blood substitution Side Effects : If infused fast, congestive heart failure, edema, electrolytes imbalance Status : Permitted 56 ♣ Drug : Sodium chloride Brand : Normal saline Available form : (0.9%) 20ml/A Indication : blood substitution Side Effects : If infused fast, congestive heart failure, edema, electrolytes imbalance Status : Permitted ♣ Drug : Sodium chloride Brand : Sodium chloride Available form : 2.34g/20ml/A (40mEq) Indication : Electrolyte supplement (USE after dilution) Side Effects : If infused fast, congestive heart failure, Edema, electrolytes imbalance Edema Etc. Status : Permitted ♣ Drug : Water for injection Brand : Water for injection Available form : 20ml/A Indication : Dissolvent Status : Permitted ♣ Drug : Sodium bicarbonate Brand : Sodium bicarbonate 8.4% Available form : 1.68g/20ml/A Indication : Acidosis, urticarial acuta Side Effects : Alkalosis, Bradycardia Etc. Status : Permitted ♣ Drug : Potassium chloride 1.491/20mL Brand : Potassium chloride Available form : 1.491g/20ml/A(20mEg) Indication : Hypokalemia, Digitalis toxicity (USE after dilution) Side Effects : Potassium poisoning (paresthesia, arrhythmia mental disorientation Etc.), vomiting, diarrhea etc. Status : Permitted 57 22. Disinfectants ♣ Drug : Povidone Iodide Brand : Povidone 10% Available form : 1000mL/BT Indication : Disinfection Status : Permitted ♣ Drug : Chlorhexidine gluconate 4% Brand : Microshield Available form : 1.5L/EA Indication : Hand sanitizer Status : Permitted 23. Others ♣ Drug: Activated charcoal Brand : Charcodote suspension Available form : 200mg/ml, 250mL/BT Indication : Emergency detoxification for medicinal and chemical substance poisoning Dosage : 65-250mL, infuse slowly for more than 15 min. Status : Permitted 58 Index Drug Name(generic name) Brand Name Acebrophylline Acebro 100mg CAP Aceclofenac Airtal 100mg Acetaminophen Tacenol ER 650mg Acetylcysteine Muterin 200mg CAP Acetylcysteine Spatam Inj., 300mg/3mL Activated charcoal Charcodote suspension 200mg/ml, 250mL/BT Acyclovir (eye Oint) Herphecid eye-oint 30mg/g, 3.5g/TU Acyclovir Zovirax 400mg Acyclovir Vivir cream 50mg/g, 5g/Tube Adsorbed Diphtheria Toxoid / Adsorbed Td-Pur 0.5mL/PFS tetanus toxoid(TD) Ambroxol HCl Aroxol 15mg/2mL Amp Ambroxol HCl Ambrect 30mg TAB Aminophylline Aminophyllin 250mg/10mL Amiodarone HCl Cordarone 150mg/3mL Amiodarone HCl Cordarone 200mg TAB Amlodipine Besylate Norvasc 5mg Ammonium chloride 10mg Cough syrup 20mL/PK Adm PO PO PO PO Inj. PO External PO External Inj. Inj. PO Inj. Inj. PO PO Chlorpheniramine maleate 0.15mg PO Dihydrocodeine tartrate 0.5mg DI-methylephedrine HCl 1.31mg/1mL 59 code Amoxicillin Sod. 250mg/Clavulanate Pot. 125mg Augmentin 375mg TAB Amoxicillin Sod. 500mg/Clavulanate Pot. 125mg Moxicle 625mg TAB Amoxicillin Sod. 1G/Clavulanate Pot. Augmentin 1.2g 0.2G Aspirin Bayer Aspirin 500mg Atenolol Tenormin 25mg Atenolol Tenormin 50mg Atropine Sulfate Atropine Sulfate 0.5mg/1mL Azelastine HCl Azeptin nasal spray 0.14mg/spray 10mL/BT Bacillus Subtilis Str.Faecium Medilac-DS Benzydamine HCl Tantum verde nebulizer 1.5mg/mL, 30mL/BT Bromelin /Dimethicone /Pancreatin Beszym Beta Sitosterol Mebo Oint 5mg/g, 40g/TUB Bisacody /Docusate Sodium Duorax Bromfenac Sodium Hydrate Bronuck oph. Soln. 1mg/mL 5mL/BT Budesonide/Formoterl Fumarate Symbicort turbuhaler 160/4.5mg dihydrate 60dose Caffeine anhydrous 10mg Neo-Medicough PO PO Inj. PO PO PO Inj. External PO External PO External PO External External Chlorpheniramine maleate 1.5mg PO Dihydrocodeine tartrate 5mg DI-methylephedrine HCL 17.5mg Calamine /Zinc Oxide Calamin lotion 100mL/BTL Calcium chloride + Potassium chloride + Hartman soln 500mL(BAG) External Inj. Sodium chloride + Sodium lactate Captopril Capril 12.5mg 60 PO Captopril Capril 25mg Captopril Capril 50mg Carboxymethylcellulose sodium 5mg Refresh Tears eye drops 5mg/mL, 15mL/BT Carvedilol Dilatrend 6.25mg Carvedilol Dilatrend 12.5mg Carvedilol Dilatrend 25mg Cefaclor Cefaclor 250mg cap Cefazolin Sodium Cefazolin 1g/Vl Cefditoren Pivoxil Meiact 100mg TAB Cefroxadine Tiroxin 250mg CAP Ceftriaxone Sodium 1G Ceftriaxone 1g/Vl Ceftriaxone Sodium 2G Ceftriaxone 2g/Vl Celecoxib Celebrex 200mg Chlorhexidine Gluconate Hexamedin 1mg/g, 250mL/BT Chlorhexidine Gluconate 4% Microshield 1.5L/EA Chlorpheniramine Maleate Pheniramin 2mg TAB Chlorpheniramine Maleate Chlorpheniramine Maleate Inj.,4mg/2mL Cimetropium Bromide Algiron 50mg Cimetropium Bromide Algiron 5mg/1mL Ciprofloxacin HCl/ Hydrocortisone / Ciprocin HC otic suspenion 7mL/BT Benzylalcohol Ciprofloxacin 250mg Cycin 250mg TAB 61 PO PO External PO PO PO PO Inj. PO PO Inj. Inj. PO External External PO Inj. PO Inj. External PO Ciprofloxacin 500mg Cycin 500mg TAB Ciprofloxacin Cycin 400mg/200ml/Bag Clindamycin Phosphate Fullgram 600mg/4mL Clobetasol propionate Prosol lotion 0.5mg/g, 110g/BT Cyclopentolate HCl (Oph. Soln) Ocucyclo eye drop 10mg/mL 5mL/BT Dexamethasone Sodium Phosphate Dexamethasone Inj. 5mg/1mL Dexibuprofen Mexibupen ER 300mg Tab Dextrose 5% D/W 500mL(Bag) Dectrose 10% D/W 500mL(Bag) Dextrose 5% D/W 1000mL(Bag) Diazepam (향)Diazepam Inj. 10mg/2mL Diazepam Diazepam 2mg Diclofenac Sodium Toraren 75mg/2mL Digoxin Digoxin 0.25mg TAB Digoxin Digoxin Inj. 0.25mg/1mL Diltiazem HCl Herben(Retard TAB) 90mg Dimenhydrinate Bonaring-A 50mg Dioctahedral Smectite Smecta Suspension 3g/20mL/PK Diomagnite Diogel Suspension 3.8g/17g/PK D-Mannitol D-Mannitol 0.15g/ml, 500ml/BT Domperidone Maleate Motilium-M 10mg TAB Dopamine HCl Dopramine 200mg/5mL 62 PO Inj. Inj. External External Inj. PO Inj. Inj. Inj. Inj. PO Inj. PO Inj. PO PO PO PO Inj. PO Inj. Dorzolamide HCl/Timolol Maleate Cosopt Oph Soln 5mL/BT Doxycycline Monohydrate Doxycycline 100mg TAB Dry ivy leaf 30% ethanol Extract (5-7.5:1) HEBron-F 25mg TAB Ebastine Ebastel 10mg TAB Eperisone HCl Mulex 50mg Epinastine HCl Relestat oph. soln 0.05% 0.5mg/mL, 5mL/BT Epinephrine Epinephrine 1mg/1mL Erdosteine Erdos CAP 300mg Etomidate Etomidate Lipuro 20mg/10mL Fexofenadine HCl Allegra 30mg TAB Fexonadine HCl Fexonadine 180mg TAB Fluorometholone (Eye Drop) Ocumetholone Eye Drop 1mg/1mL 5mL/BT Fluticasone Furoate Avamys nasal spray 27.5mcg/120DOSE Fluticasone Propionate Flixotide Diskus 250mcg/60dose Frovatriptan Succinate Monohydrate Migard 2.5mg 3.91mg Furosemide Lasix Inj. 20mg/2mL Furosemide Furix 40mg Gallamine Triethiodide Myraxan 10mg Ginkgo biloba ext. Tanamin 80mg TAB Glimepiride Euglex 2mg TAB Hemocoagulase Botropase 2IU/2mL/A Human Anti-Tetanus Immunoglobulin Hypertet 250IU/1mL/Vl 63 External PO PO PO PO External Inj. PO Inj. PO PO External External External PO Inj. PO Inj. PO PO PO Inj. Hydrochlorothiazide Dichlozid 25mg Hydroxychloroquine Sulfate Oxiklorin TAB 100mg Hydroxychloroquine Sulfate Oxiklorin TAB 200mg Hydroxyzine HCl Adipam 10mg TAB Ibuprofen 200mg/Arginine 185mg Carol - F Insulin Humulin 70/30 PEN Insulin Humalog Vial 1,000IU/10mL Itopride HCl Ganakhan 50mg Ketoprofen Kefentec-L Plasta 30mg(1sheet) Ketoprofen Gel Rheuma gel 50g/TU(30mg/g) Ketorolac Tromethamine Trolac 30mg/1mL Levocetirizine HCl Xyzal 5mg TAB Levofloxacin 5mg/mL(Oph. Soln.) Cravit oph.soln 5mg/mL, 5mL/BT Levofloxacin Levoxacin 100mg TAB Levonorgestrel Norlevo one 1.5mg/T Lidocain HCl / Epinephrine Lidocaine. Epinephrine (1:10만) Lidocaine Beracaine Spray 10mg/spray, 50mL/BT Lidocaine HCl Lidocaine 400mg/20mL/Vl Loperamide HCl loperamide HCl 2mg CAP Lorazepam Ativan 0.5mg Lorazepam Ativan 4mg/1mL Losartan Potassium Cozaar 50mg 64 PO PO PO PO PO Inj. Inj. PO External External Inj. PO External PO PO Inj. External Inj. PO PO Inj. PO Magnesium Hydroxide Magmil 500mg TAB Metformin HCL Diabex XR 500mg TAB Methylprednisolone Aceponate Advantan Cream, 1mg/g, 15g/TU Methylprednisolone Sod. Succinate Solumedrol 125mg/Vl Methylprednisolone Sod. Succinate Predisol 500mg/Vl Metoclopramide HCl Mecool 10mg/2mL Metronidazole Furacinil 250mg TAB Midazolam Midazolam 5mg/5mL Morphine Sulfate Morphine Sulfate 5mg/5mL Mosapride Citrate Gasmotin 5mg TAB Moxifloxacin HCl Vigamox eye drop 5.45mg/mL 5mL/BT Mupirocin Bactroban oint 20mg/g, 10g/TU Multi Vitamin M.V.H 5mL/VL Neomycin sulfate /polymyxin B sulfate Maxitrol eye drop 5mL/BT PO PO External Inj. Inj. Inj. PO Inj. Inj. PO External External Inj. External /Dexamethasone Nicorandil Sigmart 5mg TAB Nifedipine Adalat oros 60mg Nifedipine Nifedix ER 30mg Nitroglycerin Nitroglycerin Sublingual TAB 0.6mg Nitroglycerin Perlinganit 0.1% 50mg/50mL Norepinephrine Bitartrate Norpin 10mL Ofloxacin Effexin otic soln. 3mg/mL, 5mL/BT 65 PO PO PO PO Inj. Inj. External Ofloxacin Ocuflox eye drop 3mg/1mL, 5mL/BT Ofloxacin Ocuflox Eye oint 3.5g/TU Olopatadine HCl Olopanol Eye Drops 1.11mg/mL, 5mL/BT Oxytetracycline HCl /Polymyxin B sulfate Terramycin oph oint 3.5g Phytonadione (Vitamin K1) Vitamin K 10mg/1ml Plantaginis Ovatae Semen Alaxyl 8g/PA plantaginis ovatae testa External External External External Inj. PO Sennae fructus angustifoliae Potassium iodide/Sodium iodide Curelen eye drop 10mL/BT Potassium Chloride 1.491G/20mL Potassium chloride 1.491g/20mL Povidone 20mg Optagent eye drop(Povidone) Povidone Iodine Povidone 10%, 1000mL/BT Prednicarbate Titibe oint 2.5mg/g, 10g/TU Prednisolone Solondo 5mg TAB Prednisolone Acetate PREDForte1%EyeDrop,10mg/mL,10mL/BT Proparacaine HCl Alcain eye drop 5mg/mL, 15mL/BT Ranitidine HCl Ranibig 150mg Salbutamol Sulfate Ventolin Evohaler 200Dose Sertaconazole Nitrate Dermofix Cream 20mg/g, 30g/TUB Sodium Bicarbonate Sodium Bicarbonate 8.4% 20mL Sodium Chloride Normal saline 0.9% 500mL(BAG) Sodium Chloride Normal saline 0.9%, 1000mL(Bag) 66 External Inj. External External External PO External External PO External External Inj. Inj. Inj. Sodium Chloride Normal saline 0.9%, 100mL(PP) Sodium Chloride Normal saline 0.9%, 20ml/A Sodium Chloride Normal saline 0.9%, 20ml/A Sodium Chloride Sodium chloride, 2.34g/20ml/A(40mEq) Sodium Hyaluronate Hyaludrop Eye Drops 1mg/mL, 10mL/BT Spironolactone Aldactone 25mg TAB Streptokinase 10000IU/Streptodornase Mucolase 10mg 2500IU Sucralfate Ulcermin suspension 1g/15mL/PK Talniflumate Somalgen 370mg Theobromine Anycough cap 300mg Tobramycin Tobra Eye Drop 3mg/mL 5mL/BT Tramadol HCl Zipan inj. 50mg/mL Trimebutine Maleate Polybutin, 100mg TAB Trimethoprim / Sulfamethoxazole Septrin 480mg TAB Tropicamide Phenylephrine HCl Mydrin-P Oph Soln 10mL/BT Urea Urea Cream 200mg/g, 50g/TUB Valsartan Diovan 80mg TAB Water For Inj. Water for injection 20mL Zolpidem Stilnox 10mg 67 Inj. Inj. Inj. Inj. External PO PO PO PO PO External Inj. PO PO External External PO Inj. PO The World Anti-Doping Code THE 2015 PROHIBITED LIST INTERNATIONAL STANDARD The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. This List shall come into effect on 1 January 2015 68 THE 2015 PROHIBITED LIST WORLD ANTI-DOPING CODE Valid 1 January 2015 In accordance with Article 4.2.2 of the World Anti-Doping Code, all Prohibited Substances shall be considered as “Specified Substances” except Substances in classes S1, S2, S4.4, S4.5, S6.a, and Prohibited Methods M1, M2 and M3. SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) PROHIBITED SUBSTANCES S0. NON-APPROVED SUBSTANCES Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times. S1. ANABOLIC AGENTS Anabolic agents are prohibited. 1. Anabolic Androgenic Steroids (AAS) 69 a. Exogenous* AAS, including: 1-androstenediol (5α-androst-1-ene-3β,17β-diol ); 1-androstenedione (5α-androst-1-ene3,17-dione); bolandiol (estr-4-ene-3β,17β-diol ); bolasterone; boldenone; boldione (androsta-1,4-diene-3,17-dione); calusterone; clostebol; danazol ([1,2]oxazolo[4',5':2,3]pregna-4-en-20-yn-17α-ol); dehydrochlormethyltestosterone (4-chloro-17β-hydroxy-17α-methylandrosta-1, 4-dien-3-one); desoxymethyltestosterone (17α-methyl-5α-androst-2-en-17β-ol); drostanolone; ethylestrenol (19-norpregna-4-en-17α-ol); fluoxymesterone; formebolone; furazabol (17α-methyl [1,2,5]oxadiazolo[3',4':2,3]-5α-androstan-17β-ol); gestrinone; 4-hydroxytestosterone (4,17βdihydroxyandrost-4-en-3-one); mestanolone; mesterolone; metandienone (17β-hydroxy-17αmethylandrosta-1,4-dien-3-one); metenolone; methandriol; methasterone (17β-hydroxy-2α,17αdimethyl-5α-androstan-3-one); methyldienolone (17β-hydroxy-17α-methylestra-4,9-dien-3-one); methyl-1-testosterone (17β-hydroxy-17α-methyl-5α-androst-1-en-3-one); methylnortestosterone (17β-hydroxy-17α-methylestr-4-en-3-one); methyltestosterone; metribolone (methyltrienolone, 17β-hydroxy-17α-methylestra-4,9,11-trien-3-one); mibolerone; nandrolone; 19-norandrostenedione (estr-4-ene-3,17-dione); norboletone; norclostebol; norethandrolone; oxabolone; oxandrolone; oxymesterone; oxymetholone; prostanozol (17β[(tetrahydropyran-2-yl)oxy]-1'H-pyrazolo[3,4:2,3]-5α-androstane); quinbolone; stanozolol; stenbolone; 1-testosterone (17β-hydroxy-5α-androst-1-en-3-one); tetrahydrogestrinone (17hydroxy-18a-homo-19-nor-17α-pregna-4,9,11-trien-3-one); trenbolone (17β-hydroxyestr-4,9,11trien-3-one); and other substances with a similar chemical structure or similar biological effect(s). b. Endogenous** AAS when administered exogenously: Androstenediol (androst-5-ene-3β,17β-diol); androstenedione (androst-4-ene-3,17dione); dihydrotestosterone (17β-hydroxy-5α-androstan-3-one); prasterone (dehydroepiandrosterone, DHEA, 3β-hydroxyandrost-5-en-17-one); testosterone; and their metabolites and isomers, including but not limited to: 5α-androstane-3α,17α-diol; 5α-androstane-3α,17β-diol; 5α-androstane-3β,17α-diol; 5αandrostane-3β,17β-diol; 5β-androstane-3α,17β-diol; androst-4-ene-3α,17α-diol; androst4-ene-3α,17β-diol; androst-4-ene-3β,17α-diol; androst-5-ene-3α,17α-diol; androst-5ene-3α,17β-diol; androst-5-ene-3β,17α-diol; 4-androstenediol (androst-4-ene-3β,17βdiol); 5-androstenedione (androst-5-ene-3,17-dione); androsterone (3β-hydroxy-5αandrostan-17-one); epi-dihydrotestosterone; epitestosterone; etiocholanolone; 7αhydroxy-DHEA; 7β-hydroxy-DHEA; 7-keto-DHEA; 19-norandrosterone; 19noretiocholanolone. 2. Other Anabolic Agents Including, but not limited to: Clenbuterol, selective androgen receptor modulators (SARMs, e.g. andarine and ostarine), tibolone, zeranol and zilpaterol. 70 71 For purposes of this section: * “exogenous” refers to a substance which is not ordinarily produced by the body naturally. ** “endogenous” refers to a substance which is ordinarily produced by the body naturally. S2. PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES AND MIMETICS The following substances, and other substances with similar chemical structure or similar biological effect(s), are prohibited: 1. Erythropoietin-Receptor agonists: 1.1 Erythropoiesis-Stimulating Agents (ESAs) including e.g. darbepoietin (dEPO); erythropoietins (EPO); EPO-Fc; EPO-mimetic peptides (EMP), e.g. CNTO 530 and peginesatide; and methoxy polyethylene glycol-epoetin beta (CERA); 1.2 Non-erythropoietic EPO-Receptor agonists, e.g. ARA-290, asialo EPO and carbamylated EPO; 2. Hypoxia-inducible factor (HIF) stabilizers, e.g. cobalt and FG-4592; and HIF activators, e.g. argon, xenon; 3. Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) and their releasing factors, e.g. buserelin, gonadorelin and triptorelin, in males; 4. Corticotrophins and their releasing factors, e.g corticorelin; 5. Growth Hormone (GH) and its releasing factors including Growth Hormone Releasing Hormone (GHRH) and its analogues, e.g. CJC-1295, sermorelin and tesamorelin; Growth Hormone Secretagogues (GHS), e.g. ghrelin and ghrelin mimetics, e.g. anamorelin and ipamorelin; and GH-Releasing Peptides (GHRPs), e.g. alexamorelin, GHRP-6, hexarelin and pralmorelin (GHRP-2). Additional prohibited growth factors: Fibroblast Growth Factors (FGFs); Hepatocyte Growth Factor (HGF); Insulin-like Growth Factor-1 (IGF-1) and its analogues; Mechano Growth Factors (MGFs); Platelet-Derived Growth Factor (PDGF); Vascular-Endothelial Growth Factor (VEGF) 72 and any other growth factor affecting muscle, tendon or ligament protein synthesis/degradation, vascularisation, energy utilization, regenerative capacity or fibre type switching. S3. BETA-2 AGONISTS All beta-2 agonists, including all optical isomers, e.g. d- and l- where relevant, are prohibited. Except: Inhaled salbutamol (maximum 1600 micrograms over 24 hours); Inhaled formoterol (maximum delivered dose 54 micrograms over 24 hours); and Inhaled salmeterol in accordance with the manufacturers’ recommended therapeutic regimen. The presence in urine of salbutamol in excess of 1000 ng/mL or formoterol in excess of 40 ng/mL is presumed not to be an intended therapeutic use of the substance and will be considered as an Adverse Analytical Finding (AAF) unless the Athlete proves, through a controlled pharmacokinetic study, that the abnormal result was the consequence of the use of the therapeutic inhaled dose up to the maximum indicated above. S4. HORMONE AND METABOLIC MODULATORS The following hormones and metabolic modulators are prohibited: 1. Aromatase inhibitors including, but not limited to: aminoglutethimide; anastrozole; androsta-1,4,6-triene-3,17-dione (androstatrienedione); 4-androstene-3,6,17 trione (6-oxo); exemestane; formestane; letrozole and testolactone. 2. Selective estrogen receptor modulators (SERMs) including, but not limited to: raloxifene; tamoxifen and toremifene. 3. Other anti-estrogenic substances including, but not limited to: clomiphene; cyclofenil and fulvestrant. 4. Agents modifying myostatin function(s) including, but not limited, to: myostatin inhibitors. 73 74 5. Metabolic modulators: 5.1 Activators of the AMP-activated protein kinase (AMPK), e.g. AICAR; and Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists, e.g. GW 1516; 5.2 Insulins; 5.3 Trimetazidine. S5. DIURETICS AND MASKING AGENTS The following diuretics and masking agents are prohibited, as are other substances with a similar chemical structure or similar biological effect(s). Including, but not limited to: Desmopressin; probenecid; plasma expanders, e.g. glycerol and intravenous administration of albumin, dextran, hydroxyethyl starch and mannitol. Acetazolamide; amiloride; bumetanide; canrenone; chlortalidone; etacrynic acid; furosemide; indapamide; metolazone; spironolactone; thiazides, e.g. bendroflumethiazide, chlorothiazide and hydrochlorothiazide; triamterene and vaptans, e.g. tolvaptan. Except: Drospirenone; pamabrom; and topical dorzolamide and brinzolamide. Local administration of felypressin in dental anaesthesia. The detection in an Athlete’s Sample at all times or In-Competition, as applicable, of any quantity of the following substances subject to threshold limits: formoterol, salbutamol, cathine, ephedrine, methylephedrine and pseudoephedrine, in conjunction with a diuretic or masking agent, will be considered as an Adverse Analytical Finding unless the Athlete has an approved TUE for that substance in addition to the one granted for the diuretic or masking agent. 75 PROHIBITED METHODS M1. MANIPULATION OF BLOOD AND BLOOD COMPONENTS The following are prohibited: 1. The Administration or reintroduction of any quantity of autologous, allogenic (homologous) or heterologous blood, or red blood cell products of any origin into the circulatory system. 2. Artificially enhancing the uptake, transport or delivery of oxygen. Including, but not limited to: Perfluorochemicals; efaproxiral (RSR13) and modified haemoglobin products, e.g. haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen. 3. Any form of intravascular manipulation of the blood or blood components by physical or chemical means. M2. CHEMICAL AND PHYSICAL MANIPULATION The following are prohibited: 1. Tampering, or Attempting to Tamper, to alter the integrity and validity of Samples collected during Doping Control. Including, but not limited to: Urine substitution and/or adulteration, e.g. proteases. 2. Intravenous infusions and/or injections of more than 50 mL per 6 hour period except for those legitimately received in the course of hospital admissions, surgical procedures or clinical investigations. M3. GENE DOPING The following, with the potential to enhance sport performance, are prohibited: 1. The transfer of polymers of nucleic acids or nucleic acid analogues; 2. The use of normal or genetically modified cells. 76 SUBSTANCES AND METHODS PROHIBITED IN-COMPETITION In addition to the categories S0 to S5 and M1 to M3 defined above, the following categories are prohibited In-Competition: PROHIBITED SUBSTANCES S6. STIMULANTS All stimulants, including all optical isomers, e.g. d- and l- where relevant, are prohibited. Stimulants include: a: Non-Specified Stimulants: Adrafinil; amfepramone; amfetamine; amfetaminil; amiphenazole; benfluorex; benzylpiperazine; bromantan; clobenzorex; cocaine; cropropamide; crotetamide; fencamine; fenetylline; fenfluramine; fenproporex; fonturacetam [4-phenylpiracetam (carphedon)]; furfenorex; mefenorex; mephentermine; mesocarb; metamfetamine(d-); pmethylamphetamine; modafinil; norfenfluramine; phendimetrazine; phentermine; prenylamine and prolintane. A stimulant not expressly listed in this section is a Specified Substance. b: Specified Stimulants. Including, but not limited to: Benzfetamine; cathine**; cathinone and its analogues, e.g. mephedrone, methedrone, and α- pyrrolidinovalerophenone; dimethylamphetamine; ephedrine***; epinephrine**** (adrenaline); etamivan; etilamfetamine; etilefrine; famprofazone; fenbutrazate; fencamfamin; heptaminol; hydroxyamfetamine (parahydroxyamphetamine); isometheptene; levmetamfetamine; meclofenoxate; methylenedioxymethamphetamine; methylephedrine***; methylhexaneamine (dimethylpentylamine); methylphenidate; nikethamide; norfenefrine; octopamine; oxilofrine (methylsynephrine); pemoline; pentetrazol; phenethylamine and its derivatives; phenmetrazine; phenpromethamine; propylhexedrine; pseudoephedrine*****; selegiline; sibutramine; strychnine; tenamfetamine (methylenedioxyamphetamine), tuaminoheptane; and other substances with a similar chemical structure or similar biological effect(s). 77 Except: Imidazole derivatives for topical/ophthalmic use and those stimulants included in the 2015 Monitoring Program* * ** *** **** ***** Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradrol, and synephrine: These substances are included in the 2015 Monitoring Program, and are not considered Prohibited Substances. Cathine: Prohibited when its concentration in urine is greater than 5 micrograms per milliliter. Ephedrine and methylephedrine: Prohibited when the concentration of either in urine is greater than 10 micrograms per milliliter. Epinephrine (adrenaline): Not prohibited in local administration, e.g. nasal, ophthalmologic, or co-administration with local anaesthetic agents. Pseudoephedrine: Prohibited when its concentration in urine is greater than 150 micrograms per milliliter. S7. NARCOTICS Prohibited: Buprenorphine; dextromoramide; diamorphine (heroin); fentanyl and its derivatives; hydromorphone; methadone; morphine; oxycodone; oxymorphone; pentazocine and pethidine. S8. CANNABINOIDS Prohibited: Natural, e.g. cannabis, hashish and marijuana, or synthetic △9-tetrahydrocannabinol (THC). Cannabimimetics, e.g. “Spice”, JWH-018, JWH-073, HU-210. S9. GLUCOCORTICOIDS All glucocorticoids are prohibited when administered by oral, intravenous, intramuscular or rectal routes. 78 SUBSTANCES PROHIBITED IN PARTICULAR SPORTS P1. ALCOHOL Alcohol (ethanol) is prohibited In-Competition only, in the following sports. Detection will be conducted by analysis of breath and/or blood. The doping violation threshold is equivalent to a blood alcohol concentration of 0.10 g/L. Air Sports (FAI) Archery (WA) Automobile (FIA) ● Motorcycling (FIM) ● Powerboating (UIM) P2. BETA-BLOCKERS Beta-blockers are prohibited In-Competition only, in the following sports, and also prohibited Out-of-Competition where indicated. Archery (WA)* Automobile (FIA) Billiards (all disciplines) (WCBS) Darts (WDF) Golf (IGF) Shooting (ISSF, IPC)* Skiing/Snowboarding (FIS) in ski jumping, freestyle aerials/halfpipe and snowboard halfpipe/big air Underwater sports (CMAS) in constant-weight apnoea with or without fins, dynamic apnoea with and without fins, free immersion apnoea, Jump Blue apnoea, spearfishing, static apnoea, target shooting and variable weight apnoea. *Also prohibited Out-of-Competition Including, but not limited to: Acebutolol; alprenolol; atenolol; betaxolol; bisoprolol; bunolol; carteolol; carvedilol; celiprolol; esmolol; labetalol; levobunolol; metipranolol; metoprolol; nadolol; oxprenolol; pindolol; propranolol; sotalol and timolol. 79 THE 2015 MONITORING PROGRAM* The following substances are placed on the 2015 Monitoring Program: 1. Stimulants: In-Competition only: Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradrol and synephrine. 2. Narcotics: In-Competition only: Hydrocodone, mitragynine, morphine/codeine ratio, tapentadol and tramadol. 3. Glucocorticoids: In-competition (by routes of administration other than oral, intravenous, intramuscular or rectal) and Out-of- Competition (all routes of administration) 4. Telmisartan: In and Out-of-Competition 5. Meldonium: In and Out-of-Competition * The World Anti-Doping Code (Article 4.5) states: “WADA, in consultation with Signatories and governments, shall establish a monitoring program regarding substances which are not on the Prohibited List, but which WADA wishes to monitor in order to detect patterns of misuse in sport.” 80 2015 Prohibited List Summary of Major Modifications and Explanatory Notes SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OFCOMPETITION) PROHIBITED SUBSTANCES S1: Anabolic Agents Changes were made to reflect current scientific nomenclature. 5β-androstane-3α,17β-diol was added to the examples of testosterone metabolites. S2. Peptide Hormones, Growth Factors, Related Substances and Mimetics The title of this section has been changed: Mimetics have been added to the title to reflect the fact that synthetic analogs are also prohibited under this section. Please note that all the substances named as examples in this revised section of the 2015 Prohibited List were already considered prohibited under previous Prohibited Lists, as applicable. The ESA sub-section has been expanded by adding the non-erythropoietic EPO-Receptor agonists. In addition, the HIF stabilizer sub-section has been placed in a separate paragraph to highlight the growing importance of these drugs and to specifically identify HIF activators such as xenon and argon. Note that cyanocobalamin (vitamin B12) is not prohibited. Examples of Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) releasing factors have now been identified. 81 A Corticotrophin releasing factor has now been added as an example. GH releasing factors have been divided in a more precise categorization and several examples of each have been added to illustrate their different pharmacological properties. IGF-1 has been moved to the other growth factor section. Note that Platelet Derived Plasma preparations are not prohibited. S4. Hormone and Metabolic Modulators Trimetazidine was originally included in S6.b based upon the similarity of its chemical structure to some of the listed Stimulants. It has been moved to the newly created sub-section S4.5.c as it is pharmacologically classified as a modulator of cardiac metabolism. AMPK activators were re-described to reflect current nomenclature. S5. Diuretics and Masking Agents The title and subsequent paragraphs has been modified by the removal of the word “other” to reflect that diuretics are not only masking agents but can also be abused for other purposes such as notably the induction of rapid weight loss. The last paragraph has been reworded for the sake of clarity. The principle and processes identified in the previous version of the Prohibited List remain unchanged. PROHIBITED METHODS M2. Chemical and Physical Manipulation The term “surgical procedures” has been added to the sentence describing the situations in which the administration of intravenous infusions or injections of more than 50 mL per 6 hours are permitted when medically required. SUBSTANCES AND METHODS PROHIBITED IN-COMPETITION S6. Stimulants: For the sake of clarification, topical/ophthalmic imidazole derivatives have been mentioned as exceptions of non-prohibited stimulants. Phenmetrazine, initially in section S6.a, has been moved to section S6.b since fenbutrazate (section S6.b) can metabolize to phenmetrazine. 82 The List now clearly identifies the whole family of phenethylamine derivatives as being prohibited to address the growing number of illegal, designer stimulants derived from phenethylamine. Trimetazidine has been transferred to the newly created section S4.5.c (see above). S9: Glucocorticoids: Glucocorticosteroids are described as Glucocorticoids to reflect current nomenclature and use. SUBSTANCES PROHIBITED IN PARTICULAR SPORTS P1: Alcohol: Following the request of World Karate Federation (WKF), karate was removed from the list of sports in which alcohol is prohibited. P2. Beta-blockers The World Underwater Federation (CMAS) has, at its request, been added to the group of International Federations prohibiting the use of Beta-blockers in competition for certain disciplines. MONITORING PROGRAM Following sufficient collection of data leading to clear conclusions, monitoring of pseudoephedrine below 150 microgram per milliliter will cease in 2015. Telmisartan, an atypical angiotensin II receptor antagonist with apparent partial PPARδ receptor agonist properties (prohibited under S4.5.b), was added to the Monitoring Program to assess the abuse of this substance. Meldonium, a drug with potential cardiac effects, was added to the Monitoring Program to assess the abuse of this substance. 83