ITTP studentship awards for 2008-2015*
*Collaborators and co-supervisors in academia and industry/organizations are not
shown
To start 2015
Dr Hendrik
W. van Veen
University of Cambridge
Prof Martin Bushell
MRC Toxicology Unit
Dr V Sherwood
University of Dundee
Dr D Antoine
University of Liverpool
Molecular mechanisms of
bile salt export pump
(BSEP) inhibition in
drug-induced liver injury
Designing novel mRNAbased therapeutic
approaches for non-toxic
delivery of genetic material
Development of a
Mammalian Toxicity
Reporter Model for
Metastatic Melanoma
Therapies
Integrated imaging and
circulating biomarkers
for the assessment of
drug-induced
hepatotoxicity
To start 2014
Prof M Wright
Newcastle
Dr A Povey
University of Manchester
Dr C Goldring
University of Liverpool
Dr Muireann Coen
Imperial College
The role of gut permeability
and increased systematic
inflammatory mediators on
chemical (food and drug)
toxicity.
Origins and biological
significance of alkyl DNA
damage in human sperm.
Manipulation of the
physiological and
toxicological phenotype of
human hepatocytes by
targeting cellular
differentiation and dedifferentiation
Metabolic phenotyping, cell
Dr T Athersuch
Imperial College
death and inflammation; an
integrative mechanistic
approach for improved
stratification of
paracetamol-induced acute
liver failure.
Development of novel in
vitro systems
and quantitative structureactivity
relationships for the
prediction of
adverse xenobiotic
hydrolysis events.
Started 2013
Dr D Antoine
University of Liverpool
Dr D Meek
University of Dundee
Prof A Tobin
MRC Toxicology Unit
Prof A Willis
MRC Toxicology Unit
An integrated assessment of
miroRNA-122 and HMGB1
as mechanistic biomarkers of
drug-induced liver injury.
Influence of p53 pathway in
determining efficacy or
toxicity of treatment with
novel polo-like kinase-1
(PLK1) targeted anti-cancer
therapeutic agents.
Development and analysis of
mouse models to probe the
function and on target
toxicity of drugs that target
G-protein coupled receptors.
Developing novel
biomarkers of cardiotoxicity
Started 2012
Prof. A Willis
MRC Toxicology Unit
Prof. M.MacFarlane
MRC Toxicology Unit
Dr M. Bushell
MRC Toxicology Unit
Dr T. Athersuch
Imperial College
Predicting cell toxicity: The
role of protein synthesis in
the DNA damage response
Investigating the adverse
effects of novel tumourspecific IAP antagonists.
Determining the role of
microRNAs in the Nrf2
pathway following exposure
to toxic agents and their
effects on metabolism.
miRNA biomarkers of
inflammatory lung
pathophysiology arising
from administered
pharmaceuticals and
pollution components.
Started 2011
Dr P. Case
Bristol
Dr M. Cross
Liverpool
Prof J Hayes
Dundee
Dissecting Mechanisms of
Nanoparticle-mediated
Foetal Toxicity
Understanding the role of
micro RNA in drug-induced
cardiovascular toxicity
Mechanism of inhibition of
inflammation by the
antioxidant transcription
factor Nrf2
Start 2010
Dr M. Toledano
Imperial
Dr D. Naisbitt
Liverpool
Dr A. Mercer
Liverpool
Dr D Antoine
Liverpool
Dr J Griffin
Cambridge
Metabonomic and
epidemiological analyses of
disinfection by-products in
public water and risk of
adverse birth outcomes
An investigation to define
piperacillin and ceflazidime
antigenicity and
immunogenicity in patients
with cystic fibrosis
Defining the chemical and
molecular basis of toxicity
induced by the endoperoxide
class of antimalarials
Mechanisms of
Aminoglycoside-induced
nephrotoxicity – integrated
molecular, proteomic,
metabonomic and
histological translational
biomarkers
A metabolomics
investigation of druginduced hpatic
phospholipidosis
Started 2009
Prof. H. Clark
University of Southampton
Dr. M.Coen
Imperial College
Nanotoxicology: particle and
nanoparticles interactions
with opsonins
In vivo comparative
metabolic modelling of
interspecies variation in
hepatocytoxicity
Prof. D. Davies
University of Southampton
Dr J.Griffin
University of Cambridge
Prof. G. Hawksworth
University of Aberdeen
Dr N. Kitteringham
University of Liverpool
Dr D. Williams
University of Liverpool
Dr M. Wright
Newcastle University
Investigation of the potential
health effects of transition
metals in particulate air
pollution
A functional genomic
approach to understanding
lipid biosynthesis and
organelle proliferation in the
liver as an early indicator of
the effects of non-genotoxic
carcinogens
Regulation of hepatic drug
transporters: species
differences and effect of
cholestasis
Structure-metabolism
analysis of the disposition
and immunogenicity of
PEGylated proteins
Integrated assessment of
serum biomarkers of drug
bioactivation, lipid
peroxidation, apoptosis and
necrosis in animal models of
hepatic and renal stress.
Myofibroblasts and their
regulation of hepatic
stem/progenitor cell function
after injury
Started 2008
Dr T Gant
MRC Toxicology Unit
Prof. T Harkany
University of Aberdeen
Role of miRNA species and
mRNA translation in
mechanistic and evaluative
toxicology in differentiated
cardiac, hepatocyte and
pancreatic islet cells from
stem cells.
Cannabinoid receptor
antagonism and
malformations in developing
brain
Prof J Hayes
University of Dundee
Dr C Henderson
University of Dundee
Dr K Herbert
University of Leicester
Prof I Kimber
University of Manchester
Dr S Minger
King’ College, London
Dr Palmer
University of Dundee
Prof BK Park
University of Liverpool
Dr M Soller
University of Birmingham
Dr K Young
MRC Toxicology Unit
Inhibition of apoptosis by
transcription factors Nrf1
and Nrf2 occurs mainly
through regulation of
intracellular redox status
Non catalytic mechanisms
involved in glutathione Stransferase P (GST-P)mediated cytoprotection
Mitochondrial DNA-damage
and toxin induced vascular
endothelial cell ageing
Interleukin 17 and the
development of allergic
sensitization to chemicals
Development of human stem
cell populations for
integrative toxicology
The role of PPAR-delta
agonists in hepatic steatosis
Investigation of drugspecific cellular responses
relevant to drug-induced
immune liver injury in man
Susceptibility of alternative
mRNA processing to
interference by small
molecules; implications for
drug design and toxicity
Role of Bcl-2 family
proteins in neurotoxic cell