Committee Report
SNM Board of Directors
June 3 & 4, 2010
RADAR (RAdiation Dose Assessment Resource)
Committee Charges for 2010:
This is currently under discussion. We have proposed:
1. Compile and disseminate data in readily accessible electronic form, for practical internal dose
applications generated by RADAR and others, including radionuclide decay properties and
emissions, biokinetic model parameters, absorbed fractions, and anatomic models.
2. Maintain compendia of accepted dose estimates for established radiopharmaceuticals , in readily
accessible electronic form, including organ doses, effective doses, and other relevant quantities.
3. Develop new practical models and methods for implementation of internal and external dose
calculations.
4. Develop and implement software and internet interactive tools that implement dose-related
calculations and models.
5. Provide interpretation and guidance to the nuclear medicine community on practical issues
regarding regulatory compliance, patient and family issues regarding radiation dose, and related
areas.
6. Develop clinically useful and implementable methods for correlating dose with response to evaluate
the relevance of factors, in addition to absorbed dose, that influence biological response from
internal emitters.
Current Working Objectives/Goals:
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Continue work on the new phantoms and their use in OLINDA/EXM v2.
Continue work on SAF calculations for various models as needs arise.
Present CE sessions at SNM Annual Meetings.
A survey was developed and sent to ~60 hospitals to gather data on administered activity
typically given to patients; data will be collected and interpreted.
An article on a new dosimetry model for Rb-82 was submitted to the Health Physics Journal.
Two RADAR members are finalizing a document presenting an alternative method for improving
the correlation of absorbed dose with nephrotoxicity for PRRT treatment and addressing the
relevance of external-beam radiotherapy derived factors for use in radionuclide therapy.
Continue to update the RADAR website with data, guidance documents, dose calculation tools
and other features; constantly improving the site.
Reviewing role in standardization of dose as the conversation about cumulative dose tracking
evolves.
Respond to requests for position papers and guidance documents
Progress of Charge/Objectives/Goals to Date:
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Continue work on the new phantoms and their use in OLINDA/EXM v2
o Several articles have been accepted for publication; other submitted articles are
currently under evaluation.
Continue work on SAF calculations for various models as needs arise
o Ongoing
Will present 2 CE sessions at the upcoming SNM Annual Meeting
o George Xu has organized and will present material in a session on Dose Estimation and
Reduction in PET/CT Imaging
o Mike Stabin has organized and will present material in a session regarding New Internal
Dose Models – Evaluation and Impact
A survey was developed and sent to ~60 hospitals to gather data on administered activity
typically given to patients; data will be collected and interpreted.
o A few responses have been received, but more are needed.
An article on a new dosimetry model for Rb-82 was submitted to the Health Physics Journal
o Article accepted.
Two RADAR members are finalizing a document presenting an alternative method for improving
the correlation of absorbed dose with nephrotoxicity for PRRT treatment and addressing the
relevance of external-beam radiotherapy derived factors for use in radionuclide therapy
o Article submitted, awaiting reviews.
Continue to update the RADAR website with data, guidance documents, dose calculation tools
and other features; constantly improving the site.
o A new compilation of gamma ray constants and lead shielding requirements for over
1000 nuclides has been completed; an article is being prepared for journal submission.
o Total number of monthly “hits” on the RADAR site is up from 30K to 40K in the past few
months.
Reviewing role in standardization of dose as the conversation about cumulative dose tracking
evolves
o Ongoing discussion.
Respond to requests for position papers and guidance documents
o Has provided up-to-date dosimetry data for five different radiopharmaceutical types to
SNM leadership to aid in understand patient implications when switching from 99mTc to
different radionuclides.
o Developed a draft white paper as requested by Dr. Michael Graham regarding the
benefits of nuclear imaging procedures.
Additional Goals/Objectives Added for 2010:
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Complete quality assurance review and implementation of new generation phantom SAFs and DFs in
OLINDA/EXM.
Augment response rate to survey on radiopharmaceutical use and publish the results.
Provide CE training at 2010 meeting and prepare new sessions to be proposed for the 2011 meeting.
Complete publication of phantom descriptions, gamma ray constant data, PRRT models.
Develop guidelines to be proposed for tracking of pharmaceutical doses by adult and pediatric
patients.
Respond to further requests of SNM leadership for position papers and dosimetry for alternatives to
99m
Tc procedures.
Perform a review of dose/risk models and provide commentary on practical implementation of
these models in low dose/dose rate situations.
Augment the existing evaluation of the numerical benefits of medical examinations
(http://hps.org/hpspublications/articles/Benefitsofmedradexposures.html) using radiation and
publish the analysis.