AstraZeneca/MedImmune Oncology Portfolio Opportunities for Local Sponsorship via Combinations Alliance “Open EOI Call” April 2015 Further to the request from the Combinations Alliance for clarity on which drugs and areas of scientific interest are open for collaboration under the master terms of agreement, AstraZeneca/MedImmune are pleased to provide this detail as follows. Any proposals that are of interest and that AZ/MedImmune and our Alliance partners would be keen to progress, will be reviewed by AZ/MedImmune internal governance in order to secure appropriate funding prior to a decision All proposals will be prioritised based on scientific merit and fit with the core development program of the drug. The areas outlined below for each project are not at the exclusion of others with a strong scientific rationale, and all proposals will be considered on a case-by-case basis for External Sponsored Research (ESR) via the Combinations Alliance. Medi3617 (anti-angiogenesis monoclonal antibody) Project representative: dominic.lai@medimmune.com Development stage Phase I/2 Settings of interest Monotherapy and combination studies in glioblastoma multiforme. WEBINAIR SCHEDULE Date: Time: Topic: Monday, 27 April 2015 14:00, GMT Summer Time (London, GMT+01:00) Project Compounds AZD1775 WEE 1 Kinase Inhibitor (Rob Godin) Selumetinib MEK 1/2 Inhibitor (Desiree Headley) AZD9291 EGFR TKI (Paramjit Kaur) AZD2014 mTORC1/2 Inhibitor (Chris Shepherd) Medi 3617 anti-ANG2 mAb (Dominic Lai) Meeting Number: 680 519 483 Meeting Password: oncology To join the meeting go to: https://astrazeneca.webex.com/astrazeneca/j.php?MTID=mff6364b20aeb9c08e2927f95d32dfefd Audio Conference: Conference code: 17861443 Leader PIN: 9574 Global Access Numbers Local: United Kingdom: +44(0) 208 118 1014 United States: 678.905.7177 Sweden: 0850 619 664 For Assistance: Go to https://astrazeneca.webex.com/astrazeneca/mc . On the left navigation bar, click "Support". To add this meeting to your calendar program (for example Microsoft Outlook), click this link: https://astrazeneca.webex.com/astrazeneca/j.php?MTID=m6a033011bc0a29ee9e3a2a59d3ffe6e0 To check whether you have the appropriate players installed for UCF (Universal Communications Format) rich media files, go to https://astrazeneca.webex.com/astrazeneca/systemdiagnosis.php. http://www.webex.com Recording: The web-ex presentations on 27th April and 5th May will be recorded. Any Investigator who is unable to attend the web-ex sessions can request access to the recordings. These will be password protected and a CDA will need to be in place to enable these recordings to be shared. Please contact Graham Fisher (graham.fisher@astrazeneca.com) in the first instance. 1