Analysis of opioid prescribing: emergency departments in the U.S. military system 2006-10 Background: The recent increase in opioid-related deaths may be related to increased provider prescribing and opioid misuse. Within the Military Health System, there is a persistent concern regarding opioid-related adverse outcomes has been reported in the military although there are no published reports on opioid prescribing trends among military healthcare facilities, especially the emergency departments (ED). The military’s closed healthcare network is an optimal system to evaluate opioid prescribing patterns. Objective: To describe the opioid prescribing patterns in military EDs from 2006-2010. Methods: In collaboration with the Air Force’s Health Informatics Division, prescription data was extracted from the DoD Pharmacy Transaction Data Service. Any Tricare beneficiary >18 years of age who received an opioid prescription in a military ED from 2006 to 2010 was included. We evaluated differential trends in the number of prescriptions per patient and in the duration of opioid prescriptions per patient (prescriptiondays). Using SAS 9.2 (Cary, NC), chi square test-of-trends was performed with alpha = 0.05. Results: In the baseline year (2006), 1,284,388 opioid prescriptions were written in primary care, ED, surgical, and dental clinics; 149,322 were written in the ED. Over the study period (2006 – 2010), we found a decrease in the duration of oxycodone and hydrocodone prescriptions per patient from 2006 – 2010 as well as a decrease on opioid prescription duration among males and females. Additionally, the duration of prescriptions decreased among all ages groups while an increase in the number of prescriptions/ patient was observed only among those 25-34 years of age. Furthermore, duration of prescriptions decreased among active duty/guard, their dependents, retirees, and dependents/survivors of retirees. Conclusion: From 2006 – 2010, opioid prescriptions originating in military emergency departments decreased overall and among several subgroups suggesting the need to identify underlying factors that effected these trends. Maj Joshua B. Pead, USAF, MC, FS1 Lt Col Vikhyat S. Bebarta, USAF, MC1 Rosemarie Ramos, PhD, MPH3 Jennifer S. Potter, PhD, MPH2 Lee A. Zarzabal, MS3 Celan Alo, MD, MPH4 Lt Col David Carnahan, MD, MSCE, USAF4 Maria Castaneda, MS5 1 Dept of Emergency Medicine, San Antonio Military Medical Center, San Antonio, TX 2 University of Texas Health Sciences Center-San Antonio, TX 3 59th MDW AF Science and Technology Office 4 AFMSA Healthcare Informatics Division 5 CREST Program, Wilford Hall Ambulatory Surgical Center, Lackland AFB, TX Correspondence: Maj Joshua Pead Email: jkpead@me.com Phone: 210-563-3787