Supporting information 1 List of single layer study cases Information layer Genetic constraints Gene fusion Operons Codon Adaptation Index Genomic constraints Horizontal gene transfer Pathogenicity Antibiotic resistance DNA- repair Replication Transcription Taxonomic information Comparative genomics Metabolic information Constraints-based modeling Dynamic modeling Metabolomics Improved gene models Metabolic pathways identification Genomes re-annotations Transcriptomics Functional insights from co-expression Epigenomics Single-base and strand resolution Non-genetic individuality Gene expression regulation Structure/function relationships Adjustment to changing environment Pathogenesis/virulence Proteomics Protein-protein interactions Protein expression Phenomics Phenotype MicroArrays Single cell microscopy Protein expression Protein localization Protein interaction Interaction between host and bacterial cells Super resolution Reference(s) [1,2] [3,4] [5,6] [7] [8-10] [11] [12] [13] [14] [15,16] [17-19] [20,21] [22] [23-26] [27] [28] [29] [30,31] [32] [33,34] [35,36] [37-39] [40,41] [42,43] [44] [45] [46] [46] [47] [48,49] 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Enright AJ, Ouzounis CA. 2001. 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