Posters –
Immunology and Oncology
NAME OF THE PROJECT
NAME OF THE MAIN CONTACT
ORGANISATION NAME
Magnetic Immunoassay MAGIA
Paul.kauffmann@g2elab.grenoble-inp.fr
Grenoble INP - CNRS
A breakthrough from current magnetic immunoassays which use cm~mm scale magnets
to attract MICRO-particles, MAGIA downscales the process using MICRO-magnets to
locally attract NANO-Particles. Magnetic technology downscaling offers the unique
opportunity of increasing the magnetic force to obtain highly efficient local magnetic
capture. This results in 4 direct advantages:
Technology
1. As NANO-particles are much more diffusive than currently used MICRO- particles,
the reaction is much faster: time can be reduced below 15 min resulting in higher
throughput
2. Local magnetic capture of immuno-complexes allows highly reproducible no-wash
differential detection.
3. Surface reactions can be extended and offer better sensitivity than standard
homogeneous assay.
4. Plates are fully compatible with existing automats, requiring no investment.
Our goal is to offer a fast high-throughput no-wash magnetic-bioassay platform for
immunoassay, enzyme assay, protein-protein assay, to drug discovery and bio-pharma
RD services.
Customers / Target market
Industry and competitors
Our first step will be to offer our services to IVD laboratories. MAGIA wants to offer
its High Throughput microtiter plate immunoassay platform to manufacturers of
opened immunodiagnostic kits (who still represent 20% of the market) to give them
competitive throughput and to reduce their cost. The main targeted markets will be
emerging and developing countries lab analysis where investment in closed automats
and kits is hardly affordable.
Today, on biopharma market, very innovative detection technologies have emerged
to perform sensitive homogeneous (PerkinElmer, CisBio) and heterogeneous
(Bioscale, Singulex,) assays. Innovation has also been made on microfluidics to reduce
sample volume on magnetic carrier to obtain multiplexed assay (Luminex). Most of
those assays remain difficult and expensive to perform as they require money and
time investment. Standard ELISA/CLIA therefore currently remain by far the most
used immunoassay . MAGIA proposes fully compatible magnetic microtiter plates on
which fast and sensitive no-wash immunoassays can be performed. Besides, cost
reduction can be obtained using our no-wash detection in smaller liquid volumes.
Finally, as biochemistry and plate format are mainly unchanged, standard ELISA/CLIA
protocols can be easily transferred on MAGIA’s technology.
Financing need :
Prototype development & validation (manpower & equipment)
Marketing
Production of first immunoassay kits quality-controlled
Financing need / Commercial
opportunity
Commercial opportunity:
Definite interest of biologists in RD biopharma performing immunoassays and HTS
has been raised. MAGIA offers to immunoassay developers/users high throughput
(up to 30 plates per day instead of 5-8), and sensitive and easy to implement no-wash
solutions to HTS users.
IP – Patent situation
Our
fabrication
processes,
detection
methods
and nanoparticle
manipulations are protected by 3 patents:
Micro-magnetic Imprinting: N. M. Dempsey and F. Dumas-Bouchiat, patent FR
1254667 (2012) and US 61/650,398 (2012)
Magnetic Immuno Assay: G. Blaire, L.F. Zanini, G. Reyne, N.M. Dempsey, M.
Weindenhaupt, F. Bruckert and O. Cugat, patent FR1350421 (2013)
Magnetic Mixing Patent pending
Our Goal is from now within 1 year to sell prototypes for RD pharma to develop
their own assays, and within 2 years to sell preindustrial immunoassay kits.
Future steps / Milestones
These first steps would allow MAGIA to gain investor confidence, to raise funds to
sell immunoassay kits with Quality control in order to eventually reach diagnostic
markets.
For further reading go check out our website : www.immunomag.com
Further reading
Contact person
Some scientific publications are available online :
- F. Dumas-Bouchiat Applied Physics letters. 2010, 96
- N. M. Dempsey, Applied Physics letters. 2014,
- L.F. Zanini, Applied Physics Letters. 2011, 99, 23
- G. Blaire, Journal of Applied Physics, 2015
- O.Cugat, IEEE Trans Mag, 2003
Frédérique SOUQ, Innovation Project Manager, LINKSIUM Frederique.souq@linksium.fr
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