Crystallization and Melting Point of Ibuprofen

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Crystallization and Melting Point of Ibuprofen
Catherine Joson
Abstract
The crystallizing of ibuprofen is improved with speed via a 1:2 ratio of a water:methanol solvent.
With the theory of crystallization and the method of using the melting point apparatus, five (5)
tablets were crushed, dissolved in a hot solvent of 5 mL of distilled water and 10 mL of
methanol, and filtered by gravity filtration.
Materials



Five (5) ibuprofen tablets
Distilled water
Methanol
Procedure
1.
2.
3.
4.
5.
6.
Crush tablets.
Dissolve in hot solvent
Filter solution into an E. Flask. (KEEP FILTER PAPER for crystals)
Collect crystals.
Form crystals and ibuprofen tablet into a powder in order to perform melting point.
Measure crystals, ibuprofen, and a mixture of the both.
Results
Day 2:
No crystals. Brought solution to 1:1 ratio. Heated until clear.
Day 7:
Crystallization occurred too fast for gravity filtration. Thus, everything was on the filter paper.
Melting Point Data
Initial Temperature (°C)
Final Temperature (°C)
Crystals formed through
76°C
78°C
experiment
Ibuprofen (pill form)
76°C
77°C
Mixed
76°C
77°C
Discussion
Crystallization occurred too fast to collect the forming crystals within the E. Flask. However,
unable to realize this, a repeat of the experiment was in order except in a 1:1 ratio. Before
placing the E. Flask away to prepare for crystallization, we kept the filter paper aside just in case
crystals happened to form.
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