Trends in Biomedical Science - Lecture 1 Introduction to Trends in Biomedical Science Lecturer: Colin Browne Office: 7318 E-mail: colinbrowne@hallym.ac.kr Subject page: web.hallym.ac.kr/~colinbrowne/Trends Biomedical 2014.htm Office hours for students: 월 10 화 7,10 수 5,8, 목 5,6 Office phone: 2157 Course objectives: 1. This course lets you listen to English lectures about topics in biomedical science. 2. This course also studies trends in biomedical science. Teaching methods: 1. There will be 3 hours of class time per week. 2. The content will be delivered by lecture. 3. There will be activities to practice English reading and listening skills, especially for increasing vocabulary. 4. Course requirements consist of class attendance, classroom tests, a midterm and final exam. A. Most exam and classroom test questions will be multiple choice or fill the gap type questions. B. We will practice the question types in class. 5. I want you to understand all of the content of the course, so, if you get a low grade on a classroom test, you may do a similar test (a retest) to improve your grade. 6. You must send an email to arrange a time. A. Include your name, subject, and time in the email. B. The time should be within the office hours for students (see above). C. The time should be within ten days of getting your grade. Don’t wait. 7. If you get a low grade on the retest, you may do another retest to improve your grade. A. Your first retest grade has to be better than the first classroom test grade. That means you have to show improvement. B. The other conditions about the time for the next retest are the same: send an email to arrange a time within office hours and within ten days of getting your grade. C. You can retest as many times as you want to if your grade is improving each time. 1 Fill in the gaps Course objectives (Second Review): 1. This course lets you listen to English lectures about topics in biomedical science. 2. This course also studies trends in biomedical science. Teaching methods: 1. There will be 3 hours of class time per week. 2. The content will be delivered by lecture. 3. There will be activities to practice English reading and listening skills, especially for increasing vocabulary. 4. Course requirements consist of class attendance, classroom tests, a midterm and final exam. a. Most exam and classroom test questions will be multiple choice or fill the gap type questions. b. We will practice the question types in class. 5. I want you to understand all of the content of the course, so, if you get a low grade on a classroom test, you may do a similar test (a retest) to improve your grade. a. You must send an email to arrange a time. i. Include your name, subject, and time in the email. ii. The time should be within the office hours for students (see above). iii. The time should be within ten days of getting your grade. Don’t wait. 6. If you get a low grade on the retest, you may do another retest to improve your grade. i. Your first retest grade has to be better than the first classroom test grade. That means you have to show improvement. ii. The other conditions about the time for the next retest are the same: send an email to arrange a time within office hours and within ten days of getting your grade. 7. You can retest as many times as you want to if your grade is improving each time. Retest policy and class behavior. 1. Study and prepare to get to a high level. 2. If you do not get a high score on the first test, then I can give you a chance to retest. 3. Score will be determined by the average of the first classroom test and the highest score. TRY TO GET A HIGH SCORE THE FIRST TIME YOU TAKE A TEST. 2 No mobile phone use in class, unless there is a class activity. Using a phone in class, in the first case, will result in the student being restricted to only one retest, and the formula for the score calculated from ((2x First score ) + (Second score) ) / 3. Use of a phone in class, in the second case, will result in the student not being able to have a retest. Concentrate to understand what the lecturer is saying. Concentrate on classroom activities. Sit close enough to the front of the room so you can hear and understand what the teacher is saying. Your test will be timed and your retest can only be done within that time. This means if you finish the test in 10 minutes then you will only have 10 minutes for the retest. You cannot test the same test 2 times within 7 days. All retesting will be finished by the time of the final exam. There will be no retesting after the final exam. ALSO: please use your Hallym email account when arranging for a retest. Learning the words There are many words to learn in this course. Even if you ware an English speaker there are still many words. I have some ways of helping you with those words. Memrise Memrise is a learning program which is a little different, and some fun. Go to this webpage at www.memrise.com 3 Scroll down and you can see where you can download a mobile app. You need to sign up. When you sign up, please use BS and your Student ID as a Username. So if you Student ID is 20119876, then use the Username of BS20119876. Then put in your Hallym email address. Choose any easily remembered password. Agree to the terms of use. Then press Sign up After you have signed up you can enter a course. 4 Content: General: The understanding of life science at the cellular and molecular levels is increasing in all areas, including molecular biology, biochemistry, microbiology, molecular genetics, cell biology, immunology, and virology. Other areas of medical and life science are also advancing, areas such as: general and behavioral genetics; developmental biology; epidemiology; pharmacology, including psychopharmacology; endocrinology, including neuroendocrinology; and neuroscience. We can also see rapid development in areas like stem cell biology, animal cloning, genomics, proteomics, tissue engineering, animal testing, imaging, human experimentation, bioinformatics, and other biomedical technologies. Together these disciplines are being used to solve problems of preventive medicine, behavioral health, cancer, diseases of aging, diabetes, translational research, and many other areas of medicine. Our focus: We cannot study all of these things. We will focus on the brain and nervous system, and we will look at the development of the nervous system, and some diseases of this system. This way we can see how cells and people learn, how long term changes can happen in cells, how some changes can be inherited, and how to study some diseases, their causes and possible treatments. The study will include findings and applications of molecular biology, biotechnological research, bioinformatics, cell biology and more. Understanding cell biology, molecular and biochemical biology, and the development of tools to study these, can help us solve biomedical problems. Vocabulary 2 Break 5 Content: General: The understanding of life science at the cellular and molecular levels is increasing in all areas, including molecular biology, biochemistry, microbiology, molecular genetics, cell biology, immunology, and virology. Other areas of medical and life science are also advancing, areas such as: general and behavioral genetics; developmental biology; epidemiology; pharmacology, including psychopharmacology; endocrinology, including neuroendocrinology; and neuroscience. We can also see rapid development in areas like stem cell biology, animal cloning, genomics, proteomics, tissue engineering, animal testing, imaging, human experimentation, bioinformatics, and other biomedical technologies. Together these disciplines are being used to solve problems of preventive medicine, behavioral health, cancer, diseases of aging, diabetes, translational research, and many other areas of medicine. Together these disciplines are being used to solve problems of preventive medicine, behavioral health, cancer, diseases of aging, diabetes, translational research, and many other areas of medicine. Our focus: We cannot study all of these things. We will focus on the brain and nervous system, and we will look at the development of the nervous system, and some diseases of this system. This way we can see how cells and people learn, how long term changes can happen in cells, how some changes can be inherited, and how to study some diseases, their causes and possible treatments. The study will include findings and applications of molecular biology, biotechnological research, bioinformatics, cell biology and more. Weekly classes: Introduction to trends in biomedical science Review of cells Structure of cells Special cells – neurons Structure of neurons Neurotransmitters How do different neurons develop? Development of the nervous system. Transcription factors and cell receptors 6 Epigenetics – effects of early stress? Epigenetics – can your parents affect your brain now? Classroom test 20% Big data in Biomedical science Structural biology Learning and memory and cell structure Metabolomics Science of behavior change Summation and exam preparation Midterm Exam 10% Drugs and brain function Molecular libraries Searching for drugs and targets Treating disease of the brain The brain initiative The human microbiome New correlations of microbes and disease Brain Stem Cells Stem Cells and brain repair Classroom Test 20% Brain damage and possible prevention Brain damage and possible treatment Diseases of aging Possible prevention and possible treatments of diseases of aging RNA does many things Classroom Test 20% Extracellular RNA End of term Exam 20% 7 Some information will be available at "The Brain from Top to Bottom" http://thebrain.mcgill.ca/. This presents the information at different levels of organization and different levels of difficulty. Please download "Brain Facts - a primer on the brain and nervous system" http://www.brainfacts.org/~/media/Brainfacts/Article%20Multimedia/About%2 0Neuroscience/Brain%20Facts%20book.ashx I will also try to integrate new and important findings in biomedical science into the course. So I will include information from such websites as: http://www.nobelprize.org/nobel_prizes/medicine/ - the site for the Nobel prize in physiology or medicine http://commonfund.nih.gov/ - the site of the US National Institutes of Health “Common Fund” project which supports cross-departmental research. Why are we looking at the brain and nervous system? With nearly 100 billion neurons and 100 trillion connections, the human brain remains one of the greatest mysteries in science and one of the greatest challenges in medicine. Neurological and psychiatric disorders, such as Alzheimer’s disease, Parkinson’s disease, autism, epilepsy, schizophrenia, depression, and traumatic brain injury, exact a tremendous toll on individuals, families, and society. Despite the many advances in neuroscience in recent years, the underlying causes of most of neurological and psychiatric conditions remain largely unknown, due to the vast complexity of the human brain. Neuroscience advanced quickly over the past 50 years. Sometimes this is because of new technologies, like those of molecular biology, neuroimaging, and computer and information science. This progress plus new tools and techniques helps us understand the brain and how the brain’s activities result in mental activity. Neuroscience is multidisciplinary including biology, psychology, neurology, chemistry, mathematics, physics, engineering, computer science, and more. How does our physical body give rise to a person who can think, love, learn, and dream? Neuroscience has advanced to the point where answering those questions is truly possible. Advances in imaging technology, computer science, molecular biology, biochemistry, and neuroscience in general had made it possible for us to imagine understanding how the brain works at a fundamental level How does the brain work and produce mental activity? How does physical activity in the brain give rise to thought, emotion, and behavior? How does the interplay of biology and experience shape our brains and make us who we are today? How do we keep our brains healthy? How do we protect, restore, or enhance the functioning of our brains as we age? 8