CESCG Call 2: Collaborative Research Program Application Information (Part B) 1. Principal Investigator Name: Title: Institution: Department: Address: Phone: Email: Percent Effort on this Project: Percent Salary Charged to this Subcontract (if applicable): 2. Authorized Organization Official An AOO is an individual named by the applicant organization who is authorized to act for the applicant organization and to assume the obligations imposed by the laws, regulations, requirements, and conditions that apply to applications and contracts. Name: Title: Institution: Address: Phone: Email: Assurances (SCRO, IRB, IACUC) If your project requires review and approval for Stem Cell Research (SCRO), Human Subject Use (IRB) and / or Vertebrate Animal Use (IACUC), you will need to provide evidence of such approval prior to CRP project funding being issued. Research Area (check one) The CESCG will support all competitive genomics research projects that are relevant to the mission of CIRM, but clinically oriented projects are of particular interest. Can this project be classified as supporting translational research efforts and/or precision medicine? ( ) Yes ( ) No 3. Budget Justification CESCG Resources Justification These funds will be paid by CIRM directly to the CESCG. They will not be distributed to your institution. In this section, provide a justification for the CESCG resources requested in the context of the proposed research. Provide sufficient explanation and detail to enable CESCG and external reviewers to clearly understand the rationale and reasonableness of types and amounts of resources requested. CESCG Resources (listed on the CESCG CRP website http://med.stanford.edu/cescg/CRPs/): List all CESCG resources (types and number) you request for your project, the direct costs for each service, and justify their use. CESCG Bioinformatics Cost For most Regular CRP projects with standard analytical requirements bioinformatics resources will be available as needed and do not need to be budgeted separately. If requested, the cost of this item will be determined through consultation with CESCG (contact information at http://med.stanford.edu/cescg/CRPs/). List the negotiated amount (direct costs) and justify. Additional funds In addition to the CESCG resources, I request funds for activities in my laboratory. ( ( ) Yes ) No If No, please sign #9.,Certification If Yes, please fill out #4-9 4. Award Mailing Address Attention: Department: Address: 5. Budget Justification, continued Justification of Collaborator Budget These funds will be disbursed to your organization through a subcontract from a CESCG partner institution, Stanford University or The Salk Institute for Biological Studies. Collaborator budgets are limited to 25% of total project direct costs unless a letter from CIRM indicating prior approval for exceeding this limit is provided with the application. In this section, provide a justification and describe the basis for the costs in the proposed Collaborator Budget, i.e. for the funds requested for activities in the applicant’s laboratory. Please justify all costs in the context of the proposed activities. Provide sufficient explanation and detail to enable CESCG and external reviewers to clearly understand the rationale and reasonableness of amounts proposed in all budget categories (e.g., Personnel, Supplies). Key Personnel Sub-subcontracts / Consultants Justify key personnel needs in relation to the activities proposed. ANY INDIVIDUAL OR ORGANIZATION REFERENCED MUST HAVE BEEN LISTED IN THE KEY PERSONNEL SECTION of Part A of your application. Personnel costs are limited to $40,000 per year. A consultant is an individual who provides professional advice or research services related to the proposed project for a fee. Aside from small consulting contracts, fund recipients may not use CIRM funds to contract for research to be performed outside of California. Consulting contracts for out-of-state research are limited to $15,000 per year for a single contract, and $25,000 per year in aggregate. Any amount exceeding these limits may not be allowed should the application be approved for funding. Additional Unnamed Personnel: Describe the specific roles, activities, and number of personnel to be supported by these funds. DO NOT IDENTIFY ANY OF THESE INDIVIDUALS BY NAME. Supplies: Describe proposed expenditures for all supplies in relation to activities proposed. Travel and Equipment : These costs are not allowed under CESCG Call 2. 6. CIRM Major Facility Certification This section should be completed by your Institutional Official. For institutions that have a CIRM Major Facility, this certification is required in order to determine the level of facilities cost reimbursement that will apply to this award, if funded. (Use your institution's standard facilities rates in the application. Any necessary adjustment will be made later.) Does your organization have a CIRM Major Facility? ( ) Yes ( ) No If you answered 'Yes' above, please check the following that apply: [ ] The Principal Investigator is not associated with the research program identified in Part 1, subpart B of the Applicant Institution's Major Facilities Grant Award application that was proposed to be located in the CIRM-funded Major Facility [ ] The Applicant Institution did not identify the Principal Investigator in the Applicant Institution's space plan submitted to CIRM at the time of completion of construction as a researcher who would be located in the CIRM-funded Major Facility [ ] The institution has allocated space, outside the Major Facility, in which the PI will conduct the proposed research, and the PI will not make use of the Major Facility, aside from occasional use of shared specialized resource 7. Biosafety Certification [ ] I hereby certify that organizational approval for any proposed use of biohazardous materials, radioisotopes, and/or controlled substances is current and will remain in effect for the proposed project period. I also certify that key personnel will obtain formal training and appropriate authorization for the use of biohazardous materials, radioisotopes, and/or controlled substances prior to their commencing work on the proposed project or activity. 8. Related Business Entities Disclosure If your Application seeks funding for a for-profit organization, California conflict-of-interest laws require disclosure of business entities that are related to that "Funded Company". Disclosure is required for any company that would receive funding as the applicant organization, as a subsubcontractor, or as the employer of a co-investigator, sub-subcontractor or consultant. For-profit organization means: a sole proprietorship, partnership, limited liability company, corporation, or other legal entity Related Business Entity means: 1. a for-profit organization that owns 50% or more of the Funded Company's voting shares; 2. a for-profit organization subsidiary in which the Funded Company owns 50% or more of the voting shares; 3. a for-profit organization that is under the same management and control as the Funded Company or with which it shares a controlling owner. The Application does propose funding for one or more for-profit organizations identified by name. ( ) Yes ( ) No If yes, please provide the following information; copy and paste the below entries for more funded companies and RBEs as needed. Funded company name: List all Related Business Entities (RBE) for the Funded Company RBE name: 9. Certification I certify that the statements herein are true and complete Signature of PI: I certify that the statements herein are true and complete Signature of AOO: