Provisional Programme
Sunday 24th June
4.00-6.00pm
6.00pm
8.00pm
Registration in Hamilton Centre and room key collection in Bishop Complex
Reception
ARR Committee meeting in LC014
ARR Committee Dinner
Monday 25th June
Spatio-temporal effects of DNA damage and repair
7.30-9.00
Breakfast in Newton Room, Hamilton Centre
9.00-10.00
Registration and Welcome refreshments in Hamilton Centre.
The opening address and all lectures will take place in Lecture Centre-E
10.00-10.15
Welcome address by Chair of ARR (Kaye Williams) and Brunel PVC for Research
(Geoff Rogers)
10.15-11.45
10.15-10.45
Sensing and responding to DNA damage (Chair: Penny Jeggo)
Chromatin remodelling in response to chromosomal DNA breaks.
Haico van Attikum, Nl
The proteasomal de-ubiquitinating enzyme POH1 modulates poly-ubiquitin
responses to double-strand DNA breaks.
Jo Morris, UK
BRCA1 repositions 53BP1 during homologous recombination in G2 enabling
heterchromatin modifications and resection.
Andreas Kakarougkas, UK
The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is
dependent on the complexity of damage.
Pamela Reynolds, UK
10.45-11.15
11.15-11.30
11.30-11.45
12.00-1.30
Lunch followed by Poster and Exhibition viewing in Hamilton Centre
1.30-5.00
1.30-2.00
Dynamics of DSB Metabolism and Cellular Effects (Chair: Rhona Anderson)
Dynamics of charged particle-induced DSBs in the context of chromatin.
Burkhard Jacob, De
Cellular Mechanism of DSB Repair by Homologous Recombination.
Roland Kanaar, Nl
PARP-2 modulates PARP-1, XRCC1, and PCNA recruitment to DNA damage sites via
the modification of PARG activity.
2.00-2.30
2.30-2.45
Mohammed-Tayyib Boudra, UK
2.45-3.15
Coffee in Lecture Centre Level 1 foyer
3.15-3.45
The Ins and Outs of Interphase Chromosome Positioning and Repositioning.
Joanna Bridger, UK
DNA double-strand breaks and chromosomal rearrangements.
Tim Humphrey, UK
Loss of the Rb1 tumour suppressor gene promotes telomere attrition and genomic
instability.
Iria Gonzalez-Vasconcellos, De
3.45-4.15
4.15-4.30
4.30-5.00
Hot topic
Molecular and sub-cellular imaging of radiation events
Ultra-short Pulsed Near Infrared Laser Microbeam technique for Sub-Cellular HighResolution DNA Damage, Signalling and Repair Studies.
Stan Botchway, UK
5.00-5.30
ARR AGM in LC-E
6.30-7.30
Poster and Exhibition viewing with refreshments and cash bar in Hamilton Centre
7.30-12.00
BBQ and cash bar in ‘The Hub’
Tuesday 26th June
9.00-10.30
9.00-9.30
9.30-10.00
10.15-10.30
Human health risks: mechanisms and responses after low and high
dose exposures
Exposure to low and high doses (Chair: Mark Hill)
(Session sponsored by L H Gray Trust)
Radiation-related Heart Disease.
Sarah Darby, UK
Risks to Health from the Fukushima Dai-ichi Nuclear Power Station Accident.
Richard Wakeford, UK
Quantitative proteomic analysis of endothelial cells isolated from locally irradiated
mouse hearts.
Soile Tapio, De
10.30-11.00
Coffee in Lecture Centre Level 1 foyer
11.00-11.30
What We Know (and What We Don’t Know) about Radiation Risks Associated with
Contemporary Medical Imaging.
David Brenner, US
Mechanisms of radiogenic disease at high and low doses – challenges and rewards.
Simon Bouffler, UK
Transcriptional dose-responses of radiation biomarkers in human blood samples ex
vivo.
11.30-12.00
12.00-12.15
12.15-12.30
Grainne Manning, UK
Lack of Non-targeted Effects in Bone Marrow Cells of Mice after Low-Dose X
Irradiation.
Nikolay Zyuzikov, T&T.
12.30-2.00
Lunch followed by Poster and Exhibition viewing in Hamilton Centre
2.00-3.30
2.00-2.30
Non-targeted effects (Chair: Giuseppe Schettino)
Bystander Signalling – New approaches and new models?
Kevin Prise, UK
Radiation-Induced Tissue Damage Responses
William McBride, US
The In Vivo Expression of Radiation-Induced Chromosomal Instability Has an
Inflammatory Mechanism
Debayan Mukherjee, UK
Possible role of Exosomes cargo in mediating Non-Targeted Effect of Ionizing
Radiation.
Ammar Al-Mayah, UK
2.30-3.00
3.00-3.15
3.15-3.30
3.30-4.00
Coffee
4.00-4.45
4.00-4.15
SIT Session
(Chair: Laure Marignol)
Radiosensitization of Renal Cell Carcinoma in vitro through the induction of
autophagy.
Selvakumar Anbalagan, UK
Role of Exosomes/Microvesicles in Radiation Induced Bystander Signaling.
Kishore Kumar Jella, Ire.
Effects of the Src inhibitor saracatinib (AZD0530) on the cellular response to
radiation treatment in vitro.
Emily Rowling, UK
4.15-4.30
4.30-4.45
5.00-6:15
Break
6.15-6.45
6.45-7.00
Drinks reception and cash bar in Hamilton Centre
Seated for in Weiss Lecture and Conference Dinner
7.00-7.30
Weiss Lecture in the Newton Room, Hamilton Centre
Understanding radiation-induced cardiovascular damage and strategies for
intervention.
Fiona Stewart, Nl (Introduced by Chair of ARR and presented by Bernard Weiss)
7.30-1.00
Conference Dinner with Jazz entertainment followed by Disco
Wednesay 27th June
9.00-10.30
Translational advances
Radiosensitivity and predictive markers (Chair: Don Jones)
(Session sponsored by Xstrahl)
9.00-9.30
9.30-10.00
10.00-10.15
10.15-10.30
Biomarkers of DNA repair and DNA damage signalling as predictors of radiotherapy
outcome in bladder cancer.
Anne Kiltie, UK
Predicting Normal Tissue Toxicity in Radiotherapy Patients using DNA Repair
Biomarkers.
Chris Parris, UK
The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to
radiation and chemotherapy.
Remko Prevo, UK
Cellular radiosensitization by nitric oxide in anoxia: evidence for the formation of
specific DNA damage.
Lisa Folkes, UK
10.30-10.50
Coffee in Lecture Centre Level 1 foyer
10.50-11.50
10.50-11.20
11.20-11.50
Hot topic: Novel radiotherapy beams (Chair: Marie Boyd)
Dino Jaroszynski, UK
Novel accelerated ion beams for radiotherapy.
Guiesppe Schettino, UK
12.00-1.30
Lunch followed by Poster and Exhibition viewing in Hamilton Centre
1.30-3.00
1.30-2.00
Tumour Microenvironment (Chair: Ester Hammond)
The tumour microenvironment in combined modality therapy.
Gillies McKenna, UK
Tumor radiosensitizing by autophagy-inhibition.
Kasper Rouschop, Nl
The clinical PI3K inhibitor GDC-0941 radio-sensitises thyroid-carcinoma cells by
inhibiting both the PI3K and HIF-1 signalling pathways.
Kaye Williams, UK
Pharmacological inhibition of PI3K reduces hypoxia in 3D via alterations to cell
metabolism
Catherine Kelly, UK
2.00-2.30
2.30-2.45
2.45-3.00
3.00-3.20
Coffee in Lecture Centre Level 1 foyer
3.20-4.50
Combination therapy regimes (Chair: Kaye Williams)
(Session sponsored by CTRad)
Emerging strategies for drug/radiation interactions.
Ian Stratford, UK
Targeting the G2/M checkpoint selectively to improve radiation responses in cancer.
Kevin Harrington, UK
Inhibition of the BER factor APE1 disrupts repair of double-strand DNA damage in
cells treated with low dose-rate, but not high dose rate X-radiation.
Anthony G McCluskey
Potential improvement in the efficacy of proton radiotherapy by inhibition of the
PI3K pathway.
Ai Nagano, UK
3.20-3.50
3.50-4.20
4.20-4.35
4.35-4.50
4.50-5.00
Closing remarks and depart