Crystallization and Melting Point of Ibuprofen Catherine Joson Abstract The crystallizing of ibuprofen is improved with speed via a 1:2 ratio of a water:methanol solvent. With the theory of crystallization and the method of using the melting point apparatus, five (5) tablets were crushed, dissolved in a hot solvent of 5 mL of distilled water and 10 mL of methanol, and filtered by gravity filtration. Materials Five (5) ibuprofen tablets Distilled water Methanol Procedure 1. 2. 3. 4. 5. 6. Crush tablets. Dissolve in hot solvent Filter solution into an E. Flask. (KEEP FILTER PAPER for crystals) Collect crystals. Form crystals and ibuprofen tablet into a powder in order to perform melting point. Measure crystals, ibuprofen, and a mixture of the both. Results Day 2: No crystals. Brought solution to 1:1 ratio. Heated until clear. Day 7: Crystallization occurred too fast for gravity filtration. Thus, everything was on the filter paper. Melting Point Data Initial Temperature (°C) Final Temperature (°C) Crystals formed through 76°C 78°C experiment Ibuprofen (pill form) 76°C 77°C Mixed 76°C 77°C Discussion Crystallization occurred too fast to collect the forming crystals within the E. Flask. However, unable to realize this, a repeat of the experiment was in order except in a 1:1 ratio. Before placing the E. Flask away to prepare for crystallization, we kept the filter paper aside just in case crystals happened to form.