CURRICULUM VITAE
Tõnu Esko
Date of birth:
Citizenship:
Address:
Phone & e-mail:
27 January 1985
Estonian
Estonian Genome Center University of Tartu, 23b Riia Str.,
51010, Tartu, Estonia
+(372) 737 4028; Tonu.Esko@ut.ee
Education:
1992-2001
2001-2004
2004-2007
2007-2009
2009-2012
Vändra Gümnasium, Honorable mention
Nõo Reaalgümnaasium, Honorable mention (silver medal)
B.Sc. in Gene Technology, Faculty of Biology and Geography,
University of Tartu, Cum Laude
M.Sc. in Gene Technology, Faculty of Science and
Technology, University of Tartu, Cum Laude
Ph.D. student, Faculty of Science and Technology, University
of Tartu
Professional employment:
2007-…
2008-…
2010-…
Estonian Biocenter, Genotyping specialist
Estonian Genome Center of University of Tartu, Specialist
Estonian Genome Center of University of Tartu,
Member of Council
Scientific work:
During my M.Sc. studies I participated in a large-scale association study,
where potential candidate genes involved in the susceptibility of upper aerodigestive
tract and lung cancer were studied. In my further research I have concentrated on the
population genetics, precisely I have examined the genetic variation in human
genome and its influence on phenotypes. Also, I have studied the genetic structure in
European populations and its influence on whole-genome association studies.
ELULOOKIRJELDUS
Tõnu Esko
Sünniaeg:
Kodakondsus:
Aadress:
Telefon ja e-mail:
27 Jaanuar 1985
Eesti
Tartu Ülikooli Eesti Geenivaramu, 23b Riia,
51010, Tartu, Eesti
+(372) 737 4028; Tonu.Esko@ut.ee
Hariduskäik:
1992-2001
2001-2004
2004-2007
2007-2009
2009-2012
Vändra Gümnasium, Lõpetatud kiitusega
Nõo Reaalgümnaasium, Lõpetatud kiitusega (hõbe medal)
Bakalaureuse kraad geenitehnoloogia erialal, bioloogiageograafiateaduskond, Tartu ülikool, Cum Laude
Magistri kraad geenitehnoloogia erialal, loodus- ja
tehnoloogiateaduskond, Tartu ülikool, Cum Laude
Doktorant, loodus- ja tehnoloogiateaduskond, Tartu ülikool
Erialane teenistuskäik:
2007-…
2008-…
2010-…
Eesti Biokeskus, Genotüpiseerimise spetsialist
Tartu Ülikooli Eesti Geenivaramu, Spetsialist
Tartu Ülikooli Eesti Geenivaramu, Nõukogu liige
Teadustegevus:
Magistrantuuri õpingute ajal osalesin suuremahulise juht-kontrolluuringu
genotüpiseerimise protsessis ning hilisemas andmete analüüsimises. Antud projekti
eesmärgiks oli leida seoseid kandidaatgeenide ja ülemiste hingamisteede-, söögitoruning kopsukasvaja tekkimise vahel. Edasises teadustöös olen tegelenud peamiselt
populatsioonigeneetikaga – uurinud inimese genoomi variatsioone ja nende mõju
fenotüübile. Olen põhjalikumalt uurinud Euroopa populatsioonide geneetilist kaugust
ja selle mõju kogu-genoomi hõlmavatele assotsiatsioonuuringutele.
PUBLICATIONS:
Esko T*, Mezzavilla M*, Nelis M, et al. (2012). Genetic diversity of northeastern
Italian population isolates. Eur J Hum Genet in press
Yang J, Loos RJF, Powell JE, /…/, Esko T et al. (2012). “Genetic effects on
variability: FTO genotype is associated with phenotypic variance of body
mass index”. Nature [Epub ahead of print]
Scott RA, Lagou V, Welch RP, /.../, Esko T et al. (2012). “Large-scale association
analyses identify new loci influencing glycemic traits and provide insight
into the underlying biological pathways”. Nat Genet [Epub ahead of print]
Morris AP, Voight BF, Teslovich TM, /.../, Esko T et al. (2012). “Large-scale
association analysis provides insights into the genetic architecture and
pathophysiology of type 2 diabetes”. Nat Genet [Epub ahead of print]
Boraska V, Jeroncic A, Colonna V, /…/, Esko T et al. (2012). “Genome-wide Metaanalysis of Common Variant Differences between Men and Women”. Hum
Mol Genet [Epub ahead of print]
McQuillan R, Eklund N, Pirastu N, /…/, Esko T et al. (2012). “Evidence of
Inbreeding Depression on Human Height”. PLoS Genet 8(7): e1002655.
arcOGEN Consortium and arcOGEN Collaborators, /…/, Esko T et al. (2012).
“Identification of new susceptibility loci for osteoarthritis (arcOGEN): a
genome-wide association study”. Lancet [Epub ahead of print]
Verhoeven VJ, Hysi PG, Saw SM, /…/, Esko T et al. (2012). “Large scale
international replication and meta-analysis study confirms association of the
15q14 locus with myopia”. Hum Genet [Epub ahead of print]
Ellinghaus D, Ellinghaus E, Nair RP, /…/, Esko T et al. (2012). “Combined analysis
of genome-wide association studies for Crohn disease and psoriasis identifies
seven shared susceptibility loci”. Am J Hum Genet 90(4): 636-47.
Pattaro C, Köttgen A, Teumer A, /…/, Esko T et al. (2012). “Genome-wide
association and functional follow-up reveals new loci for kidney function”.
PLoS Genet 8(3): e1002584
Alavere H, Fischer K, Esko T, Leitsalu-Moynihan L, Metspalu A. (2012). “The
Estonian Genome Center of the University of Tartu at the disposal of
scientists”. Est Med J 91(4): 190-198
Mõttus R, Realo A, Allik J, Deary IJ, Esko T, Metspalu A. (2012). “Personality traits
and eating habits in a large sample of Estonians”. Health Psychol [Epub
ahead of print]
Stolk L, Perry JR, Chasman DI, /…/, Esko T et al. (2011). “Meta-analyses identify 13
loci associated with age at menopause and highlight DNA repair and immune
pathways”. Nat Genet 44(3): 260-8
Luciano M, Lopez LM, de Moor MH, /…/, Esko T et al. (2011). “Longevity
candidate genes and their association with personality traits in the elderly”.
Am J Med Genet B Neuropsychiatr Genet 159B(2): 192-200.
Ellinghaus E, Stuart PE, Ellinghaus D, /…/, Esko T et al. (2011). “Genome-wide
meta-analysis of psoriatic arthritis identifies susceptibility locus at REL”. J
Invest Dermatol 132(4): 1133-40.
Gieger C, Radhakrishnan A, Cvejic A, /…/, Esko T et al. (2011). “New gene
functions in megakaryopoiesis and platelet formation”. Nature 480(7376):
201-8.
Allebrandt KV, Amin N, Müller-Myhsok B, Esko T et al. (2011). “A K(ATP)
channel gene effect on sleep duration: from genome-wide association studies
to function in Drosophila”. Mol Psychiatry [Epub ahead of print]
Surakka I, Isaacs A, Karssen LC, /…/, Esko T et al. (2011). “A genome-wide screen
for interactions reveals a new locus on 4p15 modifying the effect of waist-tohip ratio on total cholesterol”. PLoS Genet 7(10): e1002333.
Chambers JC, Zhang W, Sehmi J, /…/, Esko T et al. (2011). “Genome-wide
association study identifies loci influencing concentrations of liver enzymes
in plasma”. Nat Genet 43(11): 1131-8.
Wain LV, Verwoert GC, O'Reilly PF, /…/, Esko T et al. (2011). “Genome-wide
association study identifies six new loci influencing pulse pressure and mean
arterial pressure”. Nat Genet 43(10): 1005-11.
Jacquemont S, Reymond A, Zufferey F, /…/, Esko T et al. (2011). “Mirror extreme
BMI phenotypes associated with gene dosage at the chromosome 16p11.2
locus”. Nature 478(7367): 97-102.
Strawbridge RJ, Dupuis J, Prokopenko I, /…/, Esko T et al. (2011). “Genome-wide
association identifies nine common variants associated with fasting
proinsulin levels and provides new insights into the pathophysiology of type
2 diabetes”. Diabetes 60(10): 2624-34.
Day-Williams AG, Southam L, Panoutsopoulou K, /…/, Esko T et al. (211). “A
variant in MCF2L is associated with osteoarthritis”. Am J Hum Genet 89(3):
446-50.
Schumann G, Coin LJ, Lourdusamy A, /…/, Esko T et al. (2011). “Genome-wide
association and genetic functional studies identify autism susceptibility
candidate 2 gene (AUTS2) in the regulation of alcohol consumption”. Proc
Natl Acad Sci U S A 108(17): 7119-24.
Speliotes EK, Yerges-Armstrong LM, Wu J, /…/, Esko T et al. (2011). “Genome-
wide association analysis identifies variants associated with nonalcoholic
fatty liver disease that have distinct effects on metabolic traits”. PLoS Genet
7(3): e1001324.
Middeldorp CM, de Moor MH, McGrath LM, /…/, Esko T et al. (2011). “The genetic
association between personality and major depression or bipolar disorder. A
polygenic score analysis using genome-wide association data”. Transl
Psychiatry 1:e50.
Terracciano A, Esko T, Sutin AR et al. (2011). “Meta-analysis of genome-wide
association studies identifies common variants in CTNNA2 associated with
excitement-seeking”. Transl Psychiatry 1:e49.
Panoutsopoulou K, Southam L, Elliott KS, /…/, Esko T et al. (2011). “Insights into
the genetic architecture of osteoarthritis from stage 1 of the arcOGEN
study”. Ann Rheum Dis 70(5): 864-7.
de Moor MH, Costa PT, Terracciano A, /…/, Esko T et al. (2011). “Meta-analysis of
genome-wide association studies for personality”. Mol Psychiatry 17(3):
337-49.
Männik K, Parkel S, Palta P, /…/, Esko T et al. (2011). “A parallel SNP array study
of genomic aberrations associated with mental retardation in patients and
general population in Estonia”. Eur J Med Genet 54(2): 136-43.
Allik J, Realo A, Mõttus R, Esko T et al. (2010). “Variance Determines SelfObserver Agreement on the Big Five Personality Traits”. J Res Person 44(4):
421-26.
Elks CE, Perry JR, Sulem P, /…/, Esko T et al. (2010). “Thirty new loci for age at
menarche identified by a meta-analysis of genome-wide association studies”.
Nat Genet 42(12): 1077-85.
Speliotes EK, Willer CJ, Berndt SI, /…/, Esko T et al. (2010). “Association analyses
of 249,796 individuals reveal 18 new loci associated with body mass index”.
Nat Genet 42(11): 937-48.
Heid IM, Jackson AU, Randall JC, /…/, Esko T et al. (2010). “Meta-analysis
identifies 13 new loci associated with waist-hip ratio and reveals sexual
dimorphism in the genetic basis of fat distribution”. Nat Genet 42(11): 94960.
Lango Allen H, Estrada K, Lettre G, /…/, Esko T et al. (2010). “Hundreds of variants
clustered in genomic loci and biological pathways affect human height”.
Nature 467(7317): 832-8.
Thorgeirsson TE, Gudbjartsson DF, Surakka I, /…/, Esko T et al. (2010). “Sequence
variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior”. Nat
Genet 42(5): 448-53.
Ellinor PT, Lunetta KL, Glazer NL, /.../, Esko T et al. (2010). “Common variants in
KCNN3 are associated with lone atrial fibrillation”. Nat Genet 42(3):240-4.
Walters RG, Jacquemont S, Valsesia A, /.../ Esko T et al. (2010). “A new highly
penetrant form of obesity due to deletions on chromosome 16p11.2”. Nature
463(7281): 671-5.
Nelis M*, Esko T*, Mägi R et al. (2009). “Genetic structure of Europeans: a view
from the North-East”. PLoS ONE 4(5): e5472.
*These authors contributed equally to this work // Antud autorid panustasid võrdselt.