0011/0711 Section, L07 THE IMPORTANCE OF THE DEVELOPMENT OF NEURAL PROSTHETICS AND ITS APPLICATION IN COGNITIVE REHABILITATION Erica Reiser (ELR56@pitt.edu) “physically independent, but have such significant disorders of cognition that they are unable to perform the most basic tasks.” Even patients who seem to have good cognitive skills on the surface can be presented with subtle changes in behavior and personality that make them strangers to their friends and families [2]. Although the biotechnologies applying to the physical aspect of rehabilitation and recovery are obviously essential, it is critical to give attention to the mental component as well. This component is also extremely important because “the recovery of physical abilities and functional skills such as mobility occurs rapidly, often within 3 months after injury; however, recovery of cognitive abilities (particularly higher level cognitive and communicative skills) tends to take much longer.” There doesn’t seem to be a final endpoint to the recovery process; rather, the pace of recovery slows with time and its span narrows [3]. This being said, with the continual development of neural prosthetic devices, the recovery of these cognitive skills will be faster and more efficient. The goal is to keep the mind on track with the body while the patient is going through their recovery process. The number of people with cognitive disorders is increasing along with the demand for neural prosthetic technologies which is why I think this topic is so important today. “Globally, the number of people older than 65 years is anticipated to double between 1997 and 2025” and “perceptive, cognitive, and musculoskeletal diseases that impair motor skills dramatically increase with age” [4]. So, although neural prosthetic technology has helped more people to live longer, this increase in the elderly population also means that more technology is needed to help them. “The population of people with reduced functional capabilities due to aging or disability is already a large and growing segment of our world and the number and percentage of people in need of advanced assistive technology are increasing every year. About 60 million Americans already have a disability that affects one or more of their major life activities” [4]. INTRODUCTION The continual focus on the development of neural prosthetic technology is imperative in the bioengineering field because of its application in cognitive rehabilitation. This technology includes artificial extensions to the body, especially the brain, that can restore or supplement functions of the nervous system lost during injury or disease. Helping disabled individuals acquire the ability to regain control of their bodies is important because it will help lead them to fuller and more productive lives [1]. Some examples of neural prosthetic application include the procedure of deep brain stimulation for patients with Parkinson’s disease and the cognitive rehabilitation of injured soldiers. These examples illustrate the application and importance of neural prosthetics as a way to improve people’s lives. It is important that the development and use of neural prosthetic technology follows the codes of ethics for engineers and bioengineers specifically. As a proponent of neural prosthetics, I feel that although the technology is extremely useful, it should only be developed and used in a fair and ethical way. Being a prospective engineer, the main reason I want to go into the field of bioengineering is to have an opportunity to develop medical technologies that will positively impact people’s lives. I chose to research neural prosthetics because it is a relevant and life-changing component of the bioengineering field. This demonstrates the value of such a project of research and writing within a freshman engineering education. During this assignment I learned about something I was interested in while also gaining knowledge of the realworld application and business side of engineering as well as developed my writing skills. I highly recommend that this project be included in any freshman engineering education curriculum. THE IMPORTANCE OF NEURAL PROSTHETIC TECHNOLOGY TYPES OF NEURAL PROSTHETIC TECHNOLOGIES AND HOW THEY WORK I believe that the development of neural prosthetic technology is well worth the time and energy of bioengineers because it aids in the process of cognitive rehabilitation which is extremely important although sometimes overshadowed by physical rehabilitation and recovery. Advancements in external prosthetics such as prosthetic arms and legs are often discussed; however, they are not necessarily the most crucial type of prosthetic. Often the most tragically disabled patients are those who are There are several different types of neural prosthetic technologies used in cognitive rehabilitation, but one most commonly used is the neural interface. “Neural interfaces are systems operating at the intersection of the nervous system and an internal or external device.” Research in neural interfaces and development of neural prosthetics has University of Pittsburgh, Swanson School of Engineering October 30, 2012 1 Erica Reiser benefited patients by providing substantive aid to individuals in need [1]. “One example is the development of cochlear implants, which bypasses damaged hair cells in the auditory system by direct electrical stimulation of the auditory nerve. In addition, neural interfaces that allow deep brain stimulation have been useful for some patients in reducing the motor symptoms associated with Parkinson's disease” [1]. Deep brain stimulation is used on patients whose medications do not help them overcome debilitating symptoms such as tremor, rigidity, and slowed movement. “Deep Brain Stimulation uses a surgically implanted, battery-operated medical device called a neurostimulator—similar to a heart pacemaker and approximately the size of a stopwatch—to deliver electrical stimulation to targeted areas in the brain that control movement, blocking the abnormal nerve signals that cause tremor and Parkinson’s Disease symptoms” [5]. Before the procedure, the exact location in the brain where the symptoms are being produced is targeted so that the deep brain stimulation system can be inserted. A thin insulated wire which is connected to the neurostimulator is connected to the brain through a small opening in the skull. After this system is inserted, it works by electrical impulses being sent from the neurostimulator into the brain. These impulses interfere with and block the electrical signals that cause the Parkinson’s disease symptoms. Several other diseases have been targeted for neural prosthetic applications as well. Individuals suffering from stroke, spinal cord injuries, and amyotrophic lateral sclerosis have benefitted from neural prosthetic devices that have assisted them in improving their quality of life by helping them to regain their cognitive functions such as their communicative and motor skills. One group in particular that has been dramatically impacted by this new technology is injured soldiers. Today, the rehabilitation of wounded armed service members is higher than anyone could have imagined a few years ago. Some soldiers who have gone through rehabilitation and would like to return to active duty are sometimes even given the opportunity to do so. “Robert Gailey, PT, PhD, associate professor at the University of Miami’s Department of Physical Therapy and director of the Functional Outcomes Rehabilitation and Evaluation Laboratory at the Miami VA Medical Center, has seen changes in military rehabilitation protocols over the past few years, largely due to new prosthetic technologies. He says, “The military recognized it has a large investment in the soldiers, both in their education and ability to serve, and that, if possible, it’s best to bring them back into active service”” [6]. Amputee soldiers often receive external prosthetics, but there are also a significant number of soldiers who return home with traumatic brain injury or post-traumatic stress disorder that are in need of an internal prosthetic device. With the continual development of neural prosthetics, I hope that we can help these soldiers regain themselves and live happy, healthy lives. ETHICS The NSPE Code of Ethics has several key points that I find most relate to the field of bioengineering and in particular the development and use of neural prosthetic technology. Under the first fundamental canon which is “Hold paramount the safety, health, and welfare of the public”, there is a point that states “If engineers' judgment is overruled under circumstances that endanger life or property, they shall notify their employer or client and such other authority as may be appropriate” [7]. This pertains to all types of engineering but I find it especially important in the bioengineering field because it deals most closely with the health of patients. Bioengineers sometimes perform procedures that can be very dangerous and sometimes even life-threatening, so it essential that there be a part of the code that addresses this. Some of the procedures involved in inserting neural prosthetic technologies are invasive and therefore potentially dangerous, especially because they involve the brain. It is important that clients know, before endangering their lives, if the procedure is the best for their circumstance. Another area of the NSPE Code of Ethics is under the canon which says “Perform services only in areas of their competence” [7]. This seems obvious, but in the bioengineering field, lines can be blurred between medical doctors and engineers. Concerning the medical health of a patient, an engineer should not overstep their boundaries to make important decisions about a patient’s well-being. In regard to neural prosthetics, engineers have the capability to develop the technology and put it to use on a patient, but not necessarily diagnose the patient. For example, if someone has a disease that affects their cognitive abilities, the engineer will develop the technology to help them out, but not diagnose them with the disease or decide what treatment is done. Other than the general code of ethics for engineers, there is also the BMES Code of Ethics for bioengineers. The two parts of this code that I found to be most significant are the “Biomedical Engineering Professional Obligations” and the “Biomedical Engineering Health Care Obligations”. The professional obligations section includes that engineers shall “Use their knowledge, skills, and abilities to enhance the safety, health, and welfare of the public” and “Strive by action, example, and influence to increase the competence, prestige, and honor of the biomedical engineering profession” [8]. To me, enhancing the safety, health, and welfare of people should be the main goal of bioengineers which is why I favored this section. The goal of bioengineers should not be to make money or to create ineffectual technologies; it should be to help better people’s lives. If a certain technology had only been created for profit, and it wasn’t really needed then all the time and energy it took developing that technology would have been wasted and could have been used to create something beneficial. 2 0011/0711 Section, L07 The second section I mentioned states that engineers involved in health care activities shall “Regard responsibility toward and rights of patients, including those of confidentiality and privacy, as their primary concern” and “Consider the larger consequences of their work in regard to cost, availability, and delivery of health care” [8]. This section has to do a lot with the medical side of bioengineering and particularly relates to neural prosthetics since it is in a professional, health care related field. Unlike some other types of professional engineers, bioengineers often have patients; therefore, the code of ethics regarding these patients must be similar to any other profession that deals with patients such as medical doctors and psychologists. One particular point that is relevant to the development and use of neural prosthetic devices is the second point that talks about the consequences of work in regard to cost, availability, and delivery of health care. Even though bioengineers may have the knowledge and skills needed to create a certain device doesn’t mean they have to disregard the factors of cost, availability, and delivery of the technology. These aspects are all very important when figuring the best and most efficient way to incorporate a new biomedical technology, such as neural prosthetic devices, into a system. In my opinion, these codes of ethics can be easily followed and are generally followed by all professional engineers. After researching these codes of ethics, I have come to a conclusion that the continual development and use of neural prosthetic technology is conducted under these codes and there is no ethical reason to object to this development. Neural prosthetics are designed to ameliorate the health, safety, and welfare of the people and done so in a fair and trustworthy way. broader perspective of the issues that concern their profession such as social, environmental, and economic issues, but they haven’t” [9]. Although I haven’t has much experience in the engineering world yet, I agree that having the broad perspective is crucial for future engineers. In my opinion, this writing assignment was a good way to introduce students to these areas of social, environmental, and economic issues because it forced us to learn about engineering applications in the business world and what it entails. Writing about the development and use of neural prosthetic devices and how they are used in cognitive rehabilitation made me realize that there are many social aspects to bioengineering such as dealing with patients and working with other engineers and professionals. Incorporating the codes of ethics into the assignment was also very informative because it taught me how professionals engineers are expected to behave in. One problem that the article discusses is that “Engineering curricula are too focused on engineering science and technical courses without providing sufficient integration of these topics or relating them to industrial practice. Programs are content driven” [9]. Although this may be true for many engineering schools around the world, at the University of Pittsburgh there seems to be a heavy concentration on educating students on all aspects of engineering, not just the technical ones, and this writing assignment is an example of that. In reality, professional engineers need writing skills as well as technical skills and social skills to succeed. I highly recommend that engineering schools incorporate assignments and projects like this one into their curriculum if they haven’t already to better prepare their students for future success. CONCLUSION EDUCATION The use of neural prosthetic technology is and will be continued to be used as an option in the process of cognitive rehabilitation. One of the worst impairments that a person can have is not being able to control their own mind or body, but with the continual research and development of neural prosthetics, recovery is becoming increasingly likely. Helping those unfortunate enough to be stricken with Parkinson’s disease or those who have been injured risking their lives for their country should be the number one priority to those who can help. This is especially the case for bioengineers, whose job it is to develop aids that help people in need and to use their knowledge to solve real-world, biological problems like these. Besides the examples provided in this paper, think about how many other diseases and disorders there are that could potentially be fixed using similar processes. Nothing is more valuable than life itself, and not being able to fully live is a travesty. Bioengineers have already made so many huge strides with the success of several neural prosthetics operations and they shouldn’t stop now especially since they Writing this paper and researching neural prosthetics as well as engineering ethical codes was a very eye-opening and interesting experience for me. I learned so much about neural prosthetics and their role in cognitive rehabilitation which was fascinating, but more importantly I was exposed to an example of an application of bioengineering to help me understand more about what bioengineers actually do. This pertains to researching the ethical codes also. I think it is important to be familiar with the engineering code of ethics and although I don’t feel that it necessarily needs to be incorporated into the engineering education curriculum, I think this assignment was very beneficial in providing an understanding and overview of the codes. This assignment familiarized me with the code of ethics and how it is relevant in engineering practice and I recommend that it be continued and shared with other engineering programs. A recent article on engineering education discusses several problems within the engineering education system. The article argues that engineering students “need to have a University of Pittsburgh, Swanson School of Engineering October 30, 2012 1 Erica Reiser are doing it in an ethical manner. It is important that engineering students like me learn about these codes of ethics and how they are followed in the professional engineering world. This is why I recommend that this project be included in all freshman engineering education curriculums. I have benefitted greatly from researching and writing about the codes of ethics and applications of biotechnology. The bioengineering field is one of the most relevant and essential, which is why I chose to write about it and why I aspire to become a bioengineer. [8.] "BMES | Code of Ethics." BMES | Code of Ethics. N.p., n.d. Web. 30 Oct. 2012. <http://www.bmes.org/aws/BMES/pt/sp/ethics>. REFERENCES AKNOWLEDGEMENTS [9.] Mills, Julie E., and David F. Treagust. "Engineering education—Is problem-based or project-based learning the answer?." Australasian Journal of Engineering Education 3 (2003): 2-16. <http://champs.cecs.ucf.edu/Library/Journal_Articles/pdfs/E ngineering%20Education.pdf>. [1.] "Neural Interfaces Program." : National Institute of Neurological Disorders and Stroke (NINDS). N.p., n.d. Web. 08 Oct.2012. <http://www.ninds.nih.gov/research/npp/index.htm>. I wish to express my gratitude towards Professor Bateman Newborg and Dr. Bursic for giving me all of the essential tools and information that made this assignment possible. Thank you to the library staff of the University of Pitsburgh for helping inform me about the university’s online library system. Lastly, I would like to thank Jennifer Greene for answering, to the best of her ability, all of my questions regarding this paper. [2.] Burns, Lauren. "Cognitive rehabilitation following traumatic brain injury." CME: Your SA Journal of CPD 26.3 (2008): 160+. Academic OneFile. Web. 8 Oct. 2012. <http://go.galegroup.com/ps/i.do?id=GALE%7CA20448222 8&v=2.1&u=upitt_main&it=r&p=AONE&sw=w>. [3.] Whyte J, Hart T, Laborde A, Rosenthal M. Rehabilitation of the patient with traumatic brain injury. In: Delisa JA, Gans BM, eds. Rehabilitation Medicine Principles and Practice, 3rd ed. Philadelphia: LippincottRaven, 1998: 1195-1196. [4.] Center for Health Workforce Studies. The Impact of the aging population on the health workforce in the United States. School of Public Health, University at Albany; 2006. <http://www.sciencedirect.com/science/article/pii/S1350453 308001641#>. [5.] National Institute of Neurological Disorders and Stroke (NINDS). N.p., n.d. Web. 08 Oct. 2012. <http://www.ninds.nih.gov/disorders/deep_brain_stimulation /deep_brain_stimulation.htm>. [6.] Waldrop S, Wojciechowski M. The "Bionic" Warrior: Advances in Prosthetics, Technology, and Rehabilitation. PT: Magazine Of Physical Therapy [serial online]. April 2007;15(4):60-66. Available from: Academic Search Premier, Ipswich, MA. Accessed October 8, 2012. <http://web.ebscohost.com/ehost/pdfviewer/pdfviewer?sid= 52807fcc-908b-4d17-8577e6cf9bbbe8d1%40sessionmgr115&vid=2&hid=110>. [7.] "NSPE Code of Ethics for Engineers." NSPE Code of Ethics for Engineers. N.p., n.d. Web. 30 Oct. 2012. <http://www.nspe.org/Ethics/CodeofEthics/index.html>. 2 0011/0711 Section, L07 University of Pittsburgh, Swanson School of Engineering October 30, 2012 1