—Basic Info.—
Name: Chen Leilei
Date of Birth: 1986/01/02
Native place: Weifang, Shandong
School Graduated: Hong Kong Baptist University
Major: Neuroscience &Chinese Medicine
Degree: PhD
Supervisor: Prof. Li Min
—Contact Info.—
Tel：+852-92885996 /+86 13168770209
E-mail：leilei.chen2011@gmail.com / hanbing_leilei@163.com
Address：Room 807, Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease
Research, School of Chinese Medicine, Hong Kong Baptist University,
Kowloon Tong, Hong Kong
—Education—

2012.10- now Hong Kong Baptist University Neuroscience & Chinese Medicine
Supervisor: Prof. Li Min
Lab: Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research
Graduation Project: “Study on the molecular mechanism of Chinese herbal
medicine Uncaria rhynchophylla(Gouteng) for inducing autophagy and
protecting neurons in Parkinson’s disease.”

2008.09-2011.06
Soochow University Pharmacology
Supervisor: Prof. Qin Zhenghong
Lab: Lab of Aging and Nervous Disease, Soochow University
Graduation Project: “Effects of mutant huntingtin-552 on glutamate transporter
GLT-1 in astrocytes are reversed by rapamycin.”

2004.09-2008.06
Jiangsu University Pharmaceutical Engineering
Supervisor: Prof. Gao Jing
Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s disease Research
Graduation Project：“Study on the antitumor activity and possible mechanism
of new pyridine manganese complex.”
—Work experiences—

2011.07-2012.10
Hong Kong Baptist University
Position：Research Assistant
—Awards—

2013.05. Lee Chan Yuet Ming Memorial Scholarship for Chinese Medicine
Postgraduate, 2012/2013

2008.12
Excellent graduation design (paper) in Jiangsu province
—Involved Projects—
1. NSFC/RGC-N_HKBU 213/11: “Function analysis of Corynoxine B in promoting
autophagy and protecting neurons.” 2012/01-2014/12, HKD 794,840
2. HKBU/IRMS/12-14/1-2A: “Chinese medicine for inflammatory bowel disease
and Parkinson’s disease: study about the efficacy and its underlying
mechanism”,2012/09-2015/08, HKD 687,500
3. ITS/274/12: “Chemical modification of oxindole alkaloids from Chinese herbal
medicine Gouteng for optimization of anti-Parkinson’s disease activity”,
2013/10-2015/3, HKD 999,925.
4.
RGC/HKBU-121009/14: “Understanding the molecular mechanism of
Corynoxine B in promoting autophagy and neuroprotection:Targeting
HMGB1-Beclin 1 interaction”, 2014/12-2016/11, HKD 564,833.
—Research Publications—
Published Papers:
1.
Chen L. L., Song J.X., Lu J.H., Yuan Z.W., Liu L.F., Durairajan S.S.K., Li M. *
(2014) “Corynoxine, a natural mTOR inhibitor, promotes the clearance of
alpha-synuclein by inducing autophagy” Journal of Neuroimmune
Pharmacology. 2014, DOI: 10.1007/s11481-014-9522-8. [Epub ahead of print]
Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s disease Research
〔JCR IF 2013: 3.172〕
2.
Chen LL, Wu JC, Wang LH, Wang J, Qin ZH, Difiglia M, Lin F*.(2012)
Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in
cultured astrocytes. Acta Pharmacologica Sinica 33(3):385-92, 2012.〔JCR IF
2012:2.354〕
3.
Chua KK, Chen LL, Liu LF, Duriarajan SSK, Lu JH, Li M*. (2014)The Efficacy
of Classical Chinese Medicine Formula Di-tan Decoction for Alzheimer’s
disease. Chinese Journal of Integrative Medicine (In Press), 2014. 〔JCR IF
2013:1.401〕
4.
Durairajan S.S.K.*, Chen L.L., Song J. X., Baum L. and Li M*. (2013).
Corynoxine B, a Novel Autophagy Enhancer, Promotes the Clearance of Mutant
Tau Aggregation in vitro and in vivo. Neurodegen. Dis. 2013, Vol. 1, (Suppl.1):
P120. 〔JCR IF 2013: 3.454〕
5.
Song J.X., Lu J.H., Liu L.F., Chen L. L., Durairajan S.S.K., Yue Z.Y., Zhang
H.Q*. & Li M. * (2014) “HMGB1 is involved in autophagy inhibition caused by
alpha-synuclein overexpression: a process modulated by the natural autophagy
inducer Corynoxine B”.Autophagy. 2014, 10(1):144-154.〔JCR IF 2013: 11.423〕
6.
Durairajan S.S.K.*, Huang Y.Y., Yuen P.Y., Chen L.L., Kwok K.Y., Liu L.F.,
Song J.X. Han Q.B., Xue L., Chung S.K., Huang J.D., Baum L., Senapati S., Li
M.* (2014)“Effects of Huanglian-Jie-Du-Tang and Its Modified Formula on the
Modulation of Amyloid-beta Precursor Protein Processing in Alzheimer's
Disease Models ”. PLoS ONE 2014, 3(9): e92954.〔JCR IF 2013: 3.534〕
7.
Luan H.M.,† Liu L.F.,† Meng N., Tang Z., Chua K.K., Chen L.L., Song J.X.,
Mok V., Xie L.X., Li M.* & Cai Z.W.* (2014) “LC-MS-based Urinary
Metabolite Signatures in Idiopathic Parkinson's Disease”.J. Proteome Res. DOI:
10.1021/pr500807t. [Epub ahead of print, published online 1 Oct. 2014] 〔JCR
IF 2013: 5.001〕
8.
Mok C.T., Chua K.K., Lau Y.K., Chan K.W., Chan K.H., Tse K.P., Chen L.L.
Man S.C., Wong A., Chan A., Bian Z.X., Wu J., Li M.* (2014) “Randomized
Clinical Trial Evaluating Effects of Traditional Chinese Medicine
Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s disease Research
(Jia-Wei-Liu-Jun-Zi Tang) for Non-motor Symptoms in Parkinson’s
Disease”.Mov. Disord. 2014; 29: (Suppl.1): P571〔JCR IF 2013: 5.634〕
9.
Durairajan S.S.K.*, Huang Y.Y., Chen L.L., Song J.X. and Li M*. (2013).
Corynoxine isomers decrease levels of amyloid-beta peptide and amyloid-beta
precursor protein by promoting autophagy and lysosome biogenesis. Mol.
Neurodegen. 2013, (Suppl. 1):P16. Doi: 10.1186/1750-1326-8-S1-P16. 〔JCR IF
2013: 5.286〕
10. Durairajan SS, Liu L.F., Lu J.H., Chen L.L., Yuan Q., Chung S.K., Huang L., Li
X.S., Huang J.D., Li M*. Berberine ameliorates beta-amyloid pathology, gliosis,
and cognitive impairment in an Alzheimer's disease transgenic mouse model.
Neurobiology of Aging 33(12):2903-19, 2012. 〔JCR IF 2012: 6.166〕
International Conference Presentations:
1. Chen L.L., Song J.X., Lu J.H., Yuan Z.W., Liu L.F., Duriarajan S.S.K., Li M.*
(2014)“Corynoxine, a Chinese herbal compound, induces autophagy via
Akt/mTOR pathway and promotes the clearance of alpha-synuclein”. Poster
presentation at Keystone Symposia on Autophagy: Fundamentals to Disease (E2),
Hyatt Regency Austin, Austin, Texas, USA, 23-28 May, 2014.
2. Chen L.L., Song J.X., Lu J.H., Yuan Z.W., Liu L.F., Duriarajan S.S.K., Li M.*
(2013) “Corynoxine, a natural oxindole alkaloid from Gouteng, induced neuronal
autophagy through Akt/mTOR pathway”, 2013AAPS@China Symposium, CUHK,
17-18th August 2013. (Poster presentation)
3. Duriarajan S.S.K., Huang Y.Y., Chen L.L., Liu L.F., Zhang Y.S., Malampati S.,
Zeng Y., Song J.X., Li M.* (2014) “Rhizoma Corydalis (Yanhusuo) Rescues
Neuronal Dysfunction in a Mouse Model of Taupathy”, Poster presentation at the
8th Pong Ding Yuan International Symposium on Traditional Chinese Medicine &
the 2nd International Chinese Symposium on Free Radical Research & the 6 th
Symposium for the Three Districts of Cross-straits on Free Radical Research,
Hong Kong,15-16 Nov., 2014
4. Zeng Y., Song J.X., Liu L.F., Chen L.L., Lu J.H., Huang Y.Y., Duriarajan S.S.K.,
Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s disease Research
Zhang H.Q., Li M.* (2014) “Synthesized curcumin derivatives induce neuronal
autophagy via mTOR/TFEB pathway and promote alpha-synuclein (SNCA)
degradation”. Poster presentation at Keystone Symposia on Autophagy:
Fundamentals to Disease (E2), Hyatt Regency Austin, Austin, Texas, USA, 23-28
May, 2014
5. Song J.X., Lu J.H., Liu L.F., Duriarajan S.S.K., Chen L.L., Yue Z.Y., Li M.,*
Zhang H.Q.* (2014) “Corynoxine B restores autophagy through inhibiting
alpha-synuclein- HMGB1 interaction in cell models of Parkinson’s disease”.
Poster presentation at Miami 2014 Winter Symposium: the Molecular Basis of
Brain Disorders, Miami, USA, 26-29 Jan., 2014
6. Liu L.F., Lu J.H., Song J.X., Duriarajan S.S.K., Chen L.L., Yuan Z.W., Li
M.*(2013) “Over expression of alpha-synuclein impairs the nuclear translocation
of TFEB”. Abstract to be presented at EMBO conference: Autophagy: Molecular
mechanism, physiology and pathology 2013. Hurtigruten MS Trollfjord, Norway,
5-9 May, 2013.(Poster presentation)
7. Song J.X., Lu J.H., Liu L.F., Duriarajan S.S.K., Chen L.L., Yuan Z.W., Zhang
H.Q*. & Li M.* (2013) “Alpha-synuclein over expression inhibits HMGB1mediated
autophagy:
Protection
by
Corynoxine
B” at EMBO
conference: Autophagy: Molecular mechanism, physiology and pathology 2013.
Hurtigruten MS Trollfjord, Norway, 5-9 May, 2013.(Poster presentation)
8. Yuan Z.W., Lu J.H., Liu L.F., Song J.X., Chen L.L., Durairajan. S. S. K. , Li M.*
(2013) “ Natural autophagy inducer Corynoxine B exerts neuroprotective effect on
a Drosophila model of Parkinson’s disease”. Abstract presented at the 2nd China
Drosophila Research Conference (2nd CDRC). Changsha, China, 26-28 April,
2013. (Poster presentation)
9. Durairajan S.S.K., Chen L.L., Liu L.F., Song J.X., Li M.* (2013) “Corynoxine
B, a novel autophagy enhancer, promotes the clearance of mutant Tau aggregation
in vitro and in vivo”, poster presented at AD/PDTM 2013, the 11th International
Conference on Alzheimer's & Parkinson's diseases, Florence, Italy, 6-10 March,
2013.
Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s disease Research
10. Song J.X., Lu J.H., Liu L.F., Chen L.L., Duriarajan S.S.K., Zhang H.Q . & Li
M.* (2012) “Corynoxine B protects HMGB1-Beclin-1 mediated autophagy
impaired by alpha-synuclein over expression”, poster presented at the
6th International Symposium on Autophagy (ISA 2012), Okinawa, Japan, 28
Oct.-1 Nove. 2012.
11. Duriarajan S.S.K., Liu L.F., Chen L.L., Chung S.K., Huang J.D. and Li M.*
(2012) “Beberine Improves Cognitive Impairments and Reduces Amyloid Burden
in TgCRND8 Alzheimer’s Mice via AKT/GSK 3 signaling”. Poster presentation at
Hong Kong International Integrative Medicine Conference 2012 (HKIIC 2012),
Hong Kong, 6-8 July, 2012.
12. Liu L.F., Duriarajan S.S.K., Lu J.H., Chen L.L., Koo I. and Li M.* (2012)
“Polyonum Multiflorum Thunb.(root) Can Lower Aβ Generation by Modulating
APP Processing-Results from an in Vitro Screeing”. Poster presentation at Hong
Kong International Integrative Medicine Conference 2012 (HKIIC 2012), Hong
Kong, 6-8 July, 2012.
Patent:

Li M., Durairajan S.S.K, Chen L.L., Liu L.F., Song J.X. “ Modified
Huanglian-Jie-Du-Tang for Treating Neurodegenerative Diseases ”
U.S.
Provisional Patent Application No. P7082US00, 2013
Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s disease Research