London Cardiovascular Device Innovation Summit
August 28th, 2015
Presented by
Yale University School of Medicine
University College London
Queen Mary University
The National Institute for Health Research Biomedical Research Unit and Centre
at Barts and University College London NHS Trust
Program Chairs
Mark Caulfield – Alexandra Lansky – Anthony Mathur
Program Co-Chairs
Andreas Baumbach – Mark De Belder
Charles Knight – Andrew Taylor
London Cardiovascular Device Innovation Summit
Friday August 28th, 2015
The Derek Willoughby Lecture Theatre,
The National Institute for Health Research Biomedical Research Unit at Barts Heart Centre and
The William Harvey Research Institute, Queen Mary University of London,
Charterhouse Square London EC1M 6BQ.
8:00 am
Check-In and Breakfast
8:50 am
Welcome and Introduction
Mark Caulfield
Co-Director, William Harvey Research Institute
Alexandra Lansky
Director, Yale Heart and Vascular Clinical Research Program
SESSION I
CARDIOVASCULAR INNOVATION TRENDS AND COMMISSIONING
Moderator: Anthony Mathur
Session Goals:
 To discuss trends in CV device innovation
 To discuss how UK and European reimbursement can be streamlined in early
device evaluation
 To discuss the roles and interface of academia and the private sector in
innovation
9:00 am
Device Innovation Trends in Interventional Cardiovascular Therapeutics
Alexandra Lansky
Director, Yale Heart and Cardiovascular Clinical Research
9:15 am
The Interface of Industry and Academia in Innovation: The Unique Perspective of a
Clinician in Industry
Martin Rothman
Chief Medical Officer, Medtronic
9:30 am
Streamlining the Commissioning Process: Aiming for an Early and Efficient Integrated
Clinical, Regulatory and Reimbursement Pathway
Mark De Belder
9:45 am
Discussion: Integrating Value Based Healthcare into Innovation and the Role of
Academia
Moderator: Anthony Mathur
Panel: Mark De Belder, John Martin, Martin Rothman, Alexandra Lansky, Krishna
Sudhir
10:15 am
Coffee Break- The Norfolk Cloister of the Charterhouse
SESSION II
DIGITAL HEALTH CARE AND BIG DATA IN CARDIOVASCULAR INNOVATION AND HEALTH CARE
DELIVERY
Session Goals:
 To discuss the goals of digital health to increase access, improve quality and
compliance and reduce cost
 To discuss the status and impact of digital monitoring on health care
 To explore the full potential of national databases in the innovation cycle
 To discuss the impact of health informatics and big data on population health
and innovation
Moderator: Mark Caulfield and Andrew Taylor
Panel: Bart Segers, Peter Ludman, Adam Timmis, Mark De Belder, Semih Oktay, Adi
Livneh, John Deanfield
10:45 am
NICOR in the UK Cardiovascular Innovation Life Cycle: Role of National Databases for
Cardiovascular Interventions in Streamlining Device Evaluation and Outcomes
Assessment
Peter Ludman
11:00 am
Population Genomics and Opportunities for Innovation in Cardiovascular Diseases
Mark Caulfield
11:15 am
Non invasive Hemodynamic Monitoring: Bringing Value to HealthCare
Adi Livneh
11:30 am
3D Printing in Entrepreneurship and Cardiovascular Device Innovation
Andrew Taylor
11:45 am
Computational Modeling in Device Development: Case Examples
Silvia Schievano
12:00 pm
Hilbert Paradox: A Unique Way of Worldwide Capturing and Correlating Digital Health
Data
Bart Segers
12:15 pm
Discussion: Integrating Information Technology into Health Care: Ready for Prime Time?
Moderator: Mark Caulfield and Andrew Taylor
Panel: Peter Ludman, Semih Oktay, Gunnar Brandrup-Wognsen, Adi Livneh, John
Deanfield, Bart Segers, Krishna Sudhir
12:30 pm
Lunch- The Charterhouse and Gardens
SESSION III
CORONARY INTERVENTIONS, STENTS AND SCAFFOLDS: THE NEXT GENERATION
Session Goals:
 To discuss remaining challenges in coronary intervention
 To discuss limitations of current stent technology
 To explore stents and scaffolds as delivery vehicles for biologics
 To discuss regulatory considerations and challenges in delivery of biologics
Moderator: Andreas Baumbach
Panel: Anthony Mathur, Todd Brinton, Semih Oktay, Martin Rothman, Albert Sinusas,
Krishna Sudhir, Gunnar Brandrup-Wognsen, Alvaro Mata
1:30 pm
Unmet Clinical Need in Coronary Interventions, Stenting and Scaffolds
Andreas Baumbach
1:45 pm
Lithoplasty for Calcified Vessels and Degenerative Valve Disease: In Situ Vascular
Remodeling
Todd Brinton
CMO, Shockwave Medical
2:00 pm
Smart Stents and Scaffolds: Targeted Delivery Vehicles
Anthony Mathur
2:15 pm
Advanced Imaging Techniques in Device Design and Targeted Biologic Therapies: The
Role of Imaging in the Balance of Injury, Inflammation and Healing
Albert Sinusas
2:30 pm
A Practical US Regulatory Roadmap for Combination Products: How to Get There?
Semih Oktay
3:00 pm
Discussion: The Bright Future of Percutaneous Vascular Intervention-Next Frontiers
Moderator: Andreas Baumbach
Panel: Anthony Mathur, Todd Brinton, Semih Oktay, Martin Rothman, Albert Sinusas,
Krishna Sudhir, Gunnar Brandrup-Wognsen, Alvaro Mata
3:30 pm
Tea in the Norfolk Cloister of the Charterhouse
SESSION VI
ADVANCES IN REGENERATIVE MEDICINE FOR THE HEART
Session Goals:
 To review current status of Stem Cell and pluripotent cell therapy in AMI
 To discuss novel tissue engineering applications
 To discuss different applications of gene therapy
 To discuss the role of nanotechnology and nanomaterial in regenerative
medicine
Moderator: John Martin
Panel: Anthony Mathur, Alvaro Mata, Ken Suzuki, Semih Oktay, Alexander Seifalian,
Martin Rothman
4:00 pm
Autologous Stem Cell Therapy in Acute Myocardial Infarction: Lessons learned
Anthony Mathur
4:15 pm
Nanocomposite Polymeric Percutaneous Aortic Valve: Design and Durability Features
Alexander Seifalian
4:30 pm
Biomaterial-Mediated Epicardial Placement of Stem Cells for Cardiac Repair
Ken Suzuki
4:45 pm
Local Intrauterine Delivery of Gene Therapy in Growth Retardation
John Martin
5:00 pm
Smart Nanomaterials for Regenerative Medicine
Alvaro Mata
Director, Institute of Bioengineering
5:15 pm
Discussion
Moderator: John Martin
Panel: Anthony Mathur, Alvaro Mata, Ken Suzuki, Semih Oktay, Alexander Seifalian,
Martin Rothman
5:45 pm
Closing remarks:
Charles Knight
6:00 pm
Reception in the Great Chamber of the Masters Court of the Charterhouse