Michael E. Greer, M.D.
Holistic, Herbal & Homeopathic Lectures & Consultations
737 Olive Way, Suite 1804, Seattle, WA 98101
Tele (mobile): (206) 383-9072 Fax: (206) 971-7428 (Attn: Dr. Greer)
michaelgreermd@comcast.net www.michaelgreermd.com
The Truths and Myths of Gluten and Celiac Disorders:
Inflammation and Subluxation Essentials
Hour-by-Hour Outline for CMU Certification
12- Hour Seminar
Seminar Approach
Gastrointestinal diseases are now one of the most common topics of discussion and are one of the most
common reasons patients seek medical attention. The gut mucosal surfaces deal with the largest amount
of antigens confronting the body and have a very specific anatomical configuration in order to fulfill the
delicate task of distinguishing between pathogenic bacteria and toxins, and the beneficial substances like
food particles and commensal bacteria. The gut mucosa, as well as the other mucosal surfaces, can be
seen as an extension of our sensory system, or a "sixth sense”. Exposure to Gluten in the genetically
susceptible person will trigger an avalanche of antibodies that are regarded as extreme systemic
inflammation that can manifest disorders in bone and joint diseases as a result of the Lymphocytic T-cell
response. GI malfunction including Gluten and Non-Celiac Gluten Disease can be responsible for IBS,
allergic and immune dysfunction such as asthma, Rheumatoid arthritis, Chiropractic Subluxation, Type 1
diabetes, autism and Hashimoto’s thyroiditis. A clear respect and understanding of the interworkings of
the GI system is essential to Chiropractic and Naturopathic Health. Dr. Greer will explain the intricate
details of the GI system and relate common issues such as Celiac Disease and Gluten Intolerance and
detail the “triggers” that activate these and other related conditions.
(Due to the complexity of this subject matter, this seminar is only in a 12-hour version.)
Seminar Elements
Gluten and Celiac Disease Overview (2 Hours)
Detection of CD (1 Hour)
Non- Celiac Gluten Sensitivity: Hype or new epidemic (2 Hours)
GI Digestive Health Basics (1 Hour)
Basic and Advanced Immunology T-Cell specifics (2 Hours)
Probiotics and Immunity (1 Hour)
Nutrient Insufficiencies (1 Hour)
Detoxification Factors (1 Hour)
Detoxification Suggestions Questions, Answers, Case Studies (1 Hour)
1
Gluten and Celiac Disease Overview
HOUR ONE
From Gluten to Immune Dysfunction Principles
Celiac Disease as a Role Model in Understanding Autoimmune Disorders
Gluten-Free Economics
Gluten-Free Trends
Gluten Awareness and Family Support
Gluten-Free Logic and Food Perception
Defining Celiac Disease
Dermatitis Herpetiformis – DH
Celiac Disease and its Other Associated Autoimmune Diseases
The Genetics of Celiac Disease
Progressing from Gluten to Immune Dysfunction
Celiac Disease Statistics
Other Associated Autoimmune Diseases
Subluxation Factors Secondary to Celiac Inflammation
HOUR TWO
Historical Perspective – The Birth of Celiac Disease
Prevalence of CD (Celiac Disease)
Symptoms of Celiac Disease
Increased Intestinal Permeability
Leaky Gut Syndrome
Leaky Gut Associated Diseases
Chronic Diarrhea
Fatigue and Irritability
Subluxation
Differences of Adults and Children with CD
Causes of Celiac Disease
Ingestion of Gluten
Leaky Gut
Trigger to Activate the Gene IF Present
Gluten Education Essentials
What is Gluten?
Proline Glutamine Peptides
Gluten Targets
Gluten Exposure and Timing
Basic GI Function
Autoimmunity and Subluxation
Autoimmunity and Thyroid, Cardiac, and Inflammatory disorders
Classic Celiac Presentations
2
Detection of CD
HOUR THREE
Understanding Celiac Disease
Timing
Future Incidence of Celiac Disease
Initial testing for CD
tTG – Blood Testing
Testing and Predictions of Disease
Gluten Challenge
Gluten Repair Factors
Deaminated Gliadin Peptide
Immune Globulins
IgA
EMG –IgA
Total IgA
Outdated Testing
Controversy in Testing
HLA-DQ Essential Information
Dx of Celiac vs Non – Celiac Disease
Wheat Sensitivity vs. Allergy
Variations in Wheat and Gluten
Wheat Kernel Components
FODMAPs
Wheat Production and Consumption
Information and Factors for Subluxation
Celiac Disease and Non-Celiac Gluten Disease
HOUR FOUR
Hype or New Epidemic?
Dietary Acceptable Foods for Gluten
Rice
Corn
Grits
Quinoa
Hidden Gluten Sources
Lactose Intolerance and Celiac Disease
The Gut Mucosa – The Sixth Sense
The Digestive Track
Digestive Enzymes
Digestive Health Functions
The Six Components of the Gut
Leaky Gut Definition
Leaky Gut Factors
3
Leaky Gut Associated Diseases
Leaky Gut Causes
Components of the Gut Immune Barrier
Mucosal Response to Food
Mucosal Barrier Dysregulation
Antibody Testing Specifics
ATA or anti-tTg
Tissue Transaminase
Endomysial Antibody (EMA;IgA)
IgA Deficiency
Antigens NOT Detected in Conventional Testing
Subluxation and Inflammation
Celiac Disease and Non Celiac Gluten Disease
HOUR FIVE
Frequency Within Population
Diagnosis of Celiac Disease
Prevalence of Celiac Disease
Clinical Consequences in Adults
Triggers of the Celiac Population
The Importance of Celiac Diagnosis and Timing
Increased Incidence of Type I Diabetes
Increased Incidence of Autoimmune Thyroiditis
Celiac Disease and Associated Autoimmune Diseases: The Connection
Celiac Disease – Dermatitis Herpetiformis Association
Genetic and Immunological linkages with Celiac Disease and Dermatitis Herpetiformis
Increased Risk of Developing One or More Associated Autoimmune Diseases:
Addison's Disease
Autoimmune Chronic Active Hepatitis
Insulin Dependent Diabetes Mellitus (type I)
Myasthenia Gravis
Pernicious Anemia
Raynaud’s Phenomenon
Scleroderma
Sjogren's Syndrome
Systemic Lupus Erythematosus
Thyroid disease – Graves' Disease and Hashimoto's Thyroiditis
Celiac Disease and Its Effects on Fertility
Treatment of Celiac Disease
Making the Diagnosis of Celiac Disease
HLA-DQ2
HLA –DQ8
Triggers to Activate Celiac Disease
Autoimmunity Factors
Zonulin
Irritable Bowel Syndrome (IBS)
4
Prevention
Symptoms
Influencing Factors
T-cell and Cytokines
Factors Affecting Subluxation with IBD
TNF alpha and IL-1
Extra- Intestinal Manifestations of Inflammatory Bowel Disease (IBD)
Ulcerative Colitis
Crohn’s Disease
Differences
Factors
Digestive Support Products
HOUR SIX
Products that Support Intestinal Defense
Broad Microbial Defense
Berberine Sulfate (found in goldenseal and Oregon grape)
Goldenseal Extracts
Garlic
Black Walnut Extract
Sweet Wormwood
Healthy Yeast Balance
Oregano Oil
Thyme
Pau D’Arco Bark
Enzymes for Gut Health
Basic and Advanced Immunology T-Cell Specifics
HOUR SEVEN
Cell-to-cell Communication
TH3 Helper Cells
Slanted TH2 Response
T cell Dysfunction
Stress and Immunity
Cytokines
Cortisol: Clinical Manifestations
Subluxation Factors Influenced by Cortisol
GI Tract as its Immune Role
Immune Reactivity
Immune Totality
Immune Alliance
Humoral and Cell-Mediated Immunity
GI Disease and T-Cells
Molecular Immunology
Organization of the Immune System
5
MALT
GALT
Basic Immunophysiology
HOUR EIGHT
Historical Perspective
Thymus
Lymphocytes
T Lymphocytes
B Lymphocytes
Th-1 and Th-2
Autoimmune Disease Prevention
Age Range of Autoimmune Diseases
Frequency of Women - Autoimmune Diseases
Genetic Factors Playing a Role in the Development of Autoimmune Diseases
HLA – DQ 2 and HLA – DQ 8 to Establish the Possibility of Celiac Disease
Environmental Triggers Activating Celiac Disease and Other Autoimmune Diseases
Common Genes Causing Multiple Immune Diseases
Immune Support Products
Vitamins
Mushrooms
Spleen and its Role
Ashwaganda
Echinacea
Eleuthro
Zinc
Probiotics and Immunity
HOUR NINE
Reestablishing Healthy Microflora
Lactobacillus – Primary Probiotics in the Small Intestine
Bifidobacteria – Primary Probiotics in the Large Intestine
Fructooligosaccharides
Prebiotics - Promoting Beneficial Microflora in the Large Intestine
The Vastness of Bacteria
Definitions of Probiotics
Definitions of Prebiotics
Probiotic Function
Benefits of Probiotics
Deficient Intake of Probiotics
Historical Insight for Probiotics
Lactobacilli as Probiotics
100 lactobacillus species
L acidophilus
Bifidobacterium
6
Enhanced Cholesterol Excretion with Probiotics
Benefits of Probiotics
Cancer Prevention
Immune Enhancement
The Role of Gut Health
Bacteria
Gut Flora
Antibiotics Contributing to Leaky Gut Syndrome
Zonulin – A Protein Identified as a Critical Regulator
Elevated Zonulin associated with:
Rheumatoid Arthritis
Inflammatory Bowel Disease
Type I Diabetes
Celiac Disease
Other Multiple Autoimmune Diseases
Nutrient Insufficiencies
HOUR TEN
Gut Healing Products
Omega-3 and Omega-6 Comparison
Inflammatory LOX Inhibitors
Curcumin and Boswellia
Antioxidant Function
Antineoplastic Function
Anti-inflammatory Function
Cytotoxic Function
Fish Oil and Curcumin Combination
Researched Uses for Curcumin
Benefits for Female Health
Products for GI Anti-inflammation
Ginger’s Medicinal Qualities
Green Tea
EGCG
Isoflavones
Bioflavanoids
Quercetin
Foods with Antioxidant Properties
7
Detoxification Factors
HOUR ELEVEN
GI and Liver Health
The Role of the Liver
The Role of the Biliary System
Spleen
SOD (Superoxide Dismutase)
Elimination Organs
The Regeneration Capacity of the Liver
Silymarin
Role of Liver, Gallbladder and Gut
Fiber Essentials
Progression of Toxins
Reabsorption of Toxins
Thyroid and Immune Functions
Symptoms of Reduced Liver Function
Other Causes of Liver Dysfunction
Detoxification
Phase 1 Pathways
Phase 2 Pathways
Importance of Sleep in Detoxification
Factors Affecting Subluxation
Benefits of Enhanced Liver Function
Lowered Triglycerides
Metabolic Testing
Detoxification Suggestions and Q & A
HOUR TWELVE
Respiratory Detoxification Assistance
Kidney Detoxification Support
Intestine Detoxification Support
Lymphatic Detoxification Function
Key Take Home Points - Review
Review of T-cell and Immune Essentials
Review of Subluxation and the Many Factors that Contribute to it
Benefits of DNA Content of Food
Testing for Celiac and Non-Celiac Gluten Diseases
Complexity of the GI System
Closing Remarks
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