The University of Sheffield Faculty of Medicine, Dentistry & Health School of Clinical Dentistry Chemokines in CNS disease Supervisor: Prof Fiona Biossonade Project: There is an increasing body of evidence demonstrating a role for chemokine signalling in the nervous system, where these molecules have been shown to have diverse effects in many physiological and pathological processes. Consequently, they have been implicated in a variety of CNS neurodegenerative disease states including multiple sclerosis, Parkinson’s, Huntingdon’s and Alzheimer’s diseases, and amyotrophic lateral sclerosis, as well as in chronic pain. Recent work in our laboratory provides the first demonstration that a little-studied chemokine and its receptor are expressed in the nervous system. This project will establish whether expression of this chemokine is altered in specific disease states, with initial focus on multiple sclerosis, motor neuron disease and Alzheimer’s disease where we have ready access to optimally prepared human CNS tissue and rodent models of disease. This approach will further our understanding of the disease process, and will help to identify novel therapeutic targets leading to improved treatment for these conditions. Entry Requirements: Candidates must have a first or upper second class honors degree or significant research experience. Enquiries: Interested candidates should in the first instance contact Prof Fiona Boissonade f.boissonade@shef.ac.uk How to apply: Please complete a University Postgraduate Research Application form and attach at least two references to your application. To complete the application form please visit: www.shef.ac.uk/postgraduate/research/apply. Please clearly state the prospective main supervisor in the respective box and select ‘Clinical Dentistry’ as the department. Closing date: Open