S1 Appendix. Summary of data inputs, base estimates, and sensitivity analyses for cystic echinococcosis control in Canada Costs Calculation Method Base costs Reference Direct Medical Costs Emergency Average patient cost in Hospital Costs emergency care * % of $767.83 * 0.22 =168.92 NACRS DAD patients who receive emergency care Inpatient Average patient cost in $10693.93 * 0.78 = Hospital Costs hospital $8340.55 Physician Costs Cost of physician care per $150 * 0.31 * 0.22= 10.23 Expert Opinion (Emergency) day * days in emergency * Expert Opinion % of patients who receive emergency care Physician Costs Cost of physician care day 1 ($100 + ($40 * 7.82))*0.78 = (Inpatient) + (cost of physician $321.98 subsequent days * (Length of stay in the hospital – 1)) * % of patients who receive inpatient care Average Emergency costs + $168.92 + $8,340.55+ Treatment Cost Inpatient costs + Physician $10.23 + $321.98 = per Case costs (Emergency + $8,841.68 Inpatient) Direct Prevention Program Costs Car Maintenance/depreciation $2,000 per year Expert Opinion Veterinarian Average annual salary $70,000 per year [32] PZQ Treatment Cost of PZQ tablets per dog $90.4 per dog per year * [2013 Associate (Tablets- per year (assuming 20lbs 0.06 * 19,671 = $106 695 Veterinary Purchasing Municipal) dog) * dog-person ratio Company Ltd, municipal *# of people in Municipal Records] municipal areas of KT PZQ Treatment Cost of PZQ injections per $68.25 per dog per year * [2013 Associate (Injectable- dog per year (assuming 0.24 *22,547 = $369,320 Veterinary Purchasing Rural) 20lbs dog) * dog-person Company Ltd, 30] ratio rural *# of people in rural areas of KT Surveillance ($1 (Cost of testing samples * # ($1 * 1000 samples) + for materials + of samples) + cost of $8000 wage = $9000 per student time) summer student year Total program Cost of PZQ urban dogs + $2,000 + $70,000 + $106 costs per year cost of PZQ rural dogs + 401 + $538 560 + $9000 = cost of vet salary + car costs $654,033 Cost of similar program + surveillance costs Indirect (Societal) Costs Production Loss Median wage in SK per year from Mortality of life lost $34,430 per year of life lost [33] $34,430/24 = $1,434.58 per [33] (income per year) Production loss Median monthly wage in SK from Treatment Travel (mileage) case Cost per km of travel * $0.42 per km* 500km = average return distance $210 per case Expert Opinion (KT-Saskatoon) Hotel Costs Average hotel cost per night * average length of stay $70 * 6 nights = $300 Expert Opinion