1- amoxicillin :
a- used in Rx. of shigellosis
b- penicillinase resistant
c- it's absorption is better than ampicillin
2 – Amoxycillin:
a-is better absorbed from the G.I.T than ampicillin.T
b-is primarily eliminated by the liver.F
c-is highly effective in H. influenzae infections.T
d-may be used in combination with clavulanic acid for
penicillnase–producingT
bacteria.
3 – Ceftriaxone:
a)
is effective orally.F
b)
crosses the blood – brain barrier.T
c)
is effective against gram – negative bacteria.T
d)
has a long t ½.T
4 – Imipenem:
a)
has a narrow spectrum of antibacterial activity.F
b)
is destroyed by renal dehydropeptidase enzyme.T
c)
is used for the treatment of enterobacter infections.T
d)
may cause seizuresT
5 - Clavulanic acid with amoxillin "correct answer
a)
b)
c)
d)
1
Retard it's renal excretion
Reduce in adverse effect
Inhibit beta lactemase enzyme
Eradicate resistance bacteria
6 - Which of the following cephalosporin is used in Hinfluenza meningitis :
a)
b)
c)
d)
Ciftriaxon
Cefaclor
Cefalxin
Cefnicid
7- Imepenm :
a)
b)
c)
d)
Has narrow spectrum
Is given orally
Need dose adjustment .
Should be given with clavinluic acid .
F
F
T
F
8- Misuse of antibiotics include which one of the following
uses:
Use of antibiotic for fever secondary to bacterial infections.
Use of antibiotics for too short period of time.
Use of combination of antibiotic for mixed bacterial infection.
Start impiric therapy before bacterial identification for critically ill
patients.
9- First drug of choice for gonorrhea is:
Ceftriaxone /IM
Penicillin G /IM
Gentamycin /IM
Piperacillin/ tazobactam (IV)
10- The drug which is used in hospital for treatment of
methicillin resistant staphylococci is:
Amoxicillin.
Ceftriaxone.
Vancomycin.
Cycloserine.
2
11- According to Imipenim, all of the following true except:
Safe in epileptic pt.
Degraded rapidly in the kidney.
Usually given with cilastatin.
Inhibit bacterial cell wall synthesis
12- According to Penicillin G, all are true except:
It is unstable in acidic medium.
Penicillinase resistant
Active against multiplying bacteria.
Narrow spectrum.
13- Usefulness of simullaneous administration of more than
one antimicrobial drug:
To treat mixed infec tion T
To treat sever infections T
To delay emergency of resistance . T
For synergism T
14- According to cephaclor:
a.
It has more effect on gram +ve than cephalexin
F
b.
It is used for prophylaxis from bowel organism
c.
Can cross BBB
d.
Has effect on H.influenza
e.
Can be taken orally
15- Compared to ceflexine, ceftriaxone :
a- Better for treatment of gram negative bacteria (T)
b- Are given orally (F)
c- Cross BBB freely (T)
d- Have longer T ½ (T)
3
F
F
T
T
16- Cefaclor treats all of the following except :
- Meningitis ( Because cefaclor is NOT a 3rd Generation drug
.. only 3rd G cross BBB and so, treat meningitis )
17- Pregnant women with UTI & the microorganisms were
pseudomonas which drugs can be use:
A) Gentamycin: it is contraindicated in preg. as it's crosses
placental barrier& affect fetus.
B) Cefaclone: second generation ,safe with preg.but not
effective
C) Ticarcillin: Extended penicillin, safe with preg.,it`s the
best one.**
D) Ceftriaxon:3rd generation, not contraindicated in preg.,
can be used.
18- Which one has high therapeutic index
A.
Streptomycin
B.
Cephalosporin {cifazoline} (1st generation and
safe)
C.
Vancomycine
D.
Doxycycline
E.
Tetracycline
19- Super infection common with:
A.
Narrow spectrum
B. broad spectrum as it eradicate normal floraAntibiotic which effect on gram +v
20- Bacteriostatic is not advice to use to cure bacterial
infection:
A.
B.
C.
D.
Diabetic patient.
Allergic disorder.** {hypersensitvity}
Patient on corticosteroid therapy.
U.T.I
21- Pharmacokinetics of Penicillin G :
4
A.
excreted rapidly through PCT {√}
B.
High oral bioavailablity. {√}
C.
Does not crosses BBB even when meninges is
inflamed { X } true if the meninges not inflamed.
D.
Metabolized mainly by acetylating reaction.{X} not
metabolized
22- Phenoxy meththicillin is:
A.
Acid stable & oral active
B.
Penicillinase sensitive
C.
Less effective than penicillin G but all are narrow
spectrum.
D.
Used in minor infection.
All are true.
23- regarding pencillin , all these are true except:
a-it is secreted by proximal tubules
b-all narrow spectrum can not be givin orally
c-aminopencillin and 2nd generation of cephalosporin used to
treat H-infunza
d-antistaphylococcal pencillin are resistance to B-lactmase
producer
24- all these antibiotics used in UTI except :
a-sulfa
b-2nd generation of cephalosporin
c-carbapenems
d-aminopencillin
25 - among the reasons of bacterial resistance to
aminoglycosides :
A- mutation (T)
B- Efflux pump (T)
C- failure of antibiotics to penetrate cell wall (T)
D- b/c there is enzyme production that destroy the
antibiotics (F) " lactams ‫" يصير في‬
5
26- Choose the condition in which the drug combination are
broad spectrum:
A.
Pneumonia
B.
Typhoid fever
C.
Syphilis
D.
Peritonitis - diverticulitis - stap wound ** as it is mixed
organisms
6