Official Company Communication
LifePak Nano delivers periodontal benefits comparable to PF3
The following table compares the periodontal-relevant ingredients of LifePak Nano with PF3.
Comments and discussion are found below the chart.
Nutrient
Vitamin A
Beta-carotene
Vitamin C
Vitamin B6
Folate
Vitamin B12
Vitamin E
Zinc
Selenium
Copper
Green Tea Catechins (from
Tegreen 97)
Quercetin
Citrus Bioflavonoids
Alpha-Lipoic Acid
Marine Lipid Concentrate
Phylox
Vitamin K
Thiamin
Riboflavin
Niacin
Biotin
Pantothenic Acid
Calcium
Vitamin D
Phosphorous
Iodine
Magnesium
Manganese
Chromium
Molybdenum
Resveratrol
Grape Seed Polyphenols
N-acetyl L-cysteine
CoQ10
Inositol
Lycopene
Alpha Carotene
Zeaxanthin
Astaxanthin
Lutein
Silicon
Vanadium
Other Tocopherols
Boron
Daily dose of LifePak Nano
2500 IU
12500 IU (7.5 mg)
500 mg
10 mg
600 mcg
60 mcg
200 IU
15 mg
140 mcg
1 mg
90 mg Catechins (from 140 mg
TG)
50 mg
50 mg
50 mg
3700 mg
Daily does in PF3
20,000 IU (12 mg)
800 mg
20 mg
800 mcg
60 mcg
120 IU
15 mg
100 mcg
1 mg
642.8 mg Catechins (from 1000 mg
TG)
50 mg
50 mg
60 mg
250 mg
40 mcg
7.5 mg
8.5 mg
35 mg
300 mcg
30 mg
600 mg
600 IU
125 mg
100 mcg
300 mg
2 mg
200 mcg
75 mcg
2.5 mg
25 mg
50 mg
5 mg
10 mg
5 mg
2 mg
0.5
0.5
2 mg
10 mg
20 mcg
100 mg
3 mg
Legend
Periodontal relevant
ingredient supported
by references below
Contains more of this
ingredient compared
to other product
Equal amounts
between the two
products
Not found in
the other
product
LifePak Nano delivers periodontal benefits comparable to PF3
LifePak Nano was designed to provide nutritional support for all body systems and organs, including oral
health. Among the nutrients in LifePak Nano, many directly support periodontal health. The table above
illustrates the similar periodontal-relevant ingredient-profiles between PF3 and LifePak Nano. In some
cases PF3 contains slightly higher amounts of a few ingredients, and in other cases LifePak Nano
delivers more—but both products deliver most periodontal-relevant ingredients in relatively similar
amounts. Of course due to its broader scope—LifePak Nano contains many nutrients beyond just
periodontal supporting nutrition.
LifePak Nano and PF3 both support the three most relevant areas of oral nutrition, 1) Antioxidant
Protection; 2) Nutritional Support for Healthy Oral Tissues and 3) Maintenance of Inflammatory Balance,
but not always through the same nutrients.
Both products include ingredients that confer antioxidant protection throughout the body, including
protection of gum tissues. While PF3 includes higher amounts of some antioxidants such as betacarotene and vitamin C, LifePak nano provides a greater variety of antioxidants such as resveratrol,
quercetin, tocopherols, vitamin C and a blend of carotenoids (beta-carotene, lycopene, lutein,
astaxanthin, zeaxanthin and alpha-carotene), in support of the broader antioxidant network.
Both products promote healthy gum structures by providing B vitamins and ascorbic acid (vitamin
C).While PF3 contains higher levels of ascorbic acid, LifePak Nano provides a more comprehensive
blend of B vitamins.
While PF3 contains the inflammatory-balancing benefits from the proprietary ingredient Phylox and higher
levels of Tegreen, LifePak Nano delivers the inflammatory-balancing benefits of nearly 4 grams of marine
lipid concentrate. Other nutrients in LifePak Nano that help to maintain inflammatory balance in the body,
including the gum tissues, include gamma-tocopherol, astaxanthin, N-acetylcysteine and grape seed
polyphenols,
Furthermore, LifePak Nano delivers meaningful levels of essential bone nutrients such as calcium,
magnesium, vitamin D, manganese, phosphorous, silicon, vitamin K, copper and boron all of which help
to support the health of oral bone structures.
LifePak Nano will deliver periodontal benefits comparable to the benefits of PF3. In fact, it was the
enthusiasm of Oral Healthcare Professionals reporting the periodontal benefits they observed in their
clients taking LifePak products that served as the impetus for Pharmanex to formulate PF3.
References and abstract of recent research is provided below on some of LifePak Nano’s periodontalrelevant nutrients not found in PF3. For a list of references that support LifePak Nano’s ingredients
shared with PF3 please refer to PF3 technical overview.
Periodontal relevance of Omega-3 fatty acids (from marine lipid concentrate):
1. Chapple IL. Potential mechanisms underpinning the nutritional modulation of periodontal
inflammation. J Am Dent Assoc. 2009 Feb;140(2):178-84.
2. Raffaelli L, Serini S, Piccioni E, Manicone PF, Berardi D, Perfetti G, Calviello G. N-3
polyunsaturated fatty acid effect in periodontal disease: state of art and possible mechanisms
involved. Int J Immunopathol Pharmacol. 2008 Apr-Jun;21(2):261-6.
3. Kesavalu L, Bakthavatchalu V, Rahman MM, Su J, Raghu B, Dawson D, Fernandes G, Ebersole
JL. Omega-3 fatty acid regulates inflammatory cytokine/mediator messenger RNA expression in
Porphyromonas gingivalis-induced experimental periodontal disease. Oral Microbiol Immunol.
2007 Aug;22(4):232-9.
LifePak Nano delivers periodontal benefits comparable to PF3
4. Kesavalu L, Vasudevan B, Raghu B, Browning E, Dawson D, Novak JM, Correll MC, Steffen MJ,
Bhattacharya A, Fernandes G, Ebersole JL. Omega-3 fatty acid effect on alveolar bone loss in
rats. J Dent Res. 2006 Jul;85(7):648-52.
Periodontal relevance of antioxidants:
5. Beck JD, Offenbacher S, Williams R, Gibbs P, Garcia R. Periodontitis: a risk factor for coronary
heart disease? Ann Periodontol. 1998 Jul;3(1):127-41.
6. Blum A, Front E, Peleg A. Periodontal care may improve systemic inflammation. Clin Invest Med.
2007;30(3):E114-7.
7. Chapple IL, Milward MR, Dietrich T. The prevalence of inflammatory periodontitis is negatively
associated with serum antioxidant concentrations. J Nutr. 2007 Mar;137(3):657-64.
8. Chapple IL, Brock GR, Milward MR, Ling N, Matthews JB. Compromised GCF total antioxidant
capacity in periodontitis: cause or effect? J Clin Periodontol. 2007 Feb;34(2):103-10. Epub 2006
Dec 13.
9. Demmer and Desvarieux Periodontal infections and cardiovascular disease: the heart of the
matter. JADA 2006;137: 4-20S.
10. Fentoglu and Bozkurt The Bi-Directional Relationship between Periodontal Disease and
Hyperlipidemia. Eur J Dent 2008; 2:142-49.
11. Watts A, Crimmins EM, Gatz M. Inflammation as a potential mediator for the association between
periodontal disease and Alzheimer's disease. Neuropsychiatr Dis Treat. 2008 Oct;4(5):865-76.
12. Chandra RV, Prabhuji ML, Roopa DA, Ravirajan S, Kishore HC. Efficacy of lycopene in the
treatment of gingivitis: a randomised, placebo-controlled clinical trial. Oral Health Prev Dent.
2007;5(4):327-36.
Periodontal relevance of grape extracts (resveratrol, and grape seed extract):
13. Wu CD. Grape products and oral health. J Nutr. 2009 Sep;139(9):1818S-23S.
14. Houde V, Grenier D, Chandad F. Protective effects of grape seed proanthocyanidins against
oxidative stress induced by lipopolysaccharides of periodontopathogens. J Periodontol. 2006
Aug;77(8):1371-9.
15. Park HJ, Jeong SK, Kim SR, Bae SK, Kim WS, Jin SD, Koo TH, Jang HO, Yun I, Kim KW, Bae
MK. Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial
adhesion molecule expression by suppressing NF-kappaB activation. Arch Pharm Res. 2009
Apr;32(4):583-91.
16. Andreou V, D'Addario M, Zohar R, Sukhu B, Casper RF, Ellen RP, Tenenbaum HC. Inhibition of
osteogenesis in vitro by a cigarette smoke-associated hydrocarbon combined with
Porphyromonas gingivalis lipopolysaccharide: reversal by resveratrol. J Periodontol. 2004
Jul;75(7):939-48.
17. Singh SU, Casper RF, Fritz PC, Sukhu B, Ganss B, Girard B Jr, Savouret JF, Tenenbaum HC.
Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon
receptor antagonist, resveratrol. J Endocrinol. 2000 Oct;167(1):183-95.
LifePak Nano delivers periodontal benefits comparable to PF3
Periodontal relevance of calcium & vitamin D:
18. Miley DD, Garcia MN, Hildebolt CF, Shannon WD, Couture RA, Anderson Spearie CL, Dixon DA,
Langenwalter EM, Mueller C, Civitelli R. Cross-sectional study of vitamin D and calcium
supplementation effects on chronic periodontitis. J Periodontol. 2009 Sep;80(9):1433-9.
Periodontal relevance of N-acetyl L-cysteine:
19. Kim do Y, Jun JH, Lee HL, Woo KM, Ryoo HM, Kim GS, Baek JH, Han SB. N-acetylcysteine
prevents LPS-induced pro-inflammatory cytokines and MMP2 production in gingival fibroblasts.
Arch Pharm Res. 2007 Oct;30(10):1283-92.