MOLECULAR MECHANISMS OF IMMUNE CELL DEVELOPMENT AND FUNCTION
August 16-21, 2015
Big Sky, Montana
Organizers:
Barbara Kee, Ph.D.
University of Chicago
Chicago, IL
Cornelis Murre, Ph.D.
University of California, San Diego
La Jolla, CA
Stephen Smale, Ph.D.
University of California, Los Angeles,
Los Angeles, CA
Sunday, August 16, 2015
4:00 p.m. – 9:00 p.m.
6:00 p.m. – 7:00 p.m.
7:00 p.m. – 8:00 p.m.
Conference Registration
Welcome Reception
DINNER
8:00 p.m. – 9:30 p.m.
Keynote Presentation
David Baltimore, Caltech
Monday, August 17, 2015
7:30 a.m. – 9:00 a.m.
7:30 a.m. – 12:00 p.m.
9 February 2016
BREAKFAST
Conference Registration
TBA
9:00 a.m. – 12:00 p.m.
General session 1: Lymphocyte Progenitors and Lineage
Decisions
Mikael Sigvardsson, Linkoping Univ.
Fotini Gounari, Univ. of Chicago
Transcription factor dose in Blymphocyte lineage restriction and
malignant transformation
Molecular interplay between Tcf-1/catenin and HEB in thymocyte
development
Short talk from abstracts
10:00 a.m. – 10:15 a.m.
Morning Coffee Break
Ken Dorshkind, UCLA
Lymphoid progenitors with distinct
genetic signatures emerge in layered
waves of fetal development
Alexander Rudensky, Memorial
Sloan Kettering Cancer Center
TBA
Short talk from abstracts
12:00 p.m. – 1:00 p.m.
1:00 p.m. – 4:00 p.m.
4:00 p.m. – 6:00 p.m.
LUNCH and
Meet the Speakers
Free time
General Session 2: Transcriptional Regulation of Immune Cell
Differentiation
Katia Georgopoulos, Harvard
Medical School
TBA
Matthias Merkenschlager,
Hammersmith Hospital
Cohesin regulates gene expression
through enhancer-enhancer interaction
Short talk from abstracts
Ellen Rothenberg, Caltech
Transcriptional networks in early T cell
lineage commitment
Boris Reizis, Columbia Univ.
Transcriptional regulation of dendritic
cell development
Short talk from abstracts
9 February 2016
6:00 p.m. – 7:00 p.m.
6:00 p.m. – 7:00 p.m.
Conference Registration
DINNER
7:00 p.m. – 9:00 p.m.
Poster Session
Tuesday, August 18, 2015
7:30 a.m. – 9:00 a.m.
7:30 a.m. – 12:00 p.m.
BREAKFAST
Conference Registration
9:00 a.m. – 12:00 p.m
General session 3: V(D)J Recombination, Class Switch
Recombination, and Somatic Hypermutation
Amy Kenter, Univ. of Illinois at
Chicago
Bone marrow pro-B cells express
surface immunoglobulin in response to
class switch recombination inducers
Andre Nussenzweig, NIH
Maintenance of genome stability
Short talk from abstracts
10:00 a.m. – 10:30 a.m.
Morning Coffee Break and
Group Photo
Margorie Oettinger, Harvard
Medical School
A role for nucleosome positioning in
the control of V(D)J recombination
Fred Alt, Harvard Medical School
Mechanisms of AID targeting during
SHM and CSR
Short talk from abstracts
12:00 p.m. – 1:00 p.m.
1:00 p.m. – 4:00 p.m.
4:00 p.m. – 6:00 p.m.
LUNCH and
Meet the Speakers
Free time
General session 4: Nuclear Architecture, Chromatin, and the
Control of Recombination and Development
James Hagman, National Jewish
Hospital
Epigenetic regulation of lymphocyte
development
Yehudit Bergman, Hebrew Univ. of
Jeruselem
Plasticity versus commitment of cell
fate decisions
Short talk from abstracts
9 February 2016
Cornelis Murre, UC San Diego
Space and time in gene regulation
Ann Feeney, Scripps Institute
Transcriptional control of V(D)J
recombination
Short talk from abstracts
6:00 p.m. – 7:00 p.m.
6:00 p.m. – 7:00 p.m.
Conference Registration
DINNER
7:00 p.m. – 9:00 p.m.
Workshop 1: Oral presentations selected from abstracts
Wednesday, August 19, 2015
7:30 a.m. – 9:00 a.m.
7:30 a.m. – 12:00 p.m.
BREAKFAST
Conference Registration
9:00 a.m. – 12:00 p.m.
General session 5: Innate Lymphoid Cell Development and
Function
Barbara Kee, Univ. of Chicago
The transcription factor Ets1 controls
the cytokine responses of innate
lymphoid cells
Liang Zhou, Northwestern Univ.
Regulation of innate lymphoid cell
development and function
Short talk from abstracts
10:00 a.m. – 10:15 a.m.
Morning Coffee Break
Cynthia Guidos, Hospital for Sick
Children
Functions of Notch signaling in innate T
cell development
Yuan Zhuang, Duke Univ.
Id checkpoints in NKT development
Short talk from abstracts
12:00 p.m. – 12:30 p.m.
12:30 p.m. – 2:00 p.m.
Business Meeting
LUNCH and
Meet the Speakers/Expert
1:00 p.m. – 4:00 p.m.
Free time
9 February 2016
4:00 p.m. – 6:00 p.m.
General session 6: Chromatin and miRNA Regulation of
Differentiation and Activation
Mark Ansel, UC San Francisco
miRNA regulation of helper T cell
responses
Alexander Tarakhovsky, Rockefeller
Univ.
Epigenetic control of antiviral response
Short talk from abstracts
Amy Weinmann, Univ. of Alabama
Alexander Hoffmann, UCLA
The role of helper T cell lineagespecifying factors in regulating the
glycolysis pathway gene program
From molecular network dynamics to
lymphocyte population dynamics –
towards a multi-scale understanding of
immune responses
Short talk from abstracts
6:00 p.m. – 7:00 p.m.
6:00 p.m. – 7:00 p.m.
Conference Registration
DINNER
7:00 p.m. – 9:00 p.m.
Workshop 2: Oral presentations selected from abstracts
Thursday, August 20, 2015
7:30 a.m. – 9:00 a.m.
7:30 a.m. – 12:00 p.m.
BREAKFAST
Conference Registration
9:00 a.m. – 12:00 p.m.
General session 7: Immune Responses, Effectors and
Memory I
Kristin Hogquist, Univ. of Minnesota
Self-reactivity: inside the thymus and
out
Kenneth Murphy, Washington Univ.
TBA
Short talk from abstracts
10:00 a.m. – 10:15 a.m.
9 February 2016
Morning Coffee Break
Michel Nussenzweig, Rockefeller
Univ.
Antibodies in HIV prevention and
therapy
Susan Kaech, Yale Univ.
Fattening up memory T cells
Short talk from abstracts
12:00 p.m. – 1:00 p.m.
1:00 p.m. – 4:00 p.m.
4:00 p.m. – 6:00 p.m.
LUNCH and
Meet the Speakers
Free time
General Session 8: Immune Responses, Effectors and
Memory II
Mark Davis, Stanford Univ.
The balance of genetic and
environmental influences on the
human immune system
Joseph Sun, Memorial Sloan
Kettering Cancer Center
Programming of immunological
memory in natural killer cells
Short talk from abstract
Averil Ma, UC San Francisco
Ubiquitin and innate immunity
Alan Aderem, Seattle Biomedical
Research Institute
A systems approach to dissecting
immunity
Short talk from abstracts
6:00 p.m. – 7:00 p.m.
6:00 p.m. – 7:00 p.m.
7:00 p.m. – 9:00 p.m.
Conference Registration
Special Event: DINNER
Poster Session (optional)
Friday, August 21, 2015
7:30 a.m. – 9:00 a.m.
7:30 a.m. – 12:00 p.m.
9 February 2016
BREAKFAST
Conference Registration
9:00 a.m. – 11:30 a.m.
General session 9: Innate Immunity
Lionel Ivashkiv, Hospital for Special
Surgery
Regulation of macrophage activation
and inflammatory function
Peter Murray, St. Jude Children’s
Research Hospital
Mechanisms and consequences of
macrophage polarization in cancer
Short talk from abstracts
10:00 a.m. – 10:15 a.m.
12:00 p.m.
Morning Coffee Break
Irina Udalova, Univ. of Oxford
Macrophages in inflammatory and
allergic diseases
Christopher Glass, UC San Diego
Enhancer landscapes of tissue-resident
macrophages
Stephen Smale, UCLA
Regulation of macrophage activation by
chromatin
LUNCH to Go
And DEPARTURES
END OF CONFERENCE
For additional information contact:
FASEB Science Research Conferences
9650 Rockville Pike
Bethesda, MD 20814
www.faseb.org/src
9 February 2016